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News Article | February 15, 2017
Site: www.businesswire.com

VANCOUVER, Canada--(BUSINESS WIRE)--Zymeworks Inc. (“Zymeworks”), a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation multifunctional biotherapeutics, initially focused on the treatment of cancer, today announced that Dr. Kenneth Hillan, CEO of Achaogen Inc., and Hollings Renton, former CEO and President of Onyx Pharmaceuticals Inc., have been appointed to Zymeworks’ board of directors. Concurrent with the appointment of Dr. Hillan and Mr. Renton, Zymeworks also announces that Dr. Donald Drakeman has retired from the Company’s board of directors, and is transitioning to the position of special advisor to Zymeworks and the board of directors. Dr. Drakeman will continue to contribute his knowledge and perspective to Zymeworks’ management and the board of directors. “ We are delighted to welcome Kenneth and Hollings to our board of directors,” said Ali Tehrani, Ph.D., Zymeworks’ President & CEO. “ Their collective experience working at the highest levels of the biotech and pharmaceutical industries will provide Zymeworks with valuable guidance as we move our lead product candidate, ZW25, through clinical trials and our preclinical assets closer to the clinic. We would also like thank Don for his service on the board since 2010. We look forward to continuing to benefit from his expertise as advisor to Zymeworks” “ Zymeworks’ next-generation therapies aim to advance the practice of medicine and make patients’ lives better, which is one of the most important contributions we can make to the healthcare challenges we face today,” said Dr. Hillan. “ I look forward to working with the board members and the Zymeworks leadership team to support the company’s mission of creating biotherapeutics that allow patients to return home to their loved ones, disease free.” Mr. Renton added, “ I am very pleased to join Zymeworks’ board of directors, and to work with the team to advance their versatile bispecific antibody capabilities. Zymeworks is well-positioned with their lead product candidate in clinical trials, and an exciting preclinical pipeline.” Dr. Kenneth J. Hillan is the CEO of Achaogen Inc. He has served as CEO and a member of the board of directors of Achaogen since October 2011. Prior to joining Achaogen, Dr. Hillan worked at Genentech Inc., a pharmaceutical company and a member of the Roche Group. Dr. Hillan worked in progressively senior roles after joining Genentech in 1994. He was responsible for numerous successful drug approvals and led the medical and scientific strategies for Genentech’s immunology, tissue growth and repair drug portfolio. Dr. Hillan also served on the board of directors of Relypsa Inc., a publicly traded biotechnology company that was acquired in 2016 by Galencia AG for $1.5 billion. Dr. Hillan has an M.B. Ch.B. (Bachelor of Medicine and Surgery) degree from the Faculty of Medicine at the University of Glasgow in the United Kingdom. Dr. Hillan is a Fellow of the Royal College of Surgeons, and a Fellow of the Royal College of Pathologists. Dr. Hillan has authored dozens of scientific publications and is a named inventor on approximately 50 issued patents. Hollings Renton served as CEO and President of Onyx Pharmaceuticals, Inc. from 1993 to 2008 and was the chairperson of the board of directors of Onyx from 2000 to 2008. Onyx was acquired by Amgen Inc. in 2013 for $10.4 billion. Before joining Onyx, Mr. Renton was the President and Chief Operating Officer of Chiron Corporation, a pharmaceutical company. Mr. Renton served in a variety of executive roles at Cetus Corporation from 1983 prior to its acquisition by Chiron in 1991. Mr. Renton currently serves as chairperson of the board of directors of Portola Pharmaceuticals Inc. and on the board of directors of AnaptysBio Inc. Mr. Renton received his M.B.A. from the University of Michigan and his B.S. in Mathematics from Colorado State University. Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. Zymeworks’ lead product candidate, ZW25, is a novel bispecific antibody currently being evaluated in an adaptive Phase 1 clinical trial. Zymeworks is also advancing a deep pipeline of preclinical product candidates and discovery-stage programs in immuno-oncology and other therapeutic areas. In addition to Zymeworks’ wholly-owned pipeline, its therapeutic platforms have been further leveraged through multiple strategic partnerships with global biopharmaceutical companies.


News Article | March 1, 2017
Site: www.prweb.com

Morris South (http://www.morrissouth.com), a division of Morris Group, Inc. will hold its annual technology show and open house, Southern Tech Fest, April 4-5 in Huntsville, Alabama. The regional machine tool distributor will display CNC machinery from Okuma, Tsugami, Hardinge Group and Chiron and perform live metal cutting demonstrations throughout the event. More than 20 leading suppliers of tooling, accessories, software, automation and related products will exhibit the latest advancements in productivity enhancing technology. “We’re extremely pleased with the support we receive from our technology partners at this event every year,” said Joe Hunt, Regional Vice President, Sales, Morris South (Huntsville). “We’ll have a large number and variety of machine tools on display. Live cutting demonstrations will show off the significant productivity gains made possible when the right tooling, accessories and other products are integrated with highly sophisticated CNC machinery.” Horizontal lathes, Swiss lathes, multifunction machines and machining centers are among the types of CNC equipment slated to be on display at Southern Tech Fest. Product specialists and representatives from several leading technology suppliers will be in attendance and available both days to discuss latest advancements. Manufacturers from throughout the Southeast are invited to Southern Tech Fest at Morris South, located at 350 Electronics Boulevard, Huntsville, Alabama. Event hours are Tuesday, April 4 from 9:00 a.m. to 5:00 p.m. and Wednesday, April 5 from 9:00 a.m. to 3:00 p.m. Lunch and refreshments will be served daily. For registration and other information, please visit http://www.morrissouth.com or call Joe Hunt at 256-461-8111.


News Article | February 20, 2017
Site: www.newscientist.com

As far as anyone knew, the club of astronomical objects with rings only took guests of a certain calibre. Picture Saturn floating majestically over a soundtrack of strings and softly clinking silverware. Apart from Saturn, only the solar system’s other giant planets qualified. Then a weird little asteroid named Chariklo crashed the party. It pulled the tablecloth out from under theories of ring physics, forcing astronomers to ask: if this misfit thing can have rings, what else could? The discovery came in June 2013, when observers in Brazil, Chile and Argentina all trained their telescopes on Chariklo, a lumpy rock some 240 kilometres across that orbits the sun between Saturn and Uranus. As Chariklo crossed in front of a background star, they hoped to analyse its shape and maybe find evidence of comet-like jets of ice escaping its surface. But within a day of the data arriving in the lab of Bruno Sicardy at the Paris Observatory, it started to look as if Chariklo had two narrow, sharply defined rings encircling its main body. Maryame El Moutamid of Cornell University in New York, Sicardy’s graduate student at the time, remembers him sharing the news in a conspiratorial whisper. Sicardy had also co-discovered Neptune’s rings in the 1980s – could this new find be just wishful thinking? “I was like, ‘what did you smoke? You see rings everywhere’,” she says. But the analysis kept showing rings, and so have additional observations. It’s still hard to convey just how strange that is, says Mark Showalter of the SETI Institute in California. It made sense that giant planets could be ringed: their gravitational fields are smooth, which should help rings stay stable. But we had never seen rings around an atmosphere-free object, not to mention a misshapen lump like Chariklo with a correspondingly bumpy gravitational field. Some theorists doubted it was even possible. “It still boggles my mind,” Showalter says. Since then, the questions have only multiplied. Any rings around Chariklo should fall apart after just a few thousand years – so either we spotted them in an especially lucky cosmic instant, or some poorly understood process is keeping them together. And the rings aren’t sloppy, either. They are especially tight and neat, similar to those of Uranus. One way to keep them tidy is if they are flanked by as yet undiscovered shepherd moons only about a kilometre in size, their gravity tugging stray material back in line. Since Chariklo’s position puts it in front of the dense star fields at the Milky Way’s centre, there should be plenty of chances to learn more as it crosses background stars. But even as the mystery of Chariklo’s rings lingers, the discovery has shown us that rings can exist in a far wider array of environments than we knew. Apart from Chariklo, there are hints of rings around the neighbouring asteroid Chiron, Saturn’s moons Rhea and Iapetus, Mars, Pluto, and even the enormous exoplanet J1407b. And many more bodies are now under scrutiny: Sicardy’s team is looking at other asteroids, and the New Horizons probe is searching for ring systems in the farther reaches of the solar system. In the meantime, the list of confirmed ring-bearers is still small enough to count on one hand. There’s Jupiter, Saturn, Uranus, Neptune – and then Chariklo with a foot in the door, ushering in untold others.


News Article | February 27, 2017
Site: news.yahoo.com

No Oscar party is complete without snacks. Liven up your viewing party with snacks themed to the best picture nominees. These are all pretty easy to make, and links to professional recipes are included for anything that's more than a couple steps. If you’re hosting a big Academy Awards viewing party, you could make all of the snacks! Those with smaller gatherings can pick and choose treats based on their favorite Oscar nominated films. “Hidden Figures” Fruit Rocket — There are lots of space themed snacks that could go with a movie about NASA mathematicians, but this one is probably the easiest and healthiest. Make a spaceship kebab using almost any fruit you want. Just be sure to use the tip of a strawberry or a triangle shape piece of melon to serve as the rocket’s top. “Manchester by the Sea” Chowder — New England Clam Chowder is perfect for this Boston-set movie. Serve the soup in small glasses or mini bowls to keep it a snack rather than a meal. It can be bought or you can try Boston restaurant Sam LaGrassa’s recipe. “La La Land” Popcorn — A Hollywood-set movie that’s all about show business seems like the perfect opportunity for an old standard: popcorn. To jazz it up for your Oscars viewing party, try serving it in little movie theater popcorn buckets. If you’re strapped for time, decorate the rim of a large bowl with stars like the Hollywood Walk of Fame or plain stars to represent the sky that the characters dance in at the end of the movie. “Arrival” Space Cake — A space-themed cake is perfect for a movie about aliens. There are two ways to do this. You could just make your cake, frost it blue and throw some star shaped sprinkles on it. If you have time, however, you could do a mirror glaze. Check out Rosanna Pansino’s step-by-step video on how to make your galaxy cake a stand out. “Lion” Veggie Plate — This one is a literal interpretation of the title. Set out a bowl of hummus as the lion’s face. Cut black olives to make the eyes, nose, and whiskers. Lay out cut bell peppers, carrots and/or pretzel rods to form the lion’s mane. You can buy hummus or use Ina Garten’s recipe. “Moonlight” Arroz Con Pollo — At the end of the movie, Kevin gives this dish to Chiron and says it’s the chef’s special. The chicken and rice dish is pretty easy to make. Try Melissa d’Arabian’s recipe. To make it more suited for snacking, cut up your chicken into small pieces (or use pulled chicken) and use small bowls (ramekins would be great, but paper bowls work too). Remember to adjust the recipe if you’re hosting a smaller bash. “Hell or High Water” Candy Bags — Embrace the robbery storyline, and give your guests tiny moneybags filled with green candy. A tiny canvas bag would be preferable, but small white or brown paper bags work too. Fill it with anything green. Green Skittles, M&Ms or sour patch kids would work well. “Fences” Pretzel Fence — The title of the movie comes from both metaphoric and literal fences, and this snack is inspired by the literal one. Use pretzel rods to create a fence. Place about five rods parallel to each other. Connect them with rods covered in melted chocolate or candy melts. Thinner pretzels will stick together with one chocolate covered rod and thicker ones might need two or three. If you have a love for chocolate, you could just cover the whole fence in the melted candy. “Hacksaw Ridge” BLT Ration Wraps — Andrew Garfield’s character didn’t want to use weapons, so rations seem like an appropriate choice. But these are way better than MREs! Take a green spinach wrap and place some mayo, bacon, lettuce and tomato in the wrap. Roll it like a burrito, place toothpicks an inch apart to keep the wrap together when you slice it. Cut between the toothpicks for snack-sized portions of the wrap. The Oscars air live on ABC Sunday at 8:30 p.m. EST. If you make any of the Oscar party snacks, tweet photos of your creations to @NKMass! ‘Moonlight’ Editor Joi McMillon Addresses ‘Oscars So White’ Controversy After Her Historic Nomination


News Article | February 15, 2017
Site: www.gizmag.com

When it was first announced in March last year, the AM-RB 001 was just a collection of promises made by a very excited Andy Palmer. A full styling reveal followed the detail-light announcement three months later, but technical details about the collaboration with Red Bull were still hard to come by. Finally, almost a year after being officially announced, we have concrete technical info about the nuts-and-bolts of the AM-RB 001. OK, this isn't the full specification reveal we wanted, but it certainly paints a clearer picture of the car. To start with, power will come from a hybrid powertrain. At its core is a bespoke 6.5-liter Cosworth V12, hooked up to a lightweight battery system from Croatian manufacturer Rimac. No power output has been announced yet, but Aston Martin has promised a power-to-weight ratio of 1:1, which means the combined output should be around 1,000 hp (746 kW). All this power will be put to the road (track, or polished garage floor) with a bespoke seven-speed paddleshift gearbox from Ricardo. According to Aston Martin the 'box has actually been designed by Red Bull Racing, and fits in with the lightweight ethos imbued in the rest of the car. Just how Ricardo, which also manufactures the dual-clutch in the Bugatti Chiron, plans to make the seven-speeder strong, light and aerodynamic enough to fit in the Adrian Newey-designed underbody of the AM-RB 001 remains to be seen. The whole thing will be managed by a Transmission Control Unit (TCU) from Bosch. Given the planned 1:1 power-to-weight ratio of the car, a serious set of stoppers is required. Alcon and Surface Transforms have been tasked with delivering the carbon-ceramic discs for the AM-RB 001, while Bosch will deliver the Engine Control Unit (ECU) and Electric Stability Programme (ESP) required to manage the big V12 and make sure owners don't go flying backwards into a hedge. Just 150 examples of the AM-RB 001 will be built for the road, with an additional run of 25 track-only versions planned as well.


News Article | November 30, 2016
Site: motherboard.vice.com

Last weekend I finally took the plunge and bought the iPhone 7 after several months of wavering. The phone itself is fine, but the real revelation came by equipping it with Apple's $99 Smart Battery Case, which provides enough extra battery life that I no longer have to nervously check and recheck the battery status icon throughout the day. Had I waited another week to buy the case, however, I'd have helped fund the fight against HIV/AIDS. Apple today is flipping the switch on its participation in (RED), a 10-year-old campaign that raises money for the global fund to fight HIV/AIDS, timed to coincide with World AIDS Day on December 1. Co-founded by Bono of U2 (which itself has a lengthy history of working with Apple), (RED) has to date raised $360 million, of which Apple alone has raised $120 million, according to Chrysi Philalithes, the chief digital strategist of (RED). "There has been so much progress that has been made that we can end AIDS by 2030," she told Motherboard, echoing sentiments made by the United Nations. "Now it's not a question of can we, but will we." In addition to making special Product (RED) edition iPhone cases (including the Smart Battery Case), wireless Beats Solo 3 headphones, and donating $1 for purchases made with Apple Pay on Apple.com or its retail stores, this year Apple introduced a new element to its support for the initiative. It tapped 10 mobile game developers—from the small to the big—to create exclusive content for the iOS versions of their titles as a means of raising awareness and money for (RED). Rovio has special power-ups for Angry Birds 2, Zynga created an exclusive character for FarmVille: Tropic Escape, and Bugatti—yes, the supercar maker—pitched in to help the developers of CSR Racing 2 create a Product (RED) edition Bugatti Chiron, the world's fastest production car, for the popular racing game. "We knew we had to do something a bit special," Chris Bowles, the creative director at CSR2 developer NaturalMotion, told Motherboard. "The Bugatti Chiron. 1,500 horsepower. 261 miles per hour. $2.6 million. And we're really happy to be able to offer it to our players for $19.99." And while $19.99 may only get you a digital version of the super car, Bowles was keen to stress that this is enough money to provide more than 65 days of life-saving medicine that (RED) helps provide in countries like Ghana and Kenya. "The level of detail is just stunning," Bowles said, highlighting in particular the exact red hue used for the car's body and onboard toolkit. "We were blown away when Bugatti sent this back." "Doing things like the (RED) campaign is fantastic because it helps extend the idea that we are more than just a game," Matt McMahon, of Seriously Digital Entertainment, told Motherboard. Like other games taking part in the campaign, Seriously's Best Fiends and Best Fiends Forever offer limited edition in-app purchases whose proceeds go to (RED). "At the end of the day if you can do well by doing good it's awesome."


A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein the isotopologue differs from vessel to vessel andwherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of ^(13)C, ^(15)N and ^(18)O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.


Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of ^(13)C, ^(15)N and ^(18)O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.


A test kit for the quantitative determination of narcotic drugs comprising(A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities,- wherein the isotopologue differs from vessel to vessel and- wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or(B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel;- wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs andcontain at least three stable isotopes selected from the group consisting of ^(13)C, ^(15)N and ^(18)O in the molecule with a degree of labeling of at least 95 mol-%;the use of the test kit and a method for quantitatively determining narcotic drugs.

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