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Wu J.,Beijing University of Technology | Yu K.,Beijing University of Technology | Chen T.,Beijing University of Technology | Li Y.,Chinese Astronaut Science Researching and Training Center | Wang C.,Chinese Astronaut Science Researching and Training Center
Laser and Tera-Hertz Science and Technology, LTST 2012 | Year: 2012

A new manufacture technology of micro-lens generated on needing positions is suggested. A micro-detector to fluorescence spectrum using the micro-lens is made. Experiment results indicatethat the micro-detection with the micro-lens can increase sensitivity greatly. © 2012 OSA. Source


Wu J.,Beijing University of Technology | Guo W.,Beijing University of Technology | Wang C.,Chinese Astronaut Science Researching and Training Center | Li Y.,Chinese Astronaut Science Researching and Training Center | And 2 more authors.
Surface Engineering | Year: 2015

In order to improve surface roughness and hydrophilicity of microchannels in microfluidic chip, then to achieve high fluid speed under small pressure, a technology named as coating solidifiable adhesive film is proposed. In this paper the microfluidic chip is manufactured using CO2 laser. The film is coated on inside wall of microchannels using ultraviolet optic solidifiable adhesive. Two coating methods were used to synthesise the NOA61 film. The surface roughness and waterphase contact angle of the microchannel with and without the NOA61 film are measured. The roughness is reduced from 2 μm to 243·36 nm and the contact angle is reduced from 100 to 72·55°, when NOA61 film is coated with the action of gas blowing and consequent drying by UV light. The roughness is reduced from 2 μm to 60·49 nm and the contact angle is reduced from 100 to 55·35u, when NOA61 film is obtained by gravity flow. © 2015 Institute of Materials, Minerals and Mining. Source


Wu J.,Beijing University of Technology | Guo W.,Beijing University of Technology | Wang C.,Chinese Astronaut Science Researching and Training Center | Yu K.,Beijing University of Technology | And 2 more authors.
Cell Biochemistry and Biophysics | Year: 2015

Fluorescent polymerase chain reaction (PCR) is becoming the preferred method of quantitative analysis due to its high specificity and sensitivity. We propose to use a new kind of micro-lens, dynamically solidified with optic glue, to improve the sensitivity of fluorescent PCR micro-detector. We developed light ray track equations for these lenses and used them to calculate relative light intensity distribution curve for stimulation lenses and illumination point probability distribution curve for detection lenses. We manufactured dynamically solidified micro-lenses using optic glue NOA61, and measured their light gathering ability. Lenses with radius/thickness (R/H) ratio of 4 reached light focusing ratio of 3.85 (stimulation lens) and photon collection efficiency of 0.86 (detection lens). We then used dynamically solidified lenses in PCR fluorescence micro-detector and analyzed their effect on the detector sensitivity. We showed that the use of dynamically solidified micro-lenses with R/H = 4 resulted in over 4.4-fold increased sensitivity of the detector. © 2015, Springer Science+Business Media New York. Source


Wu J.,Beijing University of Technology | Yu K.,Beijing University of Technology | Chen T.,Beijing University of Technology | Li Y.,Chinese Astronaut Science Researching and Training Center | Wang C.,Chinese Astronaut Science Researching and Training Center
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2012

In this paper a new manufacture technology of the micro-lens generated on needing positions is suggested. This technology doesn't need mould or masks, it generates the micro-lens on the needing positions directly according to needing curve shape. It is a simple and quick laser micro-manufacture technology, which solves the difficulties of high accurate separation the micro-lens from substrate and adhesion the micro-lens to working face coaxially. A microdetector to fluorescence spectrum using the micro-lens generated on needing positions is made. The detector has many advantages, for example high sensitivity and micro volume. It can be inserted in biochip, and it is used in alarm system of harmful microbes in spacecraft also. © 2012 SPIE. Source


Wu J.,Beijing University of Technology | Liu W.-C.,Beijing University of Technology | Yu K.-X.,Beijing University of Technology | Chen T.,Beijing University of Technology | And 2 more authors.
Journal of Applied Optics | Year: 2013

In order to solve the difficulty for manufacture of micro-lens in micro-detector of fluorescent spectrum, a new manufacture technique of micro-lens, molded on needing position, was proposed. Light gathering ability of the optic micro-lens was researched. Using principles of traditional geometric optics, ray tracking equations of stimulating micro-lens and detecting micro-lens were derived. Distributed probabilities of illumination points for the two micro-lenses were calculated by using these equations. Some corresponding distributed curves were given. Influence of the micro-lens's shape on the light gathering ability was discussed. Results indicate that the contact angle between optic glue and glass base can be decreased and the shape parameter of the micro-lens can be increased by adulteration in the optic glue and milling the glass. It can both strengthen adhesiveness between the glue and the glass, and increase light gathering ability of the micro-lens. A micro-detector for fluorescent spectrum with micro-lens molded on needing position was manufactured and the biological fluorescent reagent was measured. Experiment results indicate that the intensity of the biologic fluorescent spectrum can be increased more than 4 times by using micro-lens molded on needing position, the light gathering ability of the micro-lens can be increased 1.2 times though adulteration in the glue and milling the glass. Source

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