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Zeng X.,Chongqing Medical University | Zeng X.,Chongqing Key Laboratory for Research on Infectious Diseases | Xu C.,Chongqing Medical University | Xu C.,Chongqing Key Laboratory for Research on Infectious Diseases | And 15 more authors.
Ultrasound in Medicine and Biology | Year: 2015

Hepatic inflammation may affect the performance of FibroScan. This prospective study investigated the influence of hepatic inflammation on liver stiffness measurement (LSM) values by assessing FibroScan and liver biopsy findings in 325 patients with chronic hepatitis B. Liver fibrosis and inflammation were classified into five stages (S0-S4) and grades (G0-G4) according to the Scheuer scoring system. LSM values were correlated with fibrosis stage and inflammation grade ( r= 0.479, p < 0.001, and r= 0.522, p < 0.001, respectively). Although LSM values increased in parallel with inflammation grade, no significant differences were found between patients with significant fibrosis (S2-S4) ( p > 0.05). For inflammation grades G0, G1, G2 and G3, areas under receiver operating characteristic curves of FibroScan for significant fibrosis were 0.8267 ( p < 0.001), 0.6956 ( p < 0.001), 0.709 ( p= 0.0012) and 0.6947 ( p= 0.137), respectively. Inflammation has a significant influence on LSM values in patients with chronic hepatitis B with mild fibrosis, but not in those with significant fibrosis. © 2015 World Federation for Ultrasound in Medicine & Biology.

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