Chita State Medical Academy

Chita, Russia

Chita State Medical Academy

Chita, Russia
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Fine I.,Elfi Tech | Kaminsky A.,Elfi Tech | Kuznik B.,Chita State Medical Academy | Shenkman L.,Tel Aviv University
Laser Physics | Year: 2012

We present a new non-invasive method for assessing hemostasis in vivo. This method is based on the analysis of the movement characteristics of red blood cells (RBCs) during blood stasis condition. Stasis is intermittently induced by occlusion of arterial blood flow at the finger root. We assumed that under zero flow conditions, RBC movement is driven mostly by Brownian motion, and we characterized the RBC movement by utilizing the dynamic light scattering (DLS) technique in vivo. We found that during the stasis the RBCs diffusion coefficient in plasma decreases. We speculate that the RBC diffusion coefficient is most strongly related to endothelial and hemostatic activity. This assumption is supported by our findings that RBC movement, being expressed through the characteristics of the measured DLS signal, is correlative to the biological age and also is related to the coagulation factors. This new method can serve as a new diagnostic and research tool for the assessment of hemostasis and vascular function. © Pleiades Publishing, Ltd., 2012.

Lareva N.V.,Chita State Medical Academy | Govorin A.V.,Chita State Medical Academy
Terapevticheskii Arkhiv | Year: 2013

Aim: To study the prevalence of depressive and anxiety disorders in postmenopausal disorders and their relationship with the manifestations of climacteric syndrome. Subjects and methods: The study enrolled 203 women, including 142 patients with surgical menopause and 61 with natural menopause. Psychometric testing using the Hamilton depression rating scale and the Spielberger test anxiety inventory, and 24-hour blood pressure (BP) monitoring with assessment of the 24-hour BP profile were performed. Results: Depressive disorders (DD) were found in 82.5% of the postmenopausal women; all the patients had higher levels of situational and personality anxiety. The women with natural menopause developed moderate and severe DD and those who had undergone ovariectomy had mild DD. The prevalence of DD was higher in patients with essential hypertension (EH) than in those with normal BP (88.6 and 78.3%, respectively; p<0.01); DD was more marked in these patients. The severity of DD also depended on the type of diurnal BP variations; the highest level of depression was recorded in patients without nocturnal BP reduction. The same group was found to have the highest level of personality and situational anxiety. Conclusion: The magnitude of DD depends on the type of menopause, the presence of EH, and the specific features of diurnal BP variations. The findings necessitate a detail examination of postmenopausal women for identification of affective disorders and their further correction.

Baike E.V.,Chita State Medical Academy
Vestnik otorinolaringologii | Year: 2016

We present the results of the surgical treatment of 300 patients presenting with chronic suppurative otitis media. The changes in the mucous membrane of the tympanic cavity were revealed in 61% of the patients with mesotympanitis while spreading cholesteatoma occurred in 48% of the cases of «dry» perforations. The cholesteatomic process was documented in 64% of the patients with epitympanitis, the remaining patients presented with the pyo-carious process. The efficiency of the surgical intervention on the «dry» ear of the patients with the tubotympanic form of chronic suppurative otitis media (CSOM) amounted to 91.4% compared with 85% in the case of the altered mucous membrane of the tympanic cavity, 85.5% and 92.9% in the patients with the pyo-carious and cholesteatomic forms of the tympano-antral lesions, respectively. Residual cholesteatomas were found in 7.8% of the patients suffering from epitympanitis during the three year follow-up period. It is concluded that the results of clinical and morphological observations taken together with intraoperative findings give reason to consider mesotympanitis to be a prognosticallyunfavourable form of chronic suppurative otitis media.Abstract available from the publisher.

Romanova E.N.,Chita State Medical Academy | Govorin A.V.,Chita State Medical Academy
Terapevticheskii Arkhiv | Year: 2013

Aim: To study the specific features of cytokine gene polymorphisms (such asTNF C308A, IL10C592A, IL10C819T, IL10 C1082A) and vascular tone regulatory gene polymorphism (eNOS C786T) in patients with influenza A/H1N1 complicated by pneumonia. Subjects and methods: Patients treated for pneumonia in the presence of influenza A/H1N1, divided into 3 groups: 1) 37 patients with severe pneumonia; 2) 74 with mild pneumonia; and 3) 68 healthy individuals, were examined. Molecular genetic testing was made using a polymerase chain reaction technique. Serum TNFα, IL-10 and s-ICAM-1 concentrations were measured by enzyme immunoassay. Results: As compared to the control group, the patients with influenza-related pneumonia were more frequently homozygous for the G allele of the TNF 308 G/A polymorphism. The IL-10 G allele (1082 G/A) was considerably prevalent as homozygous carriage and the IL-10 G allele (592 G/A) was as a homozygous type to a greater extent. An abnormal zygote of the eNOS T/T (786 C/T) polymorphism was found to be prevalent among the patients with influenza-related pneumonia; on the contrary, there were mainly heterozygous C/T carriers in the control group. In the C/T genotype group, the level of soluble intercellular adhesion molecule 1 (slCAM-1) was lower than in other polymorphic variants (786 C/T). Conclusion: The study of the patients' genetic status in influenza A/H1N1 will be able to evaluate the severity of the disease and to predict possible complications.

Tsarenok S.Yu.,Chita State Medical Academy | Gorbunov V.V.,Chita State Medical Academy
Terapevticheskii Arkhiv | Year: 2015

Aim. To determine the serum level of cytokines in women with coronary heart disease (CHD) concurrent with osteoporosis (OP) and in those with isolated CHD; to assess a relationship of the levels of cytokines, osteoprotegerin (OPG), and transforming growth factor-β (TGF-β) to the ten-year absolute risk of osteoporotic fractures, the presence of fractures in the history, and that of CHD; and to establish the role of elevated cytokine levels in the development of future fractures. Subjects and methods. A cross-sectional cohort study included 98 women (mean age, 71.2±8.6 years) with CHD. Forty-eight patients had CHD concurrent with severe OP. The Fracture Risk Assessment Tool (FRAX) was applied to estimate a ten-year absolute risk for fractures in all the patients. The serum levels of OPG, TGF-β, interleukin (IL)-1β, IL-4, IL-6, IL-8, and IL-10, and tumor necrosis factor-α (TNF-α) were measured by enzyme immunoassay. Results. The women with comorbidity were found to have higher levels of OPG, TGF-β, IL-6, IL-8, IL-10, and TNF-α than those with isolated CHD. There was a direct correlation between fractures, CHD, and IL-10 and TNF-α levels and an inverse relationship between fractures, CHD, and IL-8; between CHD and OPG levels. Conclusion. The women with comorbidity were noted to have elevated levels of proinflammatory cytokines and OPG; a correlation was between cytokine levels and fractures and CHD. Increased OPG and IL-6 levels are independent predictors of fractures.

Lazutkina A.Yu.,Regional Dir. of Medical Supply on Transbaikal Railway | Gorbunov V.V.,Chita State Medical Academy
Terapevticheskii Arkhiv | Year: 2015

Aim. To estimate the prognostic value of risk factors for cardiovascular events and target organ damages for the occurrence of resistant hypertension (RH). Subjects and methods. The 2008-2013 survey covered 7959 members of locomotive crews of the Transbaikal Railway whose medical expert examination revealed risk factors for cardiovascular diseases and target organ damages. Results. During the survey, a group of 7959 people with final outcomes included 21 RH cases to be statistically analyzed. Atherosclerotic plaques in the carotids arteries, proteinuria, creatininemia, overweight, left ventricular hypertrophy, a family history of early cardiovascular diseases, and stress were the major predictors of RH. Conclusion. The association of the established predictors must be considered in the treatment of patients with RH.

The sampling included 231 patient with hypertension disease of stage I-II. The hypertrophy of left ventricle of heart was established in 97 patients (group I) and 134 patients had no hypertrophy of left ventricle of heart (group II). The control group consisted of 25 healthy persons. The increase of tumor necrosis factor a and interleukin βwas established in group I as compared with group II and control group. In patients of group I the expressed dysfunction of endothelium was observed. The increase of endothelin I and number of desquamated endotheliocytes as compared with group II and healthy persons was established. The direct relationship between increase of concentration of analyzed cytokines and presence of hypertrophy of left ventricle of heart is revealed.

Meglinski I.V.,University of Otago | Meglinski I.V.,Chernyshevsky Saratov State University | Kal'Chenko V.V.,Weizmann Institute of Science | Kuznetsov Yu.L.,Weizmann Institute of Science | And 2 more authors.
Doklady Physics | Year: 2013

A study was conducted to investigate the nature of biological zero in the dynamic light scattering diagnostic modalities. The standard diffusion-wave spectroscopy (DWS) system was used to measure the blood flow in the conditions of bio logical zero. The supply of low-intense laser radiation on the surface of the animal skin and the detection of the backscattered signal were performed by means of the optical-fiber contactless reflector-type transducer. The sensor part of the transducer contained a multi-mode fiber, which supplied the radiation, and a single-mode fiber in one cover. The detection of the backscattered laser radiation was performed in the photon counting mode using the avalanche photodiode (APD) whose output signal was analyzed using a digital self-corrector combined with a personal computer.

Luzina E.V.,Chita State Medical Academy
Voprosy Pitaniia | Year: 2013

Cichorium intybus is an herbaceous perennial, known as a coffee substitute. It possesses a wide range of healing characteristics particularly due to inulin, one of its components. Inulin is a natural polysaccharide, a polyfructosane containing 27-35 fructose residues in furanose form and glucose residue. When inulin is in the alimentary tract it passes to the stomach and the small intestine unchangeable. In large intestine inulin is fermented by bifidobacteria and then converted in to a great number of short-chain fatty acids. Due to the process it stimulated the growth of bifidobacteria population and reduces that of pathogenic microorganisms. The increase of pool of healthy intestinal flora normalizes the passage of fieces masses through the intestine, improves immunologic status, regulates carbohydrate and lipid metabolism. The paper presents experimental and clinic studies confirming bifidogenic, immunogenic, anticancerous, hepatoprotective characteristics of inulin and Cichorium intybus.

Kuznik B.I.,Chita State Medical Academy
Patologicheskaia fiziologiia i èksperimental'naia terapiia | Year: 2013

The review presents information by the author and his collaborators, as well as literature data on the coagulation of lymph in blood loss, convulsive syndrome, trauma, crush syndrome, bums, injections of thrombin and heparin, an experimental thrombosis and other pathological conditions. It is shown that the coagulation of lymph in the development of pathological conditions in tissues may outpace changes observed in the blood. We present evidence that dissolution of fibrin clots in the lymph tissue if damaged, is many times faster than in the blood.

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