Chongqing Medical and Pharmaceutical College

Chongqing, China

Chongqing Medical and Pharmaceutical College

Chongqing, China
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Cao J.,Chongqing Electric Power College | Wei S.,Chongqing Normal University | Cai M.,Chongqing Medical and Pharmaceutical College
Biomedical Research (India) | Year: 2017

Objective: To investigate the influence factors and manifestations between acne and psychological distress in university students, so as to reveal their social and psychological inter-reaction mechanism. Methods: A survey of 2381 college and university students in was conducted using the professional survey website. Three questionnaires were included. The prevalence and the severity of acne was determined using the Pillsbury classification, the role of stress in acne formation was examined using the Adolescent Self-Rating Life Events Check List (ASLEC), and the psychological state of acne patients was determined using the Hospital Anxiety and Depression Scale (HADS). Results: A total of 55.4% of university students reported suffering from acne and 19.7% of them were graded as having severe acne. Negative life events were found to exacerbate acne. The most frequently reported negative life event was academic stress or failure, which had a prevalence of 74%. This was followed by criticism or discrimination by others (66%), intra-family conflicts/conflicts with parents (29%) and peer bullying/interpersonal conflicts (26%). Acne-affected groups all had significantly higher HADS-A and HADS-D scores compared with controls (7.31 vs. 4.37, 7.28 vs. 3.85, respectively; P<0.01). The HADS-D score was particularly high in the group with severe acne. Conclusion: Psychological stress has a negative effect on acne and lead to acne exacerbation. The internal relationship and influence mechanism between acne and psychological distress has been complex and affected by multiple social factors. The students, who suffered from academic and interpersonal pressure, are susceptible population to acne. At the stage of semi-matured, the students tend to sustain more psychological burden from acne. More attention and psychological support from school and society should be offered to the acne-attacked university students. © 2017, Scientific Publishers of India. All rights reserved.


Tao C.,Chongqing University of Technology | Chen R.,Chongqing University of Technology | Li J.,Chongqing Medical and Pharmaceutical College
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

We report an new approach of integrating photonic crystal fiber (PCF) SERS sensors to a Raman spectrometer for high sensitivity to the explosive 2,4,6-trinitrotoluene (TNT). The PCF SERS probe can be fabricated by using gold nanoparticles immobilized on the inner surface of air channels in a PCF through polymer-mediated self-assembly. To study the response of above fabricated substrates to the TNT vapor, the PCF SERS probe integrated with a Raman spectrometer was proposed and demonstrated in this study. The TNT-induced SERS signals are measured and the sensing capability of the proposed sensors is investigated experimentally. © 2016 SPIE.


Wan D.,Chongqing Medical University | Zhu H.-F.,Southwest University | Luo Y.,Southwest University | Xie P.,Chongqing Medical University | Zhou J.-L.,Chongqing Medical and Pharmaceutical College
Chinese Pharmacological Bulletin | Year: 2012

Aim: To research time window and dose treatment with catalpol through obseversion and evaluation of a neurologic function recovery in rat after permanent middle cerebral artery occlusion (p-MCAO). Methods: Eight groups were designed as sham-operated, model, ischemia-treated with catalpol, Citicoline and saline respectively. Catalpol was injected intraperitoneally 6h and 24h after pMCAO and repeatedly each day for 7d with the doses of 1, 5, 10 mg·kg-1. The neuroprotection was estimated by the indexes of behavior: the effects of catalpol on pMCAO rats was performed in a battery behavioral testing (Bederson scores, muscle strength scores, Beam walking scores and affected forelimb skilled reaching test) at different time points of 1, 4, 7, 14, 21 d after pMCAO. Results: Bederson score, balance function, muscle strength and percent success on forelimb skilled reaching were improved at most time points after the operation. Especially the percent success on forelimb skilled reaching in catalpol group was 48.7% ± 5.4% and 47.3% ± 4.8% at doses of 5 and 10 mg·kg-1 respectively, it was increased significantly than that of control group and model group (P < 0.05). It showed that catalpol could contribute to functional recovery of nerves after pMCAO. Conclusion: Catalpol (1, 5, 10 mg·kg-1) improves SD rats neurobehavioral consequences after pMCAO is evaluated by a battery of behavioral tests. 24 h after stroke, it is still effective to give catalpol at the dose of 5 mg·kg-1.


Zhang H.-Z.,Shandong University of Technology | Zhang H.-Z.,Southwest University | Gan L.-L.,Chongqing Medical and Pharmaceutical College | Wang H.,Shandong University of Technology | Zhou C.-H.,Southwest University
Mini-Reviews in Medicinal Chemistry | Year: 2017

The increasing incidence of microbial resistance and newly emerging pathogens have become a serious challenge for public health. More and more efforts have been directed to the development of new antimicrobial agents with distinct mechanisms from the well-known classes of clinical drugs. The extensive clinical utilization of azole-based medicinal drugs has evoked numerous attentions, and their researches and developments have been a quite rapid developing and active highlight topic with an infinite space. Consideration of our researches on azole compounds and other literature in recent three years, this review scientifically reviewed the new progress of azole derivatives as antibacterial, antifungal, antitubercular and antiviral agents, including mono-nitrogen azoles (oxazoles, thiazoles and carbazoles), bis-nitrogen azoles (imidazoles, pyrazoles and benzimidazoles) and tri-nitrogen azoles (triazoles and benzotriazoles) as well as tetrazole derivatives. It was hoped that this review would be helpful for the design and development of highly efficient azole derivatives with high bioactivity and low toxicity. © 2017 Bentham Science Publishers.


Li Y.,Southwest University | Lv X.,Southwest University | Zhou J.,Chongqing Medical and Pharmaceutical College | Shi C.,Southwest University | And 2 more authors.
Biology Open | Year: 2017

The objective of this study was to examine how the respiratory metabolism of the snakehead Channa argus changed when it shifted from breathing water to breathing air, and how increased metabolic demands caused by temperature, feeding, and exhaustive exercise affect its survival in air. The results demonstrated that the oxygen consumption rate (MO2) of the snakehead was lower for aerial respiration than aquatic respiration by 12.1, 24.5 and 20.4% at 20, 25, and 30°C, respectively. Survival time was significantly shortened with increasing temperature and was negatively correlated with the resting MO2 in air (MO2Air). No obvious feeding metabolic response was observed in the snakeheads fed at 1% and 3% body mass levels while breathing air. The maximum MO2Air of the snakehead after exhaustive exercisewas significantly higher than the restingMO2Air of the control group. The results suggest that the snakehead could survive out of water by breathing air for varying lengths of time, depending on ambient temperature and metabolic demand. Additionally, some degree of metabolic depression occurs in the snakehead when breathing air. The metabolic demand associated with exercise in the snakehead, but not that associated with feeding, can be supported by its capacity for breathing air to some extent. © 2017. Published by The Company of Biologists Ltd.


Angeloni N.L.,Northwestern University | Bond C.W.,Northwestern University | Tang Y.,Chongqing Medical and Pharmaceutical College | Harrington D.A.,Rice University | And 5 more authors.
Biomaterials | Year: 2011

SHH plays a significant role in peripheral nerve regeneration and has clinical potential to be used as a regenerative therapy for the CN in prostatectomy patients and in other patients with neuropathy of peripheral nerves. Efforts to regenerate the cavernous nerve (CN), which provides innervation to the penis, have been minimally successful, with little translation into improved clinical outcomes. We propose that, Sonic hedgehog (SHH), is critical to maintain CN integrity, and that SHH delivered to the CN by novel peptide amphiphile (PA) nanofibers, will promote CN regeneration, restore physiological function, and prevent penile morphology changes that result in erectile dysfunction (ED). We performed localization studies, inhibition of SHH signaling in the CN, and treatment of crushed CNs with SHH protein via linear PA gels, which are an innovative extended release method of delivery. Morphological, functional and molecular analysis revealed that SHH protein is essential to maintain CN architecture, and that SHH treatment promoted CN regeneration, suppressed penile apoptosis and caused a 58% improvement in erectile function in less than half the time reported in the literature. These studies show that SHH has substantial clinical application to regenerate the CN in prostatectomy and diabetic patients, that this methodology has broad application to regenerate any peripheral nerve that SHH is necessary for maintenance of its structure, and that this nanotechnology method of protein delivery may have wide spread application as an in vivo delivery tool in many organs. © 2010 Elsevier Ltd.


Wang Y.,Chongqing University | Ruan C.,Chongqing University | Sun J.,Chongqing University | Zhang M.,Chongqing University | And 3 more authors.
Polymer Degradation and Stability | Year: 2011

In order to investigate the effect of different chain extenders on degradation properties of segmented polyurethanes (SPUs), three types of segmented polyurethanes (SPU-P, SPU-O and SPU-A) based on poly (d, l-lactic acid) diol, hexamethylene diisocyanate (HDI), were synthesized with three chain extenders: peperazine (PP), 1, 4-butanediol (BDO) and 1, 4-butanediamine (BDA), respectively. Thermogravimetric analysis, activation energy and in vitro degradation were used to characterize the obtained polymers, quantitatively. The results revealed that chain extender played an important role in thermal degradation and biodegradation of polyurethanes. Thermogravimetric analysis and activation energy demonstrated that SPU-O, SPU-P and SPU-A presented best, second and weakest thermostability, respectively, and the thermal degradation mechanism of three SPUs was the same and regarded as a two-stage degradation. Data of hydrolytic degradation of the polymers during 12 weeks indicated that the in vitro degradation stability of SPU-A and SPU-P was similar, but both were better than that of SPU-O. The reason for the differences among three types of SPUs was discussed in this paper. © 2011 Elsevier Ltd. All rights reserved.


Zhu H.-F.,Southwest University | Wan D.,Chongqing Medical University | Luo Y.,Chongqing Medical University | Zhou J.-L.,Chongqing Medical and Pharmaceutical College | And 2 more authors.
International Journal of Biological Sciences | Year: 2010

To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately.


Luo P.,Chongqing Medical University | Liu Y.,Chongqing Medical and Pharmaceutical College | Xia Y.,Chongqing Medical University | Xu H.,Chongqing Medical University | Xie G.,Chongqing Medical University
Biosensors and Bioelectronics | Year: 2014

A sensitive electrochemical biosensor was developed to detect toxin A (TOA) of Clostridium difficile based on an aptamer selected by the systematic evolution of ligands using exponential enrichment and gold nanoparticles (GNPS) synthesized by Bacillus stearothermophilus. The thiolated single-stranded DNA used as the capture probe (CP) was first self-assembled on a Nafion-thionine-GNPS-modified screen-printed electrode (SPE) through an Au-thiol interaction. The horseradish peroxidase (HRP)-labeled aptamer probe (AP) was then hybridized to the complementary oligonucleotide of CP to form an aptamer-DNA duplex. In the absence of TOA, the aptamer-DNA duplex modified the electrode surface with HRP, so that an amperometric response was induced based on the electrocatalytic properties of thionine. This was mediated by the electrons that were generated in the enzymatic reaction of hydrogen peroxide under HRP catalysis. After the specific recognition of TOA, an aptamer-TOA complex was produced rather than the aptamer-DNA duplex, forcing the HRP-labeled AP to dissociate from the electrode surface, which reduced the catalytic capacity of HRP and reduced the response current. The reduction in the response current correlated linearly with the concentration of TOA in the range of 0-200. ng/mL. The detection limit was shown to be 1. nM for TOA. This biosensor was applied to the analysis of TOA and showed good selectivity, reproducibility, stability, and accuracy. © 2013 Elsevier B.V.


Li Q.,Chongqing Medical University | Li J.,Chongqing Medical and Pharmaceutical College | Lv F.,Chongqing Medical University | Li K.,Chongqing Medical University | And 2 more authors.
Journal of Clinical Neuroscience | Year: 2011

The circle of Willis is a major collateral circulation that has an important role in ischemic events. The purpose of our study was to investigate the collateral circulation in a Chinese population with 64-section multidetector CT angiography (CTA). A total of 170 patients who underwent 64-section CT angiography at The First Affiliated Hospital of Chongqing Medical University were included in our study. The morphological variations in the anterior and posterior circle of Willis were assessed in each patient. A total of 160 patients were included in the final analysis, of whom 126 (79%) demonstrated a complete anterior circle of Willis, and 50 (31%) had a complete posterior circle of Willis. A complete circle of Willis was seen in 43 of 160 participants (27%). A fetal-type posterior circle of Willis was seen in 15 (9.4%) patients. This is the first report of a CTA study of collateral circulation in a Chinese population. A higher prevalence of compromised posterior collaterals was observed in this Chinese population compared to Western and Japanese populations. © 2010 Elsevier Ltd. All rights reserved.

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