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Yu C.Q.,Peking University | Chen Y.P.,University of Oxford | Lv J.,Peking University | Guo Y.,Chinese Academy of Sciences | And 7 more authors.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences | Year: 2016

OBJECTIVE: To investigate the associations of major depressive disorder with coronary heart disease (CHD) and stroke in Chinese adults aged 30-79 years.CONCLUSION: The findings from this large cross-sectional study suggest that the presence of MDE is a risk factor for both CHD and stroke in Chinese adults aged 30-79 years, but further prospective studies are warranted to validate the results.METHODS: In 2004-2008, China Kadoorie Biobank was conducted in 10 geographically defined regions (5 urban and 5 rural) of China. A total number of 512 891 participants aged 30-79 years were recruited in the baseline survey. A laptop-based electronic questionnaire was administrated face-to-face by trained health workers, collecting the general demographic and socio-economic status, dietary and other lifestyle behaviours (e.g. smoking, alcohol drinking, physical activity), medical history and family history of common chronic diseases. Major depressive episodes (MDE) in the past 12 months were assessed with the World Health Organization composite international diagnostic interview-short form (CIDI-SF). The physical measurements included the heights and weights, which were used to calculate the body mass indexes (BMI).Chi squared and t test were used to compare the differences in participants characteristics according to their major depressive disorder. Logistic models were employed to estimate the odds ratios (OR) and 95% CI of their major depressive disorder with prevalent coronary heart disease and stroke.RESULTS: Among the 512 891 participants, 3 281 (0.6%) showed an MDE in the preceding 12 months, 15 472 (3.0%) reported prevalent CHD, and 8 884 (1.7%) reported prevalent stroke. Major depressive disorder was significantly associated with an increased risk of CHD and risk of stroke. Age- and gender-adjusted ORs (95% CI) were 1.80 (1.53-2.12) for CHD and 2.53 (2.09-3.05) for stroke. The associations were significant after further adjustment for potential confounders, such as other socio-demographic status, smoking, alcohol drinking, physical activity, and BMI, prevalent hypertension, diabetes as well as family history of cardiovascular diseases (OR=1.83, 95% CI=1.54-2.18 for CHD; OR=2.19, 95% CI=1.79-2.69 for stroke). Moreover, gender significantly interacted with MDE on prevalent stroke (P for multiplicative interaction=0.013). The men with an MDE in the past 12 months had the highest risk of stroke in the joint analyses of gender and depression disorder (OR=5.02, 95% CI=3.70-6.82).


Yu C.,Peking University | Lyu J.,Peking University | Chen Y.,University of Oxford | Guo Y.,Chinese Academy of Sciences | And 7 more authors.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2015

OBJECTIVE: To examine the socio-demographic patterns on 12-month major depressive episodes (MDE) among Chinese adults aged 30-79 years.METHODS: Socio-demographic variables from half a million Chinese people aged 30-79 years in the China Kadoorie Biobank study during 2004-2008, were collected. For those showing signs of depression, an additional World Health Organization Composite International Diagnostic Interview-Short Form (CIDI-SF) was face to face administrated, to assess the MDE according to Diagnostic and Statistical Manual of Mental Disorder (DSM)- IV criteria. Chi squared and non-parametric tests were used to compare the differences between socio-demographic categories, depressive symptoms and help-seeking behaviors. Associations with MDE for socio-demographic variables were examined by logistic models.RESULTS: A total of 3 281(6.40‰) studied subjects showed an MDE in the preceding 12 months. Gender, marital status, occupation and household income were correlated with MDE. Somatization was common in Chinese MDE patients while symptoms as weight change (99.91%), sleeping disorder (83.60%) and feeling tired (81.59%), stood for the top 3. As for each episode, the proportions and the total number of depressive symptoms appeared higher among females (P < 0.05). One third of the patients did not seek for any social support or psychotherapy with only 8.99% had ever taken antidepressant drugs.CONCLUSION: Rates of depression varied significantly between social groups in Chinese adults aged 30-79. In this study, only 65.19% of the MDE patients ever has sought help or received treatment.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2016

To describe the differences in diet intake frequency of adults in 10 areas surveyed by China Kadoorie Biobank (CKB) project.CKB project recruited voluntary residents aged 30-79 years from 5 urban areas and 5 rural areas in China. The baseline survey was conducted among 512 891 eligible subjects during 2004-2008. The intake frequencies of 12 food groups were assessed through in-person interviews and analyzed. The results were adjusted for age and sex structure of the study population.Rice was the main cereal consumed every day in urban areas (99.0%) and rural areas (99.9%) in southern China, while wheat was the main cereal consumed every day in rural areas (99.0%) and Qingdao (88.4%) in northern China. Most subjects in Henan (98.8%) consumed other staple food every day. The lowest proportion of daily intake of fresh vegetables was observed in Gansu (74.0%) . In both southern and northern areas, urban subjects had higher proportions of daily intakes of fresh fruits, preserved vegetables, and meat than rural subjects. Similar results were found when comparing the proportions of intakes of poultry and fish/seafood at least 1 day every week. Contrast to southern China (urban: 6.5%, rural: 6.9%) , the proportions of daily intake of fresh eggs were higher in both urban areas (37.1%) and rural areas (14.6%) in northern China. The highest proportions of daily intake of soybean products and dairy products were observed in Harbin (10.0%) and Qingdao (34.3%).The intake of cereal, fresh eggs and soybean products differed between the south and the north of China. The intake of meat, poultry, fish/seafood, fresh fruits, preserved vegetables and dairy products varied considerably between urban areas and rural areas.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences | Year: 2016

To investigate the associations of major depressive disorder with coronary heart disease (CHD) and stroke in Chinese adults aged 30-79 years.In 2004-2008, China Kadoorie Biobank was conducted in 10 geographically defined regions (5 urban and 5 rural) of China. A total number of 512 891 participants aged 30-79 years were recruited in the baseline survey. A laptop-based electronic questionnaire was administrated face-to-face by trained health workers, collecting the general demographic and socio-economic status, dietary and other lifestyle behaviours (e.g. smoking, alcohol drinking, physical activity), medical history and family history of common chronic diseases. Major depressive episodes (MDE) in the past 12 months were assessed with the World Health Organization composite international diagnostic interview-short form (CIDI-SF). The physical measurements included the heights and weights, which were used to calculate the body mass indexes (BMI).Chi squared and t test were used to compare the differences in participants characteristics according to their major depressive disorder. Logistic models were employed to estimate the odds ratios (OR) and 95% CI of their major depressive disorder with prevalent coronary heart disease and stroke.Among the 512 891 participants, 3 281 (0.6%) showed an MDE in the preceding 12 months, 15 472 (3.0%) reported prevalent CHD, and 8 884 (1.7%) reported prevalent stroke. Major depressive disorder was significantly associated with an increased risk of CHD and risk of stroke. Age- and gender-adjusted ORs (95% CI) were 1.80 (1.53-2.12) for CHD and 2.53 (2.09-3.05) for stroke. The associations were significant after further adjustment for potential confounders, such as other socio-demographic status, smoking, alcohol drinking, physical activity, and BMI, prevalent hypertension, diabetes as well as family history of cardiovascular diseases (OR=1.83, 95% CI=1.54-2.18 for CHD; OR=2.19, 95% CI=1.79-2.69 for stroke). Moreover, gender significantly interacted with MDE on prevalent stroke (P for multiplicative interaction=0.013). The men with an MDE in the past 12 months had the highest risk of stroke in the joint analyses of gender and depression disorder (OR=5.02, 95% CI=3.70-6.82).The findings from this large cross-sectional study suggest that the presence of MDE is a risk factor for both CHD and stroke in Chinese adults aged 30-79 years, but further prospective studies are warranted to validate the results.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2015

To examine the socio-demographic patterns on 12-month major depressive episodes (MDE) among Chinese adults aged 30-79 years.Socio-demographic variables from half a million Chinese people aged 30-79 years in the China Kadoorie Biobank study during 2004-2008, were collected. For those showing signs of depression, an additional World Health Organization Composite International Diagnostic Interview-Short Form (CIDI-SF) was face to face administrated, to assess the MDE according to Diagnostic and Statistical Manual of Mental Disorder (DSM)- IV criteria. Chi squared and non-parametric tests were used to compare the differences between socio-demographic categories, depressive symptoms and help-seeking behaviors. Associations with MDE for socio-demographic variables were examined by logistic models.A total of 3 281(6.40) studied subjects showed an MDE in the preceding 12 months. Gender, marital status, occupation and household income were correlated with MDE. Somatization was common in Chinese MDE patients while symptoms as weight change (99.91%), sleeping disorder (83.60%) and feeling tired (81.59%), stood for the top 3. As for each episode, the proportions and the total number of depressive symptoms appeared higher among females (P < 0.05). One third of the patients did not seek for any social support or psychotherapy with only 8.99% had ever taken antidepressant drugs.Rates of depression varied significantly between social groups in Chinese adults aged 30-79. In this study, only 65.19% of the MDE patients ever has sought help or received treatment.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2016

To describe gender and regional differences in the prevalence of overweight/obesity in adults found by China Kadoorie Biobank (CKB) study, involving 512 489 adults, in 10 areas in China.The baseline survey of CKB was conducted in 5 urban areas and 5 rural areas in China during 2004-2008. After excluding those with extreme value of BMI (<15.0 kg/m(2) or >50 kg/m(2)), 512 489 subjects were included in the analysis. Overweight/obesity was classified according to BMI and WC, and diagnosed according to the guideline for prevention and control of overweight/obesity in Chinese adults. The gender and regional specific distributions of overweight/obesity were compared after adjusting for age.The overall prevalence of overweight/obesity was higher in females (45.3%) than in males (41.7%), and the prevalence of central obesity was also higher in females (44.6%) than in males (38.3%). Both the prevalence of overweight/obesity (66.9% in males and 67.5% in females) and the central obesity (63.3% in males and 64.9% in females) were highest in Qingdao. The area specific difference in the prevalence was more obvious in males than in females. Rural areas all had the low prevalence except Henan. Moreover, central obesity was diagnosed in some subjects (15.3% in females, 9.8% in males) with normal/low BMI (<24.0 kg/m(2)). This phenomenon was more obvious in Qingdao (22.2% in males and 23.2% in females).The prevalence of overweight/obesity in adults varied greatly across different areas in China.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2016

To describe the gender and regional differences in adults tea drinking pattern found in China Kadoorie Biobank (CKB) survey, involving half million adults, in 10 areas in China.The baseline survey of CKB was conducted in 5 urban areas and 5 rural areas in China during 2004-2008. The information on tea drinking of 512 891 adults aged 30-79 years was collected and analyzed.The overall prevalence of regular tea drinking (i.e., weekly) was 50.7% in males and 21.3% in females. Among 10 areas, Hunan reported the highest regular tea drinking prevalence (74.3% in males, 76.6% in females), while Henan reported the lowest regular tea drinking prevalence (5.5% in males, 1.0% in females). Most regular tea drinkers consumed green tea except those from Zhejiang and Haikou. Hunan reported the highest tea consumption per time (3.8 g in males, 3.1 g in females), per day (6.2 g in males, 4.1 g in females) and per week (38.4 g in males, 25.0 g in females).The adults tea drinking pattern i.e. frequency, type, amount of tea and preferred concentration of tea water, varied greatly among the 10 regions covered by CKB study.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2016

To describe the regional differences in adults smoking pattern found by China Kadoorie Biobank (CKB) study involving half million adults in 10 areas in China.After exclusion of the adults with self reported histories of coronary heart disease, stroke, cancer and chronic obstructive pulmonary disease at baseline survey, the area specific differences in smoking pattern of 452 829 subjects aged 30-79 years was analyzed.The overall rate of current smoker was higher in males (64.2%) than in females (2.1%). For females, the current smoker rate was higher in Harbin (10.5%) and Sichuan (8.5%) than in other areas. For males, the current smoker rate and the average numbers of cigarettes smoked per day were high in Hunan (68.8%, 20.9) and Sichuan (67.2%, 21.5) ; the current smoker rate was lowest (49.9%) but the average number of cigarettes smoked per day was highest (21.9) in Haikou. On the other hand, Gansu showed the highest rate of current smoker (71.4% ) with a lower mean number of cigarettes smoked per day (14.9). Most current smokers in males (88.3% ) smoked filter cigarettes, while hand-rolled cigarettes were commonly used in Sichuan (38.8%) and Gansu (37.8%) and pipes or water pipe were mainly used in Henan (14.6%).The rate of current smoker and other patterns of smoking including cigarette type, daily amount and inhalation depth varied greatly among the adults in 10 areas covered by CKB study.


PubMed | Chinese Academy of Sciences, University of Oxford, Peking University and National Center for Food Safety Risk Assessment of China
Type: Journal Article | Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2016

To describe the area specific differences in lung function indices and prevalence of airflow obstruction (AFO) in adults found by China Kadoorie Biobank (CKB) study, involving 512 495 adults, in 10 areas in China.The detailed information on lung function indices (FEV, and FVC) and prevalence of AFO (diagnosed according to GOLD and LLN criteria) of subjects aged 30-79 years were analyzed, those with abnormal lung function indices at baseline survey were excluded.The FEV1 and FVC among males (2.66 L, 3.16 L) were higher than those among females (1.99 L, 2.35 L). The FEV1 and FVC were highest in Henan and Harbin. The prevalence of AFO diaonosed according to GOLD criteria was 5.13% in males, higher than that in females (3.75%). The prevalence of AFO was higher in rural area than in urban area (males: 6.32% vs. 3.47%; females: 4.26% vs. 2.97%). The prevalence of AFO was highest in Sichuan (13.34% in males, 10.70% in females), followed by that in Suzhou, Henan and Hunan. The prevalence of AFO diagnosed according to LLN criteria (6.93% in males, 6.29% in females) was higher than that diagnosed according to GOLD criteria, but the area specific difference was similar.The lung function indices and the prevalence of AFO in adults varied greatly among the 10 areas covered by CKB study.

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