Chuanyu Branch of China Tobacco Corporation

Chengdu, China

Chuanyu Branch of China Tobacco Corporation

Chengdu, China
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Liu H.,Beijing Technology and Business University | Tao F.,Chuanyu Branch of China Tobacco Corporation | Sun B.,Beijing Technology and Business University | Yang S.,Beijing Technology and Business University | And 2 more authors.
Journal of Chemical Research | Year: 2015

1-Undecen-4-ol was converted into its benzyl ether in 92% yield by reaction with benzyl chloride in the presence of NaH and was then oxidised with a ruthenium catalysis to give the corresponding aldehyde, which was treated directly with ethylene glycol in the presence of pyridinium p-toluenesulfonate to produce 2-(2′-benzyloxynonyl)-1,3-dioxolane in an overall yield of 87%. This intermediate underwent deprotection of the benzyloxy group and mesylation to give 2-(2′-mesyloxynonyl)-1,3-dioxolane in 90% yield, treatment of which with sodium methyl mercaptide followed by cleavage of the 1,3-dioxolane group afforded 3-methylthiodecanal in 81% yield.


Ma B.,Beijing Technology and Business University | Yang S.,Beijing Technology and Business University | Tao F.,Chuanyu Branch of China Tobacco Corporation | Sun B.,Beijing Technology and Business University | And 2 more authors.
Journal of Chemical Research | Year: 2015

4-Acetoxy-2-propyltetrahydrothiophene was synthesised from 1-hepten-4-ol by a three-step route involving epoxidation and mesylation to 1,2-epoxy-4-heptyl mesylate and then reaction with thioacetate. An acetoxylated cyclic product was formed instead of the expected thioacetate, and a mechanism for its formation using an intramolecular transesterification is proposed.


Tao F.,Sichuan University | Tao F.,Chuanyu Branch of China Tobacco Corporation | Dai Y.,Chuanyu Branch of China Tobacco Corporation | Wang C.,Chuanyu Branch of China Tobacco Corporation | And 6 more authors.
Bioorganic Chemistry | Year: 2014

A cobalt porphyrin (CY-B) was presented, and its interaction with tobacco-specific nitrosamines (TSNAs) was investigated by UV-Vis spectroscopy and high-resolution mass spectrometry. The results revealed that the stoichiometry of the host-guest interaction was 1:2 and that the binding constant between CY-B and TSNAs was within the range of 0.78 × 10 8-7.83 × 108 M-2. The coordination strength between CY-B and TSNAs decreased in the sequence of NNN > NAB > NAT > NNK based on the binding constant. The interaction mechanism of CY-B with TSNAs involved a coordination interaction, and the π-π interaction between the porphyrin macrocycle and the aromatic frame of the TSNAs pyridines may also have been a driving force. The measured thermodynamic properties demonstrated that the reaction of CY-B with TSNAs was spontaneous and that the driving force for the interaction was a change in enthalpy. The reaction was exothermic, and an increasing temperature inhibited the interaction. The IR spectrum of the complex revealed that the NNO group of TSNAs and the metal cobalt of CY-B formed the six-coordinate complex. © 2014 Elsevier Inc. All rights reserved.


Tao F.Y.,Sichuan University | Tao F.Y.,Chuanyu Branch of China Tobacco Corporation | Wang C.G.,Chuanyu Branch of China Tobacco Corporation | Ma K.Y.,Chuanyu Branch of China Tobacco Corporation | And 5 more authors.
Journal of Porphyrins and Phthalocyanines | Year: 2013

Two protoporphyrin derivatives were prepared by a facile method using inexpensive hemin as starting material. They were added to cigarette filters to reduce the carcinogenic tobacco specific N-nitroamines (TSNAs), especially toward NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) and NNN (N-nitrosonornicotine) for environment protection and public health. The reduction level of TSNAs was reached to 37.6% from MSS, with greater reductions when more porphyrin was included in the filter. The decrease level for NNK by protoporphyrin derivatives is more effective than NNN. The interaction between protoporphyrin derivatives and TSNAs (NNK and NNN) were investigated by fluorescence spectra and UV-visible titration. The correlation coefficients were 0.978∼0.997 and the binding constants was the scope from 1.26 × 103 to 4.04 × 104. The interaction mechanisms between protoporphyrin derivatives and, NNK and NNN are possibly the co-interaction of hydrogen bond binding and strong π-π stacking. © 2013 World Scientific Publishing Company.


PubMed | Chuanyu Branch of China Tobacco Corporation and Sichuan University
Type: | Journal: Bioorganic chemistry | Year: 2014

A cobalt porphyrin (CY-B) was presented, and its interaction with tobacco-specific nitrosamines (TSNAs) was investigated by UV-Vis spectroscopy and high-resolution mass spectrometry. The results revealed that the stoichiometry of the host-guest interaction was 1:2 and that the binding constant between CY-B and TSNAs was within the range of 0.7810(8)-7.8310(8)M(-2). The coordination strength between CY-B and TSNAs decreased in the sequence of NNN>NAB>NAT>NNK based on the binding constant. The interaction mechanism of CY-B with TSNAs involved a coordination interaction, and the - interaction between the porphyrin macrocycle and the aromatic frame of the TSNAs pyridines may also have been a driving force. The measured thermodynamic properties demonstrated that the reaction of CY-B with TSNAs was spontaneous and that the driving force for the interaction was a change in enthalpy. The reaction was exothermic, and an increasing temperature inhibited the interaction. The IR spectrum of the complex revealed that the NNO group of TSNAs and the metal cobalt of CY-B formed the six-coordinate complex.


Ma K.,Sichuan Key Laboratory Technical Research Center | Ma K.,Chuanyu Branch of China Tobacco Corporation | Yu H.,Sichuan Key Laboratory Technical Research Center | Yu H.,Chuanyu Branch of China Tobacco Corporation | And 6 more authors.
Journal Wuhan University of Technology, Materials Science Edition | Year: 2014

The core-shell structures of ZSM-5 coated with mesoporous silica were synthesized by means of dodecylamine (DDA) surfactant. The results show that the mesoporous silica shells are coated on ZSM-5 cores and result in the formation of hierarchical porous structures. The thickness of the coating shell can be controlled by changing the adding amount of TEOS. The core-shell composites with the thickness of 35 nm possess high surface areas (about 528 m2·g−1), large pores (about 3.5 nm in diameter) on the silica shells. The composite molecular sieves display higher adsorption capacity for benzene (140.2 mg·g−1) and butyraldehyde (213.7 mg·g−1) than that of pristine ZSM-5 for benzene (99.2 mg·g−1) and butyraldehyde (134.7 mg·g−1). The composite molecular sieves show a wide application foreground for harmful gas adsorbent for environmental protection. © 2014, Wuhan University of Technology and Springer-Verlag Berlin Heidelberg.


Wang C.,Chuanyu Branch of China Tobacco Corporation | Dai Y.,Chuanyu Branch of China Tobacco Corporation | Feng G.,Chuanyu Branch of China Tobacco Corporation | Yang W.,Chuanyu Branch of China Tobacco Corporation | And 4 more authors.
Toxicological and Environmental Chemistry | Year: 2011

Cigarette filters were modified with a combination of gingko biloba extract and cobalt porphyrin (CGC) to remove harmful components from the cigarette smoke and reduce its toxicity. Smoke analysis results indicated that CGC eliminated up to 32% of benzo[a]pyrene (B[a]P), 52% of N-nitrosonornicotine (NNN), 46% of N-nitrosoanabasine (NAB), 35% of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK), 31% of N-nitrosoanatabine (NAT), 30% of gas-phase free radicals, and 33% of solid-phase free radicals. Biological experiments, including the Ames test, neutral red cytotoxicity assay and chronic toxicity, were conducted for both CGC cigarettes and control cigarettes. Results showed that the toxicity of the CGC cigarettes was lower than those of the control cigarettes. The mechanism by which the CGC components could remove harmful components from cigarette smoke is discussed. © 2011 Copyright Taylor and Francis Group, LLC.


Feng G.,Chuanyu Branch of China Tobacco Corporation | Li L.,Chuanyu Branch of China Tobacco Corporation | Li D.,Chuanyu Branch of China Tobacco Corporation | Li N.,Chuanyu Branch of China Tobacco Corporation | Dai Y.,Chuanyu Branch of China Tobacco Corporation
Advanced Materials Research | Year: 2011

Grey optimum analysis and grey equal weight cluster analysis were used to compare the chemical compositions and quality of flue-cured tobacco leaf samples from southwest China. Results showed that the sugar-protein ratio, sugar-nicotine ratio, total amount of ether extract, total alkaloid content, pH, protein content, and potassium-chloride ratio were the chemical composition indices most closely related to the sensory quality. These were used to evaluate and compare the tobacco leaf quality by grey equal weight cluster analysis. Based on the grey equal weight cluster analysis, the 30 samples of flue-cure tobacco from southwest China were divided into two grey categories. The grey categories were verified by using them to selecting similar and different substitutes for a target tobacco in a mixed tobacco formula. The new formula with the similar substitute produced comparable sensory quality results to the original formula, and formula containing the different substitute had dissimilar sensory qualities to the original formula. These results confirm that the joint application of grey optimum analysis and grey equal weight clustering has a high degree of confidence for comparison of tobacco leaf quality. © (2011) Trans Tech Publications, Switzerland.


Wang C.,Chuanyu Branch of China Tobacco Corporation | Dai Y.,Chuanyu Branch of China Tobacco Corporation | Feng G.,Chuanyu Branch of China Tobacco Corporation | He R.,Chuanyu Branch of China Tobacco Corporation | And 5 more authors.
Journal of Agricultural and Food Chemistry | Year: 2011

Tobacco-specific N-nitrosamines (TSNAs) and benzo[a]pyrene (B[a]P) in mainstream cigarette smoke (MSS) cause smoking-related diseases and environmental pollution. Porphyrins were added to cigarette filters to reduce B[a]P (porphyrins A-E) and TSNAs (porphyrin F) in MSS. The porphyrin-B[a]P and porphyrin F-TSNAs (N′-nitrosoanabasine (NAB), N′-nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N-nitrosonornicotine (NNN)) interactions were investigated by fluorescence quenching and UV-visible spectroscopy. The correlation coefficients were 0.987-0.997 (B[a]P) and 0.994-0.999 (TSNAs), and the binding constants were (1.67-5.02) × 105 (B[a]P) and 3.42 × 103-1.40 × 104 (TSNAs). Up to 36.72% of B[a]P and 46.67% of the TSNAs were eliminated from MSS, with greater reductions when more porphyrin was included in the filter. With the same mass of porphyrin in the filter, the reduction trend for B[a]P by porphyrins A-E was A > B > C > D > E. The reduction trend for TSNAs by porphyrin F was NNN > NAB > NNK > NAT. The porphyrin mode of action is possibly through strong π-π interactions. © 2011 American Chemical Society.


PubMed | Chuanyu Branch of China Tobacco Corporation
Type: Journal Article | Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering | Year: 2010

In this study, ginkgo biloba leaf extract (GBE) was added to sample cigarettes, including in the filter (0.8 mg/cigarette) and/or the cut filler (0.8 mg/cigarette). The effects of GBE in scavenging free radicals and reducing mutagenicity and toxicity of cigarette smoke in vivo were investigated. Smoke analysis results indicated that GBE eliminated up to 30% of free radicals. Biological experiments, conducted for both GBE cigarettes and control samples, included the Ames test, acute toxicity, neutral red cytotoxicity assay and chronic toxicity. Results showed that the mutagenicity and toxicity of the GBE cigarettes were lower than for the control cigarettes. A possible mechanism of GBE in scavenging free radicals is discussed in this article.

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