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Rezaei M.,Semnan University of Medical Sciences | Mamishi S.,Semnan University of Medical Sciences | Mahmoudi S.,Childrens Medical Center Hospital | Pourakbari B.,Pediatric Infectious Diseases Research Center | And 3 more authors.
British Journal of Biomedical Science | Year: 2013

Despite the fact that the prognosis of bacterial meningitis has been improved by the influence of antibiotics, this disease is still one of the significant causes of morbidity and mortality in children. Rapid differentiation between bacterial and aseptic meningitis, and the need for immediate antibiotic treatment in the former, is crucial in the prognosis of these patients. Ferritin is one of the most sensitive biochemical markers investigated in cerebrospinal fluid (CSF) for the early diagnosis of bacterial meningitis. The present study aims to evaluate the diagnostic capability of CSF ferritin in differentiating bacterial and viral meningitis in the paediatric setting. A cross-sectional study was carried out in the referral Children's Medical Center Hospital, Tehran, during 2008 and 2009. According to the inclusion criteria, CSF samples from 42 patients with suspected meningitis were obtained and divided into two meningitis groups, bacterial (n=18) and viral (n=24). Ferritin and other routine determinants (i.e., leucocytes, protein and glucose) were compared between the two groups. Ferritin concentration in the bacterial meningitis group was 106.39±86.96 ng/dL, which was considerably higher than in the viral meningitis group (10.17±14.09, P<0.001). Mean CSF protein concentration and cell count were significantly higher in the bacterial meningitis group and showed a positive correlation with CSF ferritin. In conclusion, this study suggests that CSF ferritin concentration is an accurate test for the early differentiation of bacterial and aseptic meningitis; however, further investigation on a larger cohort of patients is required to confirm this finding. Source

Hosseinverdi S.,Tehran University of Medical Sciences | Hashemi H.,Noor Ophthalmology Research Center | Aghamohammadi A.,Tehran University of Medical Sciences | Ochs H.D.,University of Washington | And 3 more authors.
Journal of Clinical Immunology | Year: 2014

Primary immunodeficiency diseases (PID) are a group of inherited disorders characterized by recurrent infections, and in many cases autoimmunity and malignancies. A number of PID patients suffer from a variety of ocular manifestations. Although these associated ocular features are not common, awareness combined with better understanding of the contributing mechanisms will allow prompt diagnosis and specific treatment, leading to reduction or prevention of serious visual morbidities. © 2013 Springer Science+Business Media New York. Source

Mahmoudi M.,Tehran University of Medical Sciences | Rezaiemanesh A.,Tehran University of Medical Sciences | Salmaninejad A.,Tehran University of Medical Sciences | Harsini S.,Tehran University of Medical Sciences | And 7 more authors.
Autoimmunity | Year: 2015

Juvenile-onset systemic lupus erythematosus (JSLE) is a multisystem autoimmune disease in which both the genetic and environmental factors seem to be involved in the etiopathogenesis of the disease. The aim of this study was to evaluate the association of programmed cell death 1 (PDCD1, also called PD-1) gene polymorphisms with JSLE susceptibility in Iranian population. In this case-control association study, three PDCD1 SNPs, including PD-1.1 G/A, PD-1.3 G/A and PD-1.9 C/T were genotyped in 50 Iranian patients with JSLE and 202 healthy unrelated controls, using PCR-RFLP method. The PD-1.1 A allele was found to be more frequent in the case group compared with controls (6% vs. 1.5%, p = 0.024). Moreover, the GG genotype was less frequent in cases than in controls (88% vs. 97%, p = 0.021). The other PDCD1 SNPs did not show association. At the haplotypic level, no significant differences was recognized between the two groups of case and control neither for the GAC (PD-1.1 G, PD-1.3 A, PD-1.9 C) nor for the GGC haplotype (PD-1.1 G, PD-1.3 G, PD-1.9 C). Our findings support the influence of the PD1.1 A SNP on the development of JSLE in Iranian population. © 2015 Informa UK Ltd. Source

Varzaneh F.N.,Tehran University of Medical Sciences | Keller B.,Albert Ludwigs University of Freiburg | Unger S.,Albert Ludwigs University of Freiburg | Aghamohammadi A.,Tehran University of Medical Sciences | And 3 more authors.
Journal of Clinical Immunology | Year: 2014

Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins and compromised specific antibody response leading to frequent infections. Cytokines play an important role in the orchestration of the antibody response. Several previous studies have attempted to identify distinct cytokines responsible for the inflammatory changes and different manifestations of CVID, but there are conflicting results regarding the cytokine profiles in CVID patients. In light of this, an extensive review regarding the level of various cytokines and their potential therapeutic role in CVID patients was performed. This review delineates the contribution of interleukin (IL)-1, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12, IL-21, interferons, tumor necrosis factor (TNF)-α, IL-17, APRIL (a proliferation inducing ligand) and BAFF (B cell activating factor) in CVID disease and outline their potential therapeutic implications in these patients. © 2014 Springer Science+Business Media. Source

Khalili A.,Tehran University of Medical Sciences | Plebani A.,University of Brescia | Vitali M.,University of Brescia | Abolhassani H.,Tehran University of Medical Sciences | And 6 more authors.
Journal of Clinical Immunology | Year: 2014

This study describes the fifth case worldwide of autosomal recessive agammaglobulinemia due to a novel non-sense mutation in CD79a gene with a severe unusual onset due to an invasive central nervous system infection. © 2014 Springer Science+Business Media New York. Source

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