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Nanchong, China

China West Normal University is a comprehensive normal university featuring teacher education and training in Nanchong, Sichuan, China.The university was established in 1946. It now has 30,343 students. Wikipedia.


Cheng Z.,China West Normal University
Journal of Pharmaceutical and Biomedical Analysis | Year: 2012

In this study, the binding modes of honokiol (HK) and magnolol (MG) with human serum albumin (HSA) have been established under imitated physiological condition, which was very important to understand the pharmacokinetics and toxicity of HK or MG. The experimental results proved that the fluorescence of HSA was quenched by HK or MG through a static quenching procedure. The binding constants of HK-HSA and MG-HSA complexes were 5.304 and 263.755×10 4Lmol -1 at 298K, respectively. The binding process was a spontaneous molecular interaction procedure, in which the hydrophobic interaction played a major role in the formation of the HK-HSA complex, whereas, the binding interaction between MG and HSA might involve the hydrophobic interaction strongly and electrostatic interaction. In addition, the effect of HK/MG on the secondary structure of HSA was analyzed using CD, UV-vis absorption, Fourier transform infrared (FT-IR), synchronous fluorescence and three-dimensional fluorescence spectra. According to Förster no-radiation energy transfer theory, the binding distance of HSA to HK or MG was calculated to be 1.842 or 1.238nm. Besides, the effects of common ions on the binding constants of HSA-HK/MG systems were also discussed. © 2012 Elsevier B.V.


The direct use of macroscopic biopolymer alginate hydrogels (AHs) as a green and effective carrier to stabilize silver nanoparticles (Ag NPs) is presented. The Ag@AHs were characterized by UV-vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electronic microscopy (SEM) and X-ray energy dispersive spectroscopy (EDS). The Ag@AHs showed excellent catalytic performance for the reduction of 4-nitrophenol by NaBH4 in aqueous solution, which can be easily separated after catalytic reaction and readily reused for three successive reaction cycles, attributing to the high stability of the Ag NPs supported by AHs. Our findings shed light on the design and fabrication of new heterogeneous catalyst with high performance based on the environmentally benign biopolymer hydrogel. Copyright © 2012 Elsevier Ltd. All rights reserved.


Cheng Z.,China West Normal University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

The interactions of tetramethylpyrazine (TMPZ) with bovine serum albumin (BSA) and human serum albumin (HSA) have been investigated by various spectroscopic techniques. Fluorescence tests showed that TMPZ could bind to BSA/HSA to form complexes. The binding constants of TMPZ-BSA and TMPZ-HSA complexes were observed to be 1.442 × 10 4 and 3.302 × 10 4 M -1 at 298 K, respectively. The thermodynamic parameters (ΔG, ΔH and ΔS) calculated on the basis of different temperatures revealed that the binding of TMPZ-HSA was mainly depended on hydrophobic interaction, and yet the binding of TMPZ-BSA might involve hydrophobic interaction strongly and electrostatic interaction. The results of synchronous fluorescence, three-dimensional fluorescence, UV-vis absorption, FT-IR and CD spectra showed that the conformations of both BSA and HSA altered with the addition of TMPZ. The binding average distance between TMPZ and BSA/HSA was evaluated according to Föster non-radioactive energy transfer theory. In addition, with the aid of site markers (such as, phenylbutazone, ibuprofen and digitoxin), TMPZ primarily bound to tryptophan residues of BSA/HSA within site I (sub-domain II A). © 2012 Elsevier B.V. All rights reserved.


Wu S.-Q.,China West Normal University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

We construct the solution for non-extremal charged rotating black holes in seven-dimensional gauged supergravity, in the case with only one rotation parameter and two independent charges. Using the Boyer-Lindquist coordinates, the metric is expressed in a generalized form of the ansatz previously presented in [S.Q. Wu, Phys. Rev. D 83 (2011) 121502(R)], which may be helpful to find the most general non-extremal two-charged rotating black hole with three unequal rotation parameters. The conserved charges for thermodynamics are also computed. © 2011 Elsevier B.V.


Wu S.-Q.,China West Normal University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

With the help of a generalized form of the metric ansatz found for the single-charge case in a previous work [S.Q. Wu, Phys. Rev. D 83 (2011) 121502(R)], I adopt a simple algorithm to construct the most general nonextremal rotating charged black hole solutions in five-dimensional U(1) 3 gauged supergravity. The general solution that is interesting for testing the AdS 5/CFT 4 correspondence in M-theory, is characterized by its mass, two unequal rotation parameters, three different U(1) charges, and a negative cosmological constant. The metric ansatz is very universal and illuminative, it is not only especially suitable for constructing solutions with multiple different electric charges in (un)gauged supergravities, but also for other dilatonic gravity theory. © 2011 Elsevier B.V.

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