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Nakhon Pathom, Thailand

Jutapakdeegul N.,Mahidol University | Afadlal S.,Mahidol University | Polaboon N.,Christian University of Thailand | Phansuwan-Pujito P.,Bangkok University | Govitrapong P.,Mahidol University
International Journal of Developmental Neuroscience | Year: 2010

In the offspring of prenatal stress animals, overactivity and impaired negative feedback regulation of the hypothalamic-pituitary-adrenal axis are consistent finding. However, little was known about how prenatal stress can permanently alter developmental trajectories of pup's brain. Growth-associated protein-43 (GAP-43) is a presynaptic membrane phosphoprotein whose expression increases during developmental events such as axonal outgrowth or remodeling and synaptogenesis. Phosphorylation of GAP-43 by protein kinase C was correlated with enhanced axonal growth and transmitter release. In adult animals, increase of GAP-43 correlated with monoaminergic deficit in neuropsychiatric disorders. The present study examines the effects of repeated maternal restraint stress on the level of GAP-43 in the brain of rat pups. The results showed that prenatal stress significantly increased GAP-43 level in the PFC of rat pup during PND 7-14 as compared to control but not significant difference when observed at PND 21. Increased GAP-43 expression was also observed in the pup's hippocampus during the same postnatal periods. However, when observed at PND 60, pups born from stressed mother showed a significant lower (p < 0.001) GAP-43 expression as compare with control group. These changes indicate the direct effect of corticosteroid hormone, since repeated maternal injection with corticosterone (CORT, 40 mg/kg) during GD 14-21 also gave the same results. PND 7-14 is the peak period of synaptogenesis in these brain areas and abnormal axon sprouting and reorganization may lead to a defect in synaptic pruning at later stage of life. The results suggested that maternal stress is harmful to the developing brain and upregulation of GAP-43 indicated a protective mechanism against the toxicity of maternal stress hormone. Prenatal stress alter the normal developmental trajectories in the pup's brain may underlies the mechanism link between early life stress and neuropsychopathology in later life. © 2009 ISDN. Source

Kittiamornkul N.,Christian University of Thailand | Jirasereeamornkul K.,Bangkok Thonburi University | Chamnongthai K.,Bangkok Thonburi University | Kittisin S.,Mahidol University
ICSEC 2015 - 19th International Computer Science and Engineering Conference: Hybrid Cloud Computing: A New Approach for Big Data Era | Year: 2015

This paper presents a simulation of electric field which resonates in circular resonator that has two waveguide applicators. This paper aims to make the electric field covered mostly in the resonator in order to apply in many applications. This simulation resonator is designed to resonate the electric field at 2.45 GHz specifically that can be applied in moisture measurement process. The Computer Simulation Technology (CST) is used to create the 3D simulation of electric field in the designed resonator. The properties of soil which use as sample are loaded to simulated resonator in order to predicate the resonator performance. The simulation results denote contour of electric field with soil sample inside. This result contour can be shown by graphs of Probability Density Function (PDF) that can be used to evaluate the probability of electric field distributions in soil sample that is contained in the proposed resonator. The result shows that this resonator can distribute electric field mostly comparing with conventional resonator which is circular resonator. So, according to the simulation result, this resonator is appropriate to apply to moisture measurement application. © 2015 IEEE. Source

Werawatganon D.,Chulalongkorn University | Pongsuchart M.,Christian University of Thailand | Sereemaspun A.,Chulalongkorn University | Hanvivatvong O.,Chulalongkorn University | Siriviriyakul P.,Chulalongkorn University
Journal of the Medical Association of Thailand | Year: 2015

Helicobacter pylori (H. pylori) plays an important role in the development of chronic gastritis, peptic ulcer diseases, gastric adenocarcinoma, and gastric mucosal associated lymphoid tissue (MALT) lymphoma. The standard methods of bacterial staining, bacterial culture, and urease test for the detection of H. pylori are time consuming and invasive. Non-invasive testing plays a significant role in the test-and-treat approach to H. pylori management. Lateral flow immunoassay (LFIA) is a promising method for pathogenic detection that is fast, easy to use, and low cost. In the present study, the authors developed an H. pylori LFIA strip using gold nanoparticles for H. pylori detection. The results reported that 20 μg of anti-H. pylori antibody mixed with 1 mL AuNPs solution and incubated for 2 hours was the best concentration preparation for application coverage over the gold nanoparticle surface. The limit of detection observable by the naked eye was 15 μg of H. pylori protein lysate. The findings of this study suggest the possible future development of an H. pylori LFIA strip for fast, easy to use, and low-cost diagnostic testing. © 2015, Medical Association of Thailand. All rights reserved. Source

Lichanporn I.,Rajamangala University of Technology at Thanyaburi | Techavuthiporn C.,Christian University of Thailand
Postharvest Biology and Technology | Year: 2013

The effect of nitric oxide and nitrous oxide on pericarp browning of longkong fruit was studied. The fruit was either dipped for 5min in 0.25mM sodium nitroprusside (SNP), a nitric oxide donor, or continually exposed to 90% nitrous oxide (N2O) vapour for 3h and was compared to the untreated fruit (control). The fruits were then stored at 13°C and RH of 90±5%. The fruit treated for 3h with nitrous oxide vapour had delayed pericarp browning with higher phenolic compounds. However, these fruit showed lower levels of phenylalanine ammonia lyase, polyphenol oxidase and peroxidase than the control fruit and those treated with 0.25mM SNP. Therefore, we conclude that nitrous oxide delays browning and reduces the activities of browning enzymes in longkong pericarp. © 2013. Source

Sritoomma N.,Griffith University | Sritoomma N.,Christian University of Thailand | Moyle W.,Griffith University | Cooke M.,Griffith University | O'Dwyer S.,Griffith University
Complementary Therapies in Medicine | Year: 2014

Objectives: To investigate the effects of Swedish massage with aromatic ginger oil (SMGO) on chronic low back pain and disability in older adults compared with traditional Thai massage (TTM). Design: Randomized controlled trial. Setting: Massage clinic in Ratchaburi province, Thailand. Participants: 164 patients were screened; 140 were eligible, and randomized to either SMGO (n= 70) or TTM (n= 70). Intervention: Trained staff provided participants with a 30-min SMGO or TTM twice a week for five weeks. Measurement: The Visual Analogue Scale (VAS) assessed immediate effect (after each massage) and the short form McGill Pain Questionnaire (MPQ) assessed effectiveness of massage in short-term (six weeks) and long-term (15 weeks). Disability improvement was measured by the Owestry Disability Questionnaire (ODQ) at baseline, short- and long-term. Results: Both SMGO and TTM led to significant improvements in pain intensity (p<. 0.05) and disability (p<. 0.05) across the period of assessments, indicating immediate, short- and long-term effectiveness. SMGO was more effective than TTM in reducing pain (p= 0.04) and improving disability at short- and long-term assessments (p= 0.04). Conclusions: These findings suggest that the integration of either SMGO or TTM therapy as additional options to provide holistic care to older people with chronic low back pain could be considered by health professionals. Further research into the use of ginger as an adjunct to massage therapy, particularly TTM, is recommended. © 2013 Elsevier Ltd. Source

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