Chandigarh, India
Chandigarh, India

Chitkara University is a private university in India with its campus in Punjab and Himachal Pradesh, India. Chitkara University is a UGC recognized university with the right to confer degrees as per the sections 2 and 22 of the UGC Act, 1956. The university offers full courses in undergraduate and postgraduate degree programs in the fields of Engineering, Information Technology, Management, Hospitality, Hotel Administration Architecture, Pharmacy, Mass Communication & Journalism, Architecture, Pharmacy, and Teacher Training. The university has over 10,000 students and more than 600 tenured faculty members. Wikipedia.

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Singh V.,Chitkara University
Medical Hypotheses | Year: 2016

Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis prevents proper treatment and timely delay in providing putative therapeutic agents. The cost effective therapies to get delayed, patient health gets compromised and ultimately requires renal transplant due to end-stage renal disease, which is another major problematic factor due to shortage kidney donors. To establish effective therapies for AKI the need will be facilitated by developing and identifying reliable, sensitive biomarkers which can be detected early during all stages of AKI, even during preclinical and clinical studies. Although reaching to human clinical trials takes years of thorough evaluations, preliminary studies should be carried out effectively by: (a) Employing cell culture analysis, (b) use of AKI animal models, studying various gene regulated networks, and biomarkers, and (c) patient serum sampling and testing. As elevated phenylalanine are indicative of AKI onset within 4 h, its levels is controlled, 4a-Hydroxy-tetrahydrobiopterin dehydratase/dimerization cofactor of HNF-1 (DCoH). There is a possibility of targeting DCoH to the current bedside list of biomarkers involved in AKI onset. © 2016 Elsevier Ltd

Sindhu R.K.,Chitkara University | Arora S.,Chitkara University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objectives: The objective of the present study was to evaluate the antioxidant potential of ethanol extract from aerial roots of Ficus lacor. Methods: Ethanol extract of aerial roots of Ficus lacor was used to study their total phenolic and flavonoids contents, in vitro antioxidant including radical scavenging of 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO). Results: The ethanol extract showed significant results Total phenolic contents were estimated to be equivalents to 46.65 ± 1.75 mg of gallic acid equivalent and total flavonoids contents were 38.42 ± 2.46 mg of catechin/g equivalent. The percentage of DPPH and NO scavenging activity increased with increasing various concentration of extract. Conclusions: The results concluded that the extract have potential source of antioxidants of natural origin that could have great importance as therapeutic agents for biological system liable to free radical mediated reactions.

Fast melt tablets, also known as fast dissolving tablets, disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate fast melt tablets of nimesulide by using Ocimum Sanctum seeds as a natural tablet superdisintegrant. Powdered Ocimum seeds were characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, loss on drying and microbial load. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in vitro and in vivo disintegration time, in-vitro dissolution and stability studies. The swelling index was evaluated to be 1600. An appreciable effect of the natural material was seen on tablet hardness and friability. The water absorption ratio increased from 56.15 +/- 0.85 to 80.76 +/- 0.70 (A1-A4). Water uptake coupled natural polymer swelling could be the most probable mechanism for concentration dependent reduction in disintegration time by the Ocimum Sanctum seeds. Porosity of the formulated tablets was found to increase from batch A1-A4. The in vitro disintegration results were in line with in vivo disintegration results. The f2 values (in comparison with Nimulid MD) of 95.90 and 93.65 were obtained with A3 and A4 batches respectively. It could be concluded that Ocimum Sanctum seeds could be used as a natural superdisintegrant in the formulation of fast melt tablets.

Kumar S.,Chitkara University
Journal of Physics: Conference Series | Year: 2011

The effects of shell closure in nuclei via cluster decay have been investigated. In this context,the Preformed Cluster Model (PCM) based on Quantum Mechanical Fragmentation Theory is used. The key point in the cluster radioactivity is that it involves the interplay of close shell effects of parent and daughter nucleus. Small half life for a parent indicates shell stabilized daughter and long half life indicates the stability of the parent against the decay. Cluster decays of rare-earth nuclei are studied with a view to look for neutron magic shells for the 50Sn nucleus as the daughter product always, to find the most probable cluster decays and the possibility, if any, of new neutron shells. The recently observed α-decay chains 293-294117 which were produced by the fusion reactions with target 249Bk and projectile 48Ca at Dubna, in Russia. The α-decay calculations are performed for all the parents of the two alpha decay chains and compared with the experimental data and with other theoretical model. © Published under licence by IOP Publishing Ltd.

Sankhyan A.,Chitkara University | Pawar P.,Chitkara University
Journal of Applied Pharmaceutical Science | Year: 2012

Over decades researchers are striving to use the drugs in an efficient manner to treat various diseases. The efficient use can be explained as reduced dose, reduced side effects, reduced dosage frequency, greater patient compliance and maximum concentration of the drug at the site of action so as to reduce the undue exposure to the entire body. The article focuses on various advantages of vesicular systems (niosomes) to develop the effective delivery system to achieve maximum effective concentration. Niosomes, nonionic surfactant vesicles with lamellar structure which may be unilamellar and multilamellar serve to be efficient in providing these required advantages. The bilayer structure of niosomes being amphiphillic in nature can be used to deliver hydrophilic drugs in its aqueous core and lipophilic drugs in the bilayer made up of surfactants. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various charge inducers which develop a charge on the surface of niosomes and stabilize the prepared formulation by the resulting repulsive forces. This article also comprises of various breakthroughs in niosomal delivery of drugs representing various classes. On the basis of above information, the niosomes have been thoroughly exploited for the drug delivery system and still offer scope for research on various drugs for their maximum therapeutic utilization in management and treatment of various dreadful diseases.

Mantri A.,Chitkara University
European Journal of Engineering Education | Year: 2014

The intent of the study presented in this paper is to show that the model of problem-based learning (PBL) can be made scalable by designing curriculum around a set of open-ended problems (OEPs). The detailed statistical analysis of the data collected to measure the effects of traditional and PBL instructions for three courses in Electronics and Communication Engineering, namely Analog Electronics, Digital Electronics and Pulse, Digital & Switching Circuits is presented here. It measures the effects of pedagogy, gender and cognitive styles on the knowledge, skill and attitude of the students. The study was conducted two times with content designed around same set of OEPs but with two different trained facilitators for all the three courses. The repeatability of results for effects of the independent parameters on dependent parameters is studied and inferences are drawn. © 2013 © 2013 SEFI.

Kumar S.,Chitkara University
Physical Review C - Nuclear Physics | Year: 2012

The Q values of α decay and the half-lives [log 10T1/ 2α(s)] are calculated for the α-decay chains of 293 ,294117 nuclei, within the framework of the isospin cluster model (ICM). In the ICM model the proximity energy is improved by using the isospin dependent radius of parent, daughter, and α particle. For the Q values the binding energy B(A i,Z i) (i=1,2) of any nucleus of mass number A and atomic number Z was obtained from a phenomenological and more generalized BW mass formula given by Samanta and Adhikari. The calculated results in ICM using different Q values, are compared with the experimental data and the other theoretical macro-microscopic (MM) Relativistic Mean Field (RMF) (with NL3 and FSU gold force parameters) model calculations. The estimated values of α-decay half-lives are in good agreement with the recent experimental data. The ICM calculation is in favor of the presence of neutron magic number at N=172. © 2012 American Physical Society.

Dutt I.,Chitkara University
AIP Conference Proceedings | Year: 2013

Using twelve different parametrized pocket formulae fusion barrier heights and positions are calculated and confronted with available experimental data. All different parametrized pocket formulae are able to reproduce fusion barrier heights and positions within ±10% and ±20%, respectively. Our detailed study investigate that the parametrized pocket formulae based on models such as Bass 1980, Winther 1995, Prox 1988, and Royer 2001 reproduce the barrier heights nicely as compared to other formulae available in the literature. © 2013 AIP Publishing LLC.

Orodispersible tablets disperse instantaneously in the mouth so that they can be swallowed without the aid of water. The aim of the present study was to formulate nimesulide orodispersible tablets using locust bean gum as a natural superdisintegrant. The gum was evaluated for powder flow properties, swelling index and loss on drying. Excellent powder flow properties were observed, swelling index was found to be 20 which indicated appreciable capability of locust bean gum to be used as superdisintegrant. The prepared tablets were evaluated against standard superdisintegrant i.e. cross-carmellose sodium. Disintegration time of tablets containing 10 % locust bean gum was found to be 13 seconds. The prepared batches were also evaluated for wetting time, water absorption ratio, effective pore radius, porosity, in vitro and in vivo disintegration time, in vitro release and stability studies. Wetting time was found to reduce from 19 +/- 2 to 11 +/- 3 sec (A1-A4) and 51 +/- 2 to 36 +/- 3 sec (B1-B4). Effective pore radius and porosity were found to be increase with increase in polymer concentration. The superdisintegrant property of locust bean gum may be due to concentration dependent wicking action leading to formation of porous structure which disintegrates the tablet within seconds. In-vivo results were complementary to in-vitro disintegration time results. The in-vitro release studies were compared against marketed nimesulide fast dissolving tablets (Nimulid MD). Stability studies showed that there was no significant change in hardness, friability, tensile strength and assay of the prepared formulations. The f2 values (in comparison with Nimulid MD) of 92.27 and 98.19 were obtained with A3 and A4 batches respectively.

The present study was aimed to formulate and evaluate oral controlled release mucoadhesive matrix tablets of taro gum incorporating domperidone as model drug. Tablets were prepared by direct compression and were evaluated for bioadhesive strength and in vitro dissolution parameters. A central composite design for 2 factors, at 3 levels each, was employed to evaluate the effect of criti cal formulation variables, namely the amount of taro gum (X1) and PVP K 30 (X2), on mucoadhesive strength, tensile strength, release exponent (n) and t50 (time for 50% drug release). The mucoadhesive detachment force (evaluated using texture analyzer) was found to be 18.266, 54.684 and 65.904 N for A4, A5 and A6 batches of the formulated tablets. The polynomial equation indicates that taro gum has dominating effect on mucoadhesive strength and both X1 and X2 have almost equal and comparable effect on tensile strength. The drug release follows first order kinetics (release of drug depends on remaining concentration of drug) and shows best linearity (r2 = 0.983) with higuchi model. The release exponent (n) lies between 0.339 and 0.543 indicating drug release from the matrix tablets may be fickian or non fickian (anamolous) depending upon the concentration of natural polymer. T50 was 58, 140 and 220 minutes for A7, A8 and A9 batches showing overriding potential of taro gum but still the effect of PVP K 30 is noteworthy. PVP K 30 has indirect effect on all the factors by increasing tensile strength and making the tablet firm and intact.

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