Hong Kong, China

The Chinese University of Hong Kong is a public research university in Shatin, Hong Kong, formally established in 1963 by a charter granted by the Legislative Council of Hong Kong. It is the territory's second oldest institution of higher learning, and the only collegiate university. The University was originally founded as a federation of three existing colleges, Chung Chi College, New Asia College and United College, the oldest of which was founded in 1949.Today, CUHK is organised into nine constituent colleges and eight academic faculties. Though the original statement in the charter of the University stipulates Chinese as the principal language, English is currently the main language of instruction in most classes, with Cantonese and Mandarin Chinese being retained only by a minority of colleges and academic departments. As of 2013, four Nobel laureates are associated with the University, making it the only tertiary institution in the territory with recipients of the Nobel Prize, Turing Award, Fields Medal and Veblen Prize as faculty in residence. Wikipedia.


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Patent
Chinese University of Hong Kong | Date: 2017-02-22

This application describes the discovery that, in a pregnant woman, certain genes (such as RASSFIA, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THYl, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.


Patent
Chinese University of Hong Kong | Date: 2017-01-20

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.


Patent
Chinese University of Hong Kong | Date: 2016-05-23

The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising:


Patent
Chinese University of Hong Kong and The Regents Of The University Of California | Date: 2016-10-03

The present invention provides isolated Met e 1 polypeptides and nucleic acids encoding the isolated polypeptides that can prevent and/or alleviate an allergic response to shellfish tropomyosin. The polypeptides are based on the shrimp tropomyosin Met e 1 protein and have been modified to act as hypoallergens. The Met e 1 hypoallergens have low to no IgE reactivity or allergenicity and are useful for prophylactic and/or therapeutic treatment of shellfish allergy in subject in need thereof.


Patent
Chinese University of Hong Kong | Date: 2017-05-03

It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. In addition, it provides a method for determining the risk of having advanced cervical dilation and/or premature cervical shortening based on differentially abundant bacterial taxa.


Patent
Chinese University of Hong Kong | Date: 2017-06-14

Whether a fetus has an aneuploidy associated with a first chromosome is detected using ratios of alleles detected in a maternal sample having a mixture of maternal and fetal DNA. DNA from the sample is enriched for target regions associated with polymorphic loci and then sequenced. Polymorphic loci (e.g., single nucleotide polymorphisms) in the target regions with fetal-specific alleles are identified on a first chromosome and on one or more reference chromosomes. A first ratio of the fetal-specific alleles and shared alleles is determined for the loci on the first chromosome. A second ratio of the fetal-specific alleles and shared alleles is determined for the loci on the reference chromosome(s). A third ratio of the first and second ratio can be compared to a cutoff to determine whether an aneuploidy is present, and whether the aneuploidy is maternally-derived or paternally-derived.


Patent
Chinese University of Hong Kong | Date: 2016-12-07

The invention provides novel high-energy density and low-cost flow electrochemical devices incorporating solid-flow electrodes, and further provides methods of using such electrochemical devices. Included are anode and cathode current collector foils that can be made to move during discharge or recharge of the device. Solid-flow devices according to the invention provide improved charging capability due to direct replacement of the conventional electrode stack, higher volumetric and gravimetric energy density, and reduced battery cost due to reduced dimensions of the ion-permeable layer.


Patent
Chinese University of Hong Kong | Date: 2016-12-20

The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mRNA with a standard control.


Accurate and effective methods for measuring cardiovascular and respiratory parameters are provided. The method for deriving a depth-specific photoplethysmography (PPG) signal from multi-wavelength PPG signals includes choosing light wavelength combinations, calibrating a multi-layer light-tissue interaction model referring to a physiological signal, and generating the depth-specific PPG signal from the multi-wavelength PPG signals based on the calibrated light-tissue interaction model. The disclosed method for cuff-less blood pressure measurement includes recording a physiological signal and multi-wavelength PPG signals of a predetermined body part, deriving the depth-specific PPG signal reflecting the arterial blood volume with the physiological signal as a reference, calculating the pulse transit time (PTT) from the physiological signal and the derived arterial blood PPG signal, and calculating the blood pressure from the calibrated PTT and blood pressure relationship.


Patent
Chinese University of Hong Kong | Date: 2017-05-24

The contributions of different tissues to a DNA mixture are determined using methylation levels at particular genomic sites. Tissue-specific methylation levels of M tissue types can be used to deconvolve mixture methylation levels measured in the DNA mixture, to determine fraction contributions of each of the M tissue types. Various types of genomic sites can be chosen to have particular properties across tissue types and across individuals, so as to provide increased accuracy in determining contributions of the various tissue types. The fractional contributions can be used to detect abnormal contributions of a particular tissue, indicating a disease state for the tissue. A differential in fractional contributions for different sizes of DNA fragments can also be used to identify a diseased state of a particular tissue. A sequence imbalance for a particular chromosomal region can be detected in a particular tissue, e.g., identifying a location of a tumor.

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