Vaskova M.,Childhood Leukemia Investigation Prague CLIP |
Vaskova M.,Charles University |
Kovac M.,Childhood Leukemia Investigation Prague CLIP |
Kovac M.,Charles University |
And 10 more authors.
Leukemia Research | Year: 2011
The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1 pos BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1 pos ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry. © 2011 Elsevier Ltd.