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Cao J.,CAS Shanghai Institutes for Biological Sciences | Cao J.,Shanghai JiaoTong University | Zhu S.,CAS Shanghai Institutes for Biological Sciences | Zhou W.,Shanghai JiaoTong University | And 12 more authors.
PLoS ONE | Year: 2013

Promyelocytic leukemia zinc finger (PLZF) protein expression is closely related to the progression of human cancers, including prostate cancer (PCa). However, the according context of a signaling pathway for PLZF to suppress prostate tumorigenesis remains greatly unknown. Here we report that PLZF is a downstream mediator of the PTEN signaling pathway in PCa. We found that PLZF expression is closely correlated with PTEN expression in a cohort of prostate cancer specimens. Interestingly, both PTEN rescue and phosphoinositide 3-kinase (PI3K) inhibitor LY294002 treatment increase the PLZF expression in prostate cancer cell lines. Further, luciferase reporter assay and chromatin immunoprecipitation assay demonstrate that FOXO3a, a transcriptional factor phosphorylated by PI3K/AKT, could directly bind to the promoter of PLZF gene. These results indicate that PTEN regulates PLZF expression by AKT/FOXO3a. Moreover, our animal experiments also demonstrate that PLZF is capable of inhibiting prostate tumorigenesis in vivo. Taken together, our study defines a PTEN/PLZF pathway and would shed new lights for developing therapeutic strategy of prostate cancer. © 2013 Cao et al.


News Article | December 20, 2016
Site: www.eurekalert.org

JUPITER, FL - Dec. 20, 2016 - Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed an efficient process to rapidly discover new "enediyne natural products" from soil microbes that could be further developed into extremely potent anticancer drugs. The study highlights microbial natural products as abundant sources of new drug leads. The researchers' discovery process involves prioritizing the microbes from the TSRI strain collection and focusing on the ones that are genetically predisposed to produce specific families of natural products. The scientists say this process saves time and resources in comparison to the traditional approaches used to identify these rare molecules. The study, led by TSRI Professor Ben Shen, was published today in the journal mBio. Shen and his colleagues uncovered a new family of enediyne natural products, called tiancimycins, (TNMs) which kill selected cancer cells more rapidly and completely in comparison to toxic molecules used in FDA-approved antibody-drug conjugates (ADCs)-- monoclonal antibodies attached to cytotoxic drugs that target only cancer cells. The scientists also discovered several new producers of C-1027, an antitumor antibiotic currently in clinical development, which can produce C-1027 at much higher levels. It has been more than a decade since Shen first reported on the C-1027 enediyne biosynthetic machinery, and he speculated then that the knowledge obtained from studying biosynthesis of C-1027, and other enediynes, could be used for the discovery of novel enediyne natural products. "The enediynes represent one of the most fascinating families of natural products for their extraordinary biological activities," Shen said. "By surveying 3,400 strains from the TSRI collection, we were able to identify 81 strains that harbor genes encoding enediynes. With what we know, we can predict novel structural insights that can be exploited to radically accelerate enediyne-based drug discovery and development." "The work described by the Shen group is an excellent example of what can be achieved by coupling state of the art genomic analyses of potential biosynthetic clusters and modern physicochemical techniques," said David J. Newman, retired chief of the National Cancer Institute's Natural Products Branch. "As a result of their work, the potential number of enediynes has significantly increased." Shen's method of strain prioritization and genome mining means a far more efficient use of resources involved in the discovery process, targeting only those strains that look to produce the most important natural compounds. "This study shows that the potential to rapidly discover new enediyne natural products from a large strain collection is within our reach," said TSRI Research Associate Xiaohui Yan, one of four first authors of the study. "We also show the feasibility of manipulating tiancimycin biosynthesis in vivo, which means that sufficient quantities of these precious natural products can be reliably produced by microbial fermentation for drug development and eventual commercialization." In addition to Shen and Yan, first authors of the study, "Strain Prioritization and Genome Mining for Enediyne Natural Products," include TSRI's Huiming Ge, Tingting Huang and Hindra. Other authors include Dong Yang, Qihui Teng, Ivana Crnovči?, Xiuling Li, Jeffrey D. Rudolf, Jeremy R. Lohman and Christoph Rader of TSRI; Yannick Gansemans and Filip Van Nieuwerburgh of Ghent University, Belgium; Yanwen Duan, Xiangcheng Zhu and Yong Huang of Xiangya International Academy of Translational Medicine, Central South University, China; Li-Xing Zhao and Yi Jiang of Yunnan University, China. The study was supported in part by the Chinese Ministry of Education (111 Project B08034), National High Technology Joint Research Program of China (grant 2011ZX09401-001), National High Technology Research and Development Program of China (grant 2012AA02A705), the National Institutes of Health (grants CA78747 and GM115575), the German Research Foundation and the Arnold and Mabel Beckman Foundation. The Scripps Research Institute (TSRI) is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs more than 2,500 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists--including two Nobel laureates and 20 members of the National Academy of Science, Engineering or Medicine--work toward their next discoveries. The institute's graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see http://www. .


News Article | November 10, 2016
Site: en.prnasia.com

GUANGDONG, China, Nov. 10, 2016 /PRNewswire/ -- LeSports, China's leading Internet-based eco-sports company and Branded, the Hong Kong-based event marketing agency responsible for the highly successful YouTube FanFest and award winning 'All That Matters' conference series, today announced the speaker line up for their upcoming joint event LeSports Connects: The China Sports Forum. The 3-day invitation-only event is being held at event partner location Mission Hills, China - the world's largest golf resort, from 28 - 30 November 2016. The event kicks off with a golf day for all delegates, followed by 2 days of conference content focusing on the rapidly growing China sports industry, with topics including: 1. The China sports industry and its influence on the international sports scene Speakers announced for the first LeSports Connects: The China Sports Forum include: Rio Ferdinand, former England professional footballer Lei Zhenjian, Founder & CEO, LeSports Ma Guoli, Vice Chairman, LeSports Tenniel Chu, Vice Chairman, Mission Hills Group Hou Yuhua, CEO, Weisai Sports Chen Xin, Vice President, WeCapital Zhang Zhe, Senior Operations Director, Weibo Sports Zhao Jun, General Manager & CEO, China Sports Media Li Sheng, Founder & CEO, SECA World Beatrice Lee, CEO, Baofeng Sports  Stephanie McMahon, Chief Brand Officer & TV Personality, WWE Peter Kenyon, Partner, Opto Advisors Andrea Radrizzani, President & Founder, Aser Media Zhang Yi, Chief Editor, Sohu Sports Liu Jianhong, Co-President, LeSports Xie Chenguang, Founding Partner, Kaixing Capital  Shi Yiying, Director of Sports, Jiemian.com  Pan Shijian, Founding Partner, Kaixing Capital Zhang Yuqiang, Co-founder, Sports Money Han Mu, Founder, Lanxiong Sports Richard Young, Managing Director, NFL China Chris Park, Senior Vice President, Major League Baseball Victor Cui, CEO, ONE Championship ONE Jamie Reigle, Commercial Director, Manchester United Xavier Asensi, Managing Director -- APAC, Barcelona FC Fernando de Matos, Head of Sponsorships AP Region, Visa Caroline Darcy, Head of Sponsorship, Asia Pacific, UBS Adrian Toy, Regional Director, Marketing, PUMA Josh Black, CEO, ESP Properties, Asia Pacific Mickael Piantchenko, Asia Pacific Director, ESL  Tom Byer, Head Technical Advisor, Chinese Ministry of Education Andrew Collins, CEO, Mailman Group Michael Cunnah, Chairman, iSportConnect Catherine Gibbs, Head of Sponsorship, AIA John Cappo, President & CEO, AEG China  Ben Flint, CEO, Asian Sponsorship News (ASN) Scarlett Li, Founder & CEO, Zebra Media Richard Welbirg, Senior Reporter, TV Sports Markets with many more to be announced Interested parties can register their interest in attending at the official website: lesportsconnects.com Established in 2014, LeSports has quickly become China's leading internet sports company with a sports ecosystem which covers 'content platform + event management and operations + smart hardware + internet services.' With rights to over 300 global sporting events and live broadcasts totaling more than 16,000 games per year, including the English Premier League, LeSports houses the largest sports content in China. These also include exclusive rights in China to the Chinese Super League (CSL), Wimbledon, Formula 1 and much more. LeSports acts an event operator and promoter, having helped bring world-renowned football tournament the International Champions Cup (ICC) to China for the past two years and will again next year. The LeSports state-of-the-art, self-produced Smart Bike is the first item of hardware LeSports released and it has proven extremely popular among cycling and sports enthusiasts. Internet services such as e-commerce and ticketing are provided by LeSports, where customers can purchase officially-licensed merchandise from top clubs and organizations through LeSports' online platforms. Furthermore, LeSports acts as Major League Baseball's (MLB) hard goods distributor in mainland China, Hong Kong and Macao, and provides fans with the platform to purchase MLB merchandise in-game through the LeSports website and app. This year, LeSports introduced its subscription and pay-per-view model, breaking down the barrier of traditional sports broadcasting in China with its OTT service, and pushed China's paid sports content market into a new age. LeSports Pass members can watch all 380 Premier League matches live this season on LeSports' OTT platform. With its Hong Kong office up and running last year, LeSports HK has proved a real game-changer and instant success by introducing its popular OTT service into an already mature and competitive Pay TV market.  LeSports HK has also secured a whole host of exclusive rights to top-notch competitions such as the English Premier League, FA Cup, National Basketball Association (NBA) and the 2018 FIFA World Cup in Russia, as well as more than 2,500 matches from the Chinese Super League, the US Open Tennis Championships and many more. LeSports has started setting up a team based in the U.S, which is focusing on new technology and gaining a foothold in the ever-growing American sports market. LeEco, the parent company of LeSports, has recently set up offices in the U.S, India, Russia and with LeSports focusing on its globalization strategy, will look to move into these territories in the near future. Branded are creators of "Live Media that Matters". Branded conceptualised and produces the YouTube FanFest global tour, It's A Girl Thing and the "Matters" series of B2B festivals. Founded in 2002, and listed as a "Top 10 Event Marketing Agency" by Marketing Magazine and winner of the Singapore Experience Best Trade Event of the Year Award in 2012 and 2014, Branded adds value and grows the media, entertainment and sports industries in Asia. Branded are experts in the conceptualisation, programming, organisation, and production of dynamic conferences, live music festivals, academies, and fan events in Asia. We are an independent company staffed by passionate multi-cultural, multi-lingual and multi-talented individuals with offices in Hong Kong and Singapore and affiliations that reach all corners of the world. www.branded.asia For further enquiries please contact: Ross Collett (Media) at ross@rococomms.com Louisa Berry (Sales/Media Partnerships enquiries) at louisa@branded.asia Krystyna Kosciuszko (Programme enquiries) at krystyna@branded.asia

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