Hsieh P.-J.,Chia Nan University of Pharmacy and Science
International Journal of Medical Informatics | Year: 2015
Purpose: Cloud computing technology has recently been seen as an important milestone in medical informatics development. Despite its great potential, there are gaps in our understanding of how users evaluate change in relation to the health cloud and how they decide to resist it. Integrating technology acceptance and status quo bias perspectives, this study develops an integrated model to explain healthcare professionals' intention to use the health cloud service and their intention to resist it. Methods: A field survey was conducted in Taiwan to collect data from healthcare professionals; a structural equation model was used to examine the data. A valid sample of 209 healthcare professionals was collected for data analysis. Results: The results show that healthcare professionals' resistance to the use of the health cloud is the result of regret avoidance, inertia, perceived value, switching costs, and perceived threat. Attitude, subjective norm, and perceived behavior control are shown to have positive and direct effects on healthcare professionals' intention to use the health cloud. The results also indicate a significant negative effect in the relationship between healthcare professionals' intention and resistance to using the health cloud. Conclusion: Our study illustrates the importance of incorporating user resistance in technology acceptance studies in general and in health technology usage studies in particular. This study also identifies key factors for practitioners and hospitals to make adoption decisions in relation to the health cloud. Further, the study provides a useful reference for future studies in this subject field. © 2015 Elsevier Ireland Ltd.
Hsieh P.-J.,Chia Nan University of Pharmacy and Science
International Journal of Medical Informatics | Year: 2015
Purpose: Electronic medical records (EMRs) exchange improves clinical quality and reduces medical costs. However, few studies address the antecedent factors of physicians' intentions to use EMR exchange. Based on institutional trust and perceived risk integrated with the decomposed theory of planned behavior (TPB) model, we propose a theoretical model to explain the intention of physicians to use an EMR exchange system. Methods: We conducted a field survey in Taiwan to collect data from physicians who had experience using the EMR exchange systems. A valid sample of 191 responses was collected for data analysis. To test the proposed research model, we employed structural equation modeling using the partial least squares method. Results: The study findings show that the following five factors have a significant influence on the physicians' intentions to use EMR exchange systems: (a) attitude; (b) subjective norm; (c) perceived behavior control; (d) institutional trust; and (e) perceived risk. These five factors are predictable by perceived usefulness, perceived ease of use, and compatibility, interpersonal and governmental influence, facilitating conditions and self-efficacy, situational normality and structural assurance, and institutional trust, respectively. The results also indicate that institutional trust and perceived risk integrated with the decomposed TPB model improve the prediction of physician's intentions to use EMR exchange. Conclusion: The results of this study indicate that our research model effectively predicts the intention of physicians to use EMR exchange, and provides valuable implications for academics and practitioners. © 2014 Elsevier Ireland Ltd.
Hou C.-K.,Chia Nan University of Pharmacy and Science
International Journal of Information Management | Year: 2012
The advent of new information technology has radically changed the end-user computing environment over the past decade. To enhance their management decision-making capability, many organizations have made significant investments in business intelligence (BI) systems. The realization of business benefits from BI investments depends on supporting effective use of BI systems and satisfying their end user requirements. Even though a lot of attention has been paid to the decision-making benefits of BI systems in practice, there is still a limited amount of empirical research that explores the nature of end-user satisfaction with BI systems. End-user satisfaction and system usage have been recognized by many researchers as critical determinants of the success of information systems (IS). As an increasing number of companies have adopted BI systems, there is a need to understand their impact on an individual end-user's performance. In recent years, researchers have considered assessing individual performance effects from IS use as a key area of concern. Therefore, this study aims to empirically test a framework identifying the relationships between end-user computing satisfaction (EUCS), system usage, and individual performance. Data gathered from 330 end users of BI systems in the Taiwanese electronics industry were used to test the relationships proposed in the framework using the structural equation modeling approach. The results provide strong support for our model. Our results indicate that higher levels of EUCS can lead to increased BI system usage and improved individual performance, and that higher levels of BI system usage will lead to higher levels of individual performance. In addition, this study's findings, consistent with DeLone and McLean's IS success model, confirm that there exists a significant positive relationship between EUCS and system usage. Theoretical and practical implications of the findings are discussed. © 2012 Elsevier Ltd. All rights reserved.
Liang C.-H.,Chia Nan University of Pharmacy and Science
Experimental Dermatology | Year: 2011
Ov-16 (4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside), a polyphenolic glycoside that is isolated from oregano (Origanum vulgare L.), can scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. This investigation is the first to study in detail the hypopigmentary properties of Ov-16. It demonstrates that 0-1000μg/ml Ov-16 inhibits the activity of mushroom tyrosinase (Tyr) in a concentration-dependent manner. The inhibitionary Tyr kinetics of Ov-16 towards the oxidation of L-DOPA was found to be uncompetitive. Following the treatment of human skin premalignant kerationcyte HaCaT cells, human skin fibroblast Hs68 cells and mice melanoma B16 cells with Ov-16 (0-100μg/ml), cell viability was >98%, suggesting that Ov-16 is non-toxic. Ov-16 can reduce cellular Tyr activity, DOPA oxidase activity and melanin synthesis in B16 cells that are stimulated by the α-melanocyte-stimulating hormone (α-MSH). Moreover, Ov-16 inhibited the production of melanin in Streptomyces bikiniensis without affecting the growth of the microorganism. The treatment of B16 cells with Ov-16 considerably reduced the gene expressions of melanocortin-1 receptor (Mc1r), microphthalmia-associated transcription factor (Mitf), Tyr, tyrosinase-related proteins-2 (Trp-2) and Trp-1, as determined by RT-PCR. The expressions of Mc1r, Mift, Tyr, Trp-2 and TrpP-1 protein in Ov-16-treated B16 cells were also significantly reduced, as determined by western blotting and fluorescent staining analysis. These results suggest that Ov-16 exhibits hypopigmentary performance. © 2011 John Wiley & Sons A/S.
Kou M.C.,Chia Nan University of Pharmacy and Science
Food & function | Year: 2013
Epidemiological and animal studies point to a possible protective effect of citrus flavonoids against cardiovascular diseases. The aim of this study is to investigate the effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF) and 3,5,6,7,8,3',4'-heptamethoxyflavone (HpMF), on the activities and expressions of macrophage scavenger receptors and the hepatic LDL receptor. Treatment of HpMF (20 μM) during THP-1 differentiation successfully attenuated 12-myristate 13-acetate (PMA)-mediated DiI-labeled oxidized low-density lipoprotein (oxLDL) uptake as evidenced by flow cytometry, indicating that the functions of scavenger receptors were blocked. RT-Q-PCR analysis suggests that the decrease in oxLDL uptake was due to the down-regulation of PMA-induced SR-A mRNA expression. In terminally differentiated THP-1 macrophages, 5-OH-HxMF and HpMF could significantly reduce DiI-oxLDL uptake, with the former having a greater effect. 5-OH-HxMF attenuated oxLDL-mediated CD36 and SR-A expression; while HpMF only decreased CD36 expression. The effects of these two flavonoids on the activity and expression of the hepatic LDL receptor (LDLR) were further investigated in HepG2 cells. 5-OH-HxMF (10-20 μM) enhanced DiI-LDL uptake by 1.33-fold due to the enhanced LDLR expression. These results imply that HpMF is better at inhibiting PMA-induced oxLDL uptake during THP-1 differentiation, while 5-OH-HxMF is more powerful in attenuating oxLDL-induced scavenger receptor expression and activity in terminally differentiated THP-1 macrophages. Furthermore, 5-OH-HxMF may have hypolipidemic activity due to its up-regulating hepatic LDLR expression.
Wang J.C.,Chia Nan University of Pharmacy and Science
Energy and Buildings | Year: 2012
This study presents a discussion on the energy performance of hotel buildings in Taiwan. Energy consumption data, building information, and other operations data were collected from 45 Taiwanese international tourist hotels, 19 standard tourist hotels, 116 hotel enterprises, and 20 bed and breakfast facilities. The energy use intensity (EUI) of the 4 rated hotels is 280.1, 237.7, 186.3, and 143.6 kWh/m 2/year. Mean energy consumption per guest room at the 4 rated hotels is 26.7, 25.0, 14.6, and 9.4 MWh/room/year. Electricity predominantly comprises total energy consumption, which accounts for 84% of total energy on average. Pearson correlations between EUI and possible explanatory indicators revealed that certain building conditions, operations, and other factors are significant. Two regression models were established to predict annual energy consumption and EUI, and gross floor area, number of guest rooms, occupancy rate, and building construction year were selected as independent variables. The coefficient of the adjusted R 2 is 0.928 and 0.612, which implies reliability. This study provides managerial suggestions according to the results for improving hotel energy performance. © 2012 Elsevier B.V. All rights reserved.
Hong C.-W.,Chia Nan University of Pharmacy and Science
Expert Systems with Applications | Year: 2012
This study proposes a clustering method based on Taguchi method for effective market segmentation. To select appropriate initial seeds, we propose the use of Taguchi method as the tools. This study compares the results of the proposed a Self-Organizing Map (SOM) for application to a real-world case of tea-beverage market segmentation. The results show that the proposed Taguchi method may improve segmentation performance. © 2011 Elsevier Ltd. All rights reserved.
Chou S.-F.,Chia Nan University of Pharmacy and Science
Analyst | Year: 2013
Interferons (IFNs) play a role in inhibition of tumor growth and participate in immunoreactions. Among IFNs, interferon-γ (IFNγ) is one of the most important therapeutic proteins and its immunodulation ability is better than that of other types. The objective of this study is to develop a manual self-assembled colloidal gold nanoparticle-immunochromatographic strip for human IFNγ using anti-human IFNγ polyclonal and monoclonal antibodies. Colloidal gold with a 25 nm diameter was made from chloroauric acid (HAuCl4), and labeled on anti-IFNγ mAbs as a chrominance reagent. A good linear relationship existed between the pixel intensity and the human IFNγ concentrations from 10-1000 ng mL-1 in mouse serum and buffer, respectively, the regression equation was Y = 0.159logX + 0.0648, R2 = 0.992 in mouse serum; Y = 0.294logX + 0.091, R2 = 0.9969 in phosphate buffer by this proposed strip. Moreover, in the determination for mouse serum samples no cross-reaction occurred and the detection time was approximately 10 minutes. The shelf life of the strip was above 28 days at room temperature. The major advantages of the manual operation model were no expensive instruments and less reagents required. This proposed strip was highly specific, economic, convenient, and no machine was needed in clinical diagnosis. This journal is © 2013 The Royal Society of Chemistry.
Ding H.-Y.,Chia Nan University of Pharmacy and Science
International Journal of Molecular Sciences | Year: 2011
The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of the fruits of Rubus chingii was studied in vitro. Ethanolic extract, ethyl acetate and n-butanol fractions from dried R. chingii fruits revealed strong DPPH free radical scavenging activity with IC 50 values of 17.9, 3.4 and 4.0 μg/mL, respectively. The ethyl acetate and n-butanol fractions were further purified by a combination of silica gel chromatography, Lobar RP-8 chromatography, and high-pressure liquid chromatography (HPLC). Nine compounds were isolated, where methyl (3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)-acetate (2), vanillic acid (5), kaempferol (7), and tiliroside (9) showed stronger DPPH free radical scavenging activity than that of ascorbic acid (131.8 μM) with IC 50 values of 45.2, 34.9, 78.5, and 13.7 μM, respectively. In addition, rubusine (1) is a new compound discovered in the present study and methyl (3-hydroxy-2-oxo-2,3-dihydroindol-3-yl)-acetate (2), methyl dioxindole-3-acetate (3), and 2-oxo-1,2-dihydroquinoline-4-carboxylic acid (4) were isolated from the fruits for the first time. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Chia Nan University of Pharmacy and Science | Date: 2012-03-21
An immunomodulatory isolated Lactobacillus strain is disclosed. The isolated Lactobacillus strain (accession No. CCTCC M 2011279) is purified from plant fermentation products. The isolated Lactobacillus strain, whatever itself or the composition including the same, can specifically enhance the amount of nitric oxide (NO), tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), and also specifically enhance phagocytosis of macrophages, thereby enhancing the immunomodulatory ability of a host. Moreover, the isolated Lactobacillus strain of the present invention itself, or a food or its ingredient, a food supplement or a medical composition including the isolated Lactobacillus strain, can enhance the immunomodulatory ability by oral administration.