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Lazutkina A.Yu.,Regional Dir. of Medical Supply on Transbaikal Railway | Gorbunov V.V.,Chita State Medical Academy
Terapevticheskii Arkhiv | Year: 2015

Aim. To estimate the prognostic value of risk factors for cardiovascular events and target organ damages for the occurrence of resistant hypertension (RH). Subjects and methods. The 2008-2013 survey covered 7959 members of locomotive crews of the Transbaikal Railway whose medical expert examination revealed risk factors for cardiovascular diseases and target organ damages. Results. During the survey, a group of 7959 people with final outcomes included 21 RH cases to be statistically analyzed. Atherosclerotic plaques in the carotids arteries, proteinuria, creatininemia, overweight, left ventricular hypertrophy, a family history of early cardiovascular diseases, and stress were the major predictors of RH. Conclusion. The association of the established predictors must be considered in the treatment of patients with RH.

Kuznik B.I.,Chita State Medical Academy | Fine I.W.,Elfi Tech | Kaminsky A.V.,Elfi Tech
Bulletin of Experimental Biology and Medicine | Year: 2011

We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the results of measurement of soluble fibrin monomer complexes, international normalized ratio (INR), prothrombin index, and protein C content. The noninvasive method of examination of the hemostatic system enable rough evaluation of the intensity of the intravascular coagulation and correction of the dose of indirect anticoagulants maintaining desired values of INR or prothrombin index. © 2011 Springer Science+Business Media, Inc.

The sampling included 231 patient with hypertension disease of stage I-II. The hypertrophy of left ventricle of heart was established in 97 patients (group I) and 134 patients had no hypertrophy of left ventricle of heart (group II). The control group consisted of 25 healthy persons. The increase of tumor necrosis factor a and interleukin βwas established in group I as compared with group II and control group. In patients of group I the expressed dysfunction of endothelium was observed. The increase of endothelin I and number of desquamated endotheliocytes as compared with group II and healthy persons was established. The direct relationship between increase of concentration of analyzed cytokines and presence of hypertrophy of left ventricle of heart is revealed.

Meglinski I.V.,University of Otago | Meglinski I.V.,Chernyshevsky Saratov State University | Kal'Chenko V.V.,Weizmann Institute of Science | Kuznetsov Yu.L.,Weizmann Institute of Science | And 2 more authors.
Doklady Physics | Year: 2013

A study was conducted to investigate the nature of biological zero in the dynamic light scattering diagnostic modalities. The standard diffusion-wave spectroscopy (DWS) system was used to measure the blood flow in the conditions of bio logical zero. The supply of low-intense laser radiation on the surface of the animal skin and the detection of the backscattered signal were performed by means of the optical-fiber contactless reflector-type transducer. The sensor part of the transducer contained a multi-mode fiber, which supplied the radiation, and a single-mode fiber in one cover. The detection of the backscattered laser radiation was performed in the photon counting mode using the avalanche photodiode (APD) whose output signal was analyzed using a digital self-corrector combined with a personal computer.

Fine I.,Elfi Tech | Kaminsky A.,Elfi Tech | Kuznik B.,Chita State Medical Academy | Shenkman L.,Tel Aviv University
Laser Physics | Year: 2012

We present a new non-invasive method for assessing hemostasis in vivo. This method is based on the analysis of the movement characteristics of red blood cells (RBCs) during blood stasis condition. Stasis is intermittently induced by occlusion of arterial blood flow at the finger root. We assumed that under zero flow conditions, RBC movement is driven mostly by Brownian motion, and we characterized the RBC movement by utilizing the dynamic light scattering (DLS) technique in vivo. We found that during the stasis the RBCs diffusion coefficient in plasma decreases. We speculate that the RBC diffusion coefficient is most strongly related to endothelial and hemostatic activity. This assumption is supported by our findings that RBC movement, being expressed through the characteristics of the measured DLS signal, is correlative to the biological age and also is related to the coagulation factors. This new method can serve as a new diagnostic and research tool for the assessment of hemostasis and vascular function. © Pleiades Publishing, Ltd., 2012.

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