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Khurana P.,Christian Medical College CMC | Dala J.S.,Government Medical College | Multani A.S.,FMT | Tejpal H.R.,FMT
Journal of Indian Academy of Forensic Medicine | Year: 2011

Trend of poisoning had been constantly changing throughout the world, as the advent of new agents, has always replaced the older one due to their innumerable merits and demerits. Similarly in India, the pattern of ingested poisons has also changed. A number of chemical substances which are developed to save the agriculturalproduct from rodents and pests are in fact themselves proving to be disastrous for mankind. Recently in the last two decades aluminium phosphide [Alphos] used as pesticide, rodenticide, fumigant for storage of food grains has created havoc with the human lives differently i.e. suicidal, accidental and very rarely homicidal poisoning agent. Alphos, a solid fumigant used for storage of food grains, freely accessible in the market is commonly used suicidal agent with high mortality rate as no antidote or specific treatment is available. The present study of 50 cases of aluminium phosphide poisoning showed male dominance, common in sikhs and educated persons. Heart is the first organ to be affected. Shock was present in majority of cases. Sufficient time was available for recording dying declaration. Source

Jain A.,All India Institute of Medical Sciences | Sharma M.C.,All India Institute of Medical Sciences | Suri V.,All India Institute of Medical Sciences | Kale S.S.,All India Institute of Medical Sciences | And 8 more authors.
Neurology India | Year: 2011

Background : Till date there is no published multi-institutional data regarding the epidemiological profile of pediatric brain tumors in India. Aim : The present retrospective study analyses the histological spectrum of pediatric age group brain tumors in seven tertiary care hospitals in India. Material and Methods : Data regarding frequencies of various primary brain tumors (diagnosed according to the World Health Organization (WHO) classification), in 3936 pediatric patients (<18 yrs of age), was collected from seven tertiary care hospitals in India.Results : The most common primary pediatric brain tumors were astrocytic tumors (34.7%), followed by medulloblastoma and supratentorial primitive neuro-ectodermal tumors (22.4%), craniopharyngiomas (10.2%) and ependymal tumors (9.8%). The most common astrocytic tumor was pilocytic astrocytoma. In comparison to adults, oligodendrogliomas and lymphomas were rare in children. Conclusions : Our study is the first such report on the histological spectrum of brain tumors in children in India. Except for a slightly higher frequency of craniopharyngiomas, the histological profile of pediatric brain tumors in India is similar to that reported in the Western literature. Source

Prabhav N.R.,Christian Medical College | Prabhav N.R.,Vellore Institute of Technology | Devasahayam S.R.,Christian Medical College | Babu K.S.,Christian Medical College CMC
International Journal of Biomedical Engineering and Technology | Year: 2014

The use of electrically powered hands is impeded by their control interfaces. EMG (electromyogram) based prosthetic control is very promising but its deployment is limited by problems with surface recording of EMG. EMG recorded from implanted electrodes seems to be good alternative. In this paper, we describe a system for artificial hand control based on implanted EMG. The system includes a data transfer link based on the IEEE 802.15.4 network, a power transfer scheme built around a pair of coupled inductors driven by a class E amplifier. The entire system can run off a mobile phone battery for around 4 hours. We describe the acquisition and classification of EMG into different groups and the effect of noise in the radio channel on the classification. ©2014 Inderscience Enterprises Ltd. Source

Rahi M.,Indian Council of Medical Research Task Force on Development of Guidelines for diagnosis | Gupte M.D.,Indian Council of Medical Research Task Force on Development of Guidelines for diagnosis | Bhargava A.,Himalayan Institute of Medical science HIMS | Varghese G.M.,Christian Medical College CMC | Arora R.,Indian Council of Medical Research Task Force on Development of Guidelines for diagnosis
Indian Journal of Medical Research | Year: 2015

Rickettsial diseases, caused by a variety of obligate intracellular, gram-negative bacteria from the genera Rickettsia, Orientia, Ehrlichia, Neorickettsia, Neoehrlichia, and Anaplasma, belonging to the Alphaproteobacteria, are considered some of the most covert emerging and re-emerging diseases and are being increasingly recognized. Among the major groups of rickettsioses, commonly reported diseases in India are scrub typhus, murine flea-borne typhus, Indian tick typhus and Q fever. Rickettsial infections are generally incapacitating and difficult to diagnose; untreated cases have case fatality rates as high as 30-45 per cent with multiple organ dysfunction, if not promptly diagnosed and appropriately treated. The vast variability and non-specific presentation of this infection have often made it difficult to diagnose clinically. Prompt antibiotic therapy shortens the course of the disease, lowers the risk of complications and in turn reduces morbidity and mortality due to rickettsial diseases. There is a distinct need for physicians and health care workers at all levels of care in India to be aware of the clinical features, available diagnostic tests and their interpretation, and the therapy of these infections. Therefore, a Task Force was constituted by the Indian Council of Medical Research (ICMR) to formulate guidelines for diagnosis and management of rickettsial diseases. These guidelines include presenting manifestations, case definition, laboratory criteria (specific and supportive investigations) and treatment. © 2015, Indian Council of Medical Research. All rights reserved. Source

Dutta A.K.,Christian Medical College CMC | Sood R.,All India Institute of Medical Sciences | Singh U.B.,All India Institute of Medical Sciences | Kapil A.,All India Institute of Medical Sciences | Samantaray J.C.,All India Institute of Medical Sciences
Journal, Indian Academy of Clinical Medicine | Year: 2013

Introduction: Bone marrow examination (BME) including bone marrow cultures (BMC) and polymerase chain reaction (PCR) are often used as diagnostic procedures for the evaluation of fever of unknown origin (FUO). However, objective data are limited about their utility in FUO. Methodology: Fifty-two patients with FUO were included in the study. After initial evaluation, BME was performed. Bone marrow aspirate was subjected to pathological examination; bacterial, fungal, and mycobacterial cultures; smear examination for AFB/ LD bodies/malarial parasite, and PCR for M. tuberculosis. Bone marrow (BM) trephine was subjected to histopathological examination. The diagnostic yield of BME and the number of patients in whom it was the only diagnostic modality were determined. Results: A definitive diagnosis could be achieved in 43(82.7%) patients. Thirty-two patients had infectious aetiology with extrapulmonary tuberculosis being the commonest cause of FUO. The diagnostic yield of BME was 38.6% and it was the only diagnostic modality in 25.6% of patients. The yield of BM aspirate smear examination was 15.4%. PCR for M. tuberculosis and fungal cultures were diagnostic in one patient each. Bacterial and mycobacterial cultures were sterile in all patients. A correlation of haematological parameters with BME showed that patients with Hb < 7.7 g% or TLC< 4,450/mm3 had a significantly higher yield on bone marrow examination. Conclusion: Conventional BME showed a good diagnostic yield in evaluation of FUO. Newer techniques had very low diagnostic yield. Source

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