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Irvine, CA, United States

ChromaDex is a publicly traded natural products company based in Irvine, California. The company is most well-known for its industry standard phytochemical testing laboratories and catalogue. In cooperation with the University of Mississippi, the company is currently exploring the effects of pterostiibene on humans. Wikipedia.

Mudge E.,British Columbia Institute of Technology | Chan M.,British Columbia Institute of Technology | Venkataraman S.,ChromaDex | Brown P.N.,British Columbia Institute of Technology
Food Analytical Methods | Year: 2015

Curcuma longa L. rhizomes are used extensively as a spice in food preparations and dietary supplements for their anti-inflammatory and antioxidant properties. An expert review panel (ERP) evaluated analytical methods for the quantitation of individual curcuminoids for the purpose of identifying a method for official method status. It was requested that several modifications be undertaken to improve method performance prior to subjecting the chosen method to a single-laboratory validation. Two separate Plackett-Burman factorial studies were used to identify factors that contributed to the chromatographic separation and extraction of curcuminoids. Significant factors were further optimized to produce the improved HPLC method for curcuminoid separation. This method was then subjected to a single-laboratory validation according to the AOAC International guidelines for linearity, detection limits, precision, and accuracy. The two most significant factors impacting the quantitation of curcuminoids were column temperature and extraction solvent, which were optimized to 55 °C and 100 % methanol, respectively. The validation was performed on 12 raw materials and finished products containing turmeric roots. The method precision was reported using HorRat values which were within recommended ranges of the AOAC guidelines. Overall accuracy of the method was accessed at three separate levels for each analyte and ranged from 99.3–100.9 %. The validated method is suitable for quantitation of individual curcuminoids in turmeric raw materials and finished products and is recommended for consideration as an official method by the AOAC International. © 2015 The Author(s)

Ibrahim M.A.,Ironstone Separations Inc. | Ibrahim M.A.,National Research Center of Egypt | Rodenburg D.L.,Ironstone Separations Inc. | Alves K.,Ironstone Separations Inc. | And 7 more authors.
Journal of Natural Products | Year: 2014

Two new diterpene glycosides in addition to five known glycosides have been isolated from a commercial extract of the leaves of Stevia rebaudiana. Compound 1 (rebaudioside KA) was shown to be 13-[(O-β-d-glucopyranosyl)oxy]ent- kaur-16-en-19-oic acid 2-O-β-d-glucopyranosyl-β-d-glucopyranosyl ester and compound 2, 12-α-[(2-O-β-d-glucopyranosyl-β-d- glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-d-glucopyranosyl ester. Five additional known compounds were identified, rebaudioside E, rebaudioside M, rebaudioside N, rebaudioside O, and stevioside, respectively. Enzymatic hydrolysis of stevioside afforded the known ent-kaurane aglycone 13-hydroxy-ent-kaur-16-en-19-oic acid (steviol) (3). The isolated metabolite 1 possesses the ent-kaurane aglycone steviol (3), while compound 2 represents the first example of the isomeric diterpene 12-α-hydroxy-ent-kaur-16-en-19-oic acid existing as a glycoside in S. rebaudiana. The structures of the isolated metabolites 1 and 2 were determined based on comprehensive 1D- and 2D-NMR (COSY, HSQC, and HMBC) studies. A high-quality crystal of compound 3 has formed, which allowed the acquisition of X-ray diffraction data that confirmed its structure. The structural similarities between the new metabolites and the commercially available stevioside sweeteners suggest the newly isolated metabolites should be examined for their organoleptic properties. Accordingly rebaudiosides E, M, N, O, and KA have been isolated in greater than gram quantities. © 2014 The American Chemical Society and American Society of Pharmacognosy.

ChromaDex | Date: 2012-09-18

Chemical reagents for non-medical purposes; Chemical test kits for analytical measurement of raw material identity, potency and formulation consistency for laboratory or research use; Chemicals for use in industry and science; Chemicals for use in the biochemical and chemical industry; Assays for research purposes. Chemical, biochemical, biological and bacteriological research and analysis; Consulting in the field of product development in the field of chemicals; Development and establishment of testing specifications and procedures in the field of chemicals; Development and test of chemical production methods; Development of voluntary standards for chemicals; Executing of chemical analyses; Industrial research in the field of chemicals; Pharmaceutical research and development; Product research and development; Research and development and consultation related thereto in the field of chemicals; Testing of raw materials.

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