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Bilāspur, India

Shruti R.,Chouksey Engineering College | Alpana R.,Guru Ghasidas University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The objective of the present study was to develop floating microspheres of doxorubicin in order to achieve an extended retention in upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavaibility. Microspheres were prepared by emulsification extraction technique using pectin as polymer and casein as emulsifier. The 3 2 full factorial design was employed to evaluate contribution of independent variables, pectin-casein ratio (X1) and stirring speed (X2) on dependent variables, particle size, % drug entrapment, % buoyancy and time required for 80% drug release (t 80%). The microsphere exhibited buoyancy more than 8 hrs, high percentage drug entrapment efficiency. Microspheres were discrete, free flowing and spherical with rough surface. The polymer to emulsifier ratio had a more significant effect on the dependent variables. The optimum batch was F 6 which shown particle size 68.8 μm, 78% entrapment efficiency and t 80% is about 420 minutes. Infrared spectroscopy analysis revealed that there was no known chemical interaction between drug and polymer. Hence this investigation demonstrated that the polymer to emulsifier ratio had a more significant effect on the dependent variables. In vitro release study reveals that the drug release from microsphere is in Fickian pattern. Pure drug and Formulation (F6) both showed cytotoxicity against Kato III cells after in vitro cytotoxicity. In vivo gamma scintillography and antitumor activity indicated that the formulation F6 remained buoyant and uniformly distributed in the gastric contents throughout the study period of 8 hours and statistically significant (P <0.05) reduction in the number of tumors obtained. Source

Mishra R.,Birla Institute of Technology | Tiwari P.,Chouksey Engineering College
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Multiple sclerosis (MS) is an autoimmune disease in which body's immune system eats away the protective sheath that covers nerves which interferes with the communication between brain and the rest of body. Ultimately this may result in deterioration of the nerves themselves a process that's irreversible. Symptoms vary widely, depending on the amount of damage and the type of nerves affected. Patients with severe cases of multiple sclerosis may lose the ability to walk or speak. Multiple sclerosis can be difficult to diagnose early in the course of the disease because symptoms often come and go sometimes disappearing for months. There's no cure for multiple sclerosis. However treatments can help treat attacks, modify the course of the disease and treat symptoms. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

Meesala S.K.,Chouksey Engineering College
2012 International Conference on Computing, Communication and Applications, ICCCA 2012 | Year: 2012

Problems from many scientific and economic fields need a large computer power for their solution. The numeric simulation of complex systems like weather forecast' climate modeling' molecular biology and circuit design are some of such problem. There are two approaches to solve them. Either an expensive parallel supercomputer has to be used [First]' or the computer power of workstations in a net can be bundle to computer the task distributed [Second]. The second approach has the advantage that we use the available hardware cost-effective. This paper describes the architecture of a heterogeneous' concurrent' and distributed system' which can be used for solving large computational problems. We present a concurrent tasks distributed application for solving complex computational tasks in parallel. The design process is parallel processing implementation on clusters of terminals using Java RMI. © 2012 IEEE. Source

Khaskel A.,National Institute of Technology Silchar | Barman P.,National Institute of Technology Silchar | Jana U.,Chouksey Engineering College
RSC Advances | Year: 2015

Environmentally benign l-tyrosine loaded nanoparticles are fabricated and characterized by PCS, TEM, FT-IR and AFM studies. A novel straightforward green approach was applied for the synthesis of dicoumarols and Hantzsch 1,4-dihydropyridines using this catalyst. The structures and purity of these compounds were confirmed by FT-IR and NMR (1H, 13C and DEPT). The flexible and swelling properties of the polymer coating increase l-tyrosine dispersion and its high catalytic activity in organic reactions. This journal is © The Royal Society of Chemistry. Source

Rathor S.,Chouksey Engineering College | Ram A.,Slt Institute Of Pharmaceutical Scinces
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The objective of the present study is to develop and characterize floating microspheres of methotrexate, which after oral administration could prolong the gastric residence time and increase the bioavailability of the drug, in order to provide the sustained release to minimize the dose dependent side effects as well as to improve patient compliance. Another aim is to investigate drug release at slight higher pH, which is due to frequent administration of water to make dosage form floating. The porous microspheres containing (1) methotrexate - antineoplastic agent, (2) casein - emulsifier which incorporate air bubbles at interface and (3) pectin - polymer, by emulsification extraction method and to evaluate gastro retentive and controlled release properties at pH 4.0. The effects of various process variables on the particle size, % buoyancy and % drug entrapment were assessed by 32 full factorial design and concluded by using two way ANOVA and polynomial regression methods. Process variables had considerable effect on all dependent variables. The microspheres were found to be regular in shape with rough surface. Microsphere formulation M9 showed particle size 59.60±0.95μm, buoyancy 82.0±0.27%, and %drug entrapment 97.54±0.53%. In vitro drug release study was done results calculated by PCP disso vi software revealed best fitted model for M9 as Korsmayer Peppas model and drug release in Fickian manner. In vitro cytotoxicity study on KATO III gastric cell line revealed methotrexate microspheres had greater cytotoxic effects on cell line in comparison to pure drug solution. In vivo gamma scintigraphy studies were done using albino mice showed more than 8 hrs retention in upper gastro intestinal tract. Source

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