Georrge J.J.,Christ College |
Umrania V.V.,MVM Science and HSc College
Applied Biochemistry and Biotechnology | Year: 2012
The prolonged use of the antibiotics over the years has transformed many organisms resistant to multiple drugs. This has made the field of drug discovery of vital importance in curing various infections and diseases. The drugs act by binding to a specific target protein of prime importance for the cell's survival. Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes are the few gram positive organisms that have developed resistance to drugs. It causes pneumonia, meningitis, pharyngitis, otitis media, sinusitis, bacteremia, pericarditis, and arthritis infections. The present study was carried out to identify potential drug targets and inhibitors for beta subunit of DNA polymerase III in these three Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. And finally 3D structure of DNA polymerase III subunit beta was modeled. The ligand library was generated from various Introduction The complete genome sequences of many microbes were completed in the past decade . Valuable information on finding the treatment of various infections caused by pathogens  can be retrieved using the comparative genomics and subtractive genomics approaches. The critical genes which are crucial for the survival of the pathogens and which are absent in the host  can be screened out by using the subtractive genomics approach. The chances of Appl Biochem Biotechnol (2012) 167:1377-1395 DOI 10.1007/s12010-012-9620-0 J. J. Georrge (*) Department of Bioinformatics, Christ College, Rajkot 360005 Gujarat, India e-mail: email@example.com V. V. Umrania Department of Microbiology, MVM Sc & HSc College, Rajkot, India databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity.HSc College, Rajkot, India databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity. © Springer Science+Business Media, LLC 2012.
Pandya J.H.,Christ College |
Jadeja R.N.,M. S. University of Baroda |
Ganatra K.J.,Mvm Science And Home Science College
Journal of Saudi Chemical Society | Year: 2014
In the present study two new series of Copper(II), Nickel(II) and Cobalt(II) complexes with two newly synthesized Schiff base ligands 4,6-bis(1-(4-bromophenylimino)ethyl)benzene-1,3-diol (H2L1), 4,6-bis(1-(4-methoxyphenylimino) ethyl)benzene-1,3-diol (H2L2) and organic ligands 8-hydroxy quinoline, 1,10-phenanthroline have been prepared. The Schiff bases H2L1 and H2L2 ligands were synthesized by the condensation of 4,6-diacetyl resorcinol with 4-bromo aniline and 4-methoxy aniline. The ligands and their metal complexes have been characterized by FT-IR, Mass, 1H NMR, UV-Vis., elemental analysis, ESR and Thermal gravimetric analysis. The Schiff base and their metal complexes were tested for antimicrobial activity against gram positive bacteria Staphylococcus aureus, Streptococcus pyogenes and gram negative bacteria Escherichia coli, Pseudomonas aeruginosa and fungus Candida albicans, Aspergillus niger and Aspergillus clavatus using Broth Dilution Method. © 2011.
Magesh N.S.,Manonmaniam Sundaranar University |
Jitheshlal K.V.,Manonmaniam Sundaranar University |
Chandrasekar N.,Manonmaniam Sundaranar University |
Jini K.V.,Christ College
Earth Science Informatics | Year: 2012
GIS and Remote Sensing have proved to be an indispensible tool in morphometric analysis. The identification of morphometric properties based on a geographic information system (GIS) was carried out in two watersheds in the Thrissur district of Kerala, India. These watersheds are parts of Western Ghats, which is an ecologically sensitive area. Quantitative geomorphometric analysis was carried out for the Chimmini and Mupily watersheds independently by estimating their (a) linear aspects like stream number, stream order, stream length, mean stream length, stream length ratio, bifurcation ratio, length of overland flow, drainage pattern (b) aerial aspects like circulatory ratio, elongation ratio, drainage density and (c) relief aspects like basin relief, relief ratio, relative relief and ruggedness number. The drainage areas of Chimmini and Mupily watersheds are 140 and 122 km 2 respectively and show patterns of dendritic to sub-dendritic drainage. The Chimmini watershed was classified as a sixth order drainage basin, whereas Mupily watershed was classified as a fifth order basin. The stream order of the basin was predominantly controlled by physiographic and structural conditions. The increase in the stream length ratio from lower to higher order suggests that the study area has reached a mature geomorphic stage. The development of stream segments is affected by rainfall and local lithology of the watersheds. The slope of both watersheds varied from 0° to 50° and 0° to 42° respectively and the slope variation is chiefly controlled by the local geology and erosion cycles. Moreover, these studies are useful for planning rain water harvesting and watershed management. © 2012 Springer-Verlag.
Sudheer K.S.,Christ College |
Sabir M.,Cochin University of Science and Technology
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2011
In this Letter we consider modified function projective synchronization of unidirectionally coupled multiple time-delayed Rossler chaotic systems using adaptive controls. Recently, delay differential equations have attracted much attention in the field of nonlinear dynamics. The high complexity of the multiple time-delayed systems can provide a new architecture for enhancing message security in chaos based encryption systems. Adaptive control can be used for synchronization when the parameters of the system are unknown. Based on Lyapunov stability theory, the adaptive control law and the parameter update law are derived to make the state of two chaotic systems are function projective synchronized. Numerical simulations are presented to demonstrate the effectiveness of the proposed adaptive controllers. © 2011 Elsevier B.V.
Andrews J.,Bharathiar University |
Andrews J.,Christ College |
Mathew V.,Thomas College |
Mathew V.,Central University of Kerala
Superconductor Science and Technology | Year: 2012
The vortex effects of high temperature superconducting (HTS) microstrip resonators have been studied using the theoretical approach developed by Coffey and Clem (CC). A rectangular HTS strip resonator printed on sapphire substrate and subjected to a static magnetic field is considered, where the HTS strip is in the mixed state. An impedance type Greens function is derived which connects the strip current to the electric field around the resonator, in the Fourier transformed domain. Galerkins procedure is used in the spectral domain to determine the resonant frequency and the unloaded Q value, both of which are computed for different applied fields, reduced temperatures and superconducting strip thicknesses. The results reveal considerable influence of applied field on resonant frequency and quality factor due to vortex motion, which should be considered when designing resonators which operate under external magnetic field. © 2012 IOP Publishing Ltd.