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Kfar Saba, Israel

Nemet D.,Tel Aviv University | Nemet D.,Child Health and Sports Center | Geva D.,Tel Aviv University | Eliakim A.,Tel Aviv University
Journal of Pediatrics | Year: 2011

Objective: To prospectively examine the effects of a randomized school-based intervention on nutrition and physical activity knowledge and preferences, anthropometric measures, and fitness in low socioeconomic kindergarten children. Study design: A total of 376 children completed a school-year combined dietary-behavioral-physical activity intervention and were compared with 349 control subjects (age 3.8 to 6.8 years). Results: The prevalence of overweight and obesity among the kindergarten children was 27.7%. Even though the intervention was not associated with between group differences in body mass index changes, it was associated with significantly (P < .05) greater increase in nutrition knowledge and preferences, physical activity knowledge and preferences, and improvement in fitness. There was a greater (P < .05) decrease in the number of overweight children in the intervention group (-31.9%) compared with the controls (-17.5%). Conclusions: A kindergarten dietary-physical activity intervention applied by the kindergarten teachers, had no effect on body mass index changes between the groups, but improved nutrition and physical activity knowledge and preferences, improved fitness, and decreased the percent of overweight children. This intervention may play an important role in health promotion, prevention and treatment of childhood obesity. © 2011 Mosby Inc. All rights reserved. Source

De Vries L.,Jesse Z And Sara Lea Shafer Institute For Endocrinology And Diabetes | De Vries L.,Tel Aviv University | Gat-Yablonski G.,Jesse Z And Sara Lea Shafer Institute For Endocrinology And Diabetes | Gat-Yablonski G.,Tel Aviv University | And 6 more authors.
Human Reproduction | Year: 2014

Central precocious puberty may be familial in about a quarter of the idiopathic cases. However, little is known about the genetic causes responsible for the disorder. In this report we describe a family with central precocious puberty associated with a mutation in the makorin RING-finger protein 3 (MKRN3) gene. A novel missense mutation (p.H420Q) in the imprinted MKRN3 gene was identified in the four affected siblings, in their unaffected father and in his affected mother. An in silico mutant MKRN3 model predicts that the mutation p.H420Q leads to reduced zinc binding and, subsequently, impaired RNA binding. These findings support the fundamental role of the MKRN3 protein in determining pubertal timing. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. Source

Ben-Zaken S.,Wingate Institute | Meckel Y.,Wingate Institute | Lidor R.,Wingate Institute | Nemet D.,Child Health and Sports Center | Eliakim A.,Child Health and Sports Center
Pediatric Exercise Science | Year: 2013

The aim of the study was to assess whether an aerobic-favoring genetic profile can predict the success of a shift from middle- to long-distance running. Thirteen elite middle-distance runners were divided into successful and nonsuccessful groups in their shift toward long-distance runs. All the runners began their training program at the age of 14-15, and after 6-7 years, changed focus and adjusted their training program to fit longer running distances. The participants' personal records in the longer events were set at the age of 25-27, about 3-5 years after the training readjustment took place. The endurance genetic score based on 9 polymorphisms was computed as the endurance genetic distance score (EGDS9). The power genetic distance score (PGDS5) was computed based on 5 power-related genetic polymorphisms. The mean EGDS9 was significantly higher among the successful group than the nonsuccessful group (37.1 and 23.3, respectively, p <.005, effect size 0.75), while the mean PGDS5 was not statistically different between the 2 groups (p =.13). Our findings suggest the possible use of genetic profiles as an added tool for determining appropriate competitive transition and specialization in young athletes involved in early phases of talent development. © 2013 Human Kinetics, Inc. Source

Eliakim A.,Child Health and Sports Center | Nemet D.,Child Health and Sports Center | Kassem E.,Hillel Yafe Medical Center
Scandinavian Journal of Medicine and Science in Sports | Year: 2015

Skeletal muscle is the major producer and user of lactate in the body. Therefore, transport of lactate across cells' membrane is of considerable importance. Lactate transport is mediated by proton-linked monocarboxylate transporter (MCT1). The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. The aim of the current study was to compare allelic and genotype frequencies of MCT1 A1470T polymorphism among Israeli track-and-field athletes, swimmers, and non-athletes. Genomic DNA was extracted from 173 track-and-field athletes (age 17-50), 80 swimmers (age 16-49), and 128 non-athletes (age 19-29). Track-and-field athletes were assigned to three subgroups: long-distance runners, middle-distance runners, and power event athletes. Swimmers were assigned to two subgroups: long-distance swimmers and short-distance swimmers. Genotyping was performed using polymerase chain reaction. T-allele frequency was significantly higher among long-distance swimmers (45%) compared with long- and middle-distance runners (27% and 30%, respectively; P<0.01). In addition, T-allele frequency was significantly higher among short-distance swimmers (40%) compared with power event athletes (25%, P<0.01). Overall, T-allele frequency was significantly higher among swimmers (42%) compared with runners (27%, P<0.001). More research is needed to clarify whether this polymorphism displays advantage for swimming performance. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source

Eynon N.,Wingate Institute | Meckel Y.,Wingate Institute | Alves A.J.,University of Porto | Nemet D.,Child Health and Sports Center | Eliakim A.,Child Health and Sports Center
Scandinavian Journal of Medicine and Science in Sports | Year: 2011

The -9 deletion allele in the BDKRB2 -9/+9 polymorphism was associated previously with improved endurance performance. We compared the frequency distribution of the BDKRB2 -9/+9 (rs5810761) polymorphism between athletes (n=155) of sports with different demands (endurance runners; n=74 vs sprinters; n=81) as well as between athletes of different competitive levels (elite level; n=46 vs national level; n=109). These results were compared with those of 240 non-athletic healthy individuals. We also tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. Genotype distribution and allele frequencies were found to be similar in the endurance athlete, sprinter, and control groups (P=0.83 for genotype distribution and P=0.9 for allele frequencies). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes and national-level endurance athletes, or between elite-level and national-level sprinters (P>0.09 for all comparisons). There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance performance (P=0.16 for interaction effect). In conclusion, the BDKRB2 +9/-9 polymorphism is not associated with endurance performance, at least among Israeli athletes, and the GNB3TT+BDKRB2 -9/-9 "optimal genotype" is not associated with endurance performance. © 2011 John Wiley & Sons A/S. Source

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