Chongqing Institute for Food and Drug Control

Chongqing, China

Chongqing Institute for Food and Drug Control

Chongqing, China
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Wu Z.,Chongqing Academy of Chinese Materia Medica | Li H.,Chongqing Institute for Food and Drug Control | Tu D.,Chongqing Institute for Food and Drug Control
Food Analytical Methods | Year: 2015

Currently, the detection of rapeseed oil (RSO) adulterated with refining and purificating waste cooking oil (WCO) is an attractive work for researchers in accordance with food safety all over the world particularly in China. There is a rapid increasing requirement for more accurate and sensitive detection method to cope the more subtle adulterations in edible oils. For this reason, Fourier transform infrared (FT-IR) spectroscopy in the combination with chemometrics was developed for detection and quantification of WCO as adulterants in RSO. The quantification of WCO was carried out by using multivariate calibrations of partial least squares (PLS) and principle component regression (PCR). PLS with first derivative FT-IR spectra was more suitable compared with PCR for quantification purposes with coefficient of determination (R2) higher than 0.998 and root mean square error of calibration (RMSEC) of 0.494 % (v/v). The PLS model was further used to predict the levels of WCO in independent samples for validation/prediction purpose. The proposed methodology is a useful tool to authenticate RSO adulterated with used WCO. [Figure not available: see fulltext.] © 2015, Springer Science+Business Media New York.

Huang X.-L.,Chongqing Institute for Food and Drug Control | Wu Y.-L.,Chongqing Institute for Food and Drug Control | Li H.,Chongqing Institute for Food and Drug Control | Tu D.-W.,Chongqing Institute for Food and Drug Control
Journal of Chinese Mass Spectrometry Society | Year: 2015

The method for determination BrO3- in packing drinking water by high performance liquid chromatography coupling with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) was developed. The detection limit, accuracy and precision of HPLC-ICP-MS and ion chromatography were compared. And the two methods were employed to determine BrO3- in 20 packing drinking water samples. The HPLC-ICP-MS shows good linearity within 1.0-50.0 μg/L with the correlation coefficient (R) 0.999 9. The limit of detection is 0.048 μg/L and the recovery is 96.8%-104.9%. The ion chromatography shows good linearity within 10.0-200.0 μg/L with the correlation coefficient (R) 0.999 2 as well. The limit of detection is 2.0 μg/L and the recovery is 85.6%-101.3%. The two methods show good accuracy, precision and consistency. Moreover, in comparison to ion chromatography, the HPLC-ICP-MS was found to be more sensitive, selective and rapid, especially suitable for the routine analysis of low concentration bromate in packing drinking water. ©, 2015, Chinese Society for Mass Spectrometry. All right reserved.

Luo J.,Chongqing Medical University | Ren X.,Chongqing Institute for Food and Drug Control | Yu T.,Chongqing Medical University
International Journal of Radiation Biology | Year: 2015

Purpose: To evaluate the efficacy of extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) based upon data in controlled clinical trials in China. Materials and methods: Data in 75 controlled trials involving in 833 cases of benign and 4559 cases of malignant diseases were re-evaluated. Results: In uterine fibroid, ectopic pregnancy and chyluria, the efficacy of HIFU was similar to that of surgery or drugs. The survival rate of HIFU plus radiotherapy was less than that of radical surgery in operable liver cancer. In inoperable liver cancer, the survival benefit of HIFU was similar to that of radio frequency, transarterial chemoembolization or γ-knife. In pancreatic cancer, HIFU and chemotherapy produced similar survival rates, and HIFU did not improve the effect of chemotherapy or radiotherapy. HIFU did not enhance hormone therapy in prostate cancer. Preoperative HIFU increased rates of complete removal and of survival in retroperitoneal sarcoma, and increased the response rate in breast cancer. The response rate agreed with the survival benefit (κ = 0.71, p = 0.0002). Conclusions: HIFU should be curtailed in resectable cases and be an alternative in inoperable cases; a combination regimen should not be recommended. The Response Evaluation Criteria in Solid Tumors can be applied to HIFU. © 2015 Informa UK, Ltd.

Zhao J.,Shenyang Pharmaceutical University | Guo J.,Shenyang Pharmaceutical University | Zhang Y.,Chongqing Institute for Food and Drug Control | Meng D.,Shenyang Pharmaceutical University | Sha Z.,Shenyang Pharmaceutical University
Journal of Functional Foods | Year: 2015

Stauntonia brachyanthera Hand-Mazz., known as zhuyaozi or north banana by Dong Ethnicity in the southwest of China, is widely accepted as a delicious fruit with high economic value because of the presence of health-promoting components and the delivery of new tastes. In search for antioxidant compounds, the activity-guided fractionation and purification processes were performed on the stems and roots of S. brachyanthera, which resulted in the isolation of six new compounds, brachyanin A-F (1-6), and seven known compounds (7-13). Their structures were elucidated by 1D and 2D NMR, and HR-ESI-MS. Brachyanin A (1) exhibited significant cytotoxicity against HepG2 and K562 cell lines with IC50 values of 6.93 and 7.89 M, respectively, and possessed antioxidant activity. Six compounds presented stronger antioxidant activities than those of vitamin C and quercetin in three tests (DPPH, ABTS, and FRAP). Among them, calceolarioside B (9) exhibited strongest activity and was present in higher amounts in the plant, which could be designated as characteristic component for the pharmacognostic identification and the quality control of S. brachyanthera. These findings laid solid theoretical references for the exploration of traditional usage of S. brachyanthera. © 2015 Elsevier Ltd.

Wu Z.,Chongqing Academy of Chinese Materia Medica | Li H.,Chongqing Institute for Food and Drug Control | Yang Y.,Chongqing Academy of Chinese Materia Medica | Tan H.,Chongqing Academy of Chinese Materia Medica
International Journal of Biological Macromolecules | Year: 2015

The dried flower buds of L. macranthoides, belong to the item Shan Yin Hua, are widely used as raw materials for pharmaceutical, food additive, healthy food and cosmetic industry in China. To optimize the effects of the ultrasonic-assisted extraction (UAE) processing parameters on the yield of L. macranthoides polysaccharides (LMPs), a response surface methodology with a central composite rotatable design was employed. Four independent variables were investigated: ultrasonic power (X1), temperature (X2), time (X3), and the ratio of water volume to raw material weight (W/M ratio, X4). The experimental data were fitted to a quadratic polynomial equation using multiple regression analysis and also examined using appropriate statistical methods. The optimum conditions were: X1, 113.6W; X2, 71.5°C; X3, 54.7min; and X4, 30.7mL/g. Under the optimal conditions, the extraction yield of LMPs was (4.81±0.12)%, which is in close agreement with the value predicted by the statistical model. Further, LMPs were characterized by FT-IR, XRD, TGA/DSC and NMR. In vitro experiments indicated that LMPs had strong scavenging capacities towards the DPPH, hydroxyl and superoxide radicals. Overall, LMPs may have potential applications in the medical and food industries. © 2014 Elsevier B.V.

Yu T.,Chongqing Medical University | Yang Y.,Chongqing Medical University | Zhang J.,Chongqing Medical University | He H.,Sichuan Provincial Peoples Hospital | Ren X.,Chongqing Institute for Food and Drug Control
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2015

Cisplatin resistance is a challenge in the treatment of ovarian cancer. The aim of this study was to explore if ultrasound can overcome chemoresistance and enhance chemosensitization due to cyclosporin A. Ultrasound and/or cyclosporin A were employed to overcome cisplatin resistance in human ovarian cancer cell line COC1/DDP. Mechanisms were explored from the perspective of: DNA damage, intracellular platinum level, detoxification, and genes related to drug efflux and DNA repair. In vivo therapeutic efficacy was validated in a short-term model (subrenal cell-clot transplantation) in mice and the survival benefit was investigated in an orthotopic cancer model in mice using HO-8910PM cells. The findings were: (i) ultrasound enhanced the effect of cisplatin leading to a lower cell-survival rate (IC50 decreased from 3.19 to 0.35 μg/ml); (ii) ultrasound enhanced cisplatin via direct (increasing the intercellular level of active platinum) and indirect (decreasing the glutathione level, and expression of LRP and ERCC1 genes) mechanisms that intensified cisplatin-induced DNA damage, thus enhancing cell apoptosis and necrosis; (iii) cisplatin followed by ultrasound led to small tumor sizes in the short-term model without exacerbation of the systemic toxicity, and prolonged the survival times in the orthotopic model; and (iv) ultrasound synergized the sensitization due to cyclosporin A in vitro and in vivo. These data demonstrated that ultrasound combined with cyclosporin A overcame cisplatin resistance in ovarian cancer. © 2015 Elsevier B.V. All rights reserved.

He D.,Chongqing Medical University | Deng P.,Chongqing Medical University | Yang L.,Chongqing Institute for Food and Drug Control | Tan Q.,Chongqing Medical University | And 3 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2013

A hydrophobic drug, rifampin (RFP), was molecularly encapsulated into hydroxylpropyl-β-cyclodextrin (HCD) to form a molecular inclusion complex (MRICD) with higher solubility and stability. A solid-state grinding method was applied to prepare MRICD for 0.5. h. The inclusion ratio, binding constant and the change of Gibbs free energy estimated from the phase solubility diagram and/or by the ultraviolet-visible spectroscopic method were 1:1, ∼218. mol/L and -1.767. KJ/mol, respectively. Differential scanning calorimetry and Fourier transformed infrared spectra of MRICD confirmed the molecular interactions between RFP and HCD. Morphological differences between MICDH and RFP further confirmed the molecular encapsulation of RFP. The most probable configuration of MRICD was estimated via computer simulation. MRICD had a higher dissolution rate than free RFP. Weibull function fit well the dissolution data of MRICD. Broth macrodilution experiments indicated that MRICD had good antibacterial activity. MRICD might be a promising system for oral or parenteral drug delivery to treat bacterial infections. © 2012 Elsevier B.V.

Yan W.-X.,Shenyang Pharmaceutical University | Zhang J.-H.,Shenyang Pharmaceutical University | Zhang Y.,Chongqing Institute for Food and Drug Control | Meng D.-L.,Shenyang Pharmaceutical University | Yan D.,Capital Medical University
Journal of Ethnopharmacology | Year: 2015

Jasminum lanceolarium Roxb is an important traditional Chinese medicine. Its stems and roots have been used for the treatment of rheumatism and fever while the leaves are used as an anti-inflammatory agent to relieve pain. In order to support its traditional Chinese medicinal uses, five animal models were designed and the anti-inflammatory and analgesic properties of the 70% EtOH-H2O extracts of J. lanceolarium (EJL) were investigated. Meanwhile, biochemical parameters such as cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) in blood serum of rats exposed to acute (carrageenan) inflammation model were evaluated. At doses of 400 mg/kg, EJL exhibited higher anti-inflammation effect than that of indomethacin and better analgesic activity than that of aspirin (P<0.001). Furthermore, eleven isolated compounds including six lignanoids (1, 2, 6, 7, 8, and 11) and five iridoids (3, 4, 5, 9, and 10) were isolated from the active extracts and showed significant anti-inflammatory activities with the IC50 values of 1.76-5.22 mg/mL, respectively, when testing their inhibitory effects on phospholipase A2 in vitro. The results demonstrated that the possible anti-inflammatory mechanisms might be attributed to inhibit the hydrolysis of membrane phospholipids, production on both COX-2 and 5-LOX, and then finally inhibit the release of prostaglandins (PGs), which suggested that EJL had a non-selective inhibitory effect on the release or actions of these mediators, and might be a dual LOX-COX inhibitor for the treatment of inflammation from the natural resource. The studies on the animals and the inflammatory mediators, along with the bioactive compounds presumed that the existences of iridoids and lignanoids could be response for their bioactivities of the whole plants. © 2015 Elsevier Ireland Ltd. All rights reserved.

PubMed | Chongqing Institute for Food and Drug Control, Southwest University for Nationalities and Chongqing University
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

The Paeonia genus, an important source of crude drugs, has been extensively used in traditional Chinese medicine (TCM) to treat cardiovascular and female-related diseases. Although many peony species have been investigated, the study of Paeonia rockii is still quite limited, especially its chemical composition. Here, an advanced ultra-high-performance liquid chromatography (UHPLC) analytical technique combined with Q-Exactive Orbitrap hybrid quadrupole-Orbitrap mass spectrometry utilizing high-resolution full MS and MS/MS scan modes was applied to screen and identify the chemical constituents of this species. As a result, a total of 46 compounds were characterized, including 11 monoterpene glycosides, five phenolic acids, six tannins and 24 flavonoids. Among them, 16 compounds were reported for the first time in Paeonia rockii.

PubMed | Chongqing Institute for Food and Drug Control and Southwest University
Type: Journal Article | Journal: Korean journal for food science of animal resources | Year: 2017

The aim of this study was to explore the volatile compounds of hind leg, foreleg, abdomen and

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