Chandigarh, India
Chandigarh, India

Chitkara University is a private university in India with its campus in Punjab and Himachal Pradesh, India. Chitkara University is a UGC recognized university with the right to confer degrees as per the sections 2 and 22 of the UGC Act, 1956. The university offers full courses in undergraduate and postgraduate degree programs in the fields of Engineering, Information Technology, Management, Hospitality, Hotel Administration Architecture, Pharmacy, Mass Communication & Journalism, Architecture, Pharmacy, and Teacher Training. The university has over 10,000 students and more than 600 tenured faculty members. Wikipedia.

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Sharma B.,Chitkara University | Sharma A.,Chitkara University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Consumers are nowadays more focussed on their health and appearance. As a result, there has been an increasing demand in topical antiageing formulations with natural and nutraceutical ingredients. Novel and innovative delivery systems are transforming the new product development in the cosmetic field because of consumer perceivable benefits and optimized sensory attributes. The applications of novel drug delivery systems can be found in many cosmetic products. Nanomaterials are nowadays used in almost all the major cosmetic industries. Nanotechnology has been used in novel cosmetic delivery systems to deliver the actives through various delivery vehicles. This review summarizes the use of nanomaterials in antiageing formulations for effective delivery of cosmeceutical ingredients.

Pahuja P.,Chitkara University | Arora S.,Chitkara University | Pawar P.,Chitkara University
Expert Opinion on Drug Delivery | Year: 2012

Introduction: Ocular drug delivery is a very challenging endeavor due to the unique anatomical and physiological barriers. The low ocular bioavailability (<10%) obtained from conventional formulations has forced the scientists to develop new formulations to deliver drugs to ocular tissues at a controlled rate to reduce frequent instillations. The natural polymers have represented the potential to deliver drugs topically through the limited precorneal area and release over a prolonged time period. Areas covered: The important points to be considered during the fabrication of ophthalmic formulations for example, properties of drug molecule and polymer which affect the release rate are discussed. Novel polymers, like arabinogalactan, xyloglucan, gum cordia, locust bean gum, carrageenan and Bletilla striata polysaccharide, besides the conventional polymers like chitosan, starch, sodium alginate, sodium hyaluronate, xanthan gum, gelatin, gellan gum, guar gum, collagen and albumin, have demonstrated the potential to safely deliver drugs at a controlled rate in different ophthalmic formulations. Expert opinion: The limitations of topical delivery of genes and chemotherapeutic drugs can be overcome by using natural polymers with characteristic properties. Despite the wide applicability, tremendous efforts are required to establish natural polymers in novel formulations on a commercial scale. © Informa UK, Ltd.

Rehni A.K.,Chitkara University | Singh T.G.,Chitkara University
Neuropharmacology | Year: 2013

Geranylgeranyltransferase and farnesyltransferase I, are noted to mediate a number of signal transduction cascades which are known to be involved in the causation of opioid withdrawal syndrome. GGTI-2133 and FTI-276 are selective modulators of geranylgeranyltransferase and farnesyltransferase subtype 1 respectively. Therefore, the present study investigated the effect of GGTI-2133 and FTI-276 on propagation of morphine dependence and resultant withdrawal signs in vivo, in sub-chronic morphine mouse model, and in vitro, in isolated rat ileum. Morphine was administered twice daily for 5 days following which a single day 6 injection of naloxone (8 mg/kg, i.p.) precipitated opioid withdrawal syndrome in mice. Withdrawal syndrome was quantitatively assessed in terms of withdrawal severity score and the frequency of jumping, rearing, fore paw licking & circling. Naloxone induced contraction in morphine withdrawn isolated rat ileum was employed as an in vitro model of opioid withdrawal syndrome. An isobolographic study design was employed to assess a potential synergistic activity between GGTI-2133 and FTI-276. GGTI-2133 and FTI-276 dose dependently attenuated naloxone induced morphine withdrawal syndrome both in vivo and in vitro. GGTI-2133 was also observed to exert a synergistic interaction with FTI-276. It is concluded that GGTI-2133 and FTI-276 attenuate the propagation of morphine dependence and reduce withdrawal signs possibly by a geranylgeranyl transferase; farnesyltransferase activation pathway linked mechanisms potentially in an interdependent manner. © 2013 Elsevier Ltd. All rights reserved.

Verma R.,Chitkara University
Advances in High Energy Physics | Year: 2016

We study the phenomenological consequences of recent results from atmospheric and accelerator neutrino experiments, favoring normal neutrino mass ordering m1

Mudgil M.,Chitkara University | Pawar P.K.,Chitkara University
Scientia Pharmaceutica | Year: 2013

The aim of the present investigation was to prepare a colloidal ophthalmic formulation to improve the residence time of moxifloxacin. Moxifloxacin-loaded poly(dl-lactide-co-glycolide) (PLGA) nanosuspensions were prepared by using the solvent evaporation technique. The nanosuspensions were characterised physically by using different techniques like particle size, zeta potential, FTIR, DSC, and XRD analysis. In vitro and ex vivo studies of nanosuspensions were carried out using a modified USP dissolution apparatus and all-glass Franz diffusion cells, respectively. The antibacterial activities of the nanosuspension and marketed formulations were performed against S. aureus and P. aeroginosa. The moxifloxacin-loaded PLGA nanosuspensions showed uniform particle size, ranging between 164-490 nm with negative zeta potential for all batches. The percentage entrapment efficiency of the drug-loaded nano- suspension was found to be between 84.09 to 92.05%. In vitro drug release studies suggest that all of the formulations showed extended drug release profiles and follow Korsemeyer-Peppas release kinetics. In vitro corneal permeability was found to be comparable with that of the marketed formulation across isolated goat cornea, indicating the suitability of the nanosuspension formulation in the ophthalmic delivery of moxifloxacin. The optimised nano- suspension was found to be more active against S. aureus and P. aeruginosa compared to the marketed eye drops. © Mudgil and Pawar; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.

Fast melt tablets, also known as fast dissolving tablets, disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate fast melt tablets of nimesulide by using Ocimum Sanctum seeds as a natural tablet superdisintegrant. Powdered Ocimum seeds were characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, loss on drying and microbial load. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in vitro and in vivo disintegration time, in-vitro dissolution and stability studies. The swelling index was evaluated to be 1600. An appreciable effect of the natural material was seen on tablet hardness and friability. The water absorption ratio increased from 56.15 +/- 0.85 to 80.76 +/- 0.70 (A1-A4). Water uptake coupled natural polymer swelling could be the most probable mechanism for concentration dependent reduction in disintegration time by the Ocimum Sanctum seeds. Porosity of the formulated tablets was found to increase from batch A1-A4. The in vitro disintegration results were in line with in vivo disintegration results. The f2 values (in comparison with Nimulid MD) of 95.90 and 93.65 were obtained with A3 and A4 batches respectively. It could be concluded that Ocimum Sanctum seeds could be used as a natural superdisintegrant in the formulation of fast melt tablets.

Sankhyan A.,Chitkara University | Pawar P.,Chitkara University
Journal of Applied Pharmaceutical Science | Year: 2012

Over decades researchers are striving to use the drugs in an efficient manner to treat various diseases. The efficient use can be explained as reduced dose, reduced side effects, reduced dosage frequency, greater patient compliance and maximum concentration of the drug at the site of action so as to reduce the undue exposure to the entire body. The article focuses on various advantages of vesicular systems (niosomes) to develop the effective delivery system to achieve maximum effective concentration. Niosomes, nonionic surfactant vesicles with lamellar structure which may be unilamellar and multilamellar serve to be efficient in providing these required advantages. The bilayer structure of niosomes being amphiphillic in nature can be used to deliver hydrophilic drugs in its aqueous core and lipophilic drugs in the bilayer made up of surfactants. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various charge inducers which develop a charge on the surface of niosomes and stabilize the prepared formulation by the resulting repulsive forces. This article also comprises of various breakthroughs in niosomal delivery of drugs representing various classes. On the basis of above information, the niosomes have been thoroughly exploited for the drug delivery system and still offer scope for research on various drugs for their maximum therapeutic utilization in management and treatment of various dreadful diseases.

Kumar S.,Chitkara University
Physical Review C - Nuclear Physics | Year: 2012

The Q values of α decay and the half-lives [log 10T1/ 2α(s)] are calculated for the α-decay chains of 293 ,294117 nuclei, within the framework of the isospin cluster model (ICM). In the ICM model the proximity energy is improved by using the isospin dependent radius of parent, daughter, and α particle. For the Q values the binding energy B(A i,Z i) (i=1,2) of any nucleus of mass number A and atomic number Z was obtained from a phenomenological and more generalized BW mass formula given by Samanta and Adhikari. The calculated results in ICM using different Q values, are compared with the experimental data and the other theoretical macro-microscopic (MM) Relativistic Mean Field (RMF) (with NL3 and FSU gold force parameters) model calculations. The estimated values of α-decay half-lives are in good agreement with the recent experimental data. The ICM calculation is in favor of the presence of neutron magic number at N=172. © 2012 American Physical Society.

Dutt I.,Chitkara University
AIP Conference Proceedings | Year: 2013

Using twelve different parametrized pocket formulae fusion barrier heights and positions are calculated and confronted with available experimental data. All different parametrized pocket formulae are able to reproduce fusion barrier heights and positions within ±10% and ±20%, respectively. Our detailed study investigate that the parametrized pocket formulae based on models such as Bass 1980, Winther 1995, Prox 1988, and Royer 2001 reproduce the barrier heights nicely as compared to other formulae available in the literature. © 2013 AIP Publishing LLC.

Orodispersible tablets disperse instantaneously in the mouth so that they can be swallowed without the aid of water. The aim of the present study was to formulate nimesulide orodispersible tablets using locust bean gum as a natural superdisintegrant. The gum was evaluated for powder flow properties, swelling index and loss on drying. Excellent powder flow properties were observed, swelling index was found to be 20 which indicated appreciable capability of locust bean gum to be used as superdisintegrant. The prepared tablets were evaluated against standard superdisintegrant i.e. cross-carmellose sodium. Disintegration time of tablets containing 10 % locust bean gum was found to be 13 seconds. The prepared batches were also evaluated for wetting time, water absorption ratio, effective pore radius, porosity, in vitro and in vivo disintegration time, in vitro release and stability studies. Wetting time was found to reduce from 19 +/- 2 to 11 +/- 3 sec (A1-A4) and 51 +/- 2 to 36 +/- 3 sec (B1-B4). Effective pore radius and porosity were found to be increase with increase in polymer concentration. The superdisintegrant property of locust bean gum may be due to concentration dependent wicking action leading to formation of porous structure which disintegrates the tablet within seconds. In-vivo results were complementary to in-vitro disintegration time results. The in-vitro release studies were compared against marketed nimesulide fast dissolving tablets (Nimulid MD). Stability studies showed that there was no significant change in hardness, friability, tensile strength and assay of the prepared formulations. The f2 values (in comparison with Nimulid MD) of 92.27 and 98.19 were obtained with A3 and A4 batches respectively.

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