China Military Institute of Chinese Medicine

Beijing, China

China Military Institute of Chinese Medicine

Beijing, China
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Zhu Y.,302 Hospital of Peoples Liberation Army | Zheng Q.,Chengdu University of Traditional Chinese Medicine | Zheng Q.,China Military Institute of Chinese Medicine | Sun Z.,the Fourth Hospital of Shijiazhuang | And 8 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2014

For quality control of Chinese herbal medicine (CHM), an attempt on fingerprint-efficacy study of Radix Aconiti Lateralis Preparata (Fuzi) was developed in this paper. The fingerprints of Fuzi from various sources were determined by UPLC and hierarchical clustering analysis. Some quantitative thermo-kinetic parameters such as the heat-flow maximum power (Pmax) and its time corresponding to tmax, which obtained from the thermogenic curves of mitochondria metabolic activity affected by Fuzi were analyzed using principal component analysis. The fingerprint-efficacy relationship of chemical fingerprint and promoting effect of Fuzi were established using canonical correlation analysis. Our results showed that the sources and places of production of Fuzi had some significant influence on the chemical fingerprints and promoting metabolic effects of this CHM. Fingerprint-efficacy study provided a powerful way and some references for the quality control of Fuzi and other CHMs. © 2014 Akadémiai Kiadó, Budapest, Hungary.


Zhu Y.,302 Hospital of Peoples Liberation Army | Zheng Q.,Chengdu University of Traditional Chinese Medicine | Zheng Q.,China Military Institute of Chinese Medicine | Sun Z.,Fourth Hospital of Shijiazhuang | And 8 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2014

For quality control of Chinese herbal medicine (CHM), an attempt on fingerprint-efficacy study of Radix Aconiti Lateralis Preparata (Fuzi) was developed in this paper. The fingerprints of Fuzi from various sources were determined by UPLC and hierarchical clustering analysis. Some quantitative thermo-kinetic parameters such as the heat-flow maximum power (P max) and its time corresponding to t max, which obtained from the thermogenic curves of mitochondria metabolic activity affected by Fuzi were analyzed using principal component analysis. The fingerprint-efficacy relationship of chemical fingerprint and promoting effect of Fuzi were established using canonical correlation analysis. Our results showed that the sources and places of production of Fuzi had some significant influence on the chemical fingerprints and promoting metabolic effects of this CHM. Fingerprint-efficacy study provided a powerful way and some references for the quality control of Fuzi and other CHMs. © 2014 Akadémiai Kiadó, Budapest, Hungary.


Chen Z.,China Military Institute of Chinese Medicine | Chen Z.,Chengdu University of Traditional Chinese Medicine | Ma X.,China Military Institute of Chinese Medicine | Ma X.,Chengdu University of Traditional Chinese Medicine | And 8 more authors.
Journal of Ethnopharmacology | Year: 2015

Ethnopharmacological relevance Yinchenhao decoction, a well-known Chinese herbal formula, has been widely used in Chinese Medicine for thousands of years. However, no systematic review of Yinchenhao decoction in treating cholestasis has been completed. This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis. Materials and methods The major databases (PubMed, Embase, Cochrane Library, Chinese Biomedical Database, Wanfang database, VIP medicine information system and China National Knowledge Infrastructure) were searched from the databases' inception through November 2014. Randomized controlled trials (RCTs) of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers. The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL). The Cochrane tool was applied to assess the risk of bias of the trials. The main outcomes of the trials were analyzed using Review Manager 5.3 software. The odds ratio (OR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect. Results Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis. Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not. Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods. Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease. Conclusion No serious adverse event was reported. This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis. © 2015 Published by Elsevier Ireland Ltd.


PubMed | Chengdu University of Traditional Chinese Medicine, 302 Military Hospital of China and China Military Institute of Chinese Medicine
Type: | Journal: Journal of ethnopharmacology | Year: 2015

Yinchenhao decoction, a well-known Chinese herbal formula, has been widely used in Chinese Medicine for thousands of years. However, no systematic review of Yinchenhao decoction in treating cholestasis has been completed. This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis.The major databases (PubMed, Embase, Cochrane Library, Chinese Biomedical Database, Wanfang database, VIP medicine information system and China National Knowledge Infrastructure) were searched from the databases inception through November 2014. Randomized controlled trials (RCTs) of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers. The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL). The Cochrane tool was applied to assess the risk of bias of the trials. The main outcomes of the trials were analyzed using Review Manager 5.3 software. The odds ratio (OR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect.Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis. Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not. Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods. Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease.No serious adverse event was reported. This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis.


Zhao Y.,China Military Institute of Chinese Medicine | Zhou G.,302 Hospital of Peoples Liberation Army | Wang J.,China Military Institute of Chinese Medicine | Jia L.,Chinese University of Hong Kong | And 7 more authors.
Food and Chemical Toxicology | Year: 2013

Paeoniflorin, one of the primary bioactive components in Chi shao, are widely used in traditional Chinese medicine. A lot of evidences suggest that Paeoniflorin has potential anti-oxidant effects. However, whether Paeoniflorin plays roles in cholestasis is unclear. In this study, we examined the protective effect of Paeoniforin against alpha-naphthylisothicaynate (ANIT)-induced cholestasis in rats. Our data demonstrated that the high (0.2. g/kg body weight) and medium (0.1. g/kg body weight) doses of Paeoniflorin significantly prevented ANIT-induced changes in bile flow and the serum levels of total bilirubin, direct bilirubin, total bile acid, γ-glutamyltranspeptidase, glutamate-pyruvate transaminase, glutamate-oxaloacetic transaminase and alkaline phosphatase. Moreover, we also found that Paeoniflorin significantly inhibited nitric oxide and malondialdehyde production, and restored glutathione decrease induced by ANIT. EPR data further indicated that Paeoniflorin inhibited ANIT-mediated reactive oxygen species (ROS) production. The overexpression of NADPH oxidase 4 induced by ANIT were significantly reversed when treated with Paeoniflorin, suggesting that Paeoniflorin could scavenge ROS via inhibiting NADPH oxidase 4 expression. Paeoniflorin treatment could also relieve ANIT-induced liver pathological injuries as indicated by histological assay. These findings indicate that Paeoniflorin exerts a dose-dependent protective effect on ANIT-induced cholestatic liver injury in rats, and the mechanism of this activity is related to its attenuation of oxidative stress in liver tissue. © 2013.


PubMed | 302 Military Hospital and China Military Institute of Chinese Medicine
Type: Journal Article | Journal: Gut and liver | Year: 2015

Drug-induced liver injury (DILI) is a frequent cause of pediatric liver disease; however, the data on DILI are remarkably limited.All 69 children hospitalized with DILI between January 2009 and December 2011 were retrospectively studied.A total of 37.7% of the children had medical histories of respiratory infection. The clinical injury patterns were as follows hepatocellular 89.9%, cholestatic 2.9%, and mixed 7.2%. Liver biopsies from 55 children most frequently demonstrated chronic (47.3%) and acute (27.3%) hepatitis. Hypersensitivity features, namely, fever (31.9%), rash (21.7%), and eosinophilia (1.4%), were found. Twenty-four children (34.8%) developed chronic DILI. Antibiotics (26.1%) were the most common Western medicines (WMs) causing DILI, and the major implicated herbs were Ephedra sinica and Polygonum multiflorum. Compared with WM, the children whose injuries were caused by Chinese herbal medicine (CHM) showed a higher level of total bilirubin (1.4 mg/dL vs. 16.6 mg/dL, p=0.004) and a longer prothrombin time (11.8 seconds vs. 17.3 seconds, p=0.012), but they exhibited less chronic DILI (2/15 vs. 18/39, p=0.031).Most cases of DILI in children are caused by antibiotics or CHM used to treat respiratory infection and present with hepatocellular injury. Compared with WM, CHM is more likely to cause severe liver injury, but liver injury caused by CHM is curable.


PubMed | China Military Institute of Chinese Medicine
Type: Evaluation Studies | Journal: Journal of separation science | Year: 2013

A new reversed phase ultra performance liquid chromatography coupled with evaporative light scattering detection is developed for the fast and direct quantification of underivatized muscone in precious herbal medicine musk. Separation of muscone was achieved on a Waters Acquity BEH C18 (50 2.1 mm id, 1.7 m) column. The runtime was as short as 5 min. The mode of evaporative light scattering detection was set at Impact On. The influence of evaporative light scattering detection condition on sensitivity was investigated. The optimized condition was: drift tube temperature at 30C, gas flow rate 4.2 L/min. The method was validated with respect to the precision, sensitivity, accuracy, linearity, stability, and robustness were measured in this paper. The calibration curves showed good linear regression (r = 0.9914) within the test range. The recovery rate was 98.6%. The limit of detection for muscone was 2.0 ng. The validated method was rapid, simple, reproducible, and convenient for the quantification of muscone in musk and the related products.

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