Chirallica Ltd.

Zagreb, Croatia

Chirallica Ltd.

Zagreb, Croatia

Time filter

Source Type

Sunjic V.,Chirallica Ltd. | Franic D.,Chirallica Ltd. | Kontrec D.,Ruder Boskovic Institute | Roje M.,Ruder Boskovic Institute
Kemija u industriji/Journal of Chemists and Chemical Engineers | Year: 2010

Simulated moving bed (SMB) technology is over half a century known in continuous chromatographic separation of binary mixtures. Invented and developed in the petrochemical and sugar industries, it was recognized by organic chemists in the pharmaceutical industry as a powerful tool in separation of racemic mixtures. Over the years, it was developed into a standard laboratory, then pilot-plant and finally large-scale method for production of chiral compounds in the optically pure form. Final products of this technology are enantiopure drugs, other biologically active compounds and their intermediates. In Part I of this review, the basic principles and selected examples of recent SMB technology applications are presented.


Sunjic V.,Chirallica Ltd. | Franic D.,Chirallica Ltd. | Kontrec D.,Ruder Boskovic Institute | Rojeb M.,Ruder Boskovic Institute
Kemija u industriji/Journal of Chemists and Chemical Engineers | Year: 2010

Progress in the method of simulated moving bed (SMB) technology and some important achievements in separation of specific classes of racemic compounds of therapeutic interest are reported in the Part I of this review. Part II describes novel methods of SMB technology. Complex technologies, such as the combination of SMB and biocatalytic reactions, and SMB with crystallization process, are presented. VariCol variant of SMB, and its application in the separation of the racemic mixtures of commercial and academic interest are discussed. In the conclusive section, comments are given concerning the economic dimension and the market of enantiomerically pure compounds.


Disputes on the topic what is in common and what differentiates scientific research in the academic institutions and in the industrial research centers are ongoing among scientists in all fields of chemistry. New, original scientific knowledge in academic research on one hand, and successful scientific and technological solutions in industry, which have substantially improved life in the developed world on the other, have opposed these achievements and put them for various reasons in the concurrent positions. If dichotomy represents division of the whole in two halves, wherein nothing which belongs to one part can be the part of the second half, then we nowadays have a large number of prophets for this relation between two approaches to scientific research. This article offers argumentation which intends to remove this division in chemistry, and describes some achievements in research but also environmental consequences due to careless technological realization.

Loading Chirallica Ltd. collaborators
Loading Chirallica Ltd. collaborators