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Yilmaz S.S.,Fatih University | Hizli D.,Fatih University | Yilmaz E.,Childrens Training and Research Hospital | Eryilmaz O.G.,Oncology Training and Research Hospital | Haltas H.,Fatih University
Journal of Reproductive Medicine | Year: 2013

Objective: To determine the role of vitamin D for preventing or reducing postoperative adhesions. Study Design: The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters. Results: Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p<0.05). On the other hand, no difference was detected between the groups according to the fibrosis score. Conclusion: Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results. © Journal of Reproductive Medicine ®, Inc.


Atay E.,Istanbul University | Tokmak M.,Istanbul University | Can E.,Istanbul Medipol Hospital | Ovali F.,Childrens Training and Research Hospital
Journal of Neonatal-Perinatal Medicine | Year: 2012

Objective: Congenital depression of the skull is a rare event and the cause is not always clear. It may be complicated by brain injury, hematoma and epilepsy. This case is presented to draw attention to this rare congenital disorder which may raise suspicions in the family and discuss treatment options. Description: This baby boy was born at term by cesarean section and the depressed fracture of the right parietal bone, 5 cm × 4 cm, with a depth of 7.7 mm was noted at the first examination. Conventional and 3-dimentional computed tomography of the skull confirmed the diagnosis. The neurological examination was unremarkable. The depressed portion was elevated by surgery; the baby was growing well in the first month. Comments: Skull fracture is frequently assumed to have resulted from trauma, but it may occur prenatally. © 2012 - IOS Press and the authors. All rights reserved.


Azik F.M.,Pediatric Hematology Unit | Tezer H.,Gazi University | Parlakay A.O.,Childrens Training and Research Hospital | Aksu T.,Pediatric Hematology Unit | And 4 more authors.
Journal of Pediatric Hematology/Oncology | Year: 2015

Invasive fungal infections (IFIs) constitute a leading cause of morbidity and infection-related mortality among hematopoietic stem cell transplant (HSCT) recipients. With the use of secondary prophylaxis, a history of IFI is not an absolute contraindication to allo-HSCT. However, still, IFI recurrence remains a risk factor for transplant-related mortality. In this study, of the 105 children undergoing HSCT between April 2010 and February 2013, 10 patients who had IFI history before transplantation and had undergone allo-HSCT were evaluated retrospectively to investigate results of secondary prophylaxis. In conclusion, our study shows that amphotericin B and caspofungin was successful as secondary antifungal prophylaxis agents with no relapse of IFI. In addition, after engraftment, secondary prophylaxis was continued with voriconazole orally in 4 patients that yielded good results. Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.


Keskin M.,Childrens Training and Research Hospital | Savas-Erdeve E.,Childrens Training and Research Hospital | Sasak E.,Childrens Training and Research Hospital | Cetinkaya S.,Childrens Training and Research Hospital | Aycan Z.,Childrens Training and Research Hospital
Journal of Pediatric Endocrinology and Metabolism | Year: 2015

The aim of the present study was to analyse the effects of combined treatment with calcitriol and phosphate, to find out the incidence of the nephrocalcinosis, and to elucidate the risk factor of nephrocalcinosis in patients with hypophosphatemic rickets. We followed six patients. The median age at diagnosis was 3.25 (0.75-10.5) years. The median follow-up duration was 8.25 (3.5-12.5) years. The mean dose of calcitriol and phosphate treatments was 39.1±8 ng/kg/day, 90.5±57.1 mg/kg/day, respectively. Nephrocalcinosis was detected in three patients (50%). The mean dose of phosphate taken by the patients found to have nephrocalcinosis was detected to be high with a statistically significant difference (p=0.041). No significant relationship was found the mean dose of calcitriol. We found no relationship between the development of nephrocalcinosis and the incidence of hypercalciuria or hypercalcemia episodes. We found the increased phosphate dose administered for treatment to play a role in nephrocalcinosis development. © 2015 by De Gruyter.


Gursoy T.,Koç University | Imamoglu E.Y.,Childrens Training and Research Hospital | Ovali F.,Childrens Training and Research Hospital | Karatekin G.,Childrens Training and Research Hospital
American Journal of Perinatology | Year: 2015

Objective This study aims to investigate the effects of antenatal magnesium sulfate on intestinal blood flow in preterm neonates. Study Design In this prospective case-match study, 25 preterm neonates exposed to magnesium sulfate antenatally were included (study group). Overall, 25 gestational age-matched neonates who had no exposure to magnesium constituted the control group. Serial daily Doppler flow measurements of superior mesenteric artery (SMA) were performed. The time to reach full feeds, first meconium passage were assessed. Presence of feeding intolerance or necrotizing enterocolitis was recorded. Results Blood flow velocities of SMA were not different between the groups during the first five postnatal days. However, SMA blood flow showed an increasing trend in the control group unlike the study group (control group, p < 0.001; study group, p = 0.29). There was no significant difference between the two groups regarding the time to reach full feeds or first meconium passage and presence of feeding intolerance. No case of necrotizing enterocolitis was seen. Conclusion Antenatal magnesium does not significantly affect intestinal blood flow, but it seems to attenuate the increasing trend of the intestinal blood flow in the early postnatal days. However, this study failed to show any impact of this finding on clinical outcomes. © 2015 by Thieme Medical Publishers, Inc.


Ovali F.,Childrens Training and Research Hospital | Gursoy T.,Childrens Training and Research Hospital | Sari I.,Childrens Training and Research Hospital | Divrikli D.,Childrens Training and Research Hospital | Aktas A.,Childrens Training and Research Hospital
Pediatrics International | Year: 2012

Background: Neonates are at high risk for nosocomial infections due to multidrug-resistant pathogens. The use of β-lactamase inhibitors in combination with β-lactam antibiotics broadens the antimicrobial spectrum. Cefoperazone/sulbactam is used in children but there are limited data on its usage in neonates. The purpose of the present study was therefore to evaluate the use of cefoperazone/sulbactam in the treatment of neonatal infections caused by multidrug-resistant pathogens. Methods: The records of neonates who were hospitalized and who received cefoperazone/sulbactam were reviewed. Results: There were 90 infants who received cefoperazone/sulbactam. A pathogen could be isolated in 41 (45.6%) of the infants. In total, 17.1% of isolated pathogens were resistant to cefoperazone/sulbactam. Side-effects were seen in four of the infants. Two infants had cholestasis, one infant had neutropenia and one had superinfection with candida. Conclusion: Cefoperazone/sulbactam can be used in the treatment of nosocomial infections caused by multidrug-resistant pathogens in neonates. © 2011 Japan Pediatric Society.

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