Child Health and Sports Center

Kfar Saba, Israel

Child Health and Sports Center

Kfar Saba, Israel

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Eliakim A.,Child Health and Sports Center | Nemet D.,Child Health and Sports Center | Kassem E.,Hillel Yafe Medical Center
Scandinavian Journal of Medicine and Science in Sports | Year: 2015

Skeletal muscle is the major producer and user of lactate in the body. Therefore, transport of lactate across cells' membrane is of considerable importance. Lactate transport is mediated by proton-linked monocarboxylate transporter (MCT1). The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. The aim of the current study was to compare allelic and genotype frequencies of MCT1 A1470T polymorphism among Israeli track-and-field athletes, swimmers, and non-athletes. Genomic DNA was extracted from 173 track-and-field athletes (age 17-50), 80 swimmers (age 16-49), and 128 non-athletes (age 19-29). Track-and-field athletes were assigned to three subgroups: long-distance runners, middle-distance runners, and power event athletes. Swimmers were assigned to two subgroups: long-distance swimmers and short-distance swimmers. Genotyping was performed using polymerase chain reaction. T-allele frequency was significantly higher among long-distance swimmers (45%) compared with long- and middle-distance runners (27% and 30%, respectively; P<0.01). In addition, T-allele frequency was significantly higher among short-distance swimmers (40%) compared with power event athletes (25%, P<0.01). Overall, T-allele frequency was significantly higher among swimmers (42%) compared with runners (27%, P<0.001). More research is needed to clarify whether this polymorphism displays advantage for swimming performance. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Eliakim A.,Child Health and Sports Center | Eliakim A.,Tel Aviv University | Cale-Benzoor M.,Wingate Institute | Klinger-Cantor B.,Endocrine Unit | And 6 more authors.
Journal of Strength and Conditioning Research | Year: 2011

Eliakim, A, Cale-Benzoor, M, Klinger-Cantor, B, Freud, E, Nemet, D, Feigin, E, and Weintrob, N. A case study of virilizing adrenal tumor in an adolescent female elite tennis player-insight into the use of anabolic steroids in young athletes. J Strength Cond Res 25(1): 46-50, 2011 - A 14-year-old Caucasian girl was referred to the endocrine clinic for evaluation of voice deepening, facial hirsutism, and acne starting 2 years previously. She had been a competitive tennis player since age 7 years, practicing for 4-6 hours daily. On physical examination she was noticed to have a masculine appearance with mild facial acne and moderate hirsutism. Tanner stage was 1 for breast tissue and 5 for pubic hair. Her androgen levels (testosterone, androstenedione, dehydroepiandrosterone sulfate) were extremely elevated. Adrenal ultrasonography revealed a round left 4.6 × 5.3-cm adrenal mass. Laparoscopic left adrenalectomy was performed. The histologic findings were compatible with a benign adrenocortical tumor. Postoperatively, androgen levels dropped to within the normal range. Breast development proceeded normally, menarche occurred 2 months after tumor resection, and menses has been regular since then. Muscle strength of the dominant and nondominant upper and lower extremities was measured 1 month before surgery and 1 year later, using an isokinetic dynamometer (Biodex Systems II, Biodex, Shirley, NY, USA). There was no significant decrease in overall muscle strength after removal of the virilizing tumor and the marked drop in circulating androgens. In addition, the patient maintained her age category, number 1, national tennis ranking. The results suggest that even extremely high levels of tumor-related circulating androgens had no evident effect on muscle strength and competitive performance in a female adolescent tennis player. The lack of beneficial effect on performance in adolescents, combined with the potentially hazardous side effects of anabolic steroids, suggests that teenage athletes should avoid their use. © 2011 National Strength and Conditioning Association.


De Vries L.,Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes | De Vries L.,Tel Aviv University | Gat-Yablonski G.,Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes | Gat-Yablonski G.,Tel Aviv University | And 6 more authors.
Human Reproduction | Year: 2014

Central precocious puberty may be familial in about a quarter of the idiopathic cases. However, little is known about the genetic causes responsible for the disorder. In this report we describe a family with central precocious puberty associated with a mutation in the makorin RING-finger protein 3 (MKRN3) gene. A novel missense mutation (p.H420Q) in the imprinted MKRN3 gene was identified in the four affected siblings, in their unaffected father and in his affected mother. An in silico mutant MKRN3 model predicts that the mutation p.H420Q leads to reduced zinc binding and, subsequently, impaired RNA binding. These findings support the fundamental role of the MKRN3 protein in determining pubertal timing. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.


Nemet D.,Tel Aviv University | Nemet D.,Child Health and Sports Center | Geva D.,Tel Aviv University | Eliakim A.,Tel Aviv University
Journal of Pediatrics | Year: 2011

Objective: To prospectively examine the effects of a randomized school-based intervention on nutrition and physical activity knowledge and preferences, anthropometric measures, and fitness in low socioeconomic kindergarten children. Study design: A total of 376 children completed a school-year combined dietary-behavioral-physical activity intervention and were compared with 349 control subjects (age 3.8 to 6.8 years). Results: The prevalence of overweight and obesity among the kindergarten children was 27.7%. Even though the intervention was not associated with between group differences in body mass index changes, it was associated with significantly (P < .05) greater increase in nutrition knowledge and preferences, physical activity knowledge and preferences, and improvement in fitness. There was a greater (P < .05) decrease in the number of overweight children in the intervention group (-31.9%) compared with the controls (-17.5%). Conclusions: A kindergarten dietary-physical activity intervention applied by the kindergarten teachers, had no effect on body mass index changes between the groups, but improved nutrition and physical activity knowledge and preferences, improved fitness, and decreased the percent of overweight children. This intervention may play an important role in health promotion, prevention and treatment of childhood obesity. © 2011 Mosby Inc. All rights reserved.


Berkovich B.-E.,Hebrew University of Jerusalem | Eliakim A.,Child Health and Sports Center | Nemet D.,Child Health and Sports Center | Stark A.H.,Hebrew University of Jerusalem | Sinai T.,Hebrew University of Jerusalem
International Journal of Sport Nutrition and Exercise Metabolism | Year: 2016

Athletes competing in individual sports such as judo are categorized by weight. Before competitions, weight cutting is common. This cross-sectional study was designed to characterize and determine the prevalence of rapid weight loss (RWL) among adolescent judo competitors. Male athletes aged 12- to 17-years old (N = 108) were recruited from local judo teams. Each participant completed a validated questionnaire regarding RWL practices. Anthropometric measurements were also performed. Average age was 14.6 ± 1.6 years and all participants were of normal body mass index (BMI). RWL was practiced by 80% of the athletes before competition, beginning at an average age of 12.5 ± 2.2 years with the highest prevalence (∼94%) in the oldest group ofjudoka (16-17.9 years). Precompetition weight loss duration was 8 ± 5.4 days, with an average weight reduction of 1.5 ± 1.1 kg. The number of weight loss efforts per athlete in the past season was 2.8 ± 2.2. RWL was achieved by increased physical activity (82.6%), skipped meals (56.3%), or fasting at least once (47%). Two-thirds of the athletes indicated that their coaches were the most influential figure in their decision to lose weight before competition. RWL is highly prevalent in adolescent judo competitors. The methods used by these athletes can potentially lead to significant health risks including compromised nutritional status, diminished physical performance and impaired growth and development. It is of great importance to insure that those who guide young adults in weight loss for competitive sports have the knowledge and understanding to make safe recommendations and appropriate decisions regarding achieving specific weight goals. © 2016 Human Kinetics, Inc.


Nemet D.,Child Health and Sports Center | Oren S.,Child Health and Sports Center | Pantanowitz M.,Child Health and Sports Center | Eliakim A.,Child Health and Sports Center
Hormone Research in Paediatrics | Year: 2013

Background/Aims: To examine the effects of a 3-month multidisciplinary intervention on anthropometric measures, physical activity patterns and fitness, inflammatory cytokines, adipocytokines, and growth mediators in obese children. Methods: 21 obese subjects completed the 3-month intervention and were compared with 20 age-, gender- and maturity-matched controls. Subjects underwent anthropometric measurements (weight, height, BMI percentile and waist circumference), blood tests (IL-6, CRP, leptin, adiponectin, insulin, IGF-I and glucose), a progressive treadmill exercise test to evaluate fitness, and habitual activity assessment before and after the intervention. Results: The intervention led to a significant change of differences in body weight (-1.3 ± 4.1 vs. 2.5 ± 3.3 kg), BMI percentile (-0.96 ± 1.29 vs. 0.19 ± 0.8), waist circumference (-2.1 ± 2.7 vs. 2.9 ± 3.0 cm) and running time (149.9 ± 86.3 vs. -8.2 ± 88.0 s) in the intervention compared to control. There was a significant increase in leisure-time physical activity (Godin questionnaire, 29.04 ± 6.8 vs. -1.3 ± 9.2) and a decrease in sedentary activity (-1.4 ± 0.73 vs. 0.02 ± 0.62 h/day) in the intervention compared to control. Significant change differences in adiponectin (2,308 ± 1,640 vs. -801 ± 465 ng/ml), IGF-I (33.8 ± 37.8 vs. -1.0 ± 36.2 ng/ml), CRP (-0.06 ± 0.29 vs. 0.5 ± 0.86 mg/dl) and HOMA-IR (-0.15 ± 0.57 vs. 0.55 ± 0.84) were found in the intervention group compared to control. Conclusions: Our results highlight the short-term beneficial effects of a childhood obesity multidisciplinary intervention on anthropometrics, habitual activity, fitness, inflammatory and metabolic measures. The longer-term effects of these changes on obesity-associated metabolic risks are yet to be determined. © 2013 S. Karger AG, Basel.


Nemet D.,Meir Medical Center | Levi L.,Child Health and Sports Center | Pantanowitz M.,Child Health and Sports Center | Eliakim A.,Child Health and Sports Center
Journal of Pediatric Endocrinology and Metabolism | Year: 2014

We assessed the effect of a weight management program on body weight, body mass index (BMI), BMI percentile, and fitness in obese children and adolescents. The study was designed as a longitudinal, non- randomized, clinical experience of 3, 6, and 12 months combined dietary- behavioral-exercise intervention. Seven hundred and forty-nine obese children (age, 6-16 years) participated in a 3 months program. Three hundred and fifty-nine of them completed a 6 months intervention and 147 completed a 1 year intervention. Sixty-seven age- and maturity- matched obese children who did not participate in the structured program served as controls. Body weight, BMI, and fitness were evaluated at baseline, and after 3, 6, and 12 months intervention. Body weight, BMI, and BMI percentiles were significantly reduced (p < 0.05) and endurance time significantly increased (p < 0.0005) following the 3 months intervention. Obese children who continued the program for 6 months maintained decreases in BMI percentiles and further improved endurance time. In contrast, obese children in the control group gained weight, increased their BMI, and had a less significant improvement in fitness. Parental obesity (both parents), degree of obesity (BMI > 97%), and more than one prior weight loss attempt were associated with lower decreases, whereas sex and pubertal status had no influence, on BMI percentiles changes. Children without parental overweight had significantly greater decreases in BMI compared with children with both parents showing obesity. In summary, a combined, structured multidisciplinary intervention for childhood obesity led to decreased body weight, BMI, and BMI percentiles, and to improved fitness.


PubMed | Israel; IDF Medical Corporation, Israel Defense Forces, Israeli Defense Forces Medical Corporation and Child Health and Sports Center
Type: Journal Article | Journal: Military medicine | Year: 2015

Submariners are known to have decreased bone mass following periods of long submersion. We examined whether this produces a higher predilection to fractures.This is a retrospective cohort study. Data were collected from the computerized medical records of 457 consecutive submariners (serving 1091.42 man-years). The control group included 3,219 consecutive sailors, (serving 5845.04 man-years). Groups were stratified according to age at induction, body mass index, place of birth, and status of service (i.e., compulsory versus professional). Analysis of fracture incidence and comparison of proportions between the groups was conducted using (2) tests and Fishers exact test. The hazard ratio for fractures was performed using a survival analysis regression model for each group (Cox Proportional Hazard Model).Nineteen submariners (4.2%) and 94 sailors (2.9%) were shown to have fractures during their service (RR = 1.42, p = 0.15). A Cox proportional hazard model was employed. No statistically significant difference was found between the 2 groups (HR = 1.037, p = 0.89). No correlation was found between length of service and risk of fracture. Most fractures suffered by submariners occurred outside their work environment.Submariners are repeatedly exposed to prolonged submersions that are deleterious to bone strength. However, no statistically significant difference in the incidence of fractures was found between submariners and surface sailors. This is an important finding for the bone and occupational health of submariners in general.

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