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Zhou J.,Chongqing Medical University | He W.,Chongqing Medical University | He W.,Chongqing Key Laboratory for Proteomics of Diseases | Luo G.,Chongqing Medical University | And 2 more authors.
Archivum Immunologiae et Therapiae Experimentalis | Year: 2013

Transplantation of allogeneic or xenogeneic skin grafts can evoke strong immune responses that lead to acute rejection of the graft tissues. In this process, donor-derived dendritic cells play crucial roles in the triggering of such immune responses. Both the innate and acquired host immune systems participate in graft rejection. At present, the rejection of skin grafts cannot be well-controlled by ordinary systemic immunosuppression therapy. Although several strategies for the long-term survival of allogeneic or xenogeneic skin grafts have been demonstrated in animal models, the induction of long-term tolerance to skin grafts is still a great challenge in clinical settings. In this article, we review the progress in the understanding of immune responses to skin grafts and discuss the possible methods that can decrease the immunogenicity of graft tissues and improve the survival of skin grafts, especially those included in preoperative pre-treatments. © 2013 L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.

Huang Z.,Chongqing Medical University | Huang Z.,Chongqing Key Laboratory for Proteomics of Diseases | Yang J.,Chongqing Medical University | Yang J.,Chongqing Key Laboratory for Proteomics of Diseases | And 24 more authors.
PLoS ONE | Year: 2010

How to improve the wound healing quality of severe burn patients is still a challenge due to lack of skin appendages and rete ridges, no matter how much progress has been made in the fields of either stem cell or tissue engineering. We thus systematically studied the growth potential and differentiation capacity of porcine embryonic skin precursors. Implantation of embryonic skin precursors (PESPs) of different gestational ages in nude mice can generate the integrity skin, including epidermis, dermis and skin appendages, such as sweat gland, hair follicle, sebaceous gland, etc.. PESPs of embryonic day 42 possess the maximal growth potential, while, the safe window time of PESPs transplantation for prevention of teratoma risk is E56 or later. In conclusion, PESPs can form the 3 dimensional structures of skin with all necessary skin appendages. Our data strongly indicate that porcine embryonic skin precursors harvested from E56 of minipig may provide new hope for high-quality healing of extensive burns and traumas. © 2010 Huang et al.

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