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Bardaa S.,University of Sfax | Jridi M.,University of Sfax | Moalla D.,University of Sfax | Mseddi M.,CHU Hedi Chaker Sfax | And 2 more authors.
Journal of Surgical Research | Year: 2016

Background Despite the achievements in modern medicine, there is no effective natural treatment of second-degree burns till now. Therefore, the purpose of this study was to assess the wound-healing efficiency of three extracted oils, from the prickly pear, pumpkin and linseed on partial-thickness burns induced by fractional CO2 laser (an innovative up-to-date technique) in rats. Materials and methods Thirty rats completing partial-thickness burns by fractional CO2 laser were randomly divided into five groups. The burns were measured, photographed, and topically treated daily with saline solution, "CYTOL BASIC," pumpkin-, linseed-, and prickly pear-extracted oils (0.52 μL/mm2 of oil) until day 7. The response to treatments was assessed by macroscopic, histologic, and biochemical parameters. Results Due to their chemical composition, the extracted oils showed significant improvements over the control and reference groups during the trial for both general wound appearance and crusting. On day 7, the prickly pear, linseed, and pumpkin oils showed a significant decrease in the healing time (0 cm2, 0.15 cm2, and 0.18 cm2, respectively) when compared to the control and reference groups (1.49 cm2 and 0.85 cm2). Histologic assessment of the prickly pear oil-treated group revealed good healing proprieties compared with the other groups. The collagen content in prickly pear oil-treated group was found to be significantly greater (270.67 ± 7.48) than that in all other groups. Conclusions Our experiment has shown, for the first time, a scientific evidence of the efficiency of extracted oils of prickly pear, pumpkin, and linseed on partial-thickness burns. © 2016 Elsevier Inc. All rights reserved.

Ksouda K.,University of Sfax | Affes H.,University of Sfax | Atheymen R.,University of Sfax | Ezzeddine M.,CHU Hedi Chaker Sfax | And 2 more authors.
Indian Journal of Pharmacology | Year: 2014

Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.

FAST-MI Tunisian registry was initiated by the Tunisian Society of Cardiology and Cardio-vascular Surgery to assess characteristics, management, and hospital outcomes in patients with ST-elevation myocardial infarction (STEMI). Methods: We prospectively collected data from 203 consecutive patients (mean age 60.3 years, 79.8 % male) with STEMI who were treated in 15 public hospitals (representing 68.2 % of Tunisian public centres treating STEMI patients) during a 3-month period at the end of 2014. The most common risk factor was tobacco (64.9 %), hypertension (38.6 %), diabetes (36.9 %) and dyslipidemia (24.6 %). Results: Among these patients, 66 % received reperfusion therapy, 35 % with primary percutaneous coronary interventions (PAMI), 31 % with thrombolysis (28.6 % of them by pre-hospital thrombolysis). The median time from symptom onset to thrombolysis was 185 and 358 min for PAMI, respectively. The in-hospital mortality was 7.0 %. Patients enrolled in interventional centers (n= 156) were more likely to receive any reperfusion therapy (19.8 % vs 44.6 %; p< 0.001) than at the regional system of care with less thrombolysis (26.9 % vs 44.6 %; p= 0.008) and more PAMI (52.8 % vs 8.5 %; p< 0.0001). Also the in-hospital mortality was lower (6.4 % vs 9.3 %) but not significant. Conclusions: Preliminary results from FAST-MI in Tunisia show that the pharmaco- invasive strategy should be promoted in non-interventional centers. © 2015.

PubMed | CHU Hedi Chaker Sfax
Type: Journal Article | Journal: La Tunisie medicale | Year: 2010

Adolescents present specific sanitary needs, linked to the physical and psychological mutations that occur during this vulnerable period of life. These needs remain little known in Tunisia. But : To describe epidemiological profile of morbidity of teenagers hospitalized in Hedi Chakers hospital center of Sfax, during a period of 5 years, between 2003 and 2007.Data exploitation of the descriptive survey of morbidity and mortality of hospitalized adolescents.During the study, 2963 adolescents of 10 to 19 years have been hospitalized (5.1 % of total of hospitalizations). Paediatrics received 36.9 % of adolescents. Paediatrics, haematology and infectious diseasess services received 58.5 % of them. According to the groups of diagnosis, genitourinary and endocrines diseases, dominate for girls, whereas infectious and parasitic diseases and tumors touched more boys. Diabetes, signs and general symptoms, leukaemia and anaemia, were the most frequent pathologies.Taking care of teenagers is often parcelled out on several hospitable services. Therefore, the improvement of the greeting services, in order to answer the teenagers relational needs home a temporary solution, while hoping, the setting up of units or specific services of adolescents that showed evidence of their utility for the development of the medicine of the teenagers in the industrialized countries.

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