China General Nuclear Power Group, Daya Bay Nuclear Power Operations, Management Co. and China Institute for Radiation Protection | Date: 2013-04-17
Disclosed are a reagent for testing the purification capacity of a radioactive gas in a nuclear power plant, preparation method thereof and an iodide filter testing equipment using this reagent. The reagent is prepared by mixing methyl phosphate compound or dimethyl acetal compound, acetonitrile, trimethyl chlorosilane and radioactive iodine sources and carrying out a reaction at a temperature of 20C-50 C under an inert gas for 10-40 min. The prepared products except methyl iodide are non-toxic or little toxic to the nuclear grade impregnated activated carbon in the iodide filter.
Li Z.,Shanxi University |
Zhao C.,Shanxi University |
Li Z.,Zhejiang Chinese Medical University |
Zhao Y.,Shanxi University |
And 3 more authors.
International Journal of Biochemistry and Cell Biology | Year: 2014
Glucose regulated protein 78 (GRP78) has been reported to be present on cell membranes of cancer cells but not the normal cells, serving as a potential anti-cancer target. In the present study, a fusion protein containing the GRP78 binding peptide WIFPWIQL and the active fragment of mung bean trypsin inhibitor was constructed, and its targeted anti-tumor effects were investigated both in vitro and in vivo. The results showed that the fusion protein specifically inhibited growth and induced apoptosis in colorectal cancer cells but not in the normal cells. Mechanistically, these anti-tumor effects were attributed to induction of G1 phase arrest and activation of multiple apoptotic pathways. Importantly, the fusion protein could also suppress the growth of xenografted human colorectal carcinoma in vivo. Our study reveals that this fusion protein may be developed as a therapeutic agent for treatment of colon cancer, and holds important implications for developing other anti-cancer peptide drugs. © 2013 Elsevier B.V. All rights reserved.
Liang S.,Guangzhou University |
Xie W.,Guangzhou University |
Sarkisyan H.A.,Russian-Armenian (Slavonic) State University |
Sarkisyan H.A.,Yerevan State University |
And 2 more authors.
Journal of Physics Condensed Matter | Year: 2011
We have studied the nonlinear optical absorption and the nonlinear optical rectification of an exciton in a nanoring in the presence of magnetic flux. The calculation results show that one can control the properties of nonlinear optical absorption and nonlinear optical rectification of a nanoring by tuning the outer and inner radius. Moreover, we find that the nonlinear optical properties of a nanoring can be modulated by the magnetic flux through the nanoring. © 2011 IOP Publishing Ltd.
Liang S.,Guangzhou University |
Xie W.,Guangzhou University |
Shen H.,China Institute for Radiation Protection
Optics Communications | Year: 2011
Optical properties of a two-dimensional quantum ring with pseudopotential in the presence of an external magnetic field and magnetic flux have been theoretically investigated. Our results show that both of the pseudopotential and magnetic field can affect the third non-linear susceptibility and oscillator strength. In addition, we found that the oscillator strength and the absolute value of the resonant peak of the linear, non-linear and total absorption coefficient demonstrates the Aharonov-Bohm oscillation with magnetic flux, moreover, changes in confinement potential can influence the Aharonov-Bohm oscillation in peak while the resonant peak value of the linear, non-linear and total refractive index changes decreases as magnetic flux increases. © 2011 Elsevier B.V. All rights reserved. © 2011 Elsevier B.V. All rights reserved.
cui H.,Taiyuan University of Technology |
Yao R.,China Institute for Radiation Protection |
Xu X.,China Institute for Radiation Protection |
Xin C.,China Institute for Radiation Protection |
Yang J.,Taiyuan University of Technology
Atmospheric Environment | Year: 2011
CALPUFF is an atmospheric source-receptor model recommended by the US Environmental Protection Agency (EPA) for use on a case-by-case basis in complex terrain and wind condition. As the bulk of validation of CALPUFF has focused on long-range or short-range but long-term dispersion, we can not gauge the reliability of the model for predicting the short-term emission in near-field especially complex terrain, and sometimes this situation is important for emergency emission. To validate the CALPUFF's application in such condition, we carried out a tracer experiment in a near-field complex terrain setting and used CALPUFF atmospheric dispersion model to simulate the tracer experiment in real condition. From the centroid trajectory comparison of predictions and measures, we can see that the model can correctly predict the centroid trajectory and shape of tracer cloud, and the results also indicate that sufficient observed weather data only can develop a good wind field for near-field. From the concentration comparison in each arc, we can see the model underestimate horizontal extent of tracer puff and can not reflect the irregular characters showed in measurements. The result of global analysis is FOEX of -25.91%, FA2 of 27.06%, FA5 of 61.41%. The simulations shows that the CALPUFF can simulate the position and direction of tracer cloud in near-field complex terrain but underestimate over measurements especially in peak concentrations. © 2011 Elsevier Ltd.
Yang K.,China Institute for Radiation Protection
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2013
To review the recent progress of the small intestinal submucosa (SIS) in application research of tissue repair and reconstruction. The domestic and international articles on the SIS were reviewed and summarized. As a natural extracellular matrix, SIS has outstanding biological advantages, such as good mechanical property, tissue compatibility, and lower immunogenicity. SIS has been used to repair and reconstruct various types of tissue defects in animal models and clinical application, especially in the treatment of hernia, urinary system disease, and refractory skin trauma. The development of the tissue engineering technology expands the field of SIS repair and reconstruction and promotes the intensive study of SIS. However, the long-term effect of SIS in tissue repair and reconstruction still remains to be further observation, while the cell/SIS material construction by tissue engineering technology also needs more studies. SIS has a widely promising application future in the tissue repair and reconstruction.
Wang X.-T.,China Institute for Radiation Protection
Hedianzixue Yu Tance Jishu/Nuclear Electronics and Detection Technology | Year: 2013
A kind of surface contamination survey tele-robot is designed. Function and structure of robot is introduced briefly, hardware designation and software development is described in detail.
Dong L.,China Institute for Radiation Protection
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012
To evaluate the effect of tissue engineered skin with isogeneic cells on repairing skin defects in inbred rat model so as to provide relevant evidences for the clinical application. The skins of newborn inbred F344 rats were harvested and treated with Dispase trypsin to isolate the epidermal cells. The skins of adult Sprague Dawley rats were obtained and treated with hypertonic sodium-SDS-trypsin to prepare the acellular dermal matrix. The tissue engineered skin was reconstructed by submerging culturing and air-liquid interface culturing in vitro. The full-thickness skin defects of 1.5 cm x 1.5 cm in size were prepared along the dorsal both sides of 36 adult inbred F344 rats, and 72 defects were repaired with tissue engineered skin in experimental group (n=24), with allogeneic acellular dermal matrix in negative control group (n=24), and with autologous full-thickness skin in positive control group (n=24). Finally the gross observation, the survival rate, wound contraction rate, and histological observation were used to evaluate the effect. The wound healed by first intension at 4 weeks postoperatively in the experimental group; the grafts connected with the adjacent tissue tightly and had normal appearance. At 4 weeks after operation, the survival rate of the graft was 0 in the negative control group; the survival rates were 62.5% (15/24) in the experimental group and 91.7% (22/24) in the positive control group, showing significant difference between 2 groups (chi2=5.779, P=0.016). The wound contraction rates of the experimental group and positive control group were significantly lower than that of the negative control group (P < 0.05), but no significant difference was found between the experimental group and positive control group (P > 0.05). Histological observation showed that slight inflammation reaction appeared at 1 week postoperatively in the experimental group; the regeneration of the blood vessel and the proliferation of the fibroblasts in dermis and the gradual maturation of epidermis were observed at 2 weeks, and new collagen deposition and collagen remodeling in the dermis of the graft were found at 4 weeks postoperatively. The tissue engineered skin is able to repair full-thickness skin defect of rats effectively, it has similar effect to the autologous full-thickness skin in preventing the wound contraction and promoting the wound healing, which provides experimental evidences for the clinical application.
Wang X.-T.,China Institute for Radiation Protection
Hedianzixue Yu Tance Jishu/Nuclear Electronics and Detection Technology | Year: 2012
A type of control system for nuclear detection robot was designed. The design is based on Radiation-Hardened optimization, the Radiation-Tolerant design of the circuit is described in detail.
Ma S.,China Institute for Radiation Protection
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2011
To research the effect of porcine acellular dermal matrix in the reconstruction of abdominal wall defects in rabbits, and to investigate the application feasibility of xeno-transplantation of acellular dermal matrix. The porcine acellular dermal matrix was prepared from a health white pig. Twenty-six Japanese white rabbits (weighing 2.2-2.3 kg, female or male) were randomly assigned to 2 groups: the control group (n=6) and the experimental group (n=20). In the control group, the full-thickness abdominal wall defect of 5.0 cm x 0.5 cm was made, and the defect was sutured directly; in the experimental group, the full-thickness abdominal wall defect of 5.0 cm x 2.5 cm was made, and the defect was repaired with porcine acellular dermal matrix patch at the same size as the defect. At 5 weeks after surgery, the incidence of hernia and the intra-abdominal adhesions were observed and the wound breaking strength was compared between the patch-fascia interface and the fascia-fascia interface. The graft vascularization was evaluated through histological analysis at 6 months after surgery in the experimental group. No hernia occurred in all rabbits of 2 groups. At 5 weeks after surgery, healing was observed between patch and the muscular fascia; the vascularization was seen in the porcine acellular dermal matrix patch. There was no significant difference in the adhesion grade (Z= -0.798, P=0.425) between the experimental group (grade 2 in 1 rabbit, grade 1 in 5, and grade 0 in 12) and the control group (grade 1 in 1 and grade 0 in 5). No significant difference was found (t= -0.410, P=0.683) in the breaking strength between the patch-fascia interface in the experimental group [(13.0 +/- 5.5) N] and the fascia-fascia interface in control group [(13.6 +/- 4.0) N]. In the experimental group, the small vessels and the infiltration of inflammatory cells were observed in the porcine acellular dermal matrix patch after 5 weeks through histological observations. The junctions of the patch-fascia interface healed with fibrous connective tissue. At 6 months after surgery, the inflammation was subsided and the collagen fiber of the patch was reconstructed. The porcine acellular dermal matrix patch has good results in repairing full-thickness abdominal wall defect. The patch-fascia interface has similar breaking strength to the fascia-fascia interface. The collagen fibers of the patch are reconstructed.