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Huo Y.-F.,Shanghai Institute of Pharmaceutical Industry | Yi B.-X.,Shanghai Institute of Pharmaceutical Industry | Wang G.-P.,Shanghai Institute for Food and Drug Safety | Shi S.-Y.,China National Pharmaceutical Group Corporation | And 2 more authors.
Chinese Journal of New Drugs

As one of the achievements of the innovation activities of biological medicine, patent innovation has important effect on the development of pharmaceutical industry. Based on R&D activities full time equivalent and the amounts of government and enterprise funds in scientific and technological activities, the effects of innovation input on pharmaceutical patent in East China was analyzed. The results suggested that our country should increase the quantity of personnel for pharmaceutical R&D activities, and the business and government should increase investment on pharmaceutical innovation. © 2015, Chinese Journal of New Drugs Co. Ltd. All right reserved. Source

He H.,U.S. Center for Disease Control and Prevention | Chen E.,U.S. Center for Disease Control and Prevention | Chen H.,China National Pharmaceutical Group Corporation | Wang Z.,U.S. Center for Disease Control and Prevention | And 6 more authors.

Two doses of measles-mumps-rubella (MMR) strategy has been recommended by World Health Organization and is also widely adopted in many countries. In order to provide the evidence for perfecting the immunization strategy of MMR, this study evaluated the safety and immunogenicity of MMR with different two-dose schedule in infants. 280 participants were enrolled and randomly allocated to Group 1 (first dose at 8 months) or Group 2 (first dose at 12 months), and both groups administered the second dose at 10 months later. Solicited local and general symptoms after each vaccination with MMR were mild and infrequent in all participants of two groups. After administration of the first dose of MMR, seropositive rates were 100% in both groups for measles, 89.3% in Group 1 and 87.1% in Group 2 for mumps (P= 0.578), 92.0% in Group 1 and 92.9% in Group 2 (P= 0.393). The seropositive rates of mumps decreased significantly (from >86% to <65%) both in two groups (P<. 0.001) 10 months after the first dose of MMR, but no significant change was found in measles and rubella. All children get the positive titer for three vaccines in two groups after given the second dose MMR, higher seroconversion rate was found for mumps both in two groups (71.7% vs 77.2%, P= 0.370). In conclusion, this study indicated that the MMR was well tolerated and immunogenic against measles, mumps and rubella with schedule of first dose both at 8 months and 12 months age. Our findings strongly supported that two doses of MMR can be introduced by replacing the first dose of MR in current EPI with MMR at 8 months age and the second dose at 18 months in China. © 2014 Elsevier Ltd. Source

Chen M.,Southwest University of Science and Technology | Tang Y.L.,Southwest University of Science and Technology | Ao J.,Southwest University of Science and Technology | Ao J.,China National Pharmaceutical Group Corporation | Wang D.,Southwest University of Science and Technology
Russian Journal of Plant Physiology

The threat of environmental strontium pollution led to an increased interest to elucidating the mechanisms of this metal toxicity in the organism. To investigate strontium effects on vital photosynthesis characteristics, three-leaf stage oilseed rape seedlings (Brassica napus L., cv. Mianyou No. 15), raised in the hydroponic culture, were provided with a nutrient solution containing 0, 10, 20, and 40 mM SrCl 2. Strontium uptake and distribution in oilseed rape plants and its effect on various aspects of photosynthesis were investigated after 0, 7, 14, and 21 days of strontium treatment. Oilseed rape seedlings demonstrated a strong ability of strontium accumulation. Strontium absorbed by roots was primarily transferred to leaves and accumulated there. The leaf photosynthetic oxygen evolution rate, chlorophyll content, and Rubisco (EC 4. 1. 3. 9) and phosphoenolpyruvate carboxylase (PEPCase; EC 4. 1. 1. 31) activities declined progressively with increasing concentration of applied strontium and also with increasing the duration of exposure time. These results indicate that strontium accumulated in leaves damaged various processes of photosynthesis, such as energy absorption, energy transfer, and photosynthetic carbon assimilation. © 2012 Pleiades Publishing, Ltd. Source

Huo Y.-F.,Shanghai Institute of Pharmaceutical Industry | Shi S.-Y.,China National Pharmaceutical Group Corporation | Wang G.-P.,Shanghai Institute for Food and Drug Safety | Chen Y.,Shanghai Institute of Pharmaceutical Industry | Yi B.-X.,Shanghai Institute of Pharmaceutical Industry
Chinese Journal of New Drugs

Innovation is the lifeblood of the pharmaceutical manufacturing industry. Technological innovation efficiency is of great significance in promoting the development of pharmaceutical manufacturing. By taking full-time equivalent of R&D personnel, the amount of internal R&D funds and technical reform funds as innovation input indicators, while the number of patent applications and new product sales as innovation output indicators, this article analyzes the pharmaceutical innovation efficiency in our country. Based on the national pharmaceutical industry data from 2004 to 2013, the efficiency of Chinese pharmaceutical technology innovation was investigated through data envelopment analysis (DEA) using Malmquist index. The results showed that the efficiency of technological innovation in Chinese pharmaceutical manufacturing industry had been steadily improved, but there was big difference between different regions. We need to scientifically allocate innovation resources, pay attention to the cultivation of scientific research personnel, and promote the development of China's pharmaceutical industry. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved. Source

Zhang X.-F.,Beijing Normal University | Zhang X.-F.,Chinese Peoples Liberation Army | Li C.,China National Pharmaceutical Group Corporation | Zhao C.-Q.,Beijing Normal University | Liu L.-H.,Chinese Peoples Liberation Army
Yaoxue Xuebao

To investigate whether a series of water-soluble cross-linked chitosan derivates synthesized in the guide of imprinting technology could be used as a uranium chelating agent to protect cells exposed to depleted uranium (DU), the imprinted chitosan derivates with high UO2 2+ chelating ability were screened, and cell model of human renal proximal tubule epithelium cells (HK-2) exposed to DU (500 μmol·L-1) was built, chitosan derivates (400 mg·L-1) was added to test group and diethylenetriaminepentaacetic acid (DTPA, 50 mg·L-1) was added to positive control group. The results showed that three Cu2+ imprinted chitosan derivates had higher uranium chelating ability (>49 μg·mg-1) than chitosan and non-imprinted chitosan derivates. Compared to the cells exposed to DU only, survival of cells in group added chitosan derivates rose up significantly (increased from 57.3% to 88.7%, and DTPA to 72.6%), and DU intracellular accumulation decreased, membrane damage and DNA damage also eased. Among the imprinted chitosan derivates, Cu 2+ imprinted penta dialdehyde cross-linked carboxymethyl chitosan (Cu-P-CMC) was the best, and better than DTPA. From ultrastructure observation, the DU precipitates of test group added Cu-P-CMC were most grouped in a big hairy clusters in a string together outside cells. It is possible that the DU-chitosan derivates precipitates are too big to enter into cells, and from this way, the DU uptake by cells decreased so as to detoxication. Source

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