The Chinese Culture University is a private Taiwanese university located in Yangmingshan in Shilin District, Taipei, Taiwan. CCU was established in 1962 and is one of the largest universities in Taiwan with an enrollment of about 32,000 students. Satellite campuses are located in the Jianguo, Ximending, and Zhongxiao East Road areas of Taipei City.Originally founded as Far East University in 1962 by Chang Chi-yun, the school was renamed College of Chinese Culture by President Chiang Kai-shek in 1963 and finally became Chinese Culture University in 1980. CCU is now organized into twelve academic colleges: Liberal Arts, Foreign Language and Literature, Social science, Science, Engineering, Business Administration, Journalism and Communications, Arts, Environmental Design, Law, Agriculture and Education. Wikipedia.
Chiang M.-C.,Chinese Culture University |
Chern Y.,Academia Sinica, Taiwan |
Huang R.-N.,National Taiwan University
Neurobiology of Disease | Year: 2012
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein (mHtt) forms aggregates in the brain (e.g., cortex and striatum), and causes devastating neuronal degeneration. Transcriptional dysfunction caused by mHtt is critical for HD. We recently demonstrated that a crucial transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) played a major function in the energy homeostasis observed in HD and that PPARγ is a potentially neuroprotective target for this disease. We report here that the transcript level of PPARγ was markedly downregulated in the cortex of a transgenic mouse model of HD (R6/2). Treatment of R6/2 mice with an agonist of PPARγ (thiazolidinedione, TZD) resulted in a beneficial effect on PPARγ. By reducing Htt aggregates and thereby ameliorating the recruitment of PPARγ into Htt aggregates, TZD treatment also elevated the availability of PPARγ level and subsequently normalized the expression of downstream genes (including PGC-1α and several mitochondrial genes) in the cortex. The above protective effects appeared to be exerted by a direct activation of the PPARγ agonist (rosiglitazone) because rosiglitazone protected a neuroblastoma cell line (N2A) from mHtt-evoked mitochondrial deficiency. Our results reveal that TZD and rosiglitazone may play a protective role in HD, and support the view that PPARγ is a potential therapeutic target in HD. © 2011 Elsevier Inc.
News Article | February 21, 2017
Monster Energy congratulates Max Parrot on his win Sunday night at the final stop of the Air + Style in Los Angeles. In what has been a remarkable season for the Canadian ripper, the win also earned him third overall in the three-stop tour, which saw events in Beijing, China and Innsbruck, Austria earlier this season. Set in historic Exposition Park in downtown LA, not the typical place for a snowboard contest, Air + Style Los Angeles is a one of a kind event mixing equal parts, music, snowboarding and party. With musical acts like TV on the Radio and Major Lasers, this was no casual gathering. The event is a full-blown music festival with one exception – a monolithic 16-story scaffold structure. And although Parrot grew up riding on actual snow covered slopes in Southern Quebec, tonight he would prove that whether the slopes are shaped by tectonic forces or engineering degrees, whether the snow fell from the sky or was basted from a gun, as long as he has a snowboard strapped to his feet, there is no issue. Coming off a victory at the Innsbruck Air + Style two weeks ago and up against familiar faces like Mark McMorris and the young Marcus Kleveland, this was to be no cakewalk. Yet, as the competition kicked off and he dropped in to his first attempt on the man-made super kicker, Parrot, without any words, told his competition what to do. Usually reserving the bangers for last, tonight the 22-year-old goofy footer wasted no time floating a lofty cab 1620 over the skies of LA, crushing the landing to the bewilderment of thousands of onlookers. It was an unusual strategy, but Parrot is far from a simple stunt monkey, he knew exactly what he was doing. Scoring a 90.00, no one would top it the rest of the evening. "It's not easy out here," said Parrot. "It's raining, not raining – we're having every weather possible." This adversity however, is what shows the true talent of these snowboarders and as competition wore many riders were having speed issues and had trouble sticking their landing's because they were actually going too big. Even Parrot, on his second attempt wasn't able to hold it together as he slid out on a cab 1440. Dressed in his trademark all black, all business attire, Parrot sealed the deal on his final attempt with a frontside triple cork 1440 landing like everyone else, at the bottom of the jump. This time he had the legs for it and muscled out the landing like a man possessed. Technicality and style considered the judges awarded him 88.66 points for a combined total of 178.66. "Dude, I can't even explain this," he smiled afterwards. "I've never won in LA, never won with this combination of tricks. I'm going to put a little check mark next to this one!" The win also put Parrot in third place in overall tour points, quite the feat considering he didn't even qualify for finals at the Beijing event. At this point we have come to understand Parrot is a man on a mission, if not a genetically altered super species of snowboarder altogether. With a history making season under his belt including the first ever landed Cab quadruple cork underflip at the X Games in Aspen in January, it's clear that as far as Big Air events go, if Parrot lands on his snowboard, he wins the contest. With the US Open and X Games Norway still to come, what's he got in store for the rest of the season? About Monster Energy Based in Corona, California, Monster Energy is the leading marketer and distributor of energy drinks and alternative beverages. Refusing to acknowledge the traditional, Monster Energy supports the scene and sport. Whether motocross, off-road, NASCAR, MMA, BMX, surf, snowboard, ski, skateboard, or the rock and roll lifestyle, Monster Energy is a brand that believes in authenticity and the core of what its sports, athletes and musicians represent. More than a drink, it’s the way of life lived by athletes, sports, bands, believers and fans. See more about Monster Energy including all of its drinks at http://www.monsterenergy.com.
News Article | February 15, 2017
Monster Energy's Jamie Anderson continued her stellar season by adding another trophy to her collection by winning Slopestyle at the final stop of the Toyota U.S. Grand Prix event at Mammoth Mountain. Battling strong competition and tough weather, Anderson leaned on focus and experience to grind out another win. Considering the winter that California has been having with Mammoth Mountain receiving over 20 feet of snow in the month of January alone, it comes with little surprise that winter was in full effect for this weekend’s event. Having to cancel or postpone most events all week, Slopestyle finals finally took place under cloudy skies, fresh snow and lots of wind. But this isn't Anderson's first rodeo and adverse conditions were not going to stop the most decorated women's Slopestyle athlete in the history of women's snowboarding. Drawing on years of experience, Anderson understood that a winning run today wouldn't necessarily be about progression but more about consistency. Just staying on her board given the low light and wind was impressive enough as she took apart the rail section. Starting with a frontside 180 on to a cab 180 off the down bar she then buttered a tail slide 270 off the signature Mammoth Pyramid feature. Transitioning into the jump line she set up with a little hand plant on the quarter pipe before boosting a method off the following side hit. Picking up speed toward the first kicker Anderson set up to spin and laid down a frontside 720 before floating one of her beautiful backside rodeos. With one jump to go the contest would be hers if she just landed on her board. Fortunately her bag of tricks is deep and all things considered a smooth cab 540 would be enough to secure the victory. "I mean conditions sucked but hey, we pulled it off," she said with a smile. Looking around and finding her family in the crowd she added, "Really, I'm just so happy my family got to be here. This doesn't happen all the time and this whole week was a family reunion so I'm very grateful." An important win for Anderson, this was the first event in which riders could start to collect points towards a bid for the 2018 U.S. Olympic Team. Anderson, you remember is the reigning Slopestyle Gold medalist from the Sochi winter games held in Russia three years ago and al things considered, a shoe in to be representing her country next year in Pyeongchang, South Korea. For more on Anderson visit http://www.monsterenergy.com. About Monster Energy Based in Corona, California, Monster Energy is the leading marketer and distributor of energy drinks and alternative beverages. Refusing to acknowledge the traditional, Monster Energy supports the scene and sport. Whether motocross, off-road, NASCAR, MMA, BMX, surf, snowboard, ski, skateboard, or the rock and roll lifestyle, Monster Energy is a brand that believes in authenticity and the core of what its sports, athletes and musicians represent. More than a drink, it’s the way of life lived by athletes, sports, bands, believers and fans. See more about Monster Energy including all of its drinks at http://www.monsterenergy.com.
Liu M.,Chinese Culture University
Reproductive Biology and Endocrinology | Year: 2011
Cortical granules are membrane bound organelles located in the cortex of unfertilized oocytes. Following fertilization, cortical granules undergo exocytosis to release their contents into the perivitelline space. This secretory process, which is calcium dependent and SNARE protein-mediated pathway, is known as the cortical reaction. After exocytosis, the released cortical granule proteins are responsible for blocking polyspermy by modifying the oocytes' extracellular matrices, such as the zona pellucida in mammals. Mammalian cortical granules range in size from 0.2 um to 0.6 um in diameter and different from most other regulatory secretory organelles in that they are not renewed once released. These granules are only synthesized in female germ cells and transform an egg upon sperm entry; therefore, this unique cellular structure has inherent interest for our understanding of the biology of fertilization. Cortical granules are long thought to be static and awaiting in the cortex of unfertilized oocytes to be stimulated undergoing exocytosis upon gamete fusion. Not till recently, the dynamic nature of cortical granules is appreciated and understood. The latest studies of mammalian cortical granules document that this organelle is not only biochemically heterogeneous, but also displays complex distribution during oocyte development. Interestingly, some cortical granules undergo exocytosis prior to fertilization; and a number of granule components function beyond the time of fertilization in regulating embryonic cleavage and preimplantation development, demonstrating their functional significance in fertilization as well as early embryonic development. The following review will present studies that investigate the biology of cortical granules and will also discuss new findings that uncover the dynamic aspect of this organelle in mammals. © 2011 Liu; licensee BioMed Central Ltd.
Peng H.T.,Chinese Culture University
Journal of Strength and Conditioning Research | Year: 2011
Peng, H-T. Changes in biomechanical properties during drop jumps of incremental height. J Strength Cond Res 25(9): 2510-2518, 2011-The purpose of this study was to investigate changing biomechanical properties with increasing drop jump height. Sixteen physically active college students participated in this study and performed drop jumps from heights of 20, 30, 40, 50, and 60 cm (DJ20-DJ60). Kinematic and kinetic data were collected using 11 Eagle cameras and 2 force platforms. Data pertaining to the dominant leg for each of 3 trials for each drop height were recorded and analyzed. Statistical comparisons of vertical ground reaction force (vGRF), impulse, moment, power, work, and stiffness were made between different drop jump heights. The peak vGRF of the dominant leg exceeded 3 times the body weight during DJ50 and DJ60; these values were significantly greater than those for DJ20, DJ30, and DJ40 (all p < 0.004). The height jumped during DJ60 was significantly less than that during DJ20 and DJ30 (both p = 0.010). Both the landing impulse and total impulse during the contact phase were significantly different between each drop height (all p < 0.036) and significantly increased with drop height. There were no significant differences in the takeoff impulse. Peak and mean power absorption and negative work at the knee and ankle joints during DJ40, DJ50, and DJ60 were significantly greater than those during DJ20 and DJ30 (all p < 0.049). Leg, knee, and ankle stiffness during DJ60 were significantly less than during DJ20, DJ30, and DJ40 (all p < 0.037). The results demonstrated that drop jumps from heights >40 cm offered no advantages in terms of mechanical efficiency (SSC power output) and stiffness. Drop jumps from heights in excess of 60 cm are not recommended because of the lack of biomechanical efficiency and the potentially increased risk of injury. © 2011 National Strength and Conditioning Association.
Chen C.-F.,Chinese Culture University
Ecological Engineering | Year: 2013
Green roofs have multiple environmental benefits and are widely used around the world. In keeping with this mainstream movement, the use of green roofs has been increasing in Taiwan in recent years. This paper reviews policies promoting green roof development in Taiwan, and compares the environmental and economic performance of green roofs in Taiwan to those in East Asian countries and worldwide. National and regional government policies have stimulated the development of green roofs by establishing goals for reducing carbon emissions of cities, promoting green construction, mitigating heat island effects, and increasing urban flood control. Local studies of green roof performance are few, other than thermal investigations. These studies have shown that green roofs significantly contribute to thermal reduction and moderate temperature variations around buildings. One study sampled stormwater runoff from green roof sites and found that sediment and nutrient concentration on these roofs are up to ten times higher than on conventional bare roofs; however, acid rain can be neutralized by green roofs. Hydrographs have shown that reductions in runoff from green roofs are not as great as expected because retention and detention are affected by high rainfall intensity, which is the typical precipitation pattern in Taiwanese cities. Without additional maintenance, green roofs can contribute to nonpoint source pollution in urban cities in wet and hot weather zones, because of high runoff and associated mass loading. Moreover, the environmental benefits of green roofs in Taiwan may not be as significant as those in other countries in which utility costs are higher, where decreasing energy consumption and CO2 emissions would be of greater benefit. © 2012 Elsevier B.V.
Su P.-G.,Chinese Culture University |
Shieh H.-C.,Chinese Culture University
Sensors and Actuators, B: Chemical | Year: 2014
Novel flexible NO2 gas sensors were fabricated by covalently bonding graphene oxide (GO) to a gold electrode on a plastic substrate using a peptide chemical protocol and then reducing in situ GO film to a reduced GO (RGO) film. A pair of comb-like Au electrodes on a polyethylene terephthalate (PET) substrate were pretreated with cysteamine hydrochloride (CH) and then reacted with GO using N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) as the peptide coupling reagent, before undergoing a final reduction by sodium borohydride (NaBH 4). The anchored RGO film was characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and Fourier transform infrared spectroscopy (FTIR). The gas sensing properties, including sensitivity, sensing linearity, reproducibility, response time, recovery time, cross-sensitivity effects and long-term stability, were investigated. Interfering gas NH3 affected the limit of detection (LOD) of a target NO2 gas in a real-world binary gas mixture. The flexible NO2 gas sensor exhibited a strong response and good flexibility that exceeded that of sensors that were made from graphene film grown by chemical vapor deposition method (CVD-graphene) at room temperature. Its use is practical because it is so easy to fabricate. © 2013 Elsevier B.V.
Yang T.,Chinese Culture University
Journal of Computer Information Systems | Year: 2012
Currently, lots of enterprises widely use social network site for marketing campaigns, however, there are still limited literature in the related fields. This study investigated the determinant factors for the successful implementation of Facebook marketing by enterprises. Using the marketing communication model developed by Hoffman & Novak  as well as source credibility, social ties, consumer value and the involvement theory, this study tested the impact transferring messages through media on the message receiver's decision-making behavior. A total of 256 smart phone Facebookers were selected as research samples, and the hypotheses was tested using regression analysis. The research findings suggested that advertising messages provided by close friends only affect consumer brand attitudes, but advertising messages provided by commercial sources affect both consumer brand attitudes and purchasing intentions. Utilitarian and recreational advertising messages affect consumer advertising attitude, brand attitudes, purchasing intentions and involvement. Lastly, consumer involvement partially mediates the effects of utilitarian advertising and recreational advertising on advertising attitude, brand attitudes and purchasing intentions.
Chen W.-R.,Chinese Culture University
Journal of Sound and Vibration | Year: 2011
Utilizing the Timoshenko beam theory and applying Hamiltons principle, the bending vibration equations of an axially loaded beam with locally distributed internal damping of the KelvinVoigt type are established. The partial differential equations of motion are then discretized into linear second-order ordinary differential equations based on a finite element method. A quadratic eigenvalue problem of a damped system is formed to determine the eigenfrequencies of the damped beams. The effects of the internal damping, sizes and locations of damped segment, axial load and restraint types on the damping and oscillating parts of the damped natural frequency are investigated. It is believed that the present study is valuable for better understanding the influence of various parameters of the damped beam on its vibration characteristics. © 2011 Elsevier Ltd.
Huang J.-T.,Chinese Culture University
IEEE Transactions on Neural Networks and Learning Systems | Year: 2012
Most existing adaptive neural controllers ensure semiglobally uniform ultimately bounded stability on the condition that the neural approximation remains valid for all time. However, such a condition is difficult to verify beforehand. As a result, deterioration of tracking performance or even instability may occur in real applications. A common recourse is to activate an extra robust controller outside the neural active region to pull back the transient. Such an approach, however, has been restricted to dynamic systems with matched uncertainty. We extend it to strict-feedback systems with mismatched uncertainties via multiswitching-based backstepping methodology. Each virtual and actual controller of the proposed design switches between an adaptive neural controller and a robust controller, with the switching algorithm being sufficiently smooth and, hence, able to be incorporated with the backstepping tool. The overall controller ensures globally uniform ultimate boundedness while simultaneously avoiding the possible control singularity. Simulation results demonstrate the validity of the proposed designs. © 2012 IEEE.