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Chigasaki, Japan

Tamaki N.,Chigasaki City Hospital | Enomoto H.,Chigasaki City Hospital | Hayama M.,Chigasaki City Hospital | Yoshitomi A.,Chigasaki City Hospital | And 2 more authors.
Practica Oto-Rhino-Laryngologica | Year: 2013

Objectives: To assess the efficacy of myringotomy for mild or severe acute otitis media cases conducted in our department and examine search backgrounds of these cases. Methods: We studied 72 cases (117 ears) in which we carried out a myringotomy. Results: The following results were obtained. 1. The frequency of detection of PISP in this study was greater than that in a 2007 National surveillance. 2. The treatment of mild acute otitis media cases with high dose AMPC, high dose CFPN-PI or AMPC/CVA (14: 1) was effective. As a result, the cases of myringotomy in our department decreased from 44 cases in 2010 to 14 cases in 2011. 3. The efficacy rate 3 weeks after myringotomy was 91. 7%, which is higher than that of other reports. On the other hand, the recurrence rate was 40. 3%, which required treatments. Source

Murai T.,International Goodwill Hospital | Osada Y.,International Goodwill Hospital | Kawai M.,International Goodwill Hospital | Kasuga J.,Chigasaki City Hospital | And 4 more authors.
Acta Urologica Japonica | Year: 2014

We performed additional administration of dutasteride in patients who did not respond sufficiently to α1-adrenoceptor antagonist treatment for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) (LUTS/BPH). Among 76 registered patients, efficacy was analyzed in 58 patients. International Prostate Symptom Score (IPSS), subscores for voiding and storage symptoms and quality of life (QQL) on the IPSS, and Overactive Bladder Symptom Score (OABSS) were all significantly improved from the third month of administration compared to the time of initiating additional administration of dutasteride. Additional administration of dutasteride also significantly reduced prostate volume, and residual urine with the exception of the sixth month after administration. Age at initiation of administration and voiding symptom subscore on the IPSS were clinical factors affecting the therapeutic effects of dutasteride. The rate of improvement with treatment decreased with increasing age at initiation of dutasteride administration, and increased as voiding symptom subscore on the IPSS increased. Therefore, additional administration of dutasteride appears useful for cases of LUTS/BPH in which a sufficient response is not achieved with α1 adrenoceptor antagonist treatment. Because patients who have severe voiding symptoms or begin dutasteride at an early age may be expected to respond particularly well to dutasteride in terms of clinical efficacy, they were considered to be suitable targets for additional administration. Source

Uemura H.,Yokohama City University | Yanagisawa M.,Yokohama Minami Kyousai Hospital | Ikeda I.,Yokohama Minami Kyousai Hospital | Fujinami K.,Chigasaki City Hospital | And 4 more authors.
International Journal of Clinical Oncology | Year: 2013

Background: To ascertain the anti-tumor effect of zoledronic acid (ZOL) treatment on clinical outcomes in patients with bone metastatic prostate cancer, we examined the effect of ZOL started simultaneously with hormonal therapy as initial treatment in these patients. Methods: Forty-seven patients with bone-metastatic prostate cancer who received a luteinizing hormone releasing-hormone (LHRH) analogue and an anti-androgen [maximal androgen blockade (MAB)] were assigned to receive ZOL (4 mg intravenous administration every month for 2 years). The time to progression (TTP) of the prostate-specific antigen (PSA), the overall survival (OS), and the rate of PSA decrease in patients with MAB and ZOL treatment (ZOL group) were compared with these parameters in patients who received only MAB at one institute as a control group (non-ZOL group). Results: Although the nadir PSA level and the rate of PSA normalization showed no significant differences between the ZOL and non-ZOL groups, the time to nadir PSA in the ZOL group was significantly shorter than that in the non-ZOL group (P < 0.05, Mann-Whitney U-test). There was a significant difference in TTP (P = 0.017, log-rank test) between the ZOL and non-ZOL groups, and statistically significant differences in TTP and OS between the ZOL and non-ZOL groups (P = 0.044 and 0.035, log-rank test) were recognized particularly in patients with advanced disease (extension of disease, grade 3 and 4). Conclusions: Simultaneous administration of ZOL and MAB as initial treatment delayed TTP in bone-metastatic prostate cancer patients. Initial treatment with ZOL has the possibility of anti-tumor activity to delay disease progression. © 2012 Japan Society of Clinical Oncology. Source

Hirasawa T.,Chigasaki City Hospital | Umemoto S.,Chigasaki City Hospital | Fujinami K.,Chigasaki City Hospital | Senga Y.,Chigasaki City Hospital | Gotou A.,Gotou Clinic
Acta Urologica Japonica | Year: 2012

Inverted papilloma of the bladder is an uncommon urothelial neoplasm. Although it is traditionally regarded as a benign tumor, there are conflicting data on multiplicity, reccurence rate, and association with urothelial carcinoma. From 2005 to 2011, 14 cases of inverted papilloma of the bladder were diagnosed at our hospital. Clinical features of 14 cases were summarized. These patients ranged in age from 25 to 81 years (mean, 61 years). The most frequently occurring symptom was gross hematuria. Eleven bladder tumors arose from the trigone or near the bladder neck. One case was associated with urothelial carcinoma. One was suspected to be a case of tumor recurrence. All other patients were free of tumor recurrence during the mean follow-up of 16.4 months (range, 0-75 months). This study does not suggest the malignant potential of inverted papilloma. However, since inverted papilloma may correlate with urothelial carcinoma. Post-treatment follow up for inverted papilloma should include cystoscopic follow up. Source

Sakane S.,Chigasaki City Hospital | Enomoto H.,Chigasaki City Hospital | Tamaki N.,Yokohama City University | Oridate N.,Yokohama City University
Practica Oto-Rhino-Laryngologica | Year: 2014

We experienced four cases of laryngeal paralysis associated with due to reactivation of the varicella-zoster virus (VZV). In all cases, the titers of the EIA antibody (IgG) were markedly increased. All patients were treated with an anti-viral agent and steroid. After treatment, there were no residual signs of the disease in all cases. In cases of unilateral cranial nerve palsy in which vesicles are either present or absent, herpes zoster should be considered and early treatment with anti-viral agent and steroid should be performed. Source

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