Chiba Prefectural Sawara Hospital

Katori-shi, Japan

Chiba Prefectural Sawara Hospital

Katori-shi, Japan
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Koda K.,Teikyo University | Miyauchi H.,Chiba University | Kosugi C.,Teikyo University | Kaiho T.,Kimitsu Chuo Hospital | And 4 more authors.
Anticancer Research | Year: 2016

Background: It has not been elucidated whether the clinical efficacy of oral fluoropyrimidines for adjuvant chemotherapy of colorectal cancer varies with tumor biological characteristics. Patients and Methods: A multicenter randomized trial was performed comparing oral tegafur/gimeracil/oteracil (S-1) and uracil-tegafur/ leucovorin (UFT/LV) as adjuvant therapy for stage III colorectal cancer. Postoperative survival was compared based on the 5-FUrelated mRNA levels in cancer tissues. Results: Among patients with tumor expressing dihydropyrimidine dehydrogenase (DPD) mRNA within the 66.7th percentile (lower 2/3) of all cases, overall survival (OS) was significantly better in the S-1 than in the UFT/LV group. In the S-1 group, patients with low DPD-expressing tumors had significantly better OS than those with highly expressing tumors. Patients with low thymidine synthase (TS)-expressing tumors had significantly better OS than those with highly expressing tumors. Conclusion: The efficacy of oral fluoropyrimidines as adjuvant chemotherapy for colorectal cancer may be influenced by the level of 5-FUrelated mRNA in cancer tissues.


PubMed | Chiba Prefectural Sawara Hospital, Chiba Prefectural Cancer Center, Funabashi Municipal Medical Center, Kimitsu Chuo Hospital and 2 more.
Type: Journal Article | Journal: Anticancer research | Year: 2016

It has not been elucidated whether the clinical efficacy of oral fluoropyrimidines for adjuvant chemotherapy of colorectal cancer varies with tumor biological characteristics.A multicenter randomized trial was performed comparing oral tegafur/gimeracil/oteracil (S-1) and uracil-tegafur/ leucovorin (UFT/LV) as adjuvant therapy for stage III colorectal cancer. Postoperative survival was compared based on the 5-FU-related mRNA levels in cancer tissues.Among patients with tumor expressing dihydropyrimidine dehydrogenase (DPD) mRNA within the 66.7th percentile (lower 2/3) of all cases, overall survival (OS) was significantly better in the S-1 than in the UFT/LV group. In the S-1 group, patients with low DPD-expressing tumors had significantly better OS than those with highly expressing tumors. Patients with low thymidine synthase (TS)-expressing tumors had significantly better OS than those with highly expressing tumors.The efficacy of oral fluoropyrimidines as adjuvant chemotherapy for colorectal cancer may be influenced by the level of 5-FU-related mRNA in cancer tissues.


Hayashi H.,University of Fukui | Tokuriki S.,University of Fukui | Okuno T.,University of Fukui | Shigematsu Y.,University of Fukui | And 4 more authors.
Pediatrics International | Year: 2014

Amino acid formulas and hydrolyzed formulas given to infants in Japan with milk allergies theoretically contain little, if any, biotin and carnitine. We assessed biotin and carnitine insufficiency in six infants with milk allergy who were fed amino acid formulas and/or hydrolyzed formulas, by measuring urine 3-hydroxyisovaleric acid (3-HIA) and serum free carnitine (C0), respectively. All patients presented with elevated urine 3-HIA and lowered serum C0 compared with post-menstrual age-matched infants who were fed breast milk or standard infant formulas. Supplementation with biotin and l-carnitine immediately improved the insufficiency. Care should be taken to avoid biotin and carnitine deficiency in allergic infants fed amino acid or hydrolyzed formulas. © 2014 Japan Pediatric Society.


Kurata Y.,Chiba University | Suzuki K.,Chiba University | Miyauchi H.,Chiba University | Ohira G.,Chiba University | And 6 more authors.
Japanese Journal of Gastroenterological Surgery | Year: 2015

A 67-year-old man experienced anal pain, and a cystic tumor in the presacral region was pointed out. Part of the tumor was extracted, and it was diagnosed to be benign cystic adenoma. The remaining tumor increased in size after the operation. Seven years later, a cystic tumor with a maximum diameter of 115 mm was observed, and the CEA level was 18.6 ng/ml. A malignant tumor was strongly suspected, so we performed a transsacral abdominoperineal resection with distal sacrectomy. The pathological findings revealed a cystic tumor lined by a columnar epithelium which contained mucinous cystic adenocarcinoma. The patient has exhibited no signs of recurrence in the three years since the operation. A literature search revealed other cases that were diagnosed to have tail gut cysts that contained a malignant tumor. Each case underwent a surgical resection, and no recurrence has been reported. © 2015 The Japanese Society of Gastroenterological Surgery.


Nonaka H.,Chiba Prefectural Sawara Hospital | Tsuchiya K.,Chiba Prefectural Sawara Hospital | Kitazaki H.,Chiba Prefectural Sawara Hospital | Yoneda M.,Chiba Prefectural Sawara Hospital | Arai G.,Chiba Prefectural Sawara Hospital
Chiba Medical Journal | Year: 2013

Bisphosphonates, which possess powerful bone resorption inhibition effect, are widely used as the first choice in the treatment and prevention of osteoporosis. Recently, femoral fractures have been shown to occur in patients who underwent long-term bisphosphonate therapy. These fractures, which extend from below the trochanter to the diaphyseal femur, are called atypical femoral fractures (AFF). We examined the cases of surgeries performed at our hospital for AFF occurring because of long-term bisphosphonate use in terms of the following: cause of fracture, bisphosphonate type, administration period, prodromes, marrow ossification, and bone density. The subjects were 5 patients (6 limbs). All the subjects had been using bisphosphonates for 5 years or more and had fractures due to slight injuries. Many patients presented with marked ossification at the fracture site, which required a special approach during surgery. The postoperative outcomes were favorable in all cases. Caution should be exercised when treating osteoporosis patients, especially when prescribing long-term bisphosphonate therapy. Further, drug withdrawal or change of drugs need to be considered for patients who have been taking the drug for 5 years or more.


Kakuta S.,Chiba Prefectural Sawara Hospital | Takayama W.,Chiba Prefectural Sawara Hospital | Kou T.,Chiba Prefectural Sawara Hospital | Satou M.,Chiba Prefectural Sawara Hospital | Sugaya M.,Chiba Prefectural Sawara Hospital
Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2016

We report a case of descending colon adenocarcinoma with neuroendocrine differentiation that was effectively treated with FOLFIRI plus bevacizumab. A 70-year-old man underwent a colonoscopy and was found to have a type 2 tumor of the descending colon. A well-to-moderately differentiated adenocarcinoma was diagnosed by biopsy. A preoperative CT scan showed paraaortic lymph node and liver metastasis, and that the tumor was directly invading the spleen. The patient underwent a left hemicolectomy with resection of the pancreas tail, spleen, and diaphragm. The pathological diagnosis was adenocarcinoma with less than 30% neuroendocrine differentiation in the primary tumor and almost 100% neuroendocrine differentiation in the metastatic lymph nodes. After surgery, FOLFIRI plus bevacizumab treatment was initiated. After 33 treatment cycles, the paraaortic lymph node and liver metastasis disappeared and the patient has remained progression-free to date. Adenocarcinoma with neuroendocrine differentiation of the colon is rare and an effective chemotherapy has not yet been established. We report this case with a review of the literature.


Yanagibashi H.,Chiba Prefectural Sawara Hospital | Takayama W.,Chiba Prefectural Sawara Hospital | Yoneyama Y.,Chiba Prefectural Sawara Hospital | Kakuta S.,Chiba Prefectural Sawara Hospital | And 2 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2015

A 62-year-old man was admitted to our hospital because of appetite loss. Computed tomography (CT) revealed thickness of the gastric wall, multiple liver tumors, and lung nodes. Upper gastrointestinal endoscopy revealed an easy bleeding type 2 tumor at the gastric antrum. We performed distal gastrectomy to control bleeding from the gastric tumor. Histological findings from the gastric lesion indicated primary gastric choriocarcinoma (PCG). Combination chemotherapy using hepatic arterial infusion chemotherapy for synchronous liver metastases and S-1 was administered for 5 months after the operation. CT revealed that the liver metastases decreased remarkably. On the other hand, lung metastases increased. Irinotecan and cisplatin were administered. Liver metastases did not increase, as observed using imaging studies. The patient died 17 months after the operation for cachexia. PCG is a highly aggressive tumor that is often associated with liver metastasis. It is important to control liver metastasis from PCG.


Yanagibashi H.,Chiba Prefectural Sawara Hospital | Takayama W.,Chiba Prefectural Sawara Hospital | Yoneyama Y.,Chiba Prefectural Sawara Hospital | Kakuta S.,Chiba Prefectural Sawara Hospital | And 2 more authors.
Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2015

A 62-year-old man was admitted to our hospital because of appetite loss. Computed tomography(CT)revealed thickness of the gastric wall, multiple liver tumors, and lung nodes. Upper gastrointestinal endoscopy revealed an easy bleeding type 2 tumor at the gastric antrum. We performed distal gastrectomy to control bleeding from the gastric tumor. Histological findings from the gastric lesion indicated primary gastric choriocarcinoma(PCG). Combination chemotherapy using hepatic arterial infusion chemotherapy for synchronous liver metastases and S-1 was administered for 5 months after the operation. CT revealed that the liver metastases decreased remarkably. On the other hand, lung metastases increased. Irinotecan and cisplatin were administered. Liver metastases did not increase, as observed using imaging studies. The patient died 17 months after the operation for cachexia. PCG is a highly aggressive tumor that is often associated with liver metastasis. It is important to control liver metastasis from PCG.


Kou T.,Chiba Prefectural Sawara Hospital | Takayama W.,Chiba Prefectural Sawara Hospital | Nishimori T.,Chiba Prefectural Sawara Hospital | Kakuta S.,Chiba Prefectural Sawara Hospital | And 3 more authors.
Japanese Journal of Gastroenterological Surgery | Year: 2013

Total gastrectomy was performed on a 79-year-old man for early gastric cancer in October 2005. Small cell carcinoma of the stomach was diagnosed based on findings of neuroendocrine characteristics on immunopathological and histopathological examination. Abdominal CT showed a tumor 4 cm diameter in S4 of the liver six months later. Angiographic examination showed a hypervascular tumor in S4 of the liver, from small cell carcinoma of the stomach was diagnosed. No other recurrences were seen, so partial resection of S4 of the liver was performed in May 2006. Metastasis to the liver from small cell carcinoma of the stomach was diagnosed by immunopathological and histopathological examination. Now he is alive and there has been no other recurrence for 6.6 years from the first operation. © 2013 The Japanese Society of Gastroenterological Surgery.

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