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Dreuil-lès-Amiens, France

Pham T.,Marseille University Hospital Center | Bachelez H.,CHU Saint Louis | Berthelot J.-M.,Nantes University Hospital Center | Blacher J.,CHU Hotel Dieu | And 32 more authors.
Joint Bone Spine | Year: 2011

Objectives: To develop and/or update fact sheets about TNFα antagonists treatments, in order to assist physicians in the management of patients with inflammatory joint disease. Methods: selection by a committee of rheumatology experts of the main topics of interest for which fact sheets were desirable;. Identification and review of publications relevant to each topic;. Development and/or update of fact sheets based on three levels of evidence: evidence-based medicine, official recommendations, and expert opinion. The experts were rheumatologists and invited specialists in other fields, and they had extensive experience with the management of chronic inflammatory diseases, such as rheumatoid. They were members of the CRI (Club Rhumatismes et Inflammation), a section of the Société Francaise de Rhumatologie. Each fact sheet was revised by several experts and the overall process was coordinated by three experts. Results: Several topics of major interest were selected: contraindications of TNFα antagonists treatments, the management of adverse effects and concomitant diseases that may develop during these therapies, and the management of everyday situations such as pregnancy, surgery, and immunizations. After a review of the literature and discussions among experts, a consensus was developed about the content of the fact sheets presented here. These fact sheets focus on several points: In RA and SpA, initiation and monitoring of TNFα antagonists treatments, management of patients with specific past histories, and specific clinical situations such as pregnancy;. Diseases other than RA, such as juvenile idiopathic arthritis. Models of letters for informing the rheumatologist and general practitioner;4.and patient information. Conclusion: These TNFα antagonists treatments fact sheets built on evidence-based medicine and expert opinion will serve as a practical tool for assisting physicians who manage patients on these therapies. They will be available continuously at www.cri-net.com and updated at appropriate intervals. © 2011 Elsevier Masson SAS. Source


Khiati S.,French Institute of Health and Medical Research | Khiati S.,University of Bordeaux 1 | Luvino D.,Aix - Marseille University | Oumzil K.,French Institute of Health and Medical Research | And 5 more authors.
ACS Nano | Year: 2011

The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside-lipids allowing the efficient encapsulation and delivery of cisplatin. We demonstrate that the nucleoside polar heads guide the self-assembly of the aggregates into highly loaded and stable nanoparticles. The nanoparticles, which are efficient vehicles for the delivery of cisplatin into different sensitive and resistant cancer cell lines, can overcome the disadvantages and limitations of drug delivery systems previously reported. © 2011 American Chemical Society. Source


Amouyel T.,CHU Amiens Picardie | Flamand O.,Clinique Saint Joseph | Katz D.,Clinique du Ter | Valenti P.,Clinique Jouvenet
International Orthopaedics | Year: 2014

Purpose: The frequency of total shoulder arthroplasty (TSA) implantation is constantly increasing. This leads to revisions because of stem or glenoid component loosening, infection, instability or glenoid subsidence. Significant rotator cuff lesions and/or bone loss necessitate reverse shoulder arthroplasty (RSA) with bone reconstruction, which is a demanding procedure. Our hypothesis is that a platform system (versatile humeral stem with metal back glenoid component) makes revision surgery less demanding and less time consuming, and helps reduce the risks of complication. The purpose of this study is to analyse our revision experience with such a system to support our hypothesis. Methods: We present 29 revision cases of a convertible platform shoulder system: five hemi arthroplasties (HA), eight TSA with cemented glenoid (TSACG) and 16 TSA with metal backed glenoid component (TSAMB). Three TSACG were switched to TSAMB, and 26 other arthroplasties were switched to RSA. The pre-operative Constant score was 27 (range, 0–38). Our revision incidence was 5.4 % (29 revisions out of 537 shoulder arthroplasties over five years). Results: At revision, Constant score was 60 (range, 42–85). The humeral stem (versatile with TSA and RSA) was kept in three out of four cases. Most of the time it was changed because of too high a position, making it impossible to reduce the RSA. Nevertheless, 12 PTAMB were switched in 12 RSA without any metal backed revisions. Conclusion: A platform shoulder system allows much easier revisions. © 2014, SICOT aisbl. Source


Gerard M.,Caen University Hospital Center | Morin G.,CHU Amiens Picardie | Bourillon A.,Biochemistry | Colson C.,Caen University Hospital Center | And 7 more authors.
European Journal of Medical Genetics | Year: 2015

The cobalamin type C deficiency is a rare condition that results from impaired biosynthesis of both methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl). Hemizygous mutations of the HCFC1 gene explain the majority of clinically and biologically compatible cblC patients without MMACHC mutations (. OMIM 309541). We report a family with two maternal half-brothers with multiple congenital anomalies and HCFC1 gene mutation in the second Kelch domain. Both presented with dysmorphic features (flat profile, cleft lip for one), increased nuchal translucency, prenatal onset microcephaly and hypospadias. Additionally to early onset intractable epilepsy and profound neurocognitive impairment, this familial observation suggests that HCFC1 gene should be considered in boys with midline malformations, even without proven cobalamin C deficiency. © 2015 Elsevier Masson SAS. Source


Sarhan F.-R.,CHU Amiens Picardie | Lecocq F.,Hopital Lariboisiere Fernand Widal AP HP
Kinesitherapie | Year: 2015

Summary The reform of the physiotherapist's education implies an increase in the salaries. However, the agreement signed in 2010 does not seem in line with our expectations. © 2015 Elsevier Masson SAS. Source

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