Yoshida M.,Chiba UniversityChiba
Advanced Science Letters | Year: 2017
This study investigated the opinions of Japanese High School teachers in terms of their perceived students’ competency regarding media information literacy (MIL) for the social network services (SNS). The valid criteria used to evaluate competencies were recently advocated by UNESCO, and 25 performance criteria items in three competence categories were selected for the questionnaire method. In particular, “participation” competence of the middle-level of competencies was designed to compare and weight its performance criteria items, and paired-comparison and the geometric mean method were used to calculate importance. As result, students’ “communication” competence was evaluated as a rather active situation and “monitoring” competence was evaluated as a rather inactive situation. In addition, counter “risk” ability was recognized as the most important item in “participation” competence. Through discussion, the author revealed the necessity to develop greater competence regarding risk and safety to use SNS. © 2017 American Scientific Publishers All rights reserved.
Tanabe K.,Chiba UniversityChiba |
Itoh M.,Chiba UniversityChiba |
Tonoki A.,Chiba UniversityChiba
Cell Reports | Year: 2017
Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment. © 2017 The Author(s)
Sasada S.,Sagami Women's University |
Endoh T.,Uekusa Gakuen UniversityChiba |
Ishii T.,Chiba UniversityChiba |
Komiyama T.,Chiba UniversityChiba
Neuroscience Letters | Year: 2017
Sprint motor performance, such as in short-distance running or cycling, gradually decreases after reaching a maximum speed or cadence. This may be attributed to the central nervous system. Brain stimulation studies have recently revealed the plastic nature of the human brain and spinal cord, but it is unclear how direct current stimulation (DCS) affects sprint motor performance. To address this issue, we investigated DCS's effect on healthy volunteers’ sprint cycling performance. DCS was applied to the lumbar spinal cord (3 mA) or the leg area of the motor cortex (2 mA) for 15 min with 3 different polarities: anodal, cathodal, and sham. After DCS, the subjects performed maximal-effort sprint cycling for 30 s under a constant load. Pooled mean power during the 30 s was significantly greater after cathodal transcutaneous spinal DCS to the lumbar spinal cord (tsDCS) than anodal or sham tsDCS. The improvement with cathodal stimulation was notable both 0–5 and 20–25 s after the performance onset. There were no significant inter-conditional differences in peak power. Pooled mean power was significantly greater after anodal transcranial DCS to the motor cortex (tDCS) than after cathodal tDCS, although mean powers of anodal and sham tDCS were not significantly different. The increase in mean power after cathodal tsDCS could result from a reduction in central fatigue. This stimulus method might improve sprint performance. © 2017 Elsevier B.V.
Kanokkarn P.,Chulalongkorn University |
Shiina T.,Chiba UniversityChiba |
Santikunaporn M.,Thammasat UniversityPathumthani |
Chavadej S.,Chulalongkorn University
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2017
The main objectives of this study were to investigate the effects of molecular structure of surfactant on surface properties and foam characteristics and to correlate surface tension to foam properties. Two series of methyl ester sulfonate with different alkyl chain lengths (MESx, x = 14, 16, and 18) and polyoxyethylated dodecyl alcohol with different head group sizes (C12EOn, n = 3, 5, 7, and 9) were measured for equilibrium and dynamic surface tension as well as foamability and foam stability. The equilibrium experimental data were well fitted with the Langmuir adsorption isotherm. The dynamic surface tension data were used to calculate diffusivity values of all studied surfactants by using Word-Tordai equation. The longer the alkyl group of MESx, the lower the diffusivity value. The larger the EO head group size, higher the diffusivity. For both studied surfactant groups, the higher the maximum rate of surface tension reduction, the higher the diffusivity and foaming properties in terms of foamability and foam stability. © 2017 Elsevier B.V.
Ebisawa M.,National Hospital Organization |
Ito K.,Aichi Childrens Health and Medical CenterAichi |
Aihara Y.,Aihara Allergy and Pediatric ClinicKanagawa |
Ito S.,Doshisha Women's College of Liberal Arts |
And 24 more authors.
Allergology International | Year: 2014
A food allergy is defined as “a phenomenon in which adverse reactions are caused through antigen-specific immunological mechanisms after exposure to given food.” Various symptoms of food allergy occur in many organs. Food allergies are classified roughly into 4 clinical types: (1) neonatal and infantile gastrointestinal allergy, (2) infantile atopic dermatitis associated with food allergy, (3) immediate-type food allergy (urticaria, anaphylaxis, etc.), and (4) food dependent exercise-induced anaphylaxis and oral allergy syndrome (i.e., specific forms of immediate food allergy). The therapy for food allergies includes treatment of and prophylactic measures against hypersensitivity such as anaphylaxis. A fundamental prophylactic measure is the elimination diet. However, elimination diets should be used only if necessary because of the patient-related burden. For this purpose, it is very important that causative foods be accurately identified. There are a number of means available to identify causative foods, including the history taking, a skin prick test, detection of antigen-specific IgE antibodies in the blood, the basophil histamine release test, the elimination diet test, and the oral challenge test, etc. Of these, the oral challenge test is the most reliable. However, it should be conducted under the supervision of experienced physicians because it may cause adverse reactions, such as anaphylaxis. © 2014 Japanese Society of Allergology.
Inagaki F.,Japan Agency for Marine - Earth Science and Technology |
Hinrichs K.-U.,University of Bremen |
Kubo Y.,Japan Agency for Marine - Earth Science and Technology |
Bowles M.W.,University of Bremen |
And 50 more authors.
Science | Year: 2015
Microbial life inhabits deeply buried marine sediments, but the extent of this vast ecosystem remains poorly constrained. Here we provide evidence for the existence of microbial communities in ∼40° to 60°C sediment associated with lignite coal beds at ∼1.5 to 2.5 km below the seafloor in the Pacific Ocean off Japan. Microbial methanogenesis was indicated by the isotopic compositions of methane and carbon dioxide, biomarkers, cultivation data, and gas compositions. Concentrations of indigenous microbial cells below 1.5 km ranged from <10 to ∼104 cells cm-3. Peak concentrations occurred in lignite layers, where communities differed markedly from shallower subseafloor communities and instead resembled organotrophic communities in forest soils. This suggests that terrigenous sediments retain indigenous community members tens of millions of years after burial in the seabed.
Yamamoto T.,Kanagawa Dental University |
Fuchida S.,Kanagawa Dental University |
Aida J.,Tohoku University |
Kondo K.,Chiba UniversityChiba |
And 2 more authors.
Tohoku Journal of Experimental Medicine | Year: 2015
Health Japan 21 plan establishes specific targets for aspects of health including oral health for 2010, in an effort to increase health expectancy. Despite this, there has been insufficient improvement in oral health status in adults. The objective of this cross-sectional study was to determine the factors associated with effective oral health programs for adults in Japanese municipalities. Questionnaires were mailed to all 1,472 municipalities in Japan and responses were obtained from 862 municipalities (response rate: 58.6%). After excluding 71 municipalities with “unknown” answer, no answer, or lack of relevant information, we analyzed the data from the remaining 791 municipalities with or without oral health programs for adults selfreported as effective within three years. Multilevel Poisson regression models were used to examine the associations of effective programs with oral health personnel, contact with related agencies, the establishment of Health Japan 21 goals, financial status, the density of dentists and population density at the municipality level, and having oral health personnel at the prefecture level. Three hundred and fifty-four municipalities reported having effective programs. In the fully adjusted model, having dental hygienists in the municipal office (P < 0.05) and a high number of contacts with related agencies (P < 0.05) were significantly associated with having effective programs. These results suggest that having dental hygienists and contact with related agencies such as residents, local dental associations, companies, community general support centers, or medical, nursing or welfare facilities are promoting factors for effective adult oral health programs in Japanese municipalities. © 2015 Tohoku University Medical Press.
Nose D.,Chiba UniversityChiba |
Dote K.,Chiba UniversityChiba |
Sato T.,Chiba UniversityChiba |
Yamamoto M.,Chiba UniversityChiba |
And 2 more authors.
Journal of Physical Chemistry C | Year: 2015
We investigated the charge transport characteristics of alkanemonothiol (CnH2n+1SH, n = number of carbons) molecular junctions by means of transition voltage spectroscopy (TVS) based on the observations of the interface electronic structures. The minimum in the Fowler-Nordheim plot was observed at the average positive and negative sample biases of +1.23 and -1.44 V. These voltages (Vmin) were insensitive to the molecular length. The low-energy ultraviolet photoelectron spectroscopy (LE-UPS) measurements revealed the presence of an Au-S bond at a binding energy of 1.4 eV with reference to the Fermi level of the Au substrates. The binding energy of the interface electronic state was independent of the molecular length. The TVS results were analyzed based on the LE-UPS results, including the differences in the measurement conditions. The results were consistently explained by the Au-S bond being responsible for Vmin at the negative bias. In addition, another interface state was suggested to be responsible for Vmin at the positive bias. The effects of the interface electronic structures besides the apparent barrier height should be considered to understand TVS of molecular junctions with wide energy gap molecules. (Graph Presented). © 2015 American Chemical Society.
Takai T.,Task Force for House Dust Mite Allergen Standardization |
Takai T.,Juntendo University |
Okamoto Y.,Task Force for House Dust Mite Allergen Standardization |
Okamoto Y.,Chiba UniversityChiba |
And 13 more authors.
Allergology International | Year: 2015
Abstract Background In the 1990s, the Japanese Society of Allergology (JSA) standardized Japanese cedar pollen allergen vaccines. In the present study, the task force for house dust mite (HDM) allergen standardization of the Committee for Allergens and Immunotherapy of JSA reports the standardization of HDM allergen vaccines in Japan. Methods In vivo allergenic potency was determined by intradermal testing of 51 Japanese adults with positive serum specific IgE to HDM allergens. In vitro total IgE binding potency was analyzed by competition ELISA using a pooled serum, with sera obtained from 10 allergic patients. The amounts of HDM group 1 (Der 1) and group 2 major allergens in eight HDM allergen extracts were measured by sandwich ELISAs. Correlation between the in vitro total IgE binding potency and major allergen levels was analyzed. Results We selected a JSA reference HDM extract and determined its in vivo allergenic potency. The in vitro total IgE binding potency significantly correlated with Der 1 content, group 2 allergen content, and their combined amount, indicating that measurement of major allergen contents can be used as a surrogate in vitro assay. Conclusions The task force determined the in vivo allergenic potency (100,000 JAU/ml) and Der 1 content (38.5 μg/ml) of the JSA reference HDM extract, selected the measurement of Der 1 content as the surrogate in vitro assay, and decided that manufacturers can label a HDM allergen extract as having a titer of 100,000 JAU/ml if it contains 22.2-66.7 μg/ml of Der 1. © 2015 Japanese Society of Allergology.