Yao Y.-G.,Chongqing Institute of Cardiovascular Disease |
Zhang M.,Chongqing Medical University |
Li M.-X.,Chongqing Institute of Cardiovascular Disease |
Zeng J.,Chongqing Institute of Cardiovascular Disease |
Zeng C.-Y.,Chongqing Institute of Cardiovascular Disease
Medical Journal of Chinese People's Liberation Army | Year: 2014
Objective To identify the protective effect of rhMG53 (exogenous recombinant human MG53 protein) on focal cerebral ischemia/reperfusion injury in a rat model. Methods The cerebral ischemia reperfusion model was reproduced in SD rats using middle cerebral artery occlusion (MCAO) method, and the rats were then randomly divided into sham operation group, ischemia reperfusion group, and ischemia reperfusion+rhMG53 group (n=7). The Zea-Longa score of nervous system, brain tissue TTC staining and pathological sections were observed. ResultCompared with the ischemia reperfusion group, nerve dysfunction was improved obviously in ischemia reperfusion+rhMG53 group. The area of cerebral infarction was reduced, and the extent of brain tissue necrosis was alleviated. Furthermore, the protective effect showed a relation with the treatment time. The time-window of effective protection of exogenous rhMG53 on cerebral ischemia reperfusion injury was within 4 hours. Conclusion The exogenous rhMG53 may have an effective protective effect on focal cerebral ischemia reperfusion injury.