Rājkot, India
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Sudheer K.S.,Christ College | Sabir M.,Cochin University of Science and Technology
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2011

In this Letter we consider modified function projective synchronization of unidirectionally coupled multiple time-delayed Rossler chaotic systems using adaptive controls. Recently, delay differential equations have attracted much attention in the field of nonlinear dynamics. The high complexity of the multiple time-delayed systems can provide a new architecture for enhancing message security in chaos based encryption systems. Adaptive control can be used for synchronization when the parameters of the system are unknown. Based on Lyapunov stability theory, the adaptive control law and the parameter update law are derived to make the state of two chaotic systems are function projective synchronized. Numerical simulations are presented to demonstrate the effectiveness of the proposed adaptive controllers. © 2011 Elsevier B.V.


Georrge J.J.,Christ College | Umrania V.V.,MVM Science and HSc College
Applied Biochemistry and Biotechnology | Year: 2012

The prolonged use of the antibiotics over the years has transformed many organisms resistant to multiple drugs. This has made the field of drug discovery of vital importance in curing various infections and diseases. The drugs act by binding to a specific target protein of prime importance for the cell's survival. Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes are the few gram positive organisms that have developed resistance to drugs. It causes pneumonia, meningitis, pharyngitis, otitis media, sinusitis, bacteremia, pericarditis, and arthritis infections. The present study was carried out to identify potential drug targets and inhibitors for beta subunit of DNA polymerase III in these three Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. And finally 3D structure of DNA polymerase III subunit beta was modeled. The ligand library was generated from various Introduction The complete genome sequences of many microbes were completed in the past decade [1]. Valuable information on finding the treatment of various infections caused by pathogens [2] can be retrieved using the comparative genomics and subtractive genomics approaches. The critical genes which are crucial for the survival of the pathogens and which are absent in the host [3] can be screened out by using the subtractive genomics approach. The chances of Appl Biochem Biotechnol (2012) 167:1377-1395 DOI 10.1007/s12010-012-9620-0 J. J. Georrge (*) Department of Bioinformatics, Christ College, Rajkot 360005 Gujarat, India e-mail: johnjgeorrge@yahoo.co.in V. V. Umrania Department of Microbiology, MVM Sc & HSc College, Rajkot, India databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity.HSc College, Rajkot, India databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity. © Springer Science+Business Media, LLC 2012.


Magesh N.S.,Manonmaniam Sundaranar University | Jitheshlal K.V.,Manonmaniam Sundaranar University | Chandrasekar N.,Manonmaniam Sundaranar University | Jini K.V.,Christ College
Earth Science Informatics | Year: 2012

GIS and Remote Sensing have proved to be an indispensible tool in morphometric analysis. The identification of morphometric properties based on a geographic information system (GIS) was carried out in two watersheds in the Thrissur district of Kerala, India. These watersheds are parts of Western Ghats, which is an ecologically sensitive area. Quantitative geomorphometric analysis was carried out for the Chimmini and Mupily watersheds independently by estimating their (a) linear aspects like stream number, stream order, stream length, mean stream length, stream length ratio, bifurcation ratio, length of overland flow, drainage pattern (b) aerial aspects like circulatory ratio, elongation ratio, drainage density and (c) relief aspects like basin relief, relief ratio, relative relief and ruggedness number. The drainage areas of Chimmini and Mupily watersheds are 140 and 122 km 2 respectively and show patterns of dendritic to sub-dendritic drainage. The Chimmini watershed was classified as a sixth order drainage basin, whereas Mupily watershed was classified as a fifth order basin. The stream order of the basin was predominantly controlled by physiographic and structural conditions. The increase in the stream length ratio from lower to higher order suggests that the study area has reached a mature geomorphic stage. The development of stream segments is affected by rainfall and local lithology of the watersheds. The slope of both watersheds varied from 0° to 50° and 0° to 42° respectively and the slope variation is chiefly controlled by the local geology and erosion cycles. Moreover, these studies are useful for planning rain water harvesting and watershed management. © 2012 Springer-Verlag.


Georrge J.J.,Christ College | Umrania V.,MVM Science and HSc College
Indian Journal of Biotechnology | Year: 2011

The prolonged use of antibiotics over the years has transformed many organisms into resistant to multiple drugs. Klebsiella pneumoniae MGH78578, a causative agent for respiratory and urinary tract infections, is one of the few Gramnegative bacteria, which has developed resistance to drugs. The present study was carried out to identify potential drug targets in K. pneumonia that might facilitate the discovery of novel drugs in near future. The present study has followed an in silico based approach for identification of drug targets. The comparison and analysis of proteomes of the causal organism and humans was made to screen out non-homologous proteins. Further, studies were carried out to list out essential proteins of the organism. KEGG pathway analysis was carried out to study the function of proteins. Different databases were used to find novel drug targets and various tools were used for the prediction of sub-cellular localization and membrane proteins. From the detailed analysis, 105 novel drug targets were identified, which have been involved in 24 specific pathways of K. pneumoniae MGH78578. Thirty nine proteins were predicted as outer membrane proteins, which could be used as potential vaccine candidates.


Andrews J.,Bharathiar University | Andrews J.,Christ College | Mathew V.,Thomas College | Mathew V.,Central University of Kerala
Superconductor Science and Technology | Year: 2012

The vortex effects of high temperature superconducting (HTS) microstrip resonators have been studied using the theoretical approach developed by Coffey and Clem (CC). A rectangular HTS strip resonator printed on sapphire substrate and subjected to a static magnetic field is considered, where the HTS strip is in the mixed state. An impedance type Greens function is derived which connects the strip current to the electric field around the resonator, in the Fourier transformed domain. Galerkins procedure is used in the spectral domain to determine the resonant frequency and the unloaded Q value, both of which are computed for different applied fields, reduced temperatures and superconducting strip thicknesses. The results reveal considerable influence of applied field on resonant frequency and quality factor due to vortex motion, which should be considered when designing resonators which operate under external magnetic field. © 2012 IOP Publishing Ltd.


Andrews J.,Christ College | Mathew V.,Central University of Kerala
Proceedings of 2015 IEEE MTT-S International Conference on Numerical Electromagnetic and Multiphysics Modeling and Optimization, NEMO 2015 | Year: 2015

A modeling technique to study the frequency response of electromagnetic signal fed to High Temperature Superconducting (HTS) microstrip and slotline exposed to a constant dc magnetic field is presented. The computation is done for a temperature close to the critical temperature where the vortex effects significantly influence the signal propagation. The flux related effects are modeled using a modified two-fluid theory proposed by Coffey and Clem (CC). The complex penetration depth obtained by CC model is used to derive a complex resistive boundary condition which, in turn, incorporates the HTS effects and modifies the dyadic Green's functions derived for microstrip and slotline using Spectral Domain Method (SDM). The propagation parameters are obtained using Galerkin procedure for a wide range of applied dc field and microwave signal frequency. Both the strip lines are of same geometrical dimensions for a comparative study. Phase constant of the signal varies with signal frequency whereas the attenuation constant is largely influenced by vortex movements. The study presents a comparative modeling method for microstrip and slotline and relates vortex physics with microwave signal propagation for a wide range of applied dc field and signal frequency. © 2015 IEEE.


Pandya J.H.,Christ College | Jadeja R.N.,M. S. University of Baroda | Ganatra K.J.,Mvm Science And Home Science College
Journal of Saudi Chemical Society | Year: 2014

In the present study two new series of Copper(II), Nickel(II) and Cobalt(II) complexes with two newly synthesized Schiff base ligands 4,6-bis(1-(4-bromophenylimino)ethyl)benzene-1,3-diol (H2L1), 4,6-bis(1-(4-methoxyphenylimino) ethyl)benzene-1,3-diol (H2L2) and organic ligands 8-hydroxy quinoline, 1,10-phenanthroline have been prepared. The Schiff bases H2L1 and H2L2 ligands were synthesized by the condensation of 4,6-diacetyl resorcinol with 4-bromo aniline and 4-methoxy aniline. The ligands and their metal complexes have been characterized by FT-IR, Mass, 1H NMR, UV-Vis., elemental analysis, ESR and Thermal gravimetric analysis. The Schiff base and their metal complexes were tested for antimicrobial activity against gram positive bacteria Staphylococcus aureus, Streptococcus pyogenes and gram negative bacteria Escherichia coli, Pseudomonas aeruginosa and fungus Candida albicans, Aspergillus niger and Aspergillus clavatus using Broth Dilution Method. © 2011.


John L.,Christ College | John G.J.,Christ College | Kholia T.,Christ College
Applied Biochemistry and Biotechnology | Year: 2012

Leishmaniasis is a group of diseases with a spectrum of clinical manifestations ranging from cutaneous ulcers to visceral leishmaniasis, which results from the bite of an infected sandfly to human. Attempts to develop an effective vaccine have been shown to be feasible but no vaccine is in active clinical use. This study adopts a Reverse Vaccinology approach to identify common vaccine candidates from both highly pathogenic species Leishmania major and Leishmania infantum. Total proteome of both species were compared to identify common proteins, which are further taken for sub-cellular localization and transmembrane helices prediction. Plasma membrane proteins having only one transmembrane helix were first identified and analyzed which are non-homologous in human and mouse in order to avoid molecular mimicry with other proteins. Selected proteins were analyzed for their binding efficiency to both major histocompatibility complex (MHC) class I and class II alleles. As a result, 19 potential epitopes are screened in this study using different approaches, which can be further verified through in vivo experiments in MHC compatible animal models. This study demonstrates that Reverse Vaccinology approach has potential in discovering various immunogenic antigens from in silico analysis of pathogen's genome or proteome instead of culturing the whole organism by conventional methods. © Springer Science+Business Media, LLC 2012.


Vincent M.,Christ College | Thomas J.,Christ College
Ichthyological Research | Year: 2011

This is the report of a new species of catfish, Kryptoglanis shajii nov. gen. and nov. sp., distinguished from all other genera of siluriform fishes by the combination of the following morphological characters: viz. the absence of dorsal fin; the presence of four pairs of barbels; an upwardly directed mouth, with a distinctly projecting lower jaw; subcutaneous eyes; anal fin completely confluent with the caudal fin; anal and caudal fins together carry 70-74 fin rays; and no spines in any of the fins. Kryptoglanis, which has a maximum recorded size of 59.1 mm in standard length, was collected from a well fed by subterranean springs. The type locality is a well located at the extreme western part of Western Ghats, near Chalakudy in Thrissur district, Kerala State, India. © 2011 The Ichthyological Society of Japan.


Joseph R.,Christ College | Tessy P.P.,Christ College
Nature Environment and Pollution Technology | Year: 2010

The present investigation deals with the analysis of water quality of Chalakudy river near Kerala Chemicals and Proteins Ltd. (KCPL) at Kathikudam, Thrissur district, Kerala. Water samples were collected monthly for a period of six months from March to August 2007 at 3 sites of Chalakudy River. Low dissolved oxygen, high values of conductivity, total hardness, biochemical oxygen demand, turbidity, nitrate and phosphate show unhealthy condition of the river. The conductivity, turbidity and pH of the water samples were not within the permissible limit in the site near KCPL during the period of study.

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