Chongqing Cancer Research Institute

Chongqing, China

Chongqing Cancer Research Institute

Chongqing, China
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Cai T.,Chongqing Medical University | Jiang Q.,Chongqing Cancer Research Institute
OncoTargets and Therapy | Year: 2014

Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/ computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic foor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period. © 2014 Cai et al.


PubMed | Chongqing Cancer Research Institute and Chongqing Medical University
Type: | Journal: OncoTargets and therapy | Year: 2014

Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic floor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period.


Li K.,Chongqing Cancer Research Institute | Li K.,Chongqing Medical University | Chen Y.,Chongqing Medical University | Jiang R.,Chongqing Medical University | And 9 more authors.
Molecular Medicine Reports | Year: 2017

3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranos yl-cycloastragenol, or Astragaloside IV (AST), is one of the major active ingredients isolated from Astragalus membranaceous with distinct pharmacological effects, and possesses anti-inflammatory, immunoregulatory and antifibrotic properties. However, the effects of AST on allergic rhinitis remain to be elucidated. The present study aimed to examine the effects of AST on immunoglobulin (Ig) E-mediated allergic reactions in vivo, by using a mouse model of allergic rhinitis established via repetitive sensitization and intranasal challenge with ovalbumin (OVA). Intragastric administration of AST (25 mg/kg or 50 mg/kg) or dexamethasone (DEX; 3 mg/kg) significantly alleviated the inflammatory response, nasal symptoms and mucosa remodeling, and decreased the serum levels of OVA-specific IgE in allergic mice. Furthermore, treatment with AST or DEX significantly suppressed the mRNA and protein expression levels of the transcription factor GATA-3 and retinoic acid receptor-related orphan nuclear receptor (ROR)γt in tissue samples isolated from the spleen and nasal mucosa of mice with allergic rhinitis. Conversely, mRNA and protein expression levels of T-box protein expressed in T cells (T-bet) and forkhead box protein 3 (Foxp3) were upregulated in the spleen and nasal mucosa of mice with allergic rhinitis following treatment with AST or DEX, and spleen protein levels of signal transducer and activator of transcription 3 followed a similar trend. In addition, treatment with AST was associated with fewer adverse events compared with treatment with DEX. The present results suggested that treatment with AST may attenuate OVA-induced allergic rhinitis via regulating the expression of the transcription factors GATA-3, RORγt, T-bet and Foxp3, which commit T helper cells to the Th1 phenotype. Therefore, AST may represent an alternative therapeutic approach for the treatment of patients with allergic rhinitis.


Shu J.,Chongqing Cancer Research Institute | Yuan L.,Chongqing Cancer Research Institute | Liu X.-M.,Chongqing Cancer Research Institute | Zhou Q.,Chongqing Cancer Research Institute
Tumor | Year: 2014

Objective: To investigate the effect of microRNA-124 (miR-124) on growth and distant metastasis of subcutaneous xenografts of SKOV3 human epithelial ovarian cancer cell line in nude mice. Methods: SKOV3 cells were transiently transfected with miR-124-mimics or miR-124-mimics-negative control (miR-124-mimics-NC) by LipofectAMINE 2000 and then subcutaneously transplanted into nude mice to establish tumor models. After the xenografts formed in nude mice, miR-124-mimics or miR-124- mimics-NC combined with liposome was injected into xenografts every four days. The tumor growth and the change of tumor volume were observed. The nude mice were dissected at day 47 after the start of intratumoral injection. The tumor growth curve was drawn and the tumor inhibition rate was calculated. The expression level of miR-124 in tumor tissues was detected by real-time fluorogenic quantitative-PCR. The expressions of Ki-67 and caspase-3 proteins in tumor tissues were examined by immunohistochemistry. The nude mice were dissected to observe the liver metastasis and the liver tissues were stained with hematoxylin-eosin (HE). Results: After transfection of miR-124-mimics into SKOV3 cells, the expression of miR-124 was significantly increased. The tumor volume of miR-124 group was significantly smaller than that of the blank control group and the negative control (NC) group 47 days after tumor formation with a statistical significance (P < 0.05), the growth inhibitory effect on tumor in miR-124 group was obvious. As compared with the blank control group and the NC group, the expression level of miR-124 was elevated, the expression level of Ki-67 was significantly decreased, while the expression level of caspase-3 was significantly increased in miR-124 group tumor tissues. The result of HE staining showed tumor cell invasion in liver tissues in the blank control group and the NC group but not in miR-124 group. Conclusion: miR-124 can inhibit the growth and distant metastasis of subcutaneous xenografts of human epithelial ovarian cancer cells in nude mice, and it may be a potenital novel target of gene therapy for ovarian carcinoma. Copyright © 2014 by TUMOR.

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