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Li X.,Hebei Medical University | Zhang L.,Hebei Medical University | Hou Z.,Hebei Medical University | Meng Z.,Childrens Hospital of Hebei Province | And 3 more authors.
International Orthopaedics | Year: 2015

Purpose: Intramedullary nailing is widely used in the treatment of stable pertrochanteric fractures. However, it remains controversial whether the distal locking with intramedullary nailing is necessary. Method: In this study, 70 patients over the age of 65 with pertrochanteric fractures (AO/OTA 31-A1 and A2) were enrolled and randomly divided into two groups for treatment by intramedullary nails either with or without distal locking. Intra-operative variables such as operation time, volume of blood loss, total fluoroscopy time, total length of incision, postoperative complications and clinical outcomes were recorded and compared between the two groups. Results: A total of 29 patients in the locking group and 30 patients in the unlocking group completed one year of follow up. Operation time (39.2 ± 7.6 min), blood loss (158.6 ± 63.6 ml), fluoroscopy time (53.7 ± 3.9 s), and total length of incision (13.1 ± 2.1 cm) in the unlocking group were significantly decreased compared with the locking group (48.5 ± 9.0 min; 194.3 ± 61.6 ml; 57.8 ± 4.3 s; 10.9 ± 1.7 cm) (p < 0.05). No significant differences in postoperative complications and fracture union were identified between the two groups. Most patients in the locking group (80.0 %) and the unlocking group (77.1 %) recovered to their pre-injury activity levels. Conclusion: This study suggests that intramedullary nails without distal locking may be a reliable and acceptable option for treating stable pertrochanteric fractures (AO/OTA 31-A1 and A2) in elderly people. Distal unlocked nails showed subtle advantages in reducing blood loss, operation time, fluoroscopy exposure time, and size of the incision. © 2015, SICOT aisbl.

Liu C.Q.,Childrens Hospital of Hebei Province
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics | Year: 2011

OBJECTIVE: To evaluate the efficacy of targeted tidal volume ventilation in the treatment of severe neonatal respiratory distress syndrome (RDS). Methods: Eighty-four neonates with severe RDS between June 2008 and January 2010 were randomly assigned to 3 groups according to the ventilation mode: synchronized intermittent positive pressure ventilation plus volume guarantee (SIPPV+VG; n=31), high frequency oscillation ventilation (HFOV; n=23) and intermittent mandatory ventilation (IMV; n=30). The oxygenation status, the durations of oxygen exposure and ventilation and the incidence of complications were observed. Results: The oxygenation status (P/F and a/APO2) in the SIPPV+VG and the HFOV groups was improved significantly 12 hrs after ventilation (P<0.05). While in the IMV group, the oxygenation status was not improved until 24 hrs after ventilation. The durations of oxygen exposure and ventilation in the SIPPV+VG and the HFOV groups were shorter than in the IMV group (P<0.05). The incidences of air leak syndrome and ventilation-associated pneumonia (VAP) were lower in the SIPPV+VG and the HFOV groups than in the IMV group (P<0.05). The incidence of severe intracranial hemorrhage in the HFOV group was higher than in the other two groups (P<0.05). Conclusions: Compared with IMV, SIPPV+VG and HFOV can improve the oxygenation status more quickly, shorten the ventilation duration and decrease the incidences of air leak syndrome and VAP in neonates with severe RDS.

Dong F.-Q.,Childrens HeBei Province | Zhang Y.-H.,Childrens HeBei Province | Li Z.-A.,Capital Medical University | Hou Z.-Z.,Childrens Hospital of Hebei Province | And 2 more authors.
Ultrasound in Obstetrics and Gynecology | Year: 2011

Objectives To explore the feasibility of using enhanced-flow (e-flow) imaging technology to identify fetal pulmonary veins and establish gestational age-specific reference values at 12-40 weeks' gestation. Methods The pulmonary venous internal diameter, peak systolic and diastolic flow velocities and visualization rate were analyzed in 332 normal fetuses at 12-40 weeks of gestation. Two-dimensional gray-scale (2D) ultrasound, color Doppler and e-flow imaging were used to detect the pulmonary veins in the four-chamber view by taking the lung as the penetration window. Results The pulmonary veins could be visualized as early as 12 weeks' gestational age by e-flow imaging. The right and left pulmonary venous internal diameters and peak systolic and diastolic flow velocities increased with increasing gestational age. Between 12 and 40 gestational weeks, the internal diameter and both the systolic and diastolic flow velocities of the fetal right pulmonary vein were significantly larger than were those of the left vein (P < 0.05). Of 118 fetuses at 12-22 gestational weeks, the visualization rate of the four pulmonary veins (left superior and inferior, right superior and inferior) was 5.9% (7/118) by 2D ultrasound, 41.5% (49/118) by color Doppler and 61.9% (73/118) by e-flow imaging. The visualization rate by e-flow imaging was significantly higher than that using the other two techniques (P < 0.001). Conclusion e-flow imaging is apparently a feasible and promising technology with which to identify the fetal pulmonary veins in the early stages of the second trimester. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.

Wang J.,Childrens Hospital of Hebei Province | Liu C.,University College London
Journal of Bionic Engineering | Year: 2014

Biomimetic collagen/hydroxyapatite scaffolds have been prepared by microwave assisted co-titration of phosphorous acid-containing collagen solution and calcium hydroxide-containing solution. The resultant scaffolds have been characterised with respect to their mechanical properties, composition and microstructures. It was observed that the in situ precipitation process could combine collagen fibril formation and hydroxyapatite (HAp) formation in one process step. Collagen fibrils guided hydroxyapatite precipitation to form bone-mimic collagen/hydroxyapatite composite containing both intrafibrillar and interfibrillar hydroxyapatites. The mineral phase was determined as low crystalline calcium-deficient hydroxyapatite with calcium to phosphorus ratio (Ca/P) of 1.4. The obtained 1% (collagen/HAp = 75/25) scaffold has a porosity of 72% and a mean pore size of 69.4 μm. The incorporation of hydroxyapatite into collagen matrix improved the mechanical modulus of the scaffold significantly. This could be attributed to hydroxyapatite crystallites in collagen fibrils which restricted the deformation of the collagen fibril network, and the load transfer of the collagen to the higher modulus mineral component of the composite. © 2014 Jilin University.

Wang Y.,Tianjin Medical University | Chen Y.,Tianjin Medical University | Geng H.,Tianjin Medical University | Qi C.,Childrens Hospital of Hebei Province | And 2 more authors.
Tumor Biology | Year: 2015

Renal cell carcinoma (RCC) is the most common type of kidney cancers in adults, and metastasis represents the major cause of mortality of RCC patients. The Y-box binding protein 1 (YB1) is a multifunctional oncoprotein in various malignancies. Enhancer of zeste homolog 2 (EZH2), a polycomb histone methyltransferase, is a key epigenetic modifier implicated in various cancer metastasis. However, the expression patterns and clinical correlations of both YB1 and EZH2 in RCC remain largely unclear. In this study, the expression of YB1 and EZH2 were examined using immunohistochemistry staining in a study cohort including 165 RCC and 80 tumor adjacent normal tissues. RCC tissues showed a significant higher nuclear expression of YB1 (p < 0.001) and EZH2 (p < 0.001) as compared with the normal counterparts. In addition, YB1 and EZH2 nuclear overexpression were found to be positively associated with RCC stage (p < 0.001 and p = 0.005), Fuhrman tumor grade (p = 0.022 and p = 0.044), and metastasis (p < 0.001 and p = 0.009). Overall survival analysis indicated patients with YB1 (p = 0.004, HR 5.656 (2.006–10.944)) and/or EZH2 (p = 0.006, HR 4.551 (2.124–9.438)) nuclear overexpression correlated with poor survival. More interestingly, YB1 and EZH2 nuclear expression was correlated (p = 0.005). Further studies demonstrated that EZH2 expression was significantly downregulated in YB1 knockdown RCC cell lines. Functionally, YB1 knockdown inhibited RCC invasion in vitro. In conclusion, YB1 and EZH2 expression was correlated and associated with RCC incidence, tumor stage, grade, metastasis, and survival. © 2015, International Society of Oncology and BioMarkers (ISOBM).

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