Chiba UniversityChiba

Chiba, Japan

Chiba UniversityChiba

Chiba, Japan

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This study investigated the opinions of Japanese High School teachers in terms of their perceived students’ competency regarding media information literacy (MIL) for the social network services (SNS). The valid criteria used to evaluate competencies were recently advocated by UNESCO, and 25 performance criteria items in three competence categories were selected for the questionnaire method. In particular, “participation” competence of the middle-level of competencies was designed to compare and weight its performance criteria items, and paired-comparison and the geometric mean method were used to calculate importance. As result, students’ “communication” competence was evaluated as a rather active situation and “monitoring” competence was evaluated as a rather inactive situation. In addition, counter “risk” ability was recognized as the most important item in “participation” competence. Through discussion, the author revealed the necessity to develop greater competence regarding risk and safety to use SNS. © 2017 American Scientific Publishers All rights reserved.


Jinno S.,Meiji Co. | Toshimitsu T.,Meiji Co. | Nakamura Y.,Meiji Co. | Kubota T.,Chiba UniversityChiba | And 10 more authors.
Nutrients | Year: 2017

Fructooligosaccharides (FOS) can selectively stimulate the growth of bifidobacteria. Here, we investigated the effect of maternal FOS ingestion on maternal and neonatal gut bifidobacteria. In a randomized, double-blind, placebo-controlled study, we administered 8 g/day of FOS or sucrose to 84 women from the 26th week of gestation to one month after delivery. The bifidobacteria count was detected using quantitative PCR in maternal (26 and 36 weeks of gestation) and neonatal (one month after delivery) stools. Maternal stool frequency was recorded from 24 to 36 weeks of gestation. The number of fecal Bifidobacterium spp. and Bifidobacterium longum in the FOS group was significantly higher than that in the placebo group at 36 weeks of gestation (2.7 × 1010/g vs. 1.1 × 1010/g and 2.3 × 1010/g vs. 9.7 × 109/g). In their neonates, these numbers did not differ between the groups. Also, stool frequency in the FOS group was slightly higher than that in the placebo group two weeks after the intervention (1.0 vs. 0.8 times/day), suggesting a potential constipation alleviation effect. In conclusion, the maternal FOS ingestion showed a bifidogenic effect in pregnant women but not in their neonates. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.


Ebisawa M.,National Hospital Organization | Ito K.,Aichi Childrens Health and Medical CenterAichi | Aihara Y.,Aihara Allergy and Pediatric ClinicKanagawa | Ito S.,Doshisha Women's College of Liberal Arts | And 24 more authors.
Allergology International | Year: 2014

A food allergy is defined as “a phenomenon in which adverse reactions are caused through antigen-specific immunological mechanisms after exposure to given food.” Various symptoms of food allergy occur in many organs. Food allergies are classified roughly into 4 clinical types: (1) neonatal and infantile gastrointestinal allergy, (2) infantile atopic dermatitis associated with food allergy, (3) immediate-type food allergy (urticaria, anaphylaxis, etc.), and (4) food dependent exercise-induced anaphylaxis and oral allergy syndrome (i.e., specific forms of immediate food allergy). The therapy for food allergies includes treatment of and prophylactic measures against hypersensitivity such as anaphylaxis. A fundamental prophylactic measure is the elimination diet. However, elimination diets should be used only if necessary because of the patient-related burden. For this purpose, it is very important that causative foods be accurately identified. There are a number of means available to identify causative foods, including the history taking, a skin prick test, detection of antigen-specific IgE antibodies in the blood, the basophil histamine release test, the elimination diet test, and the oral challenge test, etc. Of these, the oral challenge test is the most reliable. However, it should be conducted under the supervision of experienced physicians because it may cause adverse reactions, such as anaphylaxis. © 2014 Japanese Society of Allergology.


Inagaki F.,Japan Agency for Marine - Earth Science and Technology | Hinrichs K.-U.,University of Bremen | Kubo Y.,Japan Agency for Marine - Earth Science and Technology | Bowles M.W.,University of Bremen | And 50 more authors.
Science | Year: 2015

Microbial life inhabits deeply buried marine sediments, but the extent of this vast ecosystem remains poorly constrained. Here we provide evidence for the existence of microbial communities in ∼40° to 60°C sediment associated with lignite coal beds at ∼1.5 to 2.5 km below the seafloor in the Pacific Ocean off Japan. Microbial methanogenesis was indicated by the isotopic compositions of methane and carbon dioxide, biomarkers, cultivation data, and gas compositions. Concentrations of indigenous microbial cells below 1.5 km ranged from <10 to ∼104 cells cm-3. Peak concentrations occurred in lignite layers, where communities differed markedly from shallower subseafloor communities and instead resembled organotrophic communities in forest soils. This suggests that terrigenous sediments retain indigenous community members tens of millions of years after burial in the seabed.


Oide T.,Tokyo Women's Medical University | Oide T.,Chiba UniversityChiba | Yasufuku K.,Chiba UniversityChiba | Shibuya K.,Chiba UniversityChiba | And 4 more authors.
Respiratory Medicine Case Reports | Year: 2016

We report a 38-year-old woman with a left lung tumor presenting as obstructive pneumonia. Bronchoscopic examination revealed a polypoid tumor filling the left main bronchus. The tumor was partially resected by a snaring procedure for diagnostic purposes. Microscopic examination revealed a submucosal tumor located underneath normal bronchial epithelium. The tumor was composed of sheets of uniform oval to cuboidal cells encompassing numerous blood vessels. Immunohistochemically, the tumor cells exhibited smooth muscle markers, but were negative for neuroendocrine markers. The diagnosis of primary pulmonary glomus tumor was therefore made. Subsequent bronchoscopic intervention allowed us to pin-point the origin of the tumor: superior segmental B6a/b. She underwent a left lower lobe superior segmental resection successfully. Glomus tumors are relatively rare soft tissue tumors, and those of bronchopulmonary origin are exceedingly rare clinical condition. Among primary lung tumors, the carcinoid tumor is a mimic of the glomus tumor, and differentiating these tumors is known to be difficult, especially using small biopsy samples. In the present case, a large tissue sample obtained by bronchoscopic snaring was quite useful for the correct preoperative diagnosis. Because of the disease rarity, malignancy grade estimation of visceral glomus tumors has not been clearly addressed. Recently, the histopathological diagnostic criteria for malignant glomus tumors was defined in the WHO classification of soft tissue and bone tumors 4th edition. Here we also reviewed the literature on primary bronchopulmonary glomus tumors with special attention to the current concept of malignancy grade estimation. © 2016 The Authors


Yamamoto T.,Kanagawa Dental University | Fuchida S.,Kanagawa Dental University | Aida J.,Tohoku University | Kondo K.,Chiba UniversityChiba | And 2 more authors.
Tohoku Journal of Experimental Medicine | Year: 2015

Health Japan 21 plan establishes specific targets for aspects of health including oral health for 2010, in an effort to increase health expectancy. Despite this, there has been insufficient improvement in oral health status in adults. The objective of this cross-sectional study was to determine the factors associated with effective oral health programs for adults in Japanese municipalities. Questionnaires were mailed to all 1,472 municipalities in Japan and responses were obtained from 862 municipalities (response rate: 58.6%). After excluding 71 municipalities with “unknown” answer, no answer, or lack of relevant information, we analyzed the data from the remaining 791 municipalities with or without oral health programs for adults selfreported as effective within three years. Multilevel Poisson regression models were used to examine the associations of effective programs with oral health personnel, contact with related agencies, the establishment of Health Japan 21 goals, financial status, the density of dentists and population density at the municipality level, and having oral health personnel at the prefecture level. Three hundred and fifty-four municipalities reported having effective programs. In the fully adjusted model, having dental hygienists in the municipal office (P < 0.05) and a high number of contacts with related agencies (P < 0.05) were significantly associated with having effective programs. These results suggest that having dental hygienists and contact with related agencies such as residents, local dental associations, companies, community general support centers, or medical, nursing or welfare facilities are promoting factors for effective adult oral health programs in Japanese municipalities. © 2015 Tohoku University Medical Press.


Nose D.,Chiba UniversityChiba | Dote K.,Chiba UniversityChiba | Sato T.,Chiba UniversityChiba | Yamamoto M.,Chiba UniversityChiba | And 2 more authors.
Journal of Physical Chemistry C | Year: 2015

We investigated the charge transport characteristics of alkanemonothiol (CnH2n+1SH, n = number of carbons) molecular junctions by means of transition voltage spectroscopy (TVS) based on the observations of the interface electronic structures. The minimum in the Fowler-Nordheim plot was observed at the average positive and negative sample biases of +1.23 and -1.44 V. These voltages (Vmin) were insensitive to the molecular length. The low-energy ultraviolet photoelectron spectroscopy (LE-UPS) measurements revealed the presence of an Au-S bond at a binding energy of 1.4 eV with reference to the Fermi level of the Au substrates. The binding energy of the interface electronic state was independent of the molecular length. The TVS results were analyzed based on the LE-UPS results, including the differences in the measurement conditions. The results were consistently explained by the Au-S bond being responsible for Vmin at the negative bias. In addition, another interface state was suggested to be responsible for Vmin at the positive bias. The effects of the interface electronic structures besides the apparent barrier height should be considered to understand TVS of molecular junctions with wide energy gap molecules. (Graph Presented). © 2015 American Chemical Society.


Takai T.,Task Force for House Dust Mite Allergen Standardization | Takai T.,Juntendo University | Okamoto Y.,Task Force for House Dust Mite Allergen Standardization | Okamoto Y.,Chiba UniversityChiba | And 13 more authors.
Allergology International | Year: 2015

Abstract Background In the 1990s, the Japanese Society of Allergology (JSA) standardized Japanese cedar pollen allergen vaccines. In the present study, the task force for house dust mite (HDM) allergen standardization of the Committee for Allergens and Immunotherapy of JSA reports the standardization of HDM allergen vaccines in Japan. Methods In vivo allergenic potency was determined by intradermal testing of 51 Japanese adults with positive serum specific IgE to HDM allergens. In vitro total IgE binding potency was analyzed by competition ELISA using a pooled serum, with sera obtained from 10 allergic patients. The amounts of HDM group 1 (Der 1) and group 2 major allergens in eight HDM allergen extracts were measured by sandwich ELISAs. Correlation between the in vitro total IgE binding potency and major allergen levels was analyzed. Results We selected a JSA reference HDM extract and determined its in vivo allergenic potency. The in vitro total IgE binding potency significantly correlated with Der 1 content, group 2 allergen content, and their combined amount, indicating that measurement of major allergen contents can be used as a surrogate in vitro assay. Conclusions The task force determined the in vivo allergenic potency (100,000 JAU/ml) and Der 1 content (38.5 μg/ml) of the JSA reference HDM extract, selected the measurement of Der 1 content as the surrogate in vitro assay, and decided that manufacturers can label a HDM allergen extract as having a titer of 100,000 JAU/ml if it contains 22.2-66.7 μg/ml of Der 1. © 2015 Japanese Society of Allergology.


Aoki T.,Chiba UniversityChiba | Aoki T.,Saitama Childrens Medical CenterSaitama | Hino M.,Chiba UniversityChiba | Koh K.,Saitama Childrens Medical CenterSaitama | And 8 more authors.
Pediatric Blood and Cancer | Year: 2016

Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8+ T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD-L1 expression and germinoma contained abundant tumor-infiltrating CD8+ T cells and PD-L1-positive macrophages. The PD-1/PD-L1 pathway tended to be inactive in pediatric cancers. © 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.

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