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Tong T.-D.,University of Sichuan | Huang R.,University of Sichuan | Sun X.,University of Sichuan | Zhang Y.,Chongqing Yaoyou Pharmaceutical Co. | And 2 more authors.
Journal of Sichuan University (Medical Science Edition) | Year: 2013

Objective To prepare self-emulsifying delivery system (SEDDS) of Salvianolic acid B phospholipid complex (SaIB-PC) and evaluate its quality. Methods The best formulation was optimized using single-factor and pseudo-ternary phase diagrams, according to the emulsifying efficiency, the characteristics and partical size of the emulsion and other indicators. The morphology, particle size, zeta-potential and the release in artificial intestinal fluid of self-emulsifying formulation were evaluated. Results The weight ratio of SaIB-PC : Lauroglycol FCC : Cremophor EL : Transcutol P in the best formulation was 9 : 45 : 40 : 15. SaIB-PC loaded self-emulsifying formulation is yellow and transparent solution, with partical size about ( 187. 2 ± 7. 1 ) nm, polydispersity index (PDI) about 0. 267±0. 008 and zeta-potential about ( - 35. 6±2. 7) mV after diluted about 100-fold. The self-emulsifying formulation released slower than the solution with only SaIB or SaIB-PC. Conclusion Water-soluble drug Salvianolic acid B can be prepared to SEDDS, and this formulation can slow down the release of SaIB in artificial intestinal fluid.

Liu X.-W.,University of Sichuan | Fang Y.,University of Sichuan | Wang Q.,Chongqing Yaoyou Pharmaceutical Co. | Li R.,Chongqing Yaoyou Pharmaceutical Co. | And 2 more authors.
Yaoxue Xuebao | Year: 2010

To identify the structure of three related substances in potassium sodium dehydroandrographolide succinate (PSDS), an HPLC preparation method was used to separate the impurities. These main impurities were identified using LC-ESI/TOFMS, LC-ESI/MS n, NMR, UV and IR. One of the main impurities was a hydrolyzed and oxidized product of PSDS, which has not been reported previouely. The other two impurities were hydrolyzed products of PSDS after losing different succinic acids. The results indicate that PSDS can be easily hydrolyzed and oxidized. It should be stored at cool and dry places.

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