Childhood Leukemia Investigation Prague CLIP

Prague, Czech Republic

Childhood Leukemia Investigation Prague CLIP

Prague, Czech Republic
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Vaskova M.,Childhood Leukemia Investigation Prague CLIP | Vaskova M.,Charles University | Kovac M.,Childhood Leukemia Investigation Prague CLIP | Kovac M.,Charles University | And 10 more authors.
Leukemia Research | Year: 2011

The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1 pos BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1 pos ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry. © 2011 Elsevier Ltd.

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