China Rehabilitation Research Center

Beijing, China

China Rehabilitation Research Center

Beijing, China
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Tu W.-J.,China Rehabilitation Research Center | Tu W.-J.,Capital Medical University | Zhao S.-J.,China Rehabilitation Research Center | Liu T.-G.,Binzhou Medical University | And 2 more authors.
Neurological Research | Year: 2013

Background: Ischemic stroke is one of the most common causes of death worldwide. Early and accurate prediction of outcome in acute ischemic stroke (AIS) is important and influences risk-optimized therapeutic strategies. We investigated the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) levels, two of the risk factors, during the acute period of AIS and evaluated the relationship between these levels and short-term prognosis. Methods: We prospectively studied 189 patients with AIS who were admitted within 24 hours after the onset of symptoms. Serum Hs-CRP, HCY levels, and National Institutes of Health Stroke Scale (NIHSS) were measured at the time of admission. Short-term functional outcome was measured by the modified Rankin scale (mRS), 90 days after admission. Results: The median serum Hs-CRP and HCY levels were significantly higher in AIS patients as compared to normal controls (P < 0.0001, respectively). High-sensitivity C-reactive protein and HCY were independent prognostic markers of functional outcome and death (adjusted for age and the NIHSS) in patients with AIS. In receiver operating characteristic curve analysis, the prognostic accuracy of the combined model (HCY and Hs-CRP) was higher compared to all measured biomarkers individually and the NIHSS score. Conclusion: High-sensitivity C-reactive protein and HCY are independent predictors of short-term outcome and mortality after AIS. The combined model may provide additional general prognostic information. © W. S. Maney & Son Ltd 2013.


Tu W.-J.,Peking Union Medical College | He J.,Peking Union Medical College | Chen H.,China Rehabilitation Research Center | Shi X.-D.,China Rehabilitation Research Center | Li Y.,Beijing Haidian Maternal and Child Health Hospital
PLoS ONE | Year: 2012

Objectives: As more families participate expanded newborn screening for metabolic disorders in China, the overall number of false positives increases. Our goal was to assess the potential impact on parental stress, perceptions of the child's health, and family relationships. Methods: Parents of 49 infants with false-positive screening results for metabolic disorders in the expanded newborn screening panel were compared with parents of 42 children with normal screening results. Parents first completed structured interview using likert scales, closed and open questions. Parents also completed the parenting stress index. Results: A total of 88 mothers and 41 fathers were interviewed. More mothers in the false-positive group reported that their children required extra parental care (21%), compared with 5% of mothers in the normal-screened group (P<0.001). 39% of mothers in the false-positive group reported that they worry about their child's future development, compared with 10% of mothers in the normal-screened group (P<0.001). Fathers in the false-positive group did not differ from fathers in the normal-screened group in reporting worry about their child's extra care requirements, and their child's future development. Children with false-positive results compared with children with normal results were triple as likely to experience hospitalization (27%vs 9%, respectively; P<0.001). Conclusions: The results showing false-positive screening results may affect parental stress and the parent-child relationship. Parental stress and anxiety can be reduced with improved education and communication to parents about false-positive results. © 2012 Tu et al.


Tu W.-J.,Capital Medical University | Dong X.,Dalian Medical University | Zhao S.-J.,China Rehabilitation Research Center | Yang D.-G.,Capital Medical University | Chen H.,Institute of Rehabilitation Science of China
Journal of Neuroendocrinology | Year: 2013

Inflammation and activation of the neuroendocrine systems comprise important aspects of stroke pathophysiology. The present study investigated whether baseline plasma brain natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), cortisol and copeptin levels on admission can predict short-term outcomes and mortality after acute ischaemic stroke. The study group consisted of 189 patients who had their first acute ischaemic stroke. Plasma levels of BNP, NT-proBNP, cortisol and copeptin were evaluated to determine their value with respect to predicting functional outcome and mortality within 3 months. As a result of cardiovascular and neurological investigations (including imaging techniques), lesion size, stroke subtype classification and clinical outcome after 3 months were determined. Plasma levels of BNP, NT-proBNP, cortisol and copeptin were associated with stroke severity, as well as short-term functional outcomes. After adjusting for all other significant outcome predictors, NT-proBNP, cortisol and copeptin remained as independent outcome predictors. In the receiver operating characteristic curve analysis, the biomarker panel (including BNP, NT-proBNP, cortisol and copeptin) predicted functional outcome and death within 90 days significantly more efficiently than the National Institute of Health Stroke Scale (NIHSS) or the biomarker alone. Copeptin showed a significantly greater discriminatory ability as a single biomarker compared to BNP, NT-proBNP, cortisol and NIHSS score. These results suggest that a biomarker panel may add valuable and time-sensitive prognostic information in the early evaluation of acute ischaemic stroke. This may provide a channel for interventional therapy in acute stroke. © 2013 British Society for Neuroendocrinology.


Wang Y.,China Rehabilitation Research Center | Wang Y.,Capital Medical University | Liao L.,China Rehabilitation Research Center | Liao L.,Capital Medical University
BMC Urology | Year: 2014

Background: Intestinal bladder augmentation has more disadvantages. One of the most promising alternative methods is tissue engineering in combination with surgical construction. Small intestine submucosa (SIS) is commonly used materials in tissue engineer. The aim of this study is determine the histologic and functional characteristics of SIS as bladder wall replacement in a rabbit augmentation model. Methods. 18 New Zealand adult male rabbits, weight 2.5 ± 0.5Kg, were used in this study. The rabbits were divided into 3 groups of 6 based on the number of days post-operative (A, 4 weeks; B, 12 weeks; C, 24 weeks). All of the animals underwent urodynamic testing under anesthesia before cystoplasty with SIS patch. The cystometrograms were repeated 4, 12, and 24 weeks after surgery with the same method. SIS-regenerated bladder strips (10 × 3 × 3 mm) and normal bladder strips (10 × 3 × 3 mm) from the same bladder were obtained at 4, 12, and 24 weeks for in vitro detrusor strip study. The frequency and amplitude of the strip over 15 min was recorded. The regenerated tissue and normal tissue underwent histologic and immunocytochemical analysis. The results were quantified as optical density (OD) values. Results: Histologically, the SIS-regenerated bladders of group C (24 weeks post-operation) resembled normal bladder in that all 3 layers (mucosa with submucosa, smooth muscle, and serosa) were present. In the in vitro detrusor strip study, there were no significant differences in autorhythmicity and contractility between regenerated and normal tissues in group C (p > 0.05). Immunohistochemical analysis indicated that the quantity of A-actin grew to a normal level. Urodynamic testing showed that compliance remained stable in all groups post-operatively, and the volume increased 24 weeks post-operatively. Conclusion: Regenerated tissue has similar histologic and functional characteristics. SIS seems to be a viable material in the reconstruction of the rabbit urinary bladder. © 2014 Wang and Liao; licensee BioMed Central Ltd.


Zhao Q.,China Rehabilitation Research Center
Journal of Computational and Theoretical Nanoscience | Year: 2012

The partition function is a fundamental concept of equilibrium thermodynamics. It encodes the particle distribution at different energy levels within a thermal system. By modifying the partition function of a particle, the partition function of a protein conformational state has been obtained. According to the protein thermodynamic structure theory, a protein conformational state represents one thermal system within a protein. The partition function of it encodes the thermodynamic relation among the different conformational states of a protein. Many experimental observations and models in enzymology, biochemistry, and molecular biology have been summarized and reexamined by applying this concept. This paper discusses the following: (1) the partition function of a protein conformational state; (2) the conformation distribution between the two states; (3) the protein conformation distribution along the temperature gradient and the protein conformation stability curve; (4) the agonist efficiency and conformational distribution of a receptor along voltage; (5) the enzyme active conformation distribution along the temperature gradient; (6) the enzyme active conformation distribution with respect to protein flexibility; (7) a revision of the Arrhenius equation for enzymatic reactions; and (8) the biophysical nature of conformational equilibrium and deformation. Copyright © 2012 American Scientific Publishers All rights reserved.


Chen L.-H.,Capital Medical University | Chen L.,Capital Medical University | Liu L.-X.,China Rehabilitation Research Center
Clinical Neurology and Neurosurgery | Year: 2011

Objectives: The aim of this study was to evaluate visual outcome in patients with tuberculum sellae meningioma (TSM) treated microsurgically using the frontolateral or fronto-orbital approach and optic canal unroofing to resect tumor involvement of the optic canal. Methods: Data from 67 patients with TSMs who underwent microsurgical treatment by a frontolateral approach (n = 44) or fronto-orbital approach (n = 23) between January 2002 and December 2008 were retrospectively collected and analyzed. Change in visual function was evaluated as the main outcome. Results: Total tumor resection was achieved in 62 of 67 cases (92.4%). Postoperative, visual acuity was improved in 87 eyes (64.9%) and unchanged in 39 eyes (29.1%), and the optic nerve was therefore preserved in 126 of 134 eyes (94.0%). Visual field deficits were improved or stable in 65 eyes, no patient experienced worsening of vision in both eyes. There was no mortality in our series. Conclusions: The frontolateral approach with microsurgical dissection of the Sylvian fissure provides quick access to TSMs, which can be resected safely and totally. Visual function is improved and neurological and ophthalmological morbidity is minimal. Optic nerve decompression by intradural clinoidectomy and optic canal unroofing is likely to increase the rate of reducing or eliminating preoperative visual symptoms. © 2010 Elsevier B.V. All rights reserved.


Jia C.,Capital Medical University | Liao L.-M.,Capital Medical University | Chen G.,Capital Medical University | Sui Y.,China Rehabilitation Research Center
Spinal Cord | Year: 2013

Study design:The study was designed as a single-arm clinical trial.Objectives:To investigate the effect of detrusor botulinum toxin A (BoNTA) injection on urinary tract infection (UTI) in patients with spinal cord injury (SCI).Setting:The study was performed in a national rehabilitation research center of China.Methods:Between September 2010 and May 2012, 41 male inpatients with neurogenic detrusor overactivity (NDO) caused by traumatic SCI, mean age 36.0±8.8 years, duration of SCI since inclusion 21.5±17.3 months, received an injection of 300 U BoNTA into detrusor. Before and 3 months after injection, each patient kept a bladder diary, underwent video-urodynamic investigation and urine culture. All UTIs occurring in the 6 months before and the 6 months after injection were recorded.Results:Before injection, the mean number of UTI over 6 months was 1.39±1.36. After injection, the mean significantly decreased to 0.78±0.96 (P=0.023). The mean maximum detrusor pressure during filling decreased significantly in the patients of detrusor overactivity (n=24) compared with patients of normo-active detrusor (n=17) after injection (35.4±12.2 vs 20.9±7.9 cmH 2 O, P=0.000), meantime, the decrease of UTI was significant in the former (1.29±1.21 vs 0.41±0.62 cmH 2 O, P=0.015) while no significant in the latter (1.46±1.47 vs 1.04±1.08, P=0.319).Conclusion:Detrusor BoNTA injection significantly decreased UTI in SCI patients with NDO. This effect seems to be related to the decrease of detrusor pressure. © 2013 International Spinal Cord Society All rights reserved.


Sun X.,China Rehabilitation Research Center
Chinese Journal of Rehabilitation Medicine | Year: 2014

Objective: To observe the effectiveness of gastrodin on cognitive disorder of rats with traumatic brain injury (TBI) and explore the underlying mechanisms.Method: Seventy SD rats were randomized into normal group (n=10), sham operated group (n=20), untreated group (n=20) and gastrodin group (n=20). Controlled cortical impact(CCI) device was utilized to establish TBI model. The cognitive functions of rats in every group were evaluated at the 1st, 2nd, 3rd, 4th week time points post operation. The rats were sampled to test the expressions of brain derived neurotrophic factor (BDNF) mRNA and synaptophysin I(Syn I) mRNA in hippocampus with RT-PCR technique. The collected data were analyzed with SPSS 16.0.Result: There were significant differences between untreated group and gastrodin group in escape latency at the 3rd, 4th week time points post operation (P<0.05). The swimming time percentage in untreated group was significantly lower at the 4th week post operation than that in gastrodin group (P<0.05). The expressions of BDNF mRNA in gastrodin group were significantly higher at the 2nd, 3rd, 4th week time points than that in untreated group (P<0.05). The expressions of Syn I mRNA in untreated group and gastrodin group were similar at 1st, 2nd week time points(P>0.05) but significantly different at the 3rd, 4th week time points(P<0.05).Conclusion: Gastrodin may affect the neuroplasticity in hippocampus to improve the cognitive disorders of TBI rats.


Zhou H.-J.,China Rehabilitation Research Center
Spinal Cord | Year: 2016

Study design:Prospective study.Objectives:To describe the nutritional risk/status of Chinese children with spinal cord injury (SCI) at admission and determine the relationship between nutritional risk/status and demography/SCI characteristics.Setting:China Rehabilitation Research Center, Beijing, China.Methods:Baseline clinical data, appetite level, anthropometric measurements and Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) scores were obtained for pediatric SCI patients. The relationships among the demographic/SCI characteristics and STAMP score and z-scores of weight-for-age (WAZ), height-for-age (HAZ) and body mass index-for-age (BAZ) were assessed. The risk of undernutrition was compared with actual nutritional status.Results:Forty-five children including 12 boys and 33 girls were included. The risks of undernutrition using the STAMP tool and malnutrition were 51.1% and 55.6%, respectively. Children with different demographic characteristics had similar nutritional status and risk of malnutrition. The risk of undernutrition was associated with nutritional status, including WAZ (P<0.001), HAZ (P=0.001), BAZ (P<0.001) and appetite level (P<0.001). Compared with nutritional status, STAMP had a sensitivity of 100%, a specificity of 73.3% and an overall agreement of 82.2%. As the duration of SCI increased, the risks of overweight and stunting increased.Conclusions:Nutritional screening in all pediatric SCI patients should be performed periodically. The decreasing trends in nutritional status and appetite level after SCI require special attention. The STAMP may be an alternative method for assessing nutritional status in Chinese children with SCI.Spinal Cord advance online publication, 9 August 2016; doi:10.1038/sc.2016.113. © 2016 International Spinal Cord Society


Tu W.J.,China Rehabilitation Research Center
Clinical science (London, England : 1979) | Year: 2014

Low vitamin D levels have been reported to contribute to the risk of cardiovascular events and mortality, especially stroke. In the present study we therefore evaluated the short-term prognostic value of serum 25(OH)D (25-hydroxyvitamin D) in Chinese patients with AIS (acute ischaemic stroke). From February 2010 to September 2012, consecutive stroke patients admitted to the emergency department at two hospitals in Beijing, China were identified. Clinical information was collected, and the serum concentration of 25(OH)D and NIHSS (National Institutes of Health Stroke Scale) were measured at the time of admission. Short-term functional outcome was measured using a modified Rankin Scale (mRS) at 90 days after admission. Multivariate analyses were performed using logistic regression models. During the inclusion period, 231 patients were diagnosed as having AIS, and 220 completed follow-up. The median serum 25(OH)D level was significantly lower in patients with AIS compared with normal controls [14.2 (10.2-18.9) ng/ml compared with 17.9 (12.5-22.9) ng/ml; P<0.001; values are medians (interquartile range)]. 25(OH)D was an independent prognostic marker of short-term functional outcome and death {0.79 (0.73-0.85) and 0.70 (0.50-0.98) respectively [values are odds rations (95% confidence intervals)]; P<0.01 for both, adjusted for NHISS, other predictors and vascular risk factors} in patients with AIS. In ROC (receiver operating characteristic) curve analysis, the prognostic accuracy of 25(OH)D was higher compared with all of the other serum predictors and was in the range of NIHSS score. In conclusion, these findings suggest that 25(OH)D is an independent prognostic marker for death and functional outcome within 90 days in Chinese patients with AIS even after adjusting for possible confounding factors.

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