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Ho Chi Minh City, Vietnam

Le V.S.,Medisotec | Nguyen C.D.,ChoRay Hospital | Le M.K.,Medisotec
Journal of Radioanalytical and Nuclear Chemistry | Year: 2014

Method of W separation from fission-99Mo solution was studied using alumina column and H2SO4/HNO3 eluents. The distribution coefficients of WO4 2- and MoO4 2- ions and the column loading/eluting conditions were investigated to optimize the separation process. 4-6 M H2SO4 solutions were successfully used to elute/separate 99MoO4 2- ions from the alumina column which strongly retained WO4 2- ions without significant W-breakthrough. The developed W/99Mo separation process is fit for being in-line incorporated/integrated in the alkaline dissolution-based process of fission-99Mo recovery currently used in LEU target-based 99Mo production. © 2014 Akadémiai Kiadó, Budapest, Hungary.

Vuong D.A.,Hanoi University of Science and Technology | Rades D.,University of Lubeck | Le A.N.,ChoRay Hospital | Busse R.,Health Management Technology
World Neurosurgery | Year: 2012

Background: This study aims to evaluate the cost-effectiveness of the treatment of brain metastasis with surgical resection (SR) and stereotactic radiosurgery (SRS) in the lower-middle-income country of Vietnam from the perspective of patients and families. Methods: The treatment of 111 patients with brain metastases who underwent SR (n = 64) and SRS (n = 47) was retrospectively reviewed. Propensity score matching was used to adjust for selection bias (n = 30 each); mean and curves of survival time were defined by the Kaplan-Meier estimator; the cost analysis focused on the time period of relevant treatment. Results: The mean survival times of SRS and SR were 11.9 and 10.5 months, and the 18-month survival rates were 32% and 14%, respectively (P = 0.346). The mean number of hospital bed days was significantly higher for SR than SRS (16.5 versus 7.6 days, P < 0.05), but direct costs of SR were significantly lower (14.5 as opposed to 35.3 million Vietnamese dong [VND] per patient, P < 0.001). However, indirect costs of SR were 10 times higher (26.0 versus 2.5 million VND per patient, P < 0.001). The cost per life year gained was higher for SR than SRS (46.4 and 38.1 million VND, respectively). Conclusions: SRS is similarly effective as SR. However, in the broader context of the cost-effectiveness from the perspective of patients and their families, SRS is more cost-effective. The lower costs directly charged by the hospital for SR may prevent poorer and older patients from choosing SRS. Thus, the overall cost-effectiveness of each treatment option should be taken into consideration in deciding on the treatment. © 2012 Elsevier Inc.

Chow P.K.H.,Singapore General Hospital | Chow P.K.H.,National University of Singapore | Chow P.K.H.,National Cancer Center | MacHin D.,Singapore Clinical Research Institute | And 16 more authors.
British Journal of Cancer | Year: 2011

Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. Methods: From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Cooperative Oncology Group (ECOG) performance rating of 0-3) from specialist care centres in six Asia-Pacific nations. Patients received placebo or MA (320 mg day -1). End points were overall survival (OS) and quality of life. Results: An adverse but not statistically significant difference in OS was found for MA vs placebo: median values 1.88 and 2.14 months, respectively (hazard ratio (HR)=1.25, 95% CI=0.92-1.71, P=0.16). However, OS was similar among patients of good functional status (Child-Pugh A and ECOG 0, 1 or 2) (44.3%) in both treatment groups, with the adverse effect of MA confined to those of poor status. Megestrol acetate patients had a worse global health status (not statistically significant) but reduced levels of appetite loss and nausea/vomiting. Conclusion: Megestrol acetate has no role in prolonging OS in advanced treatment-naive HCC. Overall survival with placebo differed markedly from that in similar trials conducted elsewhere, suggesting therapeutic outcomes may be strongly dependent on ECOG status and Child-Pugh score. © 2011 Cancer Research UK All rights reserved.

Huong N.T.M.,Ho Chi Minh City University of Technology | Khoa T.Q.D.,International Biomedical | Cuong N.T.K.,Ho Chi Minh City University of Technology | Ha V.Q.,Ho Chi Minh City University of Technology | And 5 more authors.
IFMBE Proceedings | Year: 2010

Pervasive electroencephalographic (EEG) artifacts associated with blinks, eye-movements, muscle noise, cardiac signals, and line noise poses a major challenge for EEG interpretation and analysis. Many methods have been proposed to remove artifacts from EEG recordings, especially those arising from eye movements and blinks. In Vietnam, epilepsy analysis methods, based on the EEG, is still the visual inspection of the EEG by a highly skilled electroencephalographer or neurophysiologist. But the doctors meet with the difficulties when the obtained scalp EEG recording have not only brain activities sginals but also the artifacts. Here, we use the independent components analysis (ICA) method to separate the clean data from the rest of the sources, artifacts within the brain. The separated independent components are good, we will clear the indpendent components is not brain activity sources and get EEG signals without the artifacts. © Springer-Verlag 2010.

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