Ching Kuo Institute of Management and Health
Kaohsiung, Taiwan

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Kuo S.-Y.,Ching Kuo Institute of Management and Health | Lin K.-M.,National Health Research Institute | Chen C.-Y.,National Health Research Institute | Chen C.-Y.,National Yang Ming University | And 3 more authors.
Psychological Medicine | Year: 2011

Background The present study aimed to (a) characterize 10-year trajectory patterns of depressive symptoms and (b) investigate the association between depressive trajectory and subsequent obesity, metabolic function and cortisol level.Method In a prospective study of Taiwanese adults aged 60 years (n=3922) between 1989 and 1999, depression was assessed using a 10-item short-form of the Center for Epidemiologic Studies Depression Scale and information on body mass index (BMI) was collected by self-report. A subsample (n=445) of the original cohort in 1989 was drawn to assess metabolic variables and cortisol levels in a 2000 follow-up. After trajectory analyses were performed, multinomial logistic regression analyses were used to estimate the association estimates.Results We identified four distinctive trajectories of depressive symptoms: class 1 (persistent low, 41.8%); class 2 (persistent mild, 46.8%); class 3 (late peak, 4.2%); and class 4 (high-chronic, 7.2%). The results from both complete cases and multiple imputation analyses indicated that the odds of obesity were lower in the class 2, 3 or 4 elderly, as compared with those in class 1, while the odds of underweight were higher. The classes of older adults with more and persistent depressive symptoms showed a trend toward having both a lower BMI (p=0.01) and a higher cortisol level (p=0.04) compared with those with low depressive symptoms.Conclusions Incremental increases in depressive symptoms over time were associated with reduced risk of obesity and higher cortisol levels. © 2011 Cambridge University Press.

Lin C.-H.,Ching Kuo Institute of Management and Health | Lin Y.-M.,Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing | Liu C.-F.,Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing
American Journal of Chinese Medicine | Year: 2010

This study evaluates the effects of electrical stimulation on body composition and the meridian system in postmenopausal women with obesity. Forty-one postmenopausal women were recruited in Taiwan. The body composition was used as a screening test for obesity (percentage of body fat: > 30%, waist circumference: > 80 cm). The experimental group (EG, n = 20) received modulated middle-frequency electrical stimulation treatment for 20 min twice a week for 12 consecutive weeks at the Zusanli (ST36) and Sanyinjiao (SP6) acupoints. The control group (CG, n = 21) did not receive any intervention. The measurements of body composition and the meridian system were recorded for both groups in the pre- and post-study. The results showed that the data of body composition (weight, waist and hip circumference, percentage of body fat, and percentage of lean muscle mass) changed considerably in the EG (p < 0.05); however, no significant difference was observed in the CG. The left triple burner meridian changed notably in both EG and CG throughout the study (p < 0.05), however there was no difference between the two groups in the overall mean value, up-down ratio, qi and blood ratio, and yin-yang ratio. Our findings suggest that modulated middle-frequency electrical stimulation could help to improve body composition in postmenopausal women with obesity, potentially providing them with better care and health by integrating Western medicine and traditional Chinese medicine. © 2010 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine.

Wang J.-J.,National Cheng Kung University | Lin Y.-H.,Ching Kuo Institute of Management and Health | Hsieh L.-Y.,Chia Yi Christian Hospital
Aging and Mental Health | Year: 2011

Objective: The purpose of this research was to test the clinical use of the gerotranscendence (GT) theory and its influence on GT perspective, depression, and life satisfaction among a group of institutionalized elders. Methods: An experimental study utilizing pre-post group design and random assignment of elders into intervention and control group was conducted. The intervention support group was implemented in the experimental group once a week for eight weeks for 60 min. Over the eight-week period, 35 subjects in the experimental group and 41 in the control group completed the study. Data were collected one week before and one week after the intervention for both groups. Instruments include the GT Scale, Geriatric Depression Scale short form, and Life Satisfaction scale. Data were analyzed by paired t-test, Wilcoxon, McNemar, and analysis of co-variance. Results: Pre- and post-test scores on the GT perspective and life satisfaction were significantly increased (p = 0.000) in the experimental group. The mean depression score of the experimental group showed a slight but not significant decrease (p = 0.06). However, significant post-test differences were noted between groups in GT perspective, depression, and life satisfaction (p = 0.000, 0.01, and 0.000). Conclusion: The findings of this study suggest that after participating in a GT support group, institutionalized elders' GT perspective and life satisfaction were enhanced, and depression reduced. The positive effects demonstrated by this study can be extended and applied to the clinical health promotion of institutionalized elders. Ongoing GT intervention is encouraged to promote mental and spiritual health among institutionalized elders. © 2011 Taylor & Francis.

Lai J.C.-Y.,Ching Kuo Institute of Management and Health
Menopause | Year: 2016

OBJECTIVE:: The study compared the in-hospital complications and related outcomes between women who underwent bilateral salpingo-oophorectomy at hysterectomy for benign diseases and those who had hysterectomy only. METHODS:: We conducted a population-based, retrospective cohort study using data from Taiwanʼs National Health Insurance program. Women who underwent concurrent bilateral salpingo-oophorectomy at hysterectomy for benign indications (n?=?34,509) were compared with those who had hysterectomy only (n?=?176,305). Separate models were estimated to account for the effect of baseline comorbid condition, age, and hysterectomy approach on the relationship between bilateral salpingo-oophorectomy and study outcomes. A secondary analysis was also performed to evaluate the association of inpatient readmission within 30 days and complications among women who underwent bilateral salpingo-oophorectomy. RESULTS:: The addition of a bilateral salpingo-oophorectomy to hysterectomy was associated with a lower risk of surgical complications, a longer length of hospital stay, and an increased risk of inpatient readmission within 30 days. Among women who underwent bilateral salpingo-oophorectomy, women with complications were also more likely to require inpatient readmission within 30 days than those without complications. Our data also suggested that bilateral salpingo-oophorectomy was not associated with an overall risk of medical complications, with the exception of urethral obstruction. The relationships remained even after adjustments by age, surgical indications, hysterectomy approach, and health-related risk factors, such as baseline comorbid condition and status of any prior catastrophic illness. CONCLUSIONS:: Bilateral salpingo-oophorectomy at hysterectomy for benign conditions is not associated with an increased risk of in-hospital complications. © 2016 by The North American Menopause Society.

Chen Y.,National Defense Medical Center | Chou W.-C.,National Defense Medical Center | Ding Y.-M.,National Defense Medical Center | Wu Y.-C.,Ching Kuo Institute of Management and Health
Cellular Physiology and Biochemistry | Year: 2014

Aims: Glioma is the most malignant brain tumor that has the ability to migrate and invade the CNS. In this study, we investigated the signaling mechanism of caffeine on the migration of glioma cells. Methods: The effect of caffeine on cell migration was evaluated using Transwell and wound healing assays. The expression of the focal adhesion complex as it related to cell migration was assayed using Western blotting and immunostaining. Results: Caffeine decreased the migration of rat C6 and human U87MG glioma cells and down-regulated the expression of phosphorylated focal adhesion kinase (p-FAK) and p-paxillin. Caffeine also decreased p-FAK staining at the edge of glioma cells and disassembled actin stress fibers. Additionally, caffeine elevated expression of phosphorylated myosin light chain (p-MLC), an effect that could be blocked by Y27632, a rho-Associated protein kinase (ROCK) inhibitor, but not myosin light chain kinase inhibitor, ML-7. Y27632 also inhibited the caffeine-reduced expression of p-FAK and p-paxillin as well as cell migration. Conclusion: Caffeine decreased the migration of glioma cell through the ROCK-focal adhesion complex pathway; this mechanism may be useful as part of clinical therapy in the future. © 2014 S. Karger AG, Basel.

Hsu P.-S.,Ching Kuo Institute of Management and Health
Applied Mechanics and Materials | Year: 2013

The purpose of this study is aims to develop an inventory assessing self-determined motivation for e-Learning courses in college. The study involves 397 college students, with exploratory factor analysis and Cronbach alpha scale reliability, and the validity of the test. Selfdetermined learning motivation scale is accordance with the Learning Self-Regulation Questionnaire (SRQ-L) by Williams & Deci (1996) and Black & Deci (2000). It compiled and revised the initial inventory consisted of 14 items, it divided into four dimensions, such as, "Intrinsic motivation", " Identified regulation", "Introjected Regulation ", and "External regulation", the total explained variance was 71.35%. The Cronbach alpha is.87, with acceptable construct validity and reliability of measurement tools, it can provide the future development of e-Learning courses. © (2013) Trans Tech Publications, Switzerland.

Hsiao W.-L.,National Taiwan University of Science and Technology | Ho W.-L.,Ching Kuo Institute of Management and Health | Chou C.-C.,National Taiwan University of Science and Technology
International Journal of Food Microbiology | Year: 2010

Cronobacter spp., formerly Enterobacter sakazakii, are considered emerging opportunistic pathogens and the etiological agent of life-threatening bacterial infections in infants. In the present study, C. sakazakii BCRC 13988 was first subjected to sub-lethal heat treatment at 47 °C for 15 min. Survival rates of the heat-shocked and non-shocked C. sakazakii cells in phosphate buffer solution (PBS, pH 4.0) containing organic acids (e.g. acetic, propionic, citric, lactic or tartaric acid), simulated gastric juice (pH 2.0-4.0), and bile solution (0.5 and 2.0%) were examined. Results revealed that sub-lethal heat treatment enhanced the test organism's tolerance to organic acids, although the extent of increased acid tolerance varied with the organic acid examined. Compared with the control cells, heat-shocked C. sakazakii cells after 120-min of exposure, exhibited the largest increase in tolerance in the lactic acid-containing PBS. Furthermore, although heat shock did not affect the behavior of C. sakazakii in bile solution, it increased the test organism's survival when exposed to simulated gastric juice with a pH of 3.0-4.0. © 2010.

Huang M.-H.,Chia Nan University of Pharmacy and Science | Chu H.-L.,Chia Nan University of Pharmacy and Science | Juang L.-J.,Ching Kuo Institute of Management and Health | Wang B.-S.,Chia Nan University of Pharmacy and Science
Food Chemistry | Year: 2010

The inhibitory effects of a water extract of sweet potato leaves (WSPL) on nitric oxide (NO) production and protein tyrosine residue nitration were investigated. The results showed that WSPL inhibited NO production in a concentration-dependent manner. In the range of 0-1.0 mg/ml, the inhibitory effect on NO generation in macrophages increased with increasing concentration of WSPL. Meanwhile, the protein tyrosine residue nitration in mouse heart homogenates was inhibited by 1 mg/ml WSPL. In addition, WSPL, in the range of 0-0.4 mg/ml, also exhibited radical scavenging, reducing and chelating activities and protected liposomes against oxidative damage. A high performance liquid chromatography analysis revealed that phenolic acids and flavonols such as chlorogenic acid, caffeic acid, and quercetin were present in the WSPL, which could contribute to the protective effect against oxidative damage. Thus, WSPL might be useful in preventing protein nitration and oxidative stress. © 2010 Elsevier Ltd. All rights reserved.

Fong J.J.,University of California at Berkeley | Chen T.-H.,Ching Kuo Institute of Management and Health
Conservation Genetics | Year: 2010

Field surveys in Taiwan have uncovered turtles presumed to be hybrids based on their intermediate morphology. We sequenced a mitochondrial (ND4) and nuclear (R35) gene of two putative hybrid individuals, along with representatives of the potential parental species (Mauremys mutica, M. reevesii, M. sinensis), to determine their genetic identity. Based on our data, both individuals are hybrids, with independent, recent origins resulting from the mating of a female M. reevesii and a male M. sinensis. Since we question whether the highly traded M. reevesii is endemic to Taiwan, this hybridization could represent human-mediated genetic pollution. We also discuss the implications of our findings on turtle conservation in Taiwan. © 2010 The Author(s).

Tsai C.-J.,National Taiwan Ocean University | Tsai C.-J.,Ching Kuo Institute of Management and Health | Sun Pan B.,National Taiwan Ocean University
Journal of Agricultural and Food Chemistry | Year: 2012

The fatty acid compositions of 21 species of marine macroalgae, including 5 species of Chlorophyta (green algae), 13 of Rhodophyta (red algae), and 3 of Heterokontophyta (brown algae), were collected from northeastern Taiwan to survey their functional lipids. The lipid contents of green algae ranged from 15.36 to 20.15 mg/g, dry basis (db), and were characterized by a high content of C18:2 and C18:3, red algae (18.57-28.34 mg/g db) were high in C20:4 and C20:5, and brown algae (13.11-19.56 mg/g db) were high in C18:4, C20:4, and C:20:5. All algal lipids contained fatty acids of odd-number carbons, C17:0, and C17:1. Red algae had relatively higher levels of polyunsaturated fatty acids (PUFAs) and were richer in eicosapentaenoic acid (EPA) than green and brown algae. A red alga, Porphyra crispata, was extracted with ethanol and separated on a hydrophobic column (Diaion HP-20 column) to obtain sulfoglycolipids (sulfoquinovosyldiacylglycerols, SQDGs). The main fatty acids in SQDGs were palmitic acid (C16:0), 33.3%; EPA (C20:5), 30.0%; arachidonic acid (C20:4), 12.7%; oleic acid (C18:1), 7.52%; and stearic acid (C18:0), 6.83%. The n-3/n-6 ratio was 1.9, whereas the authentic standard, spinach SQDG, did not contain n-3 fatty acids. Sulfoglycolipids inhibited the growth of human hepatocellular carcinoma cell line (HepG2). The IC50 was 126 μg/mL, which is lower than that of the spinach SQDG (255 μg/mL). © 2012 American Chemical Society.

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