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Gururajan P.,A Unit of Frontier Lifeline Private Ltd | Gurumurthy P.,A Unit of Frontier Lifeline Private Ltd | Nayar P.,Chettinad Hospitals and Research Institute | Srinivasa Nageswara Rao G.,Tagore Medical College | And 3 more authors.
Indian Heart Journal | Year: 2012

Aims and objectives: Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. Methods and results: Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and nonischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P < 0.0001). The cut-off value from the ROC curve was 0.55 μg/ mL above which PAPP-A was considered to be positive. Conclusion: Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS. © 2012, Cardiological Society of India. All rights reserved. Source


Mohammed H.,Chettinad Hospitals and Research Institute | Sandeep U.,Chettinad Hospitals and Research Institute | Mathangi K.,Chettinad Hospitals and Research Institute | Premalatha S.,Chettinad Hospitals and Research Institute
Biomedicine (India) | Year: 2012

Thyrotoxicosis in Multinodular goitre is usually associated with benign lesions. Hyperthyroidism is thus a rare manifestation of thyroid malignancy. It is usually seen in association with metastatic lesions. Papillary carcinoma is commonly associated with metastasis and presents as solitary nodule. A rare case of papillary carcinoma of thyroid in a patient presenting with multinodular goitre with thyrotoxicosis is discussed in this case report. Source


Sandeep U.,Chettinad Hospitals and Research Institute | Habeeb M.,Chettinad Hospitals and Research Institute | Mathangi K.,Chettinad Hospitals and Research Institute | Karunanithi R.,Chettinad Hospitals and Research Institute
Biomedicine (India) | Year: 2012

Breast tuberculosis is one of the uncommon manifestations of tuberculosis. It commonly presents as lump or as a discharging sinus. Histopathology and imaging remain the main stay for diagnosis. Primary breast tuberculosis is commonly treated with the standard Anti tuberculosis treatment (ATT) regimen. A case of primary breast tuberculosis treated surgically is discussed in this case report. Source


Lakshmipathy prabhu R.,Chettinad Hospitals and Research Institute | Ruckmani A.,Chettinad Hospitals and Research Institute | Venkatesan D.,Chettinad Hospitals and Research Institute | Madhusudhanan N.,Chettinad Hospitals and Research Institute | Pavithra R.,Chettinad Hospitals and Research Institute
Homeopathy | Year: 2012

Background: The homeopathic preparation of . Pulsatilla nigricans is used in the treatment of anxiety related disorders. Though in clinical use for many years, the anxiolytic activity of . Pulsatilla nigricans (. Puls) has not been evaluated experimentally. Hence the present study was conducted in Swiss albino mice to evaluate the anxiolytic activity of . Puls and compare its activity with the standard anxiolytic drug, diazepam. Methods: Twenty four mice were divided into 4 groups of 6 animals each, control, standard and two test groups. The control group was treated Ethyl alcohol 10. ml/kg. The standard group received Diazepam, 1. mg/kg. . Puls 3x and 6x solutions were given at the dose of 10. ml/kg to the test groups. All animals were given the test and control treatments orally for 15 days. The anxiolytic effect was tested on days 1, 8 and 15 using the Elevated Plus Maze (EPM) and Open Field Test (OFT). Results: Both diazepam and . Puls showed significant anxiolytic activity in EPM and OFT test compared to control. The total number of entries and time spent in open arm in EPM was increased by both diazepam and . Puls, the effect of 3x dilution of . Puls was greater than diazepam.In the OFT the number of squares crossed, rearing and assisted rearings decreased with both diazepam and . Puls compared to control and the anxiolytic effect of diazepam was greater than Puls. The anxiolytic effect is greater for the 3x dilution than 6x dilution of Puls. Conclusion: The study showed an anxiolytic effect of homeopathic preparation of . Pulsatilla nigricans comparable to that found with a standard drug. © 2012 The Faculty of Homeopathy. Source


Ruckmani A.,Chettinad Hospitals and Research Institute | Nayar P.G.,Chettinad Hospitals and Research Institute | Konda V.G.R.,Chettinad Hospitals and Research Institute | Madhusudhanan N.,Chettinad Hospitals and Research Institute | And 4 more authors.
Research Journal of Environmental Toxicology | Year: 2011

The adverse effects of spraying pesticides to the ecosystem are being widely studied. While the effects of their oral and topical exposure have been reported, especially on carbohydrate metabolism, the effects of inhalational exposure have not been reported. Hence, this study was undertaken to investigate the effects of malathion, a commonly used pesticide, on blood glucose and antioxidant status in rats. In acute study, 8 groups of 6 animals each were exposed to 50% malathion for 5 min. Blood glucose level was estimated for all the rats before exposure and at 5, 10, 20, 30, 60 120, 180 and 240 min after exposure for groups 1 to 8, respectively. Blood glucose increased from the basal level of 88 mg dL -1, reached 131 mg dL -1 in 60 min and attained basal level at 240 min. In sub chronic study, there were two groups of 6 animals each control and test. Test group was exposed to malathion vapours for 5 min every day for 28 days. Glucose level was estimated on days 0, 7, 14, 21 and 28 for both groups. The base line value of 93 mg dL -1 increased to 178 mg dL -1 on day 28 in test group. Test animals also showed weight loss of 9.2% and significant reduction of anti oxidants level compared to control group. Thus acute malathion exposure has caused transient hyperglycemia and sub chronic exposure, progressive hyperglycemia (p<0.05) and weight loss. In conclusion, sub chronic malathion exposure causes progressive hyperglycemia which can be a risk factor for diabetes. © 2011 Academic Journals Inc. Source

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