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Hashemipour M.,Isfahan Endocrine and Metabolism Research Center | Hashemipour M.,Child Health Promotion Research Center | Dehkordi E.H.,Isfahan Endocrine and Metabolism Research Center | Javanmard S.H.,Isfahan University of Medical Sciences | And 8 more authors.
Hormone Research in Paediatrics | Year: 2011

Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the possible involvement of endothelial dysfunction in the pathogenesis of CH and the lack of studies in this field, the aim of this study was to determine the endothelial function in CH patients. Methods: During this case-control study, the endothelial function in CH neonates and in those with normal screening results was evaluated during a CH screening program in Isfahan. Peripheral blood samples were obtained for measurement of the von Willebrand factor (vWf), and intercellular and vascular cell adhesion molecule (ICAM and VCAM). In CH patients these biomarkers were measured twice: before and 4 weeks after treatment. Results: In this study, 56 neonates were evaluated: 30 of them were neonates with normal screening results and 26 were diagnosed with CH and classified into two groups according to their TSH levels. The mean ICAM and VCAM were higher in CH patients than in the control group (p < 0.05). The mean ICAM and VCAM decreased significantly after treatment in CH patients (p < 0.05). There is no significant relationship between TSH, ICAM, VCAM and vWf (p > 0.05). Conclusion: The findings of this study demonstrate the possible involvement of the endothelial system in the pathogenesis of CH and its cardiovascular complications. Further studies with a larger sample size and with the measurement of other endothelial function markers are needed. Copyright © 2011 S. Karger AG, Basel.

Hakanson C.,Goldfields Womens Health Care Center | Hakanson C.,Goldfields Population Health | Douglas C.,Goldfields Population Health | Robertson J.,Princess Margaret Hospital for Children | Lester L.,Child Health Promotion Research Center
Australian Journal of Rural Health | Year: 2014

Objective: The objective of this study was to explore changes in the sexual function of women who attended a rural nurse-led female sexual dysfunction clinic. Design: This exploratory study was designed as a one-group pre-test/post-test design from a convenience sample of women attending the clinic. Setting: The setting was a women's health centre located in regional Western Australia. Participants: One hundred eleven women aged between 18 and 65 years were recruited from clinic attendees. Main outcome measure(s): The Australian version of the validated McCoy Female Sexuality Questionnaire was completed before the first appointment (T0), and 1 (T1) and 6 months (T2) after the last appointment. Results: Women attending the clinic reported significant increases in sexual desire, satisfaction and orgasm quality and achievement at 1 and 6 months after their last appointment. There was also a significant increase in satisfaction with their main sexual partner at 6 months. Conclusions: This study confirmed the value of an innovative approach to managing female sexual dysfunction in a rural area with workforce shortages and limited health services. It is recommended that care by a nurse-led multidisciplinary team be used in the management of sexual dysfunction. Further research is needed to see if this model of care would be effective in other settings. © 2014 National Rural Health Alliance.

PubMed | Child Health Promotion Research Center
Type: Journal Article | Journal: Psychological assessment | Year: 2013

The study of bullying behavior and its consequences for young people depends on valid and reliable measurement of bullying victimization and perpetration. Although numerous self-report bullying-related measures have been developed, robust evidence of their psychometric properties is scant, and several limitations inhibit their applicability. The Forms of Bullying Scale (FBS), with versions to measure bullying victimization (FBS-V) and perpetration (FBS-P), was developed on the basis of existing instruments, for use with 12- to 15-year-old adolescents to economically, yet comprehensively measure both bullying perpetration and victimization. Measurement properties were estimated. Scale validity was tested using data from 2 independent studies of 3,496 Grade 8 and 783 Grade 8-10 students, respectively. Construct validity of scores on the FBS was shown in confirmatory factor analysis. The factor structure was not invariant across gender. Strong associations between the FBS-V and FBS-P and separate single-item bullying items demonstrated adequate concurrent validity. Correlations, in directions as expected with social-emotional outcomes (i.e., depression, anxiety, conduct problems, and peer support), provided robust evidence of convergent and discriminant validity. Responses to the FBS items were found to be valid and concurrently reliable measures of self-reported frequency of bullying victimization and perpetration, as well as being useful to measure involvement in the different forms of bullying behaviors. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

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