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Li J.,Southwest University for Nationalities | Kuang G.,Chongqing University | Chen X.,Chongqing Institute for Food and Drug Control | Zeng R.,Southwest University for Nationalities
Molecules | Year: 2016

The Paeonia genus, an important source of crude drugs, has been extensively used in traditional Chinese medicine (TCM) to treat cardiovascular and female-related diseases. Although many peony species have been investigated, the study of Paeonia rockii is still quite limited, especially its chemical composition. Here, an advanced ultra-high-performance liquid chromatography (UHPLC) analytical technique combined with Q-Exactive Orbitrap hybrid quadrupole-Orbitrap mass spectrometry utilizing high-resolution full MS and MS/MS scan modes was applied to screen and identify the chemical constituents of this species. As a result, a total of 46 compounds were characterized, including 11 monoterpene glycosides, five phenolic acids, six tannins and 24 flavonoids. Among them, 16 compounds were reported for the first time in Paeonia rockii. © 2016 by the authors; licensee MDPI, Basel, Switzerland. Source

Zhong M.,Chongqing Medical University | Yang L.,Chongqing Institute for Food and Drug Control | Yang M.,Chongqing Medical University | Hu X.-Y.,Chongqing Medical University | Zhang J.-Q.,Chongqing Medical University
Academic Journal of Second Military Medical University | Year: 2014

Objective To study the role of azithromycin niosomes (AM-NS) in promoting the intestinal absorption of AM in rats. Methods Six healthy male rates were randomly divided into two groups. Single-pass intestinal perfusion was employed to investigate the intestinal absorption of the duodenum, jejunum, ileum and colon when the perfusion rate was 0. 2 mL/min and period was 1 h. The concentrations of the drugs were determined by HPLC; the drug absorption rate constant (Ka) and the intestinal apparent permeation coefficients (Peff) were calculated. Results The absorption Ka of AM-NS in the duodenum, jejunum, ileum and colon were 2. 41, 2. 35, 2. 54 and 2. 95 folds that of the free AM, and the Peff were 2. 34, 1. 47, 2. 20, and 1. 40 folds that of the free AM, respectively, with significant differences found between the two groups for both Ka and Peff (P<0. 05). Conclusion AM-NS can significantly improve the absorption of azithromycin in the intestine of rats. Source

Luo J.,Chongqing Medical University | Ren X.,Chongqing Institute for Food and Drug Control | Yu T.,Chongqing Medical University
International Journal of Radiation Biology | Year: 2015

Purpose: To evaluate the efficacy of extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) based upon data in controlled clinical trials in China. Materials and methods: Data in 75 controlled trials involving in 833 cases of benign and 4559 cases of malignant diseases were re-evaluated. Results: In uterine fibroid, ectopic pregnancy and chyluria, the efficacy of HIFU was similar to that of surgery or drugs. The survival rate of HIFU plus radiotherapy was less than that of radical surgery in operable liver cancer. In inoperable liver cancer, the survival benefit of HIFU was similar to that of radio frequency, transarterial chemoembolization or γ-knife. In pancreatic cancer, HIFU and chemotherapy produced similar survival rates, and HIFU did not improve the effect of chemotherapy or radiotherapy. HIFU did not enhance hormone therapy in prostate cancer. Preoperative HIFU increased rates of complete removal and of survival in retroperitoneal sarcoma, and increased the response rate in breast cancer. The response rate agreed with the survival benefit (κ = 0.71, p = 0.0002). Conclusions: HIFU should be curtailed in resectable cases and be an alternative in inoperable cases; a combination regimen should not be recommended. The Response Evaluation Criteria in Solid Tumors can be applied to HIFU. © 2015 Informa UK, Ltd. Source

Zhao J.,Shenyang Pharmaceutical University | Guo J.,Shenyang Pharmaceutical University | Zhang Y.,Chongqing Institute for Food and Drug Control | Meng D.,Shenyang Pharmaceutical University | Sha Z.,Shenyang Pharmaceutical University
Journal of Functional Foods | Year: 2015

Stauntonia brachyanthera Hand-Mazz., known as zhuyaozi or north banana by Dong Ethnicity in the southwest of China, is widely accepted as a delicious fruit with high economic value because of the presence of health-promoting components and the delivery of new tastes. In search for antioxidant compounds, the activity-guided fractionation and purification processes were performed on the stems and roots of S. brachyanthera, which resulted in the isolation of six new compounds, brachyanin A-F (1-6), and seven known compounds (7-13). Their structures were elucidated by 1D and 2D NMR, and HR-ESI-MS. Brachyanin A (1) exhibited significant cytotoxicity against HepG2 and K562 cell lines with IC50 values of 6.93 and 7.89 M, respectively, and possessed antioxidant activity. Six compounds presented stronger antioxidant activities than those of vitamin C and quercetin in three tests (DPPH, ABTS, and FRAP). Among them, calceolarioside B (9) exhibited strongest activity and was present in higher amounts in the plant, which could be designated as characteristic component for the pharmacognostic identification and the quality control of S. brachyanthera. These findings laid solid theoretical references for the exploration of traditional usage of S. brachyanthera. © 2015 Elsevier Ltd. Source

Wu Z.,Chongqing Academy of Chinese Materia Medica | Li H.,Chongqing Institute for Food and Drug Control | Yang Y.,Chongqing Academy of Chinese Materia Medica | Tan H.,Chongqing Academy of Chinese Materia Medica
International Journal of Biological Macromolecules | Year: 2015

The dried flower buds of L. macranthoides, belong to the item Shan Yin Hua, are widely used as raw materials for pharmaceutical, food additive, healthy food and cosmetic industry in China. To optimize the effects of the ultrasonic-assisted extraction (UAE) processing parameters on the yield of L. macranthoides polysaccharides (LMPs), a response surface methodology with a central composite rotatable design was employed. Four independent variables were investigated: ultrasonic power (X1), temperature (X2), time (X3), and the ratio of water volume to raw material weight (W/M ratio, X4). The experimental data were fitted to a quadratic polynomial equation using multiple regression analysis and also examined using appropriate statistical methods. The optimum conditions were: X1, 113.6W; X2, 71.5°C; X3, 54.7min; and X4, 30.7mL/g. Under the optimal conditions, the extraction yield of LMPs was (4.81±0.12)%, which is in close agreement with the value predicted by the statistical model. Further, LMPs were characterized by FT-IR, XRD, TGA/DSC and NMR. In vitro experiments indicated that LMPs had strong scavenging capacities towards the DPPH, hydroxyl and superoxide radicals. Overall, LMPs may have potential applications in the medical and food industries. © 2014 Elsevier B.V. Source

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