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Huang X.,Chongqing Medical University | Huang X.,Chongqing Key Laboratory of Neurobiology | Huang P.,Chongqing Medical University | Li D.,Chongqing Medical University | And 5 more authors.
International Journal of Psychophysiology | Year: 2014

Background: Major depressive disorder (MDD) is associated with dysfunction of the emotional circuitry in the brain. Psychotherapy and antidepressant treatment both aid in modulating this dysfunction, albeit probably through different mechanisms. A plausible "top-down" emotional regulation mechanism for psychotherapy has been described in previous studies, but the underlying findings are still contradictory. Methods: A total of 23 MDD patients and 20 healthy controls were enrolled. The early neural effects within 5. weeks of guided imagery-a psychotherapeutic method for treating depression-were assessed through resting-state functional magnetic resonance imaging using the regional homogeneity analytical method. Results: At baseline, regional homogeneity was reduced in cortical regions and increased in limbic areas in the pre-treatment scans of MDD patients as compared to controls. After 5. weeks of guided imagery therapy, regional homogeneity in the ventromedial prefrontal cortex and the anterior cingulate gyrus both increased. Higher pre-treatment regional homogeneity in the dorsal anterior cingulate gyrus was positively correlated with an improved response to guided imagery therapy. Conclusion: The changes in regional homogeneity induced by guided imagery therapy demonstrate that this method of psychotherapy takes effect through a "top-down" mechanism. Future studies comparing various psychotherapeutic methodologies across multiple time points in the treatment course should yield more valuable insights on this topic. © 2014 Elsevier B.V.

Zhang K.,Chongqing Key Laboratory of Neurobiology | Zhang K.,Chongqing Medical University | Zhang Y.,Chongqing Key Laboratory of Neurobiology | Zhang Y.,Chongqing Medical University | And 4 more authors.
International Journal of Oncology | Year: 2014

MicroRNAs (miRNAs) are non-coding single-stranded RNAs in eukaryotes and are involved in the regulation of the post-transcriptional expression of specific genes. Studies have demonstrated that miRNAs play important roles in regulating diverse physiological events such as cell proliferation, differentiation and embryo development. In recent decades, considerable attention has been given to the relationship between miRNA and the pathology of cancers, particularly breast cancer. A large number of miRNAs have been shown to be involved in the pathophysiology of breast cancer. Studies have revealed that some miRNAs might regulate the oncogenesis and growth of breast cancer by acting on breast tumor-initiating cells or other downstream targets. Studies have also demonstrated that some miRNAs act as suppressors of metastasis or promoters of breast cancer. Additionally, certain miRNAs are involved in cancer tissue angiogenesis (one of the most important mechanisms of tumor growth and metastasis). Clinical evidence indicates that some miRNAs can be used as diagnostic and prognostic biomarkers for breast cancer due to their significantly increased or decreased expression in cancer tissue. Moreover, certain miRNAs may have therapeutic potential for targeting ER-α/HER, breast tumor-initiating cells and metastasis as well as multidrug resistance. In this review, we discuss the relationship between miRNAs and the pathogenesis of breast cancer as well as the progress of current research on the miRNA-specific diagnosis, prognosis and treatment of breast cancer.

Wei Y.,Chongqing Medical University | Wei Y.,Chongqing Key Laboratory of Neurobiology | Zou D.,Chongqing Medical University | Zou D.,Chongqing Key Laboratory of Neurobiology | And 4 more authors.
Nutrition | Year: 2015

Objective: Epidemiologic studies evaluating the association between processed meat and red meat consumption and glioma risk have produced inconsistent results. Thus, the aim of this study was to conduct a meta-analysis to test the hypothesis that high levels of processed meat consumption could increase the risk for glioma. Methods: Pertinent studies were identified by a search of PubMed and Web of Knowledge up to February 2014. Random-effects model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test. Results: Fourteen studies involving 3641 cases about processed meat consumption and 3 studies involving 1156 cases about red meat consumption with risk for glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with processed meat consumption was 1.25 (95% confidence interval [CI], 1.08-1.45) overall, and 1.28 (95% CI, 1.09-1.50) in the United States. For subgroup of study design, significant association was also found in case-control studies (RR, 1.33; 95% CI, 1.09-1.62), but not in the cohort studies. The association was not significant between red meat consumption and glioma risk (summary RR, 0.89; 95% CI, 0.71-1.12). No publication biases were found. Conclusions: Our analysis indicated that high levels of processed meat consumption might increase the risk for glioma, and findings are consistent with the hypothesis. No association was found between red meat consumption and glioma risk. © 2015 Elsevier Inc.

Huang P.,Chongqing Medical University | Huang P.,Chongqing Key Laboratory of Neurobiology | Qiu L.,University of Sichuan | Shen L.,Chongqing Medical University | And 8 more authors.
Human Brain Mapping | Year: 2013

As a complex mental process, creativity requires the coordination of multiple brain regions. Previous pathological research on figural creativity has indicated that there is a mechanism by which the left side of the brain inhibits the activities of the right side of the brain during figural creative thinking, but this mechanism has not been directly demonstrated. In this study, we used functional magnetic resonance imaging (fMRI) to demonstrate the existence of this inhibitory mechanism in young adults (15 women, 11 men, mean age: 22 years) that were not artists. By making comparisons between brain activity during creative and uncreative tasks, we found increased activity in the left middle and inferior frontal lobe and strong decreases in activity in the right middle frontal lobe and the left inferior parietal lobe. As such, these data suggest that the left frontal lobe may inhibit the right hemisphere during figural creative thinking in normal people. Moreover, removal of this inhibition by practicing artistry or through specific damage to the left frontal lobe may facilitate the emergence of artistic creativity. © 2012 Wiley Periodicals, Inc.

Zheng P.,Chongqing Medical University | Zheng P.,Chongqing Key Laboratory of Neurobiology | Gao H.C.,Wenzhou Medical College | Li Q.,Chongqing Medical University | And 16 more authors.
Journal of Proteome Research | Year: 2012

Major depressive disorder (MDD) is a socially detrimental psychiatric disorder, contributing to increased healthcare expenditures and suicide rates. However, no empirical laboratory-based tests are available to support the diagnosis of MDD. In this study, a NMR-based plasma metabonomic method for the diagnosis of MDD was tested. Proton nuclear magnetic resonance ( 1H NMR) spectra of plasma sampled from first-episode drug-naïve depressed patients (n = 58) and healthy controls (n = 42) were recorded and analyzed by orthogonal partial least-squares discriminant analysis (OPLS-DA). The OPLS-DA score plots of the spectra demonstrated that the depressed patient group was significantly distinguishable from the healthy control group. Moreover, the method accurately diagnosed blinded samples (n = 26) in an independent replication cohort with a sensitivity and specificity of 92.8% and 83.3%, respectively. Taken together, NMR-based plasma metabonomics may offer an accurate empirical laboratory-based method applicable to the diagnosis of MDD. © 2012 American Chemical Society.

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