PA Childrens Hospitals and Clinics of Minnesota

Saint Cloud, MN, United States

PA Childrens Hospitals and Clinics of Minnesota

Saint Cloud, MN, United States
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Arkilo D.,PA Childrens Hospitals and Clinics of Minnesota | Devinsky O.,NYU Langone Medical Center | Mudigoudar B.,Comprehensive NeuroScience | Boronat S.,Autonomous University of Barcelona | And 7 more authors.
Epilepsy and Behavior | Year: 2016

Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized:. Pattern 1: Alpha-delta sleep was noted in 14 children (33%), not associated with any clinical changes.Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatment-resistant epilepsy. Thirteen of the 15 children had clinical seizures.Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12-15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy.This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies. © 2016 Elsevier Inc.


PubMed | Comprehensive NeuroScience, PA Childrens Hospitals and Clinics of Minnesota, Autonomous University of Barcelona, Reims University Hospital Center and 6 more.
Type: Journal Article | Journal: Epilepsy & behavior : E&B | Year: 2016

Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized: Pattern 1: Alphadelta sleep was noted in 14 children (33%), not associated with any clinical changes. Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatmentresistant epilepsy. Thirteen of the 15 children had clinical seizures. Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (1215 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy. This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies.

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