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Kasugai, Japan

Chubu University is located in Kasugai, Aichi, Japan. It was founded in 1938 by Kohei Miura, originally a professor at Nagoya Institute of Technology. Masters courses were added in 1971, and Doctoral courses in 1973.The school has courses in many disciplines in both the humanities and the science.The university has a number of affiliations with foreign schools, including Universiti Sains Malaysia, Longwood University , Royal Melbourne Institute of Technology , University of Newcastle , University of Essex , Ohio University , West Virginia University , Wonkwang University , and Harbin Institute of Technology . Wikipedia.

Kobayashi T.,Chubu University
Biotechnology Journal | Year: 2011

Magnetic-nanoparticle-mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue followed by application of an external alternating magnetic field that induces heat through Néel relaxation loss of the magnetic nanoparticles. The temperature in tumor tissue is increased to above 43°C, which causes necrosis of cancer cells, but does not damage surrounding normal tissue. Among magnetic nanoparticles available, magnetite has been extensively studied. Recent years have seen remarkable advances in magnetite-nanoparticle-mediated hyperthermia; both functional magnetite nanoparticles and alternating-magnetic-field generators have been developed. In addition to the expected tumor cell death, hyperthermia treatment has also induced unexpected biological responses, such as tumor-specific immune responses as a result of heat-shock protein expression. These results suggest that hyperthermia is able to kill not only local tumors exposed to heat treatment, but also tumors at distant sites, including metastatic cancer cells. Currently, several research centers have begun clinical trials with promising results, suggesting that the time may have come for clinical applications. This review describes recent advances in magnetite nanoparticle-mediated hyperthermia. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Teshima T.,Chubu University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We analyzed the S 3 invariant Higgs potential with S 3 singlet and doublet Higgs. We obtained a relation (|v 1|/|v 2|)2=-sin 2φ 2/sin 2φ 1 from this S 3 invariant Higgs potential, where v 1, v 2 and φ 1, φ 2 are vacuum expectation values and phases of S 3 doublet Higgs, respectively. This relation could be satisfied exactly by the results |v 1|/|v 2|=0.207, φ 1=-74.9°, and φ 2=0.74° obtained from our previous work analyzing the quark/lepton mass and mixing in the S 3 invariant Yukawa interaction. Furthermore, the relation v S∼v D=√|v 1|2+|v 2|2=174GeV is obtained, and then the coupling strength of the Higgs to the top quark gH Stt=m t/v S is altered by a factor √2 from the standard value. Introducing the S 3 doublet Higgs, flavor changing neutral currents are produced at tree level. The predicted branching ratios for rare decays μ -→e -e +e -, KL0→μ +μ -, etc., induced by the flavor changing neutral currents, are sufficiently below the present experimental upper bounds. © 2012 American Physical Society. Source

Tsuda T.,Chubu University
Molecular Nutrition and Food Research | Year: 2012

Anthocyanins are one type of flavonoid phytopigment. Although the role of anthocyanins as a functional food factor remains relatively less established than that of other flavonoids, progress in this area has been made at the molecular level in recent years. This review discusses the potential health benefits of plant-derived anthocyanin-rich foods, with a focus on the role of anthocyanins in obesity control, diabetes control, cardiovascular disease prevention, and improvement of visual and brain functions, areas that have attracted much attention. Such health benefits are not necessarily derived from the antioxidant effect of anthocyanins, but in fact are produced by currently unestablished chemical properties beyond the antioxidant capacity of the molecules. However, a better understanding of the physiological functionality of anthocyanins remains to be elucidated. It is desirable, therefore, to clarify the molecular type and composition of the anthocyanins that confer specific health benefits and to conduct further investigation into the underlying molecular mechanisms. The pharmacological actions of anthocyanins could not be fully established without knowledge on the effects of treatment of anthocyanins alone, the effects of non-anthocyanin components, and the possible interactions between anthocyanin and non-anthocyanin species. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Yokoyama S.,Chubu University
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids | Year: 2014

Cholesteryl ester transfer protein (CETP)-deficiency manifests a unique plasma lipoprotein profile without other apparent symptoms. It is highly common in East Asia while rather rare anywhere else. A potential environmental screening factor(s) may therefore contribute to this eccentric distribution, such as its selective advantage against a regional illness, most likely an infectious disease, in relation to plasma lipoproteins. Blood flukes use the host plasma lipoproteins as nutrient sources through the lipoprotein receptor-like systems. Its Asian-specific species, Schistosoma (S) japonicum, which has been endemic in East Asia, takes up cholesteryl ester (CE) from high-density lipoprotein (HDL) for the embryonation of their eggs to miracidia, a critical step of the hepatic pathogenesis of this parasite, but poorly from HDL of CETP-deficiency. CD36-related protein (CD36RP) was cloned from the adults and the eggs of S. japonicum, with 1880-bp encoding 506 amino-acid residues exhibiting the CD36 domains and two transmembrane regions. Its extracellular domain selectively bound human HDL but neither LDL nor CETP-deficiency HDL, and the antibody against the extracellular domain suppressed the selective HDL-CE uptake and embryonation of the eggs. When infected with S. japonicum, wild-type mice developed less hepatic granulomatosis than CETP-transgenic mice by the ectopic egg embryonation. CD36RP is thus a candidate receptor of S. japonicum to facilitate uptake of HDL-CE necessary for egg embryonation. Abnormal HDL caused by CETP-deficiency retards this process and thereby protects the patients from development of hepatic lesions. S. japonicum infection is a potential screening factor for high prevalence of CETP deficiency in East Asia. © 2013 Elsevier B.V. Source

Hashimoto M.,Chubu University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

In this note, we study the coupling of the technidilaton to the weak bosons. We consider two cases: (1) The dilaton directly couples to the weak bosons in a similar way as in the standard model. (2) The coupling in question is effectively induced only through the technifermion loops. In both cases, we find that the coupling is essentially determined by the mass-squared of the weak bosons over the dilaton decay constant. © 2011 American Physical Society. Source

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