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Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2012-08-02

An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2012-10-24

The invention relates to a passive solid tumor-targeted anticancer prodrug and a preparation method thereof, belonging to the field of antitumor drugs. The preparation method comprises the following steps: reacting small molecular pectin with Mw of 5,000 - 45,000 with doxorubicin to obtain a pectin-doxorubicin conjugate with Mw of 100,000 - 1,000,000, preparing the conjugate into a suspension, and treating the suspension in an ultra-high pressure nano homogenizer to obtain the passive solid tumor-targeted anticancer prodrug with particle size of 100nm - 200nm and melting point of 220 - 245C, wherein the pectin and doxorubicin are linked by an amide bond, and the pectin is linked by an ester bond formed by condensing carboxyl groups and hydroxyl groups of pectin molecules. Cell inhibition rate of the anticancer prodrug for humanized lung cancer cells NCI-H446 and A549 is equivalent to that of doxorubicin hydrochloride. In the efficacy research of melanoma B16 pulmonary metastasis model mice, the life span of tumor-bearing mice is 42.312.4 days, which is remarkably higher than that of the doxorubicin hydrochloride group (23.110.2 days).


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2013-03-06

The invention belongs to the pharmaceutical field, and particularly relates to a lyophilized formulation of pectin-adriamycin conjugate and a preparation method thereof. In order to solve insolubility problem of the pectin-adriamycin conjugate (hereinafter referred to as PAC), improve bioavailability and facilitate preparation, the inventor prepared the PAC into a nanosuspension. However, as long-term stability of the nanosuspension is poor, the inventor proposed to prepare the nanosuspension into a lyophilized formulation, that is, an insoluble pectin-adriamycin conjugate is prepared into a suspension or nanosuspension, and a lyophilized support agent is added to the suspension for lyophilization treatment to prepare the lyophilized formulation. Lyophilized products prepared from the nanosuspension are characterized by enhanced stability of nano-particle size and enhanced stability of drug loading rate, which provides a new solution for clinical application of the PAC.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2012-08-01

A double-headed transfusion container comprises a body portion (1), both the top and the bottom of the body portion (1) being provided with an opening portion (2). The body portion (1) and the opening portion (2) are integrally formed of polypropylene blending plastic through blow molding, so as to obtain a seamless transparent polypropylene blending plastic transfusion container, which has advantages of a light weight and a low cost, further has good self-draining performance, and can steadily drain the liquid in the container from the container without any vent needle. Both the top and the bottom of the body portion (1) are provided with the opening portion (2), which facilitates connection to another independent auxiliary instrument better and can improve the safety of the transfusion product.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2012-08-02

A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7). In use, the rotary sleeve (4) is rotated to drive the guide part to rapidly move downwards and push a medicine container (17); an upper needle tip of the dosing double needle (2) pierces a sealing plug on the medicine container (17), and a lower needle tip pierces a diaphragm (23) in an interface (22), so that the medicine container (17) is instantly communicated with an infusion container (14), thereby implementing sterile closeness during the entire process of transportation, storage, butt joint, medicine mixing, and infusion.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2015-03-11

A double-headed transfusion container comprises a body portion (1), both the top and the bottom of the body portion (1) being provided with an opening portion (2). The body portion (1) and the opening portion (2) are integrally formed of polypropylene blending plastic through blow molding, so as to obtain a seamless transparent polypropylene blending plastic transfusion container, which has advantages of a light weight and a low cost, further has good self-draining performance, and can steadily drain the liquid in the container from the container without any vent needle. Both the top and the bottom of the body portion (1) are provided with the opening portion (2), which facilitates connection to another independent auxiliary instrument better and can improve the safety of the transfusion product.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2015-06-10

An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2015-03-11

A doser having two needles. The two needles consist of a needle seat (1), an upper needle (2), and a lower needle (3). The upper needle (2) and the lower needle (3) are arranged at two sides of the needle seat (1), and the upper needle (2) and the lower needle (3) both have a hollow structure and are in communication with each other. A medicine mixing body (4) of a cup structure is formed through extension in the direction along the edge of the needle seat (1) toward the upper needle (2). When the doser having two needle is used, it is only required that the upper needle (1) penetrates through a sealing plug of a medicine container and the lower needle (3) simultaneously penetrates through a sealing plug inside a sealing cover on a transfusion container, and by squeezing the transfusion container, medicine in the medicine container can be mixed with a solution in the transfusion container, which makes the medicine mixing operation simpler and more time saving.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2015-03-11

A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7). In use, the rotary sleeve (4) is rotated to drive the guide part to rapidly move downwards and push a medicine container (17); an upper needle tip of the dosing double needle (2) pierces a sealing plug on the medicine container (17), and a lower needle tip pierces a diaphragm (23) in an interface (22), so that the medicine container (17) is instantly communicated with an infusion container (14), thereby implementing sterile closeness during the entire process of transportation, storage, butt joint, medicine mixing, and infusion.


Patent
Chongqing Lummy Pharmaceutical Co. | Date: 2012-08-02

A doser having two needles. The two needles consist of a needle seat (1), an upper needle (2), and a lower needle (3). The upper needle (2) and the lower needle (3) are arranged at two sides of the needle seat (1), and the upper needle (2) and the lower needle (3) both have a hollow structure and are in communication with each other. A medicine mixing body (4) of a cup structure is formed through extension in the direction along the edge of the needle seat (1) toward the upper needle (2). When the doser having two needle is used, it is only required that the upper needle (1) penetrates through a sealing plug of a medicine container and the lower needle (3) simultaneously penetrates through a sealing plug inside a sealing cover on a transfusion container, and by squeezing the transfusion container, medicine in the medicine container can be mixed with a solution in the transfusion container, which makes the medicine mixing operation simpler and more time saving.

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