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Tingskull S.,Child and Adolescent Psychiatry Clinic | Svedin C.G.,Linkoping University | Agnafors S.,Linkoping University | Sydsjo G.,Linkoping University | And 2 more authors.
Child Abuse Review

The purpose of this study was to investigate the agreement between parent and child report of potential traumas experienced, to look at the agreement by interpersonal versus non-interpersonal traumas and by gender. A birth cohort of 1723 children and their parents was followed from three months until 12 years after birth (South East Sweden Birth Cohort (SESBiC) study). At 12-year follow-up, 1174 children, 875 mothers and 601 fathers completed the Life Incidence of Traumatic Events (LITE) questionnaire. Cohen's kappa was used to assess the agreement between parent and child reports of traumas experienced by the child. The group was split by gender and kappa statistics were computed to determine the level of agreement between the different informants. The sample was also analysed according to the nature of the traumatic event: interpersonal or non-interpersonal. Agreement was low across most types of traumas reported between parents and children and moderate between mothers and fathers. Agreement was lower when the trauma was interpersonal. No significant discrepancies in general were found on gender. The study highlights the importance of from whom the researcher collects information. In future research, it is important to study the significance the choice of information source might have on reported symptoms and behavioural problems. © 2013 John Wiley & Sons, Ltd. Source

van Balkom I.D.C.,Child and Adolescent Psychiatry Clinic | van Balkom I.D.C.,Lentis Psychiatric Institute | van Balkom I.D.C.,University of Groningen | Bresnahan M.,Columbia University | And 8 more authors.

Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west. Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (≤29, 30-39, 40-49, ≥50y). The analysis was made, using conditional logistic regression. Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (≤29y), risk of autism increased 2.18 times for children born from fathers in their thirties, 2.71 times for fathers in their forties, and 3.22 thereafter. Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age. © 2012 van Balkom et al. Source

Sahin S.,Child and Adolescent Psychiatry Clinic | Sahin S.,Ondokuz Mayis University | Yuce M.,Ondokuz Mayis University | Alacam H.,Ondokuz Mayis University | And 3 more authors.
International Journal of Psychiatry in Clinical Practice

Objectives. We aimed to explore whether the use of methylphenidate relates leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor (BDNF). In addition, the relationship between methylphenidate-related weight loss in attention deficit hyperactivity disorder (ADHD) patients and these biomolecules were evaluated.Methods. Thirty ADHD patients receiving methylphenidate and 20 healthy controls were included. Leptin, ghrelin, adiponectin, and BDNF levels were measured at baseline and after two-month treatment in both groups.Results. At baseline, leptin, ghrelin, adiponectin, and BDNF levels were similar in the ADHD and control groups. The most common adverse events occurring in the ADHD group after a 2-month treatment period included loss of appetite (70%) and weight loss (66.7%). A significant difference was found in body weight, BMI, and CGI scores of the ADHD patients after the treatment. While post-treatment ghrelin and adiponectin levels were significantly higher in the ADHD group, BDNF level was significantly lower. Post-treatment decrease in leptin levels was not significant.Conclusions. Leptin and BDNF were not associated with poor appetite and/or weight loss due to methylphenidate treatment. However, ghrelin and adiponectin might be biomolecules that play a role in underlying neurobiological mechanisms of methylphenidate-related appetite or weight loss. © 2014 Informa Healthcare. Source

Tanidir C.,Child and Adolescent Psychiatry Clinic | Tanidir I.C.,Thoracic and Cardiovascular Surgery Center and Research Hospital | Tuzcu V.,Istanbul University
Cardiology in the Young

Patients with cardiomyopathy have a higher incidence of mood and anxiety disorders, resulting in greater probability for hospitalisation and increased risk for arrhythmia and death. We report a case of a 16-year-old boy with Danon disease, Wolff-Parkinson-White syndrome, and hypertrophic cardiomyopathy, who later developed depression and significant weight loss. The patient was successfully treated for his anxiety and depression with mirtazapine without any adverse cardiac effects. © 2015 Cambridge University Press. Source

Risperidone treatment in preschool children with disruptive behavior disorders: a chart review study Objective: To gather data about the efficacy and safety of risperidone in normally developing preschool children with disruptive behavior disorders (DBDs). Methods: This is a retrospective chart review study of preschool aged children who were referred to a university hospital or a private child psychiatry clinic and treated with risperidone for the presence of DBDs. Charts of the subjects were reviewed for psychiatric characteristics of the subjects as well as the efficacy and safety of risperidone. Symptom severity and improvement were assessed with Clinical Global Impression- Severity (CGI-S) and Improvement (CGI-I) scales. Results: The subjects were 21 boys (84%) and 4 girls (16%) with an age range of 26-64 months (45.79±11). The duration of risperidone treatment ranged from 2-60 weeks (18.87±15.19). Risperidone dosage ranged from 0.25-1 mg/ day (0.52±0.22 mg). Baseline and end point CGI-S scores ranged from 6-7 (6.56±0.5) and 2-7 (3.96±1.3), respectively. A nonparametric Wilcoxon t-test revealed significant differences between baseline and end point CGI-S scores (p>0.001). The majority of the subjects (n=18; 72%) showed much to very much improvement in target disruptive behavior symptoms. Overall five subjects (20%) did not report any side effects. The most frequently reported side effects were sedation, increased appetite, weight gain, enuresis, headache, dermatological reactions, and fatigue. Four subjects discontinued the medication due to side effects. Side effects were generally transient and mild to moderate in severity and no life threatening side effects were reported.Conclusions: Psychosocial interventions should be the first-line of treatment in preschool children with DBDs. Psychopharmacological treatment may be considered in severely impaired subjects with careful monitoring. Risperidone may generally be a safe and effective option in treating DBDs in preschool children; however, relatively high rates of side effects should suggest caution in the use of this drug. Further systematically designed studies are needed on this topic. Source

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