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Yang L.,Chongqing Academy of Animal Science
Chinese Journal of Biologicals

Phage, a virus using different bacteria as hosts, has strictly bacterial host specificity, and parasitizes only in the susceptible hosted bacteria. Without toxicity to animal or plant cells, phage has simple structure and a small quantity of gene, which becomes a fine operating system for molecular biology and genetic engineering. Based on phage display technology, phage particles are safe, reliable and have good immune effect. Satisfactory results in study on prophylactic and therapeutic vaccines indicate that, as a delivery vehicle, phage provides a new approach for developing novel vaccine. This paper reviews the advantage and prospect of phage particles in research on vaccine. Source

Liu L.,Chongqing Medical University | Li D.,Chongqing Medical University | Wang Y.,Chongqing Medical University | Xu H.,Chongqing Medical University | And 2 more authors.
International Urogynecology Journal and Pelvic Floor Dysfunction

Introduction and hypothesis: Xenogeneic (porcine) extracellular matrix (ECM) scaffolds have been suggested as ideal biomaterials for regeneration medicine; however, ECM prepared from different tissue sources has shown distinctive biological properties. Therefore, a comprehensive understanding of biological characteristics of different tissue-derived ECM is essential in the design of scaffolds for pelvic reconstruction. Methods: We compared the biological properties of ECM derived from different tissue sources of Bama miniature pigs as a pelvic biological patch in terms of histological structure, water absorption ability, biodegradation ability, mechanical properties, antimicrobial activity, and biocompatibility in vitro. Results: Different ECM scaffolds have distinct structural differences, and all have good biocompatibility, and UBM exhibited better water uptake ability (above 500%), anti-biodegradation ability, mechanical properties, antimicrobial activity, and stem cell attachment properties than other tissue-derived ECM. Conclusions: Porcine UBM might serve as an ideal pelvic biological patch. © 2010 The International Urogynecological Association. Source

Liu L.,China Agricultural University | Liu L.,Chongqing Academy of Animal Science | Pang C.,China Agricultural University | Wu S.,China Agricultural University | Dong R.,China Agricultural University
Process Safety and Environmental Protection

An air-recirculated stripping involved two processes and did not require any pretreatment. First, stripping CO2 decreased the buffer capacity of the anaerobic digestate, thereby reducing the amount of lime used to achieve a high pH. Second, lime was added to increase pH and remove ammonia from the anaerobic digestate of pig manure. pH increased from 8.03 to 8.86 by stripping CO2 in the first process (gas-to-liquid ratio = 180) and further reached 12.38 in the second process (gas-to-liquid ratio = 300). During process optimization, the maximum ammonia removal efficiency reached 96.78% with a lime dose of 22.13 g. The value was close to 98.25%, which was the optimal result predicted by response surface methodology using the software Design-Expert 8.05b. All these results indicated that air-recirculated stripping coupled with absorption was a promising technology for the removal and recovery of nitrogen in the anaerobic digestate of pig manure. © 2014 The Institution of Chemical Engineers. Source

Ge L.,Chongqing Academy of Animal Science | Ge L.,University of Manitoba | Ge L.,Manitoba Institute of Child Health | Ge L.,Key Laboratory of Pig Industry science | And 9 more authors.
International Journal of Nanomedicine

Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs' biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed. © 2014 Ge et al. Source

Chen X.,Sichuan Agricultural University | Huang Z.,Sichuan Agricultural University | Wang H.,Sichuan Agricultural University | Jia G.,Sichuan Agricultural University | And 4 more authors.
International Journal of Molecular Sciences

Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin and discuss recent advances in our understanding of its role and signal pathway in skeletal myogenesis. © 2013 by the authors; licensee MDPI, Basel, Switzerland. Source

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