Joué-lés-Tours, France
Joué-lés-Tours, France

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Kergosien Y.,University of Tours | Tournamille J.-F.,CHRU de Tours DAEL | Laurence B.,Eticsys | Billaut J.-C.,University of Tours
International Journal of Medical Informatics | Year: 2011

Purpose: Chemotherapy drugs are intended for the treatment of cancer. The production of such drugs and their administration to the patient is a delicate and expensive operation. The study deals with the acquisition and processing of data regarding the production of intravenous chemotherapy, from the production request (the medical prescription), the production itself (pharmaceutical process), to the delivery in the health care unit, for the administration of the chemotherapy. The goal of this study is to develop a system that can schedule, control and track the chemotherapy preparations and satisfy a certification process of quality management (" ISO 9001 version 2000" standard). Methods: The solution proposed in this paper was developed within the framework of a common certification process at the Biopharmaceutical Unit of the Oncology Clinic (UBCO) of the Bretonneau hospital in Tours (France). The system consists of two software programs: a software to insure traceability and a decision making software to plan the production. To simplify the data entry process, some mobile entry points with bar code reader have been deployed. These tools enable an accurate tracking of the production, a security and control for the schedule production phases, and a full traceability of each operation leading to the administration of the chemotherapy drug. Results: The first result is a software that creates the production schedule, allows a real time control of the production process and a full traceability of each step. Computational experiments are based on real data sets, with a comparison of a time period before and after the implementation of this solution. The results show the positive impacts of this software, like the reduction of delayed deliveries, real time generation of production indicators, optimization of the production and a saving of staff time. Conclusions: This intuitive system guarantees a traceability in connection with a high quality system certified ISO 9001-v2000 (with a rapid data entry), an assistant to schedule the production of preparations in a better way, a permanent follow-up and analysis of operations. This project proves the benefits of implementing computer solutions for the traceability and assistance in decision making in the hospital systems. © 2011 Elsevier Ireland Ltd.


Kergosien Y.,University of Tours | Lente C.,University of Tours | Billaut J.-C.,University of Tours | Perrin S.,CHRU de Tours DAEL
Computers and Operations Research | Year: 2013

This paper addresses a real-life logistic problem arising in the hospital complex of Tours (France). The two-level vehicle routing problem has time windows, a heterogeneous fleet, and multi-depot, multi-commodity and split deliveries. The first level concerns the routing problem for a fleet of vehicles serving several hospital units that delivers medicines, clean linen, meals, various supplies, patient files and picks up waste and dirty linen. The second level concerns the problem of routing employees between buildings within a large hospital unit. Both levels are interconnected. In addition, decisions about sizing and planning the teams of drivers and warehouse employees have to be made. Two metaheuristic algorithms are proposed to solve the entire problem: a genetic algorithm and a tabu search. The algorithms are tested on 100 instances, randomly generated on the basis of real-life instances. © 2013 Elsevier Ltd.

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