Chiba University and it is also abbreviated as Chibadai is a national university in the city of Chiba, Japan. It offers Doctoral degrees in education as part of a coalition with Tokyo Gakugei University, Saitama University, and Yokohama National University. The university was formed in 1949 from existing educational institutions in Chiba Prefecture, and absorbed over a period of years Chiba Medical University , a preparatory department of the Tokyo Medical and Dental University, Chiba Normal School , Tokyo Polytechnic High School , Chiba Horticultural High School, and others. Chiba University was reincorporated in 2010 under the National University Corporation Act. Chiba University has been ranked 75th on the Asia University Rankings 2013 Top 100 by "The Times Higher Education".Currently, Chiba University consists of nine faculties, the university library, the university hospital and other educational and research facilities. With 11,179 students in the undergraduate program, it has long been one of the largest universities in Japan. As for the graduate school, there are about 2,354 students in ten master's programs and 1,220 in nine doctoral programs.Chiba University is proud of its productive faculties and varied courses, the particulars of which will be introduced in the following sections. The University's four campuses, Nishi-Chiba, Inohana, Matsudo, and Kashiwanoha are ideally located in Chiba Prefecture, an area noted for its industrial, intellectual and international achievements. In recent decades Chiba has undergone rapid development which in many ways rivals the neighboring Tokyo Metropolis. Many national projects have been based in Chiba Prefecture, and now Chiba has one of the main international transport centers and one of the largest business centers in Japan . Many new academic and industrial complexes for the advanced science are located in Chiba Prefecture. The developments in Chiba today are representative of tomorrow's Japan. Matters occurring in the most progressive parts of Japan, or even in the world, will provide rich materials for research in various aspects of the human, social, industrial and natural science.Chiba University has achieved a high degree of participation in international cooperative research projects. Chiba University presently has a large body of international research scholars and students studying on its various campuses. As of 2009, there are approximately 477 international researcher and 957 international students. Starting October, 1996, Chiba University launched a one-year scholarship program designed to provide international students with the opportunity to take courses in English. Wikipedia.
Chiba University | Date: 2017-01-27
Methods of producing hepatocyte lineage cells are provided. The method can include transfecting a cell with one or more expression vectors. For example, a cell can be transfected with a first expression vector containing a first gene that encodes CCAAT/enhancer binding protein alpha (CEBPA), a second expression vector containing a second gene that encodes CCAAT/enhancer binding protein beta (CEBPB), a third expression vector containing a third gene that encodes forkhead box A1 (FOXA1), and a fourth expression vector containing a fourth gene that encodes forkhead box A3 (FOXA3). The method can include culturing the transfected cell obtained in a growth environment. The transfected cell can be cultured in Williams E medium, ReproFF (feeder-free media maintaining pluripotency) medium, or both. Transfected and/or hepatocyte lineage cells obtained by a method of the present invention are also provided.
LSI Corporation and Chiba University | Date: 2017-07-12
Provided are novel polymer particles for carrying a physiologically active substance and a method of preparing the same. The polymer particles for carrying a physiologically active substance can provide an analytical reagent, which has high analytical precision and sensitivity and can be stably prepared; can easily and precisely control the amount of functional groups carrying the physiologically active substance; can introduce, onto the surface of latex particles, a hydrophilic compound for inhibiting a nonspecific reaction; and can be prepared to have a narrow and uniform particle size distribution. The polymer particles for carrying a physiologically active substance are obtained by polymerizing a monomer, a radical polymerization initiator, and an emulsifier, and the emulsifier is an amphiphilic block polymer of the general formula (1):
Advanced Healthcare Co. and Chiba University | Date: 2017-01-25
This invention provides a simple projector system that can be operated by a user who is not an expert of image processing technology. The projector system comprises a projector (1), a personal computer (2), a mouse (3), and a calibration board (4). A checker flag pattern is added to the calibration board (4), and an intersection point serves as a marker. A cursor, which is projected from the projector (1) onto the calibration board (4), is used as an intuitive input interface. An operator, while seeing the cursor, operates the mouse (3), thereby placing the cursor onto the calibration marker. In this state, the operator clicks the mouse (3), thereby selecting the calibration marker. The operator then acquires the corresponding projection image coordinates on the basis of the selection instruction.
Chiba University | Date: 2016-11-16
A method for quantitatively evaluating chromatin structural changes using pixel imaging of the nucleus is provided. Pixel imaging of the nucleus can include capturing one or more images of a nucleus of one or more nucleic acid stain treated cells. The stain intensity can be measured by quantitating the intensity. The mean and/or standard deviation of stain intensity per pixel can be used to determine chromatin condensation levels or chromatin structural change.
Chiba University | Date: 2016-08-24
An object of the present invention is to provide a film which has high visibility in solid state and a product which has the film, with simple material composition. One aspect of the present invention is a film which comprises a core-shell particle which has a core and a shell which covers the core. Moreover, another aspect of the present invention is a product which is covered with the film. Further, another aspect of the present invention is a solution in which core-shell particles are dispersed. Hereby, the present invention is possible to realize a film which has high visibility in solid state and a product which has the film, with simple material composition.
Chiba University and Godo Shusei Co. | Date: 2017-06-07
A novel composition for decolorizing a dye is provided. A composition for decolorizing a dye contains a multi copper oxidase and an iodide ion.
Olympus Corporation and Chiba University | Date: 2016-10-28
Provided is an image processing apparatus including a transformation unit that is configured to deform images so that corresponding points in a plurality of images obtained from several viewpoints with respect to the same subject are matched; a separating unit that is configured to separate specular-reflection components from the plurality of images transformed by the transformation unit and create an image from which the specular-reflection component is removed; and an image reconstructing unit that is configured to combine at least one of the specular-reflection components of the plurality of images, separated by the separating unit, and the image from which the specular-reflection component is removed.
Chiba University and Surgical Alliance Inc. | Date: 2015-07-21
[Problem] To provide a system for installing and storing a traction operating table for lower limb joint surgery, the system enabling a traction operating table for lower limb joint surgery to be more easily installed on an operating table main body. [Solution] A traction operating table for lower limb joint surgery according to an aspect of the present invention comprises: a main frame part provided with a main frame having two rod-shaped members; a position adjusting part provided with a moving frame that is movable, and a foot fixing portion for fixing a foot; and a supporting leg part joined to the position adjusting part to support the main frame part, and capable of adjusting the incline of the main frame part. The position adjusting part includes a grip portion cap able of setting, by one gripping action, a first mode in which a moving action along the main frame and an incline adjusting action of the supporting leg part are fixed; a second mode in which the moving action along the main frame is released and the incline adjusting action of the supporting leg part is fixed; and a third mode in which the moving action along the main frame and the incline adjusting action of the supporting leg part are released.
Fujikura Ltd and Chiba University | Date: 2017-09-13
The present inventors have surprisingly found that a deoxyhypusine synthase (DHPS) gene, which was previously reported to correlate with prostate cancer and cervical cancer, is highly responsive to arteriosclerosis or digestive system cancer, whereby the gene can be used as a desired marker for arteriosclerosis or digestive system cancer. The present invention has been accomplished on the basis of this finding. Specifically, the present invention provides a method for determining arteriosclerosis or digestive system cancer, which method includes detecting expression of a deoxyhypusine synthase gene in a test sample (preferably a blood sample), and determining arteriosclerosis or digestive system cancer of a test subject from which the test sample has been obtained, on the basis of an increase in the gene expression as an index.
Hashimoto K.,Chiba University
Progress in Neurobiology | Year: 2013
Epidemiological studies have demonstrated a close relationship between depression and cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) contributes to this relationship, the detailed mechanisms involved in this process remain unclear. Recent studies suggest that the endoplasmic reticulum (ER) molecular chaperone sigma-1 receptor and brain-derived neurotrophic factor (BDNF) play a role in the pathophysiology of CVD and depression. Several meta-analysis studies have showed that levels of BDNF in the blood of patients with major depressive disorder (MDD) are lower than normal controls, indicating that blood BDNF might be a biomarker for depression. Furthermore, blood levels of BDNF in patients with CVD are also lower than normal controls. A recent study using conditional BDNF knock-out mice in animal models of myocardial infarction highlighted the role of CNS-mediated mechanisms in the cardioprotective effects of BDNF. In addition, a recent study shows that decreased levels of sigma-1 receptor in the mouse brain contribute to the association between heart failure and depression. Moreover, sigma-1 receptor agonists, including the endogenous neurosteroid dehydroepiandosterone (DHEA) and the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, show potent cardioprotective and antidepressive effects in rodents, via sigma-1 receptor stimulation. Interestingly, agonist activation of sigma-1 receptors increased the secretion of mature BDNF from its precursor proBDNF via chaperone activity in the ER. Given the role of ER stress in the pathophysiology of CVD and MDD, the author will discuss the potential link between sigma-1 receptors and BDNF-TrkB pathway in the pathophysiology of these two diseases. Finally, the author will make a case for potent sigma-1 receptor agonists and TrkB agonists as new potential therapeutic drugs for depressive patients with CVD. © 2012 Elsevier Ltd.