Bilāspur, India
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Chandy A.,Chouksey Engineering College | Thakur A.S.,Chouksey Engineering College | Singh M.P.,Chouksey Engineering College
Asian Pacific Journal of Tropical Medicine | Year: 2011

Filariasis is result of parasitic infection caused by three specific kinds of round worm. Lymphatic filariasis is found in under developed region of South America, Central Africa, pacific and Caribbian. It has been found for centuries, with main symptoms as elephant like swelling of the arms, legs and genitals. It is estimate that 120 millions peoples in the world have lymphatic filariasis. The spread of diseases and the challenge encountered in its management are discussed along with a review on drugs against filariasis in this article. Detail on clinical effect of drugs on the infection, safety profile, status in clinical practices and drug resistances are also covered. © 2011 Hainan Medical College.


Mishra R.,Birla Institute of Technology | Tiwari P.,Chouksey Engineering College
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Multiple sclerosis (MS) is an autoimmune disease in which body's immune system eats away the protective sheath that covers nerves which interferes with the communication between brain and the rest of body. Ultimately this may result in deterioration of the nerves themselves a process that's irreversible. Symptoms vary widely, depending on the amount of damage and the type of nerves affected. Patients with severe cases of multiple sclerosis may lose the ability to walk or speak. Multiple sclerosis can be difficult to diagnose early in the course of the disease because symptoms often come and go sometimes disappearing for months. There's no cure for multiple sclerosis. However treatments can help treat attacks, modify the course of the disease and treat symptoms. © 2012 Asian Pacific Tropical Biomedical Magazine.


Rathor S.,Chouksey Engineering College | Ram A.,Slt Institute Of Pharmaceutical Scinces
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The objective of the present study is to develop and characterize floating microspheres of methotrexate, which after oral administration could prolong the gastric residence time and increase the bioavailability of the drug, in order to provide the sustained release to minimize the dose dependent side effects as well as to improve patient compliance. Another aim is to investigate drug release at slight higher pH, which is due to frequent administration of water to make dosage form floating. The porous microspheres containing (1) methotrexate - antineoplastic agent, (2) casein - emulsifier which incorporate air bubbles at interface and (3) pectin - polymer, by emulsification extraction method and to evaluate gastro retentive and controlled release properties at pH 4.0. The effects of various process variables on the particle size, % buoyancy and % drug entrapment were assessed by 32 full factorial design and concluded by using two way ANOVA and polynomial regression methods. Process variables had considerable effect on all dependent variables. The microspheres were found to be regular in shape with rough surface. Microsphere formulation M9 showed particle size 59.60±0.95μm, buoyancy 82.0±0.27%, and %drug entrapment 97.54±0.53%. In vitro drug release study was done results calculated by PCP disso vi software revealed best fitted model for M9 as Korsmayer Peppas model and drug release in Fickian manner. In vitro cytotoxicity study on KATO III gastric cell line revealed methotrexate microspheres had greater cytotoxic effects on cell line in comparison to pure drug solution. In vivo gamma scintigraphy studies were done using albino mice showed more than 8 hrs retention in upper gastro intestinal tract.


Jhade D.,Chouksey Engineering College | Jain S.,IPS Academy | Jain A.,IPS Academy | Sharma P.,IPS Academy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: Pharmacognostic Screening and evaluate the in-vitro free radical scavenging activity of roots Acacia leucophloea. Methods: Pharmacognostic Standardization, Physico-chemical evaluation of the roots of Acacia leucophloea was carried out to determine its macro-and microscopical characters and also some of its quantitative standards. Microscopical studies were done by using trinocular microscope. Microscopically, root showed cork, cortex, stellar region and calcium oxalate crystals. Petroleum ether, ethanol, aqueous extracts of Acacia leucophloea were prepared, with successive extraction in soxhlet apparatus. Each extract was selected to study the free radical scavenging activity by superoxide scavenging assay method. Results: It was found that aqueous extract contained carbohydrates, glycosides amino acids flavonoids, tannins, alkaloids, steroids; ethanolic extract contained glycosides amino acids flavonoids, tannins, alkaloids, steroids. Ethanolic extract of Acacia leucophloea shows maximam inhibition in superoxide scavenging model. Aqueous extract also showed almost similar activity compared to ethanolic extract), while Petroleum ether extract showed poor inhibition of superoxide scavenging activity. Conclusion: The present study on pharmacognostic standardization, physico and phytochemical evaluation of Acacia leucophloea root might be useful to supplement information about its identification parameters assumed significantly in the way of acceptability of herbal drugs in present scenario lacking regulatory laws to control quality of herbal drugs. © 2012 Asian Pacific Tropical Biomedical Magazine.


Tiwari P.,Chouksey Engineering College | Ahirwae D.,Chouksey Engineering College | Chandy A.,Chouksey Engineering College | Ahirwar B.,Chouksey Engineering College
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To screen Selaginella lepidophylla (S. lepidophylla) that are used in traditional medicine for their claimed hepatoprotective properties. Methods: Alcoholic and aqueous extracts of S. lepidophylla were evaluated for their hepatoprotective activity using CCl4 and paracetamol induced acute hepatic injury model. Results: Treatment with CCl4 and paracetamol significantly increased liver weight and volume compared to the normal group. Pretreatment with silymarin alcoholic and aqueous extracts significantly prevent increase in liver weight and volume. Conclusions: From the present experimental study it can be concluded that alcoholic and aqueous extract of S. lepidophylla exhibited significant hepatoprotective activity against CCl4 and paracetamol induced hepatotoxicity in rats, as result showed in physical, biochemical and histopathological parameters. © 2014 Asian Pacific Tropical Medicine Press.


Shruti R.,Chouksey Engineering College | Alpana R.,Guru Ghasidas University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The objective of the present study was to develop floating microspheres of doxorubicin in order to achieve an extended retention in upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavaibility. Microspheres were prepared by emulsification extraction technique using pectin as polymer and casein as emulsifier. The 3 2 full factorial design was employed to evaluate contribution of independent variables, pectin-casein ratio (X1) and stirring speed (X2) on dependent variables, particle size, % drug entrapment, % buoyancy and time required for 80% drug release (t 80%). The microsphere exhibited buoyancy more than 8 hrs, high percentage drug entrapment efficiency. Microspheres were discrete, free flowing and spherical with rough surface. The polymer to emulsifier ratio had a more significant effect on the dependent variables. The optimum batch was F 6 which shown particle size 68.8 μm, 78% entrapment efficiency and t 80% is about 420 minutes. Infrared spectroscopy analysis revealed that there was no known chemical interaction between drug and polymer. Hence this investigation demonstrated that the polymer to emulsifier ratio had a more significant effect on the dependent variables. In vitro release study reveals that the drug release from microsphere is in Fickian pattern. Pure drug and Formulation (F6) both showed cytotoxicity against Kato III cells after in vitro cytotoxicity. In vivo gamma scintillography and antitumor activity indicated that the formulation F6 remained buoyant and uniformly distributed in the gastric contents throughout the study period of 8 hours and statistically significant (P <0.05) reduction in the number of tumors obtained.


Meesala S.K.,Chouksey Engineering College
2012 International Conference on Computing, Communication and Applications, ICCCA 2012 | Year: 2012

Problems from many scientific and economic fields need a large computer power for their solution. The numeric simulation of complex systems like weather forecast' climate modeling' molecular biology and circuit design are some of such problem. There are two approaches to solve them. Either an expensive parallel supercomputer has to be used [First]' or the computer power of workstations in a net can be bundle to computer the task distributed [Second]. The second approach has the advantage that we use the available hardware cost-effective. This paper describes the architecture of a heterogeneous' concurrent' and distributed system' which can be used for solving large computational problems. We present a concurrent tasks distributed application for solving complex computational tasks in parallel. The design process is parallel processing implementation on clusters of terminals using Java RMI. © 2012 IEEE.


Choudhary B.,Chouksey Engineering College | Rakesh S.K.,Chouksey Engineering College
2016 1st International Conference on Innovation and Challenges in Cyber Security, ICICCS 2016 | Year: 2016

Agile software development has rapidly gained a lot of interest in the field of software engineering. Agile software development, despite its novelty, is an important domain of research within software engineering discipline. Agile software development methods have caught the attention of software engineers and researchers worldwide. Scientific research is yet scarce, there has been little detailed reporting of the usage, penetration and success of agile methodologies in traditional, professional software development organizations. We report on the results of an empirical study conducted at Microsoft to learn about agile development and its perception by people in development, testing, and management. This paper reports results from a study, which aims to organize, analyse and make sense out of the dispersed field of agile software development methods. © 2016 IEEE.


Khaskel A.,National Institute of Technology Silchar | Barman P.,National Institute of Technology Silchar | Jana U.,Chouksey Engineering College
RSC Advances | Year: 2015

Environmentally benign l-tyrosine loaded nanoparticles are fabricated and characterized by PCS, TEM, FT-IR and AFM studies. A novel straightforward green approach was applied for the synthesis of dicoumarols and Hantzsch 1,4-dihydropyridines using this catalyst. The structures and purity of these compounds were confirmed by FT-IR and NMR (1H, 13C and DEPT). The flexible and swelling properties of the polymer coating increase l-tyrosine dispersion and its high catalytic activity in organic reactions. This journal is © The Royal Society of Chemistry.


Tiwari P.,Chouksey Engineering College | Verma R.,Chouksey Engineering College | Ahirwar D.,Chouksey Engineering College | Chandy A.,Chouksey Engineering College | Dwivedi S.,Chouksey Engineering College
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To evaluate the anxiolytic effect of Syzygium aromaticum (S. aromaticum). Methods: Anxiolytic activity of S. aromaticum was evaluated by using two method i.e. elevated plus maze and light-dark model. Results: Hydroalcholic extract of S. aromaticum exhibited a prominent anxiolytic effect. Conclusions: The hydroalcholic extract of S. aromaticum showed statistically significant anxiolytic effect. © 2014 Asian Pacific Tropical Medicine Press.

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